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https://www.readbyqxmd.com/read/30517619/male-female-differences-in-characteristics-and-early-outcomes-of-patients-undergoing-tricuspid-valve-surgery-a-national-cohort-study-in-the-netherlands
#1
Kevin M Veen, Mostafa M Mokhles, Jerry Braun, Michel I M Versteegh, Ad J J C Bogers, Johanna J M Takkenberg
OBJECTIVES: This study aims to explore male-female differences in baseline and procedural characteristics, and outcomes of patients undergoing isolated or concomitant tricuspid valve (TV) surgery. METHODS: All TV procedures registered between 2007 and 2016 in the database of the Netherlands Association for Cardio-Thoracic Surgery were analysed. Logistic regression analyses with interaction terms were used to determine whether sex was associated with hospital mortality...
December 4, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/30516801/association-of-prevalence-of-benign-pathologic-findings-after-partial-nephrectomy-with-preoperative-imaging-patterns-in-the-united-states-from-2007-to-2014
#2
Jae Heon Kim, Shufeng Li, Yash Khandwala, Kyung Jin Chung, Hyung Keun Park, Benjamin I Chung
Importance: Although the intent of nephron-sparing surgery is to eradicate malignant tumors found on preoperative imaging, benign masses often cannot be differentiated from malignant tumors. However, in the past there have been discrepancies in the reported percentages of benign masses removed by partial nephrectomy (PNx). Objective: To investigate the annual trend of prevalence of benign pathologic findings after PNx and to investigate what potential factors are associated with this prevalence...
December 5, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/30514165/effect-of-age-on-leukopenia-following-renal-transplantation-at-a-single-center
#3
Yanmen Yang, Christina M Guerra, Nabil Sumrani
INTRODUCTION: Leukopenia in renal transplant recipients occurs commonly within the first year following transplantation; however, literature on the effects of age on leukopenia is scarce. DESIGN: A single-center, retrospective review was conducted on 141 recipients transplanted from January 2011 to December 2015. Transplant recipients were characterized by age <60 years (n = 94) or age 60 years and older (n = 47) for analysis. RESULTS: A greater incidence of leukopenia was seen in the older cohort compared to the younger cohort (64% vs 55%)...
December 4, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/30511258/efficacy-and-safety-of-more-potent-antiplatelet-therapy-with-vorapaxar-in-patients-with-impaired-renal-function
#4
Simon Correa, Marc P Bonaca, Benjamin M Scirica, Sabina A Murphy, Erica L Goodrich, David A Morrow, Michelle L O'Donoghue
Patients with renal disease are often undertreated with antiplatelet therapy due to concerns about bleeding. Vorapaxar blocks platelet activation via the PAR-1 receptor and reduces cardiovascular events in patients with stable atherosclerosis, but with increased bleeding. We examined the efficacy and safety of vorapaxar in patients with impaired renal function. TRA2°P-TIMI 50 randomized patients with stable atherosclerosis to vorapaxar or. We analyzed patients with eGFR assessed who qualified with a history of MI or PAD (without stroke or TIA) (n = 19,932)...
December 3, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/30509849/influence-of-age-gender-smoking-diabetes-thyroid-and-cardiac-dysfunctions-on-cystatin-c-biomarker
#5
O Al Musaimi, A H Abu-Nawwas, D Al Shaer, N Y Khaleel, M Fawzi
BACKGROUND: Creatinine is the most widely used renal failure biomarker; however, it has a lot of drawbacks. One of the major drawbacks is the blind range (does not increase until 50% of the kidney deteriorates). On the other hand, cystatin C has gained more attention as a promising biomarker due to several advantages over creatinine. Cystatin C levels are elevated as soon as any mild defect in the kidney occurs. Furthermore, cystatin C is influenced by several non-renal diseases which provide an additional prognostic value for this promising biomarker...
November 30, 2018: Semergen
https://www.readbyqxmd.com/read/30509506/potential-association-of-weight-based-gentamicin-with-increased-acute-kidney-injury-in-urologic-prosthetic-surgery
#6
R Hart Moore, Uzoma A Anele, Sarah C Krzastek, Adam P Klausner, J Tyler Roseman
BACKGROUND: Despite the known nephrotoxicity of gentamicin, in 2008 the American Urological Association recommended a weight-based gentamicin dose of 5 mg/kg for antimicrobial prophylaxis during urologic prosthetic surgery. AIM: To identify and characterize rates of acute kidney injury (AKI) in urologic prosthetic surgery, both before and after the implementation of weight-based gentamicin dosing. METHODS: We performed a single-institution retrospective study of patients receiving perioperative gentamicin during implant, revision, salvage, or explant of inflatable penile prostheses, malleable penile prostheses, or artificial urinary sphincters between the years 2000 and 2017...
