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Paired kidney exchange

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https://www.readbyqxmd.com/read/30063811/temporal-changes-in-the-composition-of-a-large-multicenter-kidney-exchange-clearinghouse-do-the-hard-to-match-accumulate
#1
Courtenay M Holscher, Kyle Jackson, Alvin G Thomas, Christine E Haugen, Sandra R DiBrito, Karina Covarrubias, Sommer E Gentry, Matthew Ronin, Amy D Waterman, Allan B Massie, Jacqueline Garonzik Wang, Dorry L Segev
One criticism of kidney paired donation (KPD) is that easy-to-match candidates leave the registry quickly, thus concentrating the pool with hard-to-match sensitized and blood type O candidates. We studied candidate/donor pairs who registered with the National Kidney Registry, the largest US KPD clearinghouse, from 1/2012-6/2016. There were no changes in age, gender, BMI, race, ABO, or PRA of newly registering candidates over time, with consistent registration of hard-to-match candidates (59% type O and 38% PRA‚Č•97%)...
July 31, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30028086/thiol-disulfide-exchange-reactions-in-human-serum-albumin-the-apparent-paradox-of-the-redox-transitions-of-cys-34
#2
Alessio Bocedi, Giada Cattani, Lorenzo Stella, Renato Massoud, Giorgio Ricci
Human serum albumin (HSA) is characterized by 17 disulfides and by only one unpaired cysteine (Cys34 ), which can be free in the reduced albumin or linked as a mixed disulfide with cysteine, or in minor amount with other natural thiols, in the oxidized albumin. In healthy subjects, the level of the oxidized form is about 35%, but it rises up to 70% after oxidative insults or in patients with kidney diseases. Oxidized albumin is therefore considered a short-term biomarker of oxidative stress as its level may increase or decrease under appropriate redox inputs in discrete temporal spans...
July 20, 2018: FEBS Journal
https://www.readbyqxmd.com/read/30019502/determination-of-four-main-components-of-gentamicin-in-animal-tissues-after-solid-phase-extraction-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#3
Congcong Zhang, Jian Hu, Fengmei Sun, Man Jia, Gang Chen, Cuiling Wu, Lufei Zheng
RATIONAL: An analysis method of gentamicin in animal tissues was developed and validated. The alkaline mobile phase with an HPH C8 column was selected so that all the four gentamicin components were retained and eluted without using fluorinated ion-pair reagents. METHODS: The method is sufficiently sensitive and highly selective, using a strong cation-exchange solid-phase cartridge (PCX) to clean up the samples. The different types of solid-phase extraction column and membrane were considered to obtain a high recovery...
July 17, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/30011934/accounting-for-fairness-in-a-two-stage-stochastic-programming-model-for-kidney-exchange-programs
#4
Hyunwoo Lee, Seokhyun Chung, Taesu Cheong, Sang Hwa Song
Kidney exchange programs, which allow a potential living donor whose kidney is incompatible with his or her intended recipient to donate a kidney to another patient in return for a kidney that is compatible for their intended recipient, usually aims to maximize the number of possible kidney exchanges or the total utility of the program. However, the fairness of these exchanges is an issue that has often been ignored. In this paper, as a way to overcome the problems arising in previous studies, we take fairness to be the degree to which individual patient-donor pairs feel satisfied, rather than the extent to which the exchange increases social benefits...
July 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29988896/kidney-exchange-transplantation-current-status-an-update-and-future-perspectives
#5
REVIEW
Vivek B Kute, Narayan Prasad, Pankaj R Shah, Pranjal R Modi
Kidney exchange transplantation is well established modality to increase living donor kidney transplantation. Reasons for joining kidney exchange programs are ABO blood group incompatibility, immunological incompatibility (positive cross match or donor specific antibody), human leukocyte antigen (HLA) incompatibility (poor HLA matching), chronological incompatibility and financial incompatibility. Kidney exchange transplantation has evolved from the traditional simultaneous anonymous 2-way kidney exchange to more complex ways such as 3-way exchange, 4-way exchange, n -way exchange,compatible pair, non-simultaneous kidney exchange,non-simultaneous extended altruistic donor, never ending altruistic donor, kidney exchange combined with desensitization, kidney exchange combined with ABO incompatible kidney transplantation, acceptable mismatch transplant, use of A2 donor to O patients, living donor-deceased donor list exchange, domino chain, non-anonymous kidney exchange, single center, multicenter, regional, National, International and Global kidney exchange...
