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https://www.readbyqxmd.com/read/29151033/induction-of-dendritic-cell-mediated-activation-of-t-cells-from-atherosclerotic-plaques-by-human-heat-shock-protein-60
#1
Mizanur Rahman, Johnny Steuer, Peter Gillgren, Assim Hayderi, Anquan Liu, Johan Frostegård
BACKGROUND: Atherosclerosis is characterized by the presence of activated immune-competent cells including dendritic cells (DCs) and T cells, dead cells, and oxidized low-density lipoprotein. HSP60 (Heat shock protein 60) has been implicated in atherosclerosis. A plasma protein, Annexin A5, has atheroprotective properties. METHODS AND RESULTS: Human DCs differentiated from peripheral blood monocytes were treated with human HSP60 or HSP90 and autologous T cells were cocultured with these pretreated DCs (mDCs)...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29151031/significant-association-between-low-mitochondrial-dna-content-in-peripheral-blood-leukocytes-and-ischemic-stroke
#2
Li-Ming Lien, Hung-Yi Chiou, Hsu-Ling Yeh, Shang-Yen Chiu, Jiann-Shing Jeng, Huey-Juan Lin, Chaur-Jong Hu, Fang-I Hsieh, Yau-Huei Wei
BACKGROUND: Cumulative evidence has shown that low mitochondrial DNA (mtDNA) content is related to elevated oxidative stress and atherosclerosis, which play important roles in ischemic stroke. The objective of this study was to explore the association between mtDNA content in peripheral blood leukocytes and ischemic stroke. METHODS AND RESULTS: A total of 350 patients with first-ever ischemic stroke and 350 healthy controls were recruited in this case-control study...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29151018/study-of-the-nlrp3-inflammasome-component-genes-and-downstream-cytokines-in-patients-with-type-2-diabetes-mellitus-with-carotid-atherosclerosis
#3
Junli Lee, Jing Wan, Linyun Lee, Changhua Peng, Hailong Xie, Chengbin Lee
BACKGROUND: A role for the NLRP3 inflammasome has been reported in various diseases, such as diabetes mellitus, atherosclerosis (AS), nephropathy, rheumatism, and others, although limited information is available concerning the role of the NLRP3 inflammasome, interleukin-1β (IL-1β) and interleukin-18 (IL-18) in patients with type 2 diabetes mellitus (T2DM) and carotid atherosclerosis (CAS). Therefore, this cross-sectional study investigated these inflammatory components in patients with T2DM complicated with carotid atherosclerosis (T2DM + CAS)...
November 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29150750/technical-considerations-for-quantification-of-18-f-fdg-uptake-in-carotid-atherosclerosis
#4
EDITORIAL
Sina Tavakoli
No abstract text is available yet for this article.
November 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29150407/disease-trends-over-time-and-cd4-ccr5-t-cells-expansion-predict-carotid-atherosclerosis-development-in-patients-with-systemic-lupus-erythematosus
#5
A Baragetti, G A Ramirez, M Magnoni, K Garlaschelli, L Grigore, M Berteotti, I Scotti, E Bozzolo, A Berti, P G Camici, A L Catapano, A A Manfredi, E Ammirati, G D Norata
BACKGROUND AND AIM: Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies have assessed the long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the association of clinical and laboratory markers of disease activity and classical cardiovascular risk factors (CVRF) with carotid atherosclerosis development in SLE patients in a prospective 5-year study...
September 18, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29150341/increased-prevalence-of-clinical-and-subclinical-atherosclerosis-in-patients-with-damaging-mutations-in-abca1-or-apoa1
#6
Omar Abdel-Razek, Singh N Sadananda, Xuan Li, Lubomira Cermakova, Jiri Frohlich, Liam R Brunham
BACKGROUND: A low level of high-density lipoprotein cholesterol (HDL-C) is a common clinical scenario and poses challenges for management. Many patients with low HDL-C harbor a damaging mutation in ABCA1 or APOA1, but the clinical implications of genetic testing for these mutations are unclear. OBJECTIVE: The purpose of this study was to investigate the prevalence of clinical or subclinical atherosclerosis among patients with low HDL-C due to a mutation in ABCA1 or APOA1, compared with patients with low HDL-C without such a mutation...