November 30, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30504712/patients-with-atrial-fibrillation-and-chronic-kidney-disease-more-often-undergo-angioplasty-of-left-main-coronary-artery-a-867-patient-study
#7
Anna Tomaszuk-Kazberuk, Dimitrios Nikas, Paulina Lopatowska, Elzbieta Młodawska, Jolanta Malyszko, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Bożena Sobkowicz, Ioannis Goudevenos
BACKGROUND/AIMS: Several studies have implicated atrial fibrillation (AF) as a contributing factor in chronic kidney disease (CKD) and cardiovascular events. The prevalence of coronary artery disease (CAD) in patients with AF varies substantially from 17% to 46.5%. There are only few studies concerning renal function in population with AF undergoing coronary angiography. The aim of the present study was to assess which type of AF is dominant in CKD population scheduled for coronary angiography and if it can influence patients' outcome, the association between renal impairment and the type of coronary procedures in AF patients and the influence of renal function on in-hospital mortality...
November 30, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30504296/approach-to-the-treatment-of-the-older-unfit-patient-with-myeloma-from-diagnosis-to-relapse-perspectives-of-a-us-hematologist-and-a-geriatric-hematologist
#8
REVIEW
Tanya M Wildes, Kenneth C Anderson
Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. The pain limits her exercise tolerance such that she can now walk only 1 block. She is a retired schoolteacher who does volunteer efforts in her community but has limited her activities due to fatigue. Karnofsky performance status is 70%. She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504295/treatment-approach-for-the-older-unfit-patient-with-myeloma-from-diagnosis-to-relapse-perspectives-of-a-european-hematologist
#9
REVIEW
Thierry Facon, Kenneth Anderson
Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. The pain limits her exercise tolerance such that she can now walk only 1 block. She is a retired schoolteacher who does volunteer efforts in her community but has limited her activities due to fatigue. Karnofsky performance status is 70%. She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30501869/combination-of-hyper-cvad-with-ponatinib-as-first-line-therapy-for-patients-with-philadelphia-chromosome-positive-acute-lymphoblastic-leukaemia-long-term-follow-up-of-a-single-centre-phase-2-study
#10
Elias Jabbour, Nicholas J Short, Farhad Ravandi, Xuelin Huang, Naval Daver, Courtney D DiNardo, Marina Konopleva, Naveen Pemmaraju, William Wierda, Guillermo Garcia-Manero, Koji Sasaki, Jorge Cortes, Rebecca Garris, Joseph D Khoury, Jeffrey Jorgensen, Nitin Jain, Joie Alvarez, Susan O'Brien, Hagop Kantarjian
BACKGROUND: The combination of chemotherapy and ponatinib in Philadelphia chromosome-positive acute lymphoblastic leukaemia has the potential to be a new standard of care for the disease; however, long-term efficacy and safety data are needed. Our aim was to evaluate the long-term efficacy and safety of this regimen in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia in this ongoing phase 2 trial. METHODS: In our single-centre, phase 2, single-arm trial in the USA, adult patients with previously untreated Philadelphia chromosome-positive acute lymphoblastic leukaemia were sequentially enrolled...
December 2018: Lancet Haematology
https://www.readbyqxmd.com/read/30501702/-clinical-analysis-of-maintenance-therapy-with-thalidomine-and-bortezomib-for-multiple-myeloma
#11
Yan-Jie Xu, Bing Xia, Lu Wang, Chao-Yu Wang, Hai-Feng Zhao, Hong-Liang Yang, Xiao-Fang Wang, Ya-Fei Wang, Yong Yu, Yi-Zhuo Zhang
OBJECTIVE: To evaluate the therapeutic effect and adverse reactions of the maintenance therapies with Thalidomine or Bortezomib in the patients with newly diagnosed multiple myeloma (MM), so as to provide a reference for clinical treatment. METHODS: A retrospective analysis was conducted to compare the progression-free survival (PFS), overall survival (OS) and adverse reaction rate of 23 MM patients received the maintenance therapies of Bortezomib and of 68 MM patients received maintenance therapy of Thalidomine...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30501514/the-effect-of-age-on-fracture-healing-time-in-metacarpal-fractures
#12
Ronit Wollstein, Arie Trouw, Lois Carlson, Ilene Staff, Daniel J Mastella, Duffield Ashmead
BACKGROUND: Older patients are treated for fracture with increasing frequency. Although studies on animals suggest that older mice and rats heal fractures more slowly, the clinical implications remain unclear. A better understanding of differences in healing with age can help customize fracture treatment. Our purpose was to retrospectively evaluate metacarpal fractures for healing time looking specifically at age-related differences. METHODS: A retrospective review of patients treated for metacarpal fractures was conducted...
December 2, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/30498772/impact-of-donor-age-on-clinical-outcomes-of-primary-single-kidney-transplantation-from-maastricht-category-iii-donors-after-circulatory-death
#13
Evaldo Favi, Carmelo Puliatti, Samuele Iesari, Andrea Monaco, Mariano Ferraresso, Roberto Cacciola
Background: Standard-criteria donation after circulatory death (DCD) kidney transplants (KTx) have higher primary nonfunction, delayed graft function (DGF), and rejection rates than age-matched donation after brain death (DBD) but similar graft survival. Data on expanded-criteria DCD are conflicting and many centers remain concerned regarding their use. Methods: In this single-center observational study with 5-year follow-up, we analyzed data from 112 primary DCD Maastricht category-III single KTx receiving similar organ preservation and maintenance immunosuppression...