June 28, 2018: World Journal of Transplantation
https://www.readbyqxmd.com/read/29880340/risk-taking-and-decision-making-in-kidney-paired-donation-a-qualitative-study-by-semistructured-interviews
#6
L S Baines, H Dulku, R M Jindal, V Papalois
INTRODUCTION: Despite excellent outcomes of kidney paired donation (KPD), little is known about how a patient's frame (apply cognitive bias) or weight (attribute value) and concerns relating to risk, justice, and equity affect his or her decision-making process. MATERIALS AND METHODS: A pilot study consisting of 3 KPD transplant recipients and 3 KPD kidney donors in the last year was conducted to identify and explore themes in decision making and risk taking. The pilot study was followed by the main study comprised of 20 recipients who had already undergone KPD transplantation and 20 donors who had undergone donor nephrectomy...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29796411/optimizing-live-kidney-donor-workup-a-decision-analysis-approach
#7
Jian Y Cheng, Andrew Martin, Ganesh Ramanathan, Bruce A Cooper
Background: Screening potential live kidney donors is an intense process for both candidates and the healthcare system. It is conventionally implemented using a standard generic protocol. Efficiencies in this process could potentially be achieved using personalized protocols that are optimized for a given candidate. Aim: To create personalized protocols (by age, sex, and paired exchange status) and evaluate them relative to the standard generic protocol. Methods: Two personalized protocols were created...
May 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29764323/swaps-and-chains-and-vouchers-oh-my-evaluating-how-saving-more-lives-impacts-the-equitable-allocation-of-live-donor-kidneys
#8
Evelyn M Tenenbaum
Live kidney donation involves a delicate balance between saving the most lives possible and maintaining a transplant system that is fair to the many thousands of patients on the transplant waiting list. Federal law and regulations require that kidney allocation be equitable, but the pressure to save patients subject to ever-lengthening waiting times for a transplant has been swinging the balance toward optimizing utility at the expense of justice. This article traces the progression of innovations created to make optimum use of a patient's own live donors...
March 2018: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/29723232/ant-lion-optimization-algorithm-for-kidney-exchanges
#9
Eslam Hamouda, Sara El-Metwally, Mayada Tarek
The kidney exchange programs bring new insights in the field of organ transplantation. They make the previously not allowed surgery of incompatible patient-donor pairs easier to be performed on a large scale. Mathematically, the kidney exchange is an optimization problem for the number of possible exchanges among the incompatible pairs in a given pool. Also, the optimization modeling should consider the expected quality-adjusted life of transplant candidates and the shortage of computational and operational hospital resources...
2018: PloS One
https://www.readbyqxmd.com/read/29582750/kidney-paired-donation-and-the-unique-challenges-of-kidney-shipment-in-canada
#10
Thomas McGregor, Alp Sener, Steven Paraskevas, Brian Reikie
Kidney paired donation (KPD) programs are an effort to bridge the disparity between kidney supply and demand. These programs combine several incompatible donor-recipient pairs in a national paired exchange database, thereby increasing the number of compatible matches. But KPD programs face unique challenges, particularly the large distances that often separate donors and recipients. Here we discuss key factors to consider when transitioning from a donor travelling model to a kidney shipment model in the Canadian context...
April 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29442420/a-liver-for-a-kidney-ethics-of-trans-organ-paired-exchange
#11
Benjamin Samstein, Inmaculada de Melo-Martin, Sandip Kapur, Lloyd Ratner, Jean Emond
Living donation provides important access to organ transplantation, which is the optimal therapy for patients with end-stage liver or kidney failure. Paired exchanges have facilitated thousands of kidney transplants and enable transplantation when the donor and recipient are incompatible. However, frequently willing and otherwise healthy donors have contraindications to the donation of the organ that their recipient needs. Trans-organ paired exchanges would enable a donor associated with a kidney recipient to donate a lobe of liver and a donor associated with a liver recipient to donate a kidney...
May 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29437286/kidney-exchange-match-rates-in-a-large-multicenter-clearinghouse
#12
Courtenay M Holscher, Kyle Jackson, Eric K H Chow, Alvin G Thomas, Christine E Haugen, Sandra R DiBrito, Carlin Purcell, Matthew Ronin, Amy D Waterman, Jacqueline Garonzik Wang, Allan B Massie, Sommer E Gentry, Dorry L Segev
Kidney paired donation (KPD) can facilitate living donor transplantation for candidates with an incompatible donor, but requires waiting for a match while experiencing the morbidity of dialysis. The balance between waiting for KPD vs desensitization or deceased donor transplantation relies on the ability to estimate KPD wait times. We studied donor/candidate pairs in the National Kidney Registry (NKR), a large multicenter KPD clearinghouse, between October 2011 and September 2015 using a competing-risk framework...
June 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29427562/liver-paired-exchange-can-the-liver-emulate-the-kidney
#13
Ashish Mishra, Alexis Lo, Grace S Lee, Benjamin Samstein, Peter S Yoo, Matthew H Levine, David S Goldberg, Abraham Shaked, Kim M Olthoff, Peter L Abt
Kidney paired exchange (KPE) constitutes 12% of all living donor kidney transplantations (LDKTs) in the United States. The success of KPE programs has prompted many in the liver transplant community to consider the possibility of liver paired exchange (LPE). Though the idea seems promising, the application has been limited to a handful of centers in Asia. In this article, we consider the indications, logistical issues, and ethics for establishing a LPE program in the United States with reference to the principles and advances developed from experience with KPE...