November 10, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29150290/premature-atherosclerosis-in-premenopausal-women-does-cytokine-balance-play-a-role
#7
Jo-Ann Eastwood, Doris A Taylor, B Delia Johnson, Micheline Resende, Barry L Sharaf, Bina Ahmed, Margo Minissian, Chrisandra Shufelt, Noel Bairey Merz
Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the profile of circulating cytokines reflects both endothelial integrity and the presence of immune and progenitor cells. Significant differences in pro- and anti-inflammatory cytokine concentrations between patients with and without CAD exist...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29150207/carotid-and-femoral-atherosclerosis-in-antiphospholipid-syndrome-equivalent-risk-with-diabetes-mellitus-in-a-case-control-study
#8
Evrydiki Kravvariti, George Konstantonis, Nikolas Tentolouris, Petros P Sfikakis, Maria G Tektonidou
BACKGROUND: Antiphospholipid syndrome (APS) may carry a worse prognosis for vascular complications when co-existing with subclinical atherosclerosis; however, the association between the two conditions remains ambiguous. METHODS: We evaluated ultrasonographic markers of subclinical atherosclerosis in carotid and femoral arteries of 86 patients with thrombotic APS [43 primary APS (PAPS), 43 systemic lupus erythematosus-associated APS (SLE/APS)], 86 patients with diabetes mellitus (DM) and 86 healthy controls, individually matched for age and gender, and investigated their associations with traditional and disease-related factors in APS...
October 23, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29149823/olive-oil-related-anti-inflammatory-effects-on-atherosclerosis-potential-clinical-implications
#9
Tanakal Wongwarawipat, Nikolaos Papageorgiou, Dimitrios Bertsias, Gerasimos Siasos, Dimitris Tousoulis
BACKGROUND AND OBJECTIVE: Atherosclerosis is characterized by a chronic low-grade inflammatory process which can result in atherothrombosis and a number of cardiovascular diseases (CVD). It is believed to be caused by multiple processes that involve inflammation and immunity. Mediterranean Diet (MedD) has been discovered to possess anti-inflammatory properties and associated with a reduction in the CVD risk and mortality. Its main component, extra-virgin olive oil (EVOO), is believed to be largely responsible for these effects and therefore, has been investigated in various studies...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149821/statins-therapy-for-connective-tissue-diseases-new-therapeutic-opportunities
#10
Przemyslaw J Kotyla, Eugene J Kucharz
Background and Objective Statins, 3-hydroxyl-3-methyl-glutharyl Coenzyme A reductase inhibitors showed their therapeutic potential in the treatment of atherosclerosis-related diseases. Recently, the properties of statins, separate from their lipid lowering activity have attracted much attention. These properties that cover a wide area of physiopathological activities including cell maturation, immune response regulation, tissue fibrosis, endothelial activity and are called pleiotropic activity. Many in vitro studies demonstrated significant, statins-dependent regulation of immune system reactivity, reduction of pro-inflammatory and pro-fibrotic cytokines as well as suppression of endothelial activity and damage...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149816/maternal-dyslipidaemia-in-pregnancy-with-gestational-diabetes-mellitus-possible-impact-in-the-foetoplacental-vascular-function-and-the-lipoprotein-in-the-neonatal-circulation
#11
Susana Contreras-Duarte, Lorena Carvajal, Barbara Fuenzalida, Claudette Cantin, Luis Sobrevia, Andrea Leiva
Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia in pregnancy). However, in some women pregnancy-associated dyslipidaemia exceeds this physiological adaptation. The consequences of this condition on the developing foetus include endothelial dysfunction of the foetoplacental vasculature and development of foetal aortic atherosclerosis. Gestational diabetes mellitus (GDM) associates with abnormal function of the foetoplacental vasculature due to foetal hyperglycaemia and hyperinsulinaemia, and associates with development of cardiovascular disease in adulthood...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29149184/health-effects-of-saturated-and-trans-fatty-acid-intake-in-children-and-adolescents-systematic-review-and-meta-analysis
#12
Lisa Te Morenga, Jason M Montez
BACKGROUND: Elevated cholesterol has been linked to cardiovascular disease in adults and preclinical markers of atherosclerosis in children, thus reducing saturated (SFA) and trans-fatty acids (TFA) intake from an early age may help to reduce cholesterol and the risk of cardiovascular disease later in life. The aim of this review is to examine the evidence for health effects associated with reducing SFA and TFA intake in free-living children, adolescents and young adults between 2 to 19 years of age...