October 2018: Transplantation Direct
https://www.readbyqxmd.com/read/30497972/-strategic-plan-for-reduction-of-hospital-stay-in-renal-transplantation
#14
G Fragale, L Mainetti, S Montal, V Beitía, P Lovisolo, A Karl, E Schnitzler, G Soler Pujol, M Tisi Baña
Since January 2015 we have carried out a multiple-intervention strategic plan to reduce hospital stay in renal transplant recipients. The main objective of this study is to compare results of renal transplantation before and after putting into effect this plan in terms of graft and patient survival, readmissions and incidence of acute rejection during the first year post transplantation. In this retrospective analysis we included all patients 18 years of age or older who were transplanted at our institution...
November 26, 2018: Journal of healthcare quality research
https://www.readbyqxmd.com/read/30487057/contemporary-trend-of-reduced-dose-non-vitamin-k-anticoagulants-in-japanese-patients-with-atrial-fibrillation-a-cross-sectional-analysis-of-a-multicenter-outpatient-registry
#15
Tomohiko Ono, Nobuhiro Ikemura, Takehiro Kimura, Ikuko Ueda, Hiroaki Tanaka, Hanako Tokuda, Noriyuki Yajima, Keisuke Matsumura, Masahiro Suzuki, Keiichi Fukuda, Shun Kohsaka, Seiji Takatsuki
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) have been widely used to prevent stroke in non-valvular atrial fibrillation (NVAF) patients. Stringent monitoring is not required for NOACs, albeit dose adjustments are needed based on specific patient factors, such as renal function, body weight and age, or concomitant medications. We investigated the NOAC dosing patterns and evaluated the predictors of the non-standardized dose reduction (NSDR). METHODS: A total of 2452 newly diagnosed NVAF patients were consecutively recruited from secondary- and tertiary-care hospitals between 2012 and 2017...
January 2019: Journal of Cardiology
https://www.readbyqxmd.com/read/30484732/changes-in-the-diagnosis-of-glomerular-diseases-in-east-china-a-15-year-renal-biopsy-study
#16
Qin Zhou, Xin Yang, Meifang Wang, Huiping Wang, Jie Zhao, Yan Bi, Xiayue Wang, Jihong Yao, Ying Chen, Chuan Lin, Xishao Xie, Hong Jiang, Jianghua Chen
BACKGROUND: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years. METHODS AND RESULTS: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/30484240/aging-in-primary-systemic-vasculitis-implications-for-diagnosis-clinical-manifestations-and-management
#17
REVIEW
Alvise Berti, Roberto Caporali, Carlomaurizio Montecucco, Giuseppe Paolazzi, Sara Monti
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e., granulomatosis with polyangiitis [GPA], microscopic polyangiitis, and eosinophilic GPA) and serological phenotypes (i.e., anti-MPO-ANCA, anti-PR3-ANCA and ANCA negative) within AAV differ substantially for clinical, demographic, and epidemiological features, including age at presentation. Whether and how aging could contribute to the clinical expression of these disease phenotypes is intriguing and still overlooked...
November 28, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/30482647/analysis-of-the-quality-of-patient-therapeutic-education-and-information-in-a-high-complexity-reference-hospital
#18
M Jansà, M J Bertran, J Vilardell, F Garcia, J Escarrabill
BACKGROUND AND OBJECTIVES: The application and monitoring of quality criteria in information and therapeutic patient education can identify areas to improve care. The objectives of this study were: (1) To analyze the characteristics of patient information materials, educational activities, and self-management programs, and (2) to determine health care provider (HCP) proposals on therapeutic patient education. MATERIALS AND METHODS: Using a cross-sectional study, an online questionnaire was sent to hospital departments in a high complexity reference hospital from September to December 2013 to record: (a) information materials, (b) patient educational activities, and self-management program characteristics, (c) HCP proposals...
November 24, 2018: Journal of healthcare quality research
https://www.readbyqxmd.com/read/30481749/relationship-between-aortic-arch-calcification-detected-by-chest-x-ray-and-renal-resistive-index-in-patients-with-hypertension-br-br
#19
Adem Adar, Orhan Onalan, Fahri Cakan, Hakan Keles, Ugur Kokturk
OBJECTIVE: Aortic arch calcification is a surrogate marker for arterial stiffness and hypertension-related vascular damage. Renal Resistive Index, a renal Doppler ultrasound parameter, is used to assess renal hemodynamics. In this study, the authors aimed to evaluate the relationship between Renal Resistive Index and aortic arch calcification in patients with hypertension. MATERIALS AND METHODS: Patients with hypertension underwent a chest x-ray and renal Doppler ultrasound...
November 27, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/30481402/prevalence-and-characteristics-of-hepatitis-e-virus-infection-in-kidney-transplant-recipients-a-single-center-experience-in-japan
#20
Koji Nanmoku, Yohei Owada, Yukio Oshiro, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Yasunaru Sakuma, Nobuo Ishikawa, Nobuhiro Ohkohchi, Hiroaki Okamoto, Takashi Yagisawa
BACKGROUND: Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital. METHODS: Our cross-