May 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29376820/kidney-paired-donation-and-the-unique-challenges-of-kidney-shipment-in-canada
#14
Thomas McGregor, Alp Sener, Steven Paraskevas, Brian Reikie
Kidney paired donation (KPD) programs are an effort to bridge the disparity between kidney supply and demand. These programs combine several incompatible donor-recipient pairs in a national paired exchange database, thereby increasing the number of compatible matches. But KPD programs face unique challenges, particularly the large distances that often separate donors and recipients. Here we discuss key factors to consider when transitioning from a donor travelling model to a kidney shipment model in the Canadian context...
January 24, 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29349948/case-report-of-kidney-paired-donation-kpd-with-desensitization-the-strategy-and-experience-of-3-way-kpd-in-samsung-medical-center
#15
Dongkyu Oh, Eun Suk Kang, Shinae Yu, Kyoungsuk Chun, Wooseong Huh, Hye Ryoun Jang, Chan Woo Cho, Nuri Lee, Kyo Won Lee, Hyojun Park, Jae Berm Park, Sung Joo Kim
As the need for the organ donation increases, strategies to increase kidney transplantation (KT) through expanded living donation have become essential. These include kidney paired donation (KPD) programs and desensitization in incompatible transplantations. KPD enables kidney transplant candidates with incompatible living donors to join a registry with other incompatible pairs in order to find potentially compatible living donor. Positive cross match and ABO incompatible transplantation has been successfully accomplished in selective cases with several pre-conditionings...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29332219/desensitisation-strategies-in-high-risk-children-before-kidney-transplantation
#16
Ankit Sharma, Anne M Durkan
BACKGROUND: Transplantation is the preferred modality for renal replacement therapy in children. With increasing rates of re-transplantation within the paediatric population, there are more sensitised children on waiting lists. One issue with developing strategies to treat these children is the number of different definitions of sensitisation. and we would therefore recommend an immunological risk stratification approach. METHODS: We discuss methods of sensitisation prevention, assessment and management, including paired exchange programmes and desensitisation protocols...
January 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29225712/a-look-ahead-strategy-for-non-directed-donors-in-kidney-paired-donation
#17
Wen Wang, Mathieu Bray, Peter X-K Song, John D Kalbfleisch
While there is a growing need for kidney transplants to treat end stage kidney disease, the supply of transplantable kidneys is in serious shortage. Kidney paired donation (KPD) programs serve as platforms for candidates with willing but incompatible donors to assess the possibility of exchanging donors, thus opening up new transplant opportunities for these candidates. In recent years, non-directed (or altruistic) donors (NDDs) have been incorporated into KPD programs beginning chains of transplants that benefit many candidates...
December 2017: Statistics in Biosciences
https://www.readbyqxmd.com/read/29157730/donor-and-recipient-perspectives-on-anonymity-in-kidney-donation-from-live-donors-a-multicenter-survey-study
#18
Dorthe Slaats, Annette Lennerling, Mathilde C Pronk, Karlijn A M I van der Pant, Ine M Dooper, Judith M Wierdsma, Carla Schrauwers, Hannah Maple, Jacqueline van de Wetering, Willem Weimar, Willij C Zuidema, Nizam Mamode, Frank J M F Dor, Emma K Massey
BACKGROUND: Maintaining anonymity is a requirement in the Netherlands and Sweden for kidney donation from live donors in the context of nondirected (or unspecified) and paired exchange (or specified indirect) donation. Despite this policy, some donors and recipients express the desire to know one another. Little empirical evidence informs the debate on anonymity. This study explored the experiences, preferences, and attitudes of donors and recipients toward anonymity. STUDY DESIGN: Retrospective observational multicenter study using both qualitative and quantitative methods...
January 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29087017/effect-of-match-run-frequencies-on-the-number-of-transplants-and-waiting-times-in-kidney-exchange
#19
Itai Ashlagi, Adam Bingaman, Maximilien Burq, Vahideh Manshadi, David Gamarnik, Cathi Murphey, Alvin E Roth, Marc L Melcher, Michael A Rees
Numerous kidney exchange (kidney paired donation [KPD]) registries in the United States have gradually shifted to high-frequency match-runs, raising the question of whether this harms the number of transplants. We conducted simulations using clinical data from 2 KPD registries-the Alliance for Paired Donation, which runs multihospital exchanges, and Methodist San Antonio, which runs single-center exchanges-to study how the frequency of match-runs impacts the number of transplants and the average waiting times...
May 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/28979784/seventy-seven-kidney-paired-donation-transplantations-at-a-single-transplant-centre-in-india-led-to-an-increase-in-living-donor-kidney-transplantations-in-2015
#20
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Sayyed J Rizvi, Bipin C Pal, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Vijay A Ghodela, Varsha B Trivedi, Minaxi H Patel, Hargovind L Trivedi
BACKGROUND: To ascertain the validity of kidney paired donations (KPDs) as an alternative strategy for increasing living donor kidney transplantations (LDKTs) in an LDKT-dominated transplant programme since directed kidney transplantation, ABO-incompatible or crossmatch-positive pairs are not feasible due to costs and infectious complications. METHODS: This was a prospective single-centre study of 77 KPD transplantations (25 two-way, 7 three-way and 1 six-way exchange) from 1 January 2015 to 1 January 2016 of 158 registered donor recipient pairs...
October 2017: Clinical Kidney Journal
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