2017: PloS One
https://www.readbyqxmd.com/read/29149179/postmenopausal-hormone-therapy-and-risk-of-stroke-a-pooled-analysis-of-data-from-population-based-cohort-studies
#13
Germán D Carrasquilla, Paolo Frumento, Anita Berglund, Christer Borgfeldt, Matteo Bottai, Chiara Chiavenna, Mats Eliasson, Gunnar Engström, Göran Hallmans, Jan-Håkan Jansson, Patrik K Magnusson, Peter M Nilsson, Nancy L Pedersen, Alicja Wolk, Karin Leander
BACKGROUND: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke risk. The importance of the route of administration, type, active ingredient, and duration of HT for stroke risk is also unclear...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29148412/psychological-comorbidities-associated-with-subclinical-atherosclerosis-in-greek-patients-with-primary-sj%C3%A3-gren-s-syndrome-a-potential-contribution-of-sleep-impairment
#14
Theofanis Karageorgas, Dimitrios Ioakeimidis, Clio P Mavragani
OBJECTIVES: Impaired sleep and psychological disorders are increasingly recognised as prevalent comorbidities in patients with primary Sjögren's syndrome (pSS), as well as important contributors of atherosclerosis in the general population. In the current study we sought to explore a potential role of psychological comorbidities in the pronounced atherosclerotic risk of pSS patients. METHODS: Fifty-nine pSS patients fulfilling the ACR/EULAR criteria completed specific validated questionnaires assessing fatigue, depression, anxiety and sleep disturbances...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148336/predictors-of-medication-adherence-in-the-elderly-the-role-of-mental-health
#15
Jo E Rodgers, Emily M Thudium, Hadi Beyhaghi, Carla A Sueta, Khalid A Alburikan, Anna M Kucharska-Newton, Patricia P Chang, Sally C Stearns
The aging population routinely has comorbid conditions requiring complicated medication regimens, yet nonadherence can preclude optimal outcomes. This study explored the association of adherence in the elderly with demographic, socioeconomic, and disease burden measures. Data were from the fifth visit (2011-2013) for 6,538 participants in the Atherosclerosis Risk in Communities Study, conducted in four communities. The Morisky-Green-Levine Scale measured self-reported adherence. Forty percent of respondents indicated some nonadherence, primarily due to poor memory...
March 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29148006/autogenous-forearm-loop-arteriovenous-fistula-creation
#16
Weng Jun Tang, Arman Zaharil Mat Saad
INTRODUCTION: Arteriovenous fistula is a lifeline for end-stage kidney disease patients on dialysis. The quality of the vein and artery to be used plays a crucial role in attaining a functioning, reliable and long-lasting arteriovenous fistula. The aim of the study is to present an alternative for haemodialysis access to preserve the upper arm vasculature for future use - the forearm loop arteriovenous fistula. METHODS: From October 2015 to September 2016, 202 patients with chronic kidney disease (CKD), stages 4 and 5, underwent arteriovenous fistula creation at the Universiti Sains Malaysia Hospital, Malaysia...
November 13, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29147907/protein-repair-from-glycation-by-glyoxals-by-the-dj-1-family-maillard-deglycases
#17
Mouadh Mihoub, Jad Abdallah, Gilbert Richarme
DJ-1 and its prokaryotic homologs, Hsp31, YhbO and YajL from Escherichia coli and PfpI from Pyrococcus furiosus, repair proteins from glycation by glyoxals (R-CO-CHO), which constitute their major glycating agents. Glycation is a non-enzymatic covalent reaction discovered by Louis Camille Maillard in 1912, between reactive carbonyls (reducing sugars and glyoxals) and amino acids (cysteine, arginine and lysine), which inactivates proteins. By degrading Maillard adducts formed between carbonyls and thiols or amino groups, the DJ-1 family Maillard deglycases prevent the formation of the so-called advanced glycation end products (AGEs) that arise from Maillard adducts after dehydrations, oxidations and rearrangements...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29147824/an-integrated-qsar-modeling-approach-to-explore-the-structure-property-and-selectivity-relationships-of-n-benzoyl-l-biphenylalanines-as-integrin-antagonists
#18
Sk Abdul Amin, Nilanjan Adhikari, Sonam Bhargava, Shovanlal Gayen, Tarun Jha
Integrins [Formula: see text] and [Formula: see text] are important targets to treat different inflammatory diseases, such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, atherosclerosis, and asthma. Despite being valuable targets, only a few work has been reported to date regarding molecular modeling studies on these integrins. Not only that, none of these reports addressed the selectivity issue between integrins [Formula: see text] and [Formula: see text]. Therefore, a major challenge regarding the design and discovery of selective integrin antagonists remains...
November 17, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/29147634/intracranial-ischemic-infarct-due-to-blunt-force-trauma-in-a-high-school-football-player
#19
Brandon I Esianor, Ali S Haider, Margaret I Engelhardt, Tijani Osumah, Steven Vayalumkal, Richa Thakur, Dean Leonard, Jeffrey Haithcock, Kennith F Layton
Ischemic stroke is an uncommon cause of death among teenagers and young adults; however, the etiologies differ when compared to ischemic strokes in older individuals. Large-vessel atherosclerosis and small-vessel disease causing ischemic stroke are rare for the teenage population, while cervicocerebral arterial dissections account for up to 20% of ischemic strokes. Here, we present the case of a 16-year-old male who developed internal carotid artery dissection (ICAD) after a head injury and subsequently developed ischemic stroke and seizures...
September 7, 2017: Curēus
https://www.readbyqxmd.com/read/29147127/association-between-abo-blood-group-and-severity-of-coronary-artery-disease-in-unstable-angina
#20
Negar Omidi, Mohammad Rafie Khorgami, Mohammad Effatpanah, Farnaz Khatami, Mehrpouya Mashhadizadeh, Arash Jalali, Hamidreza Hekmat
BACKGROUND: ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease. METHODS: Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated...
July 2017: ARYA Atherosclerosis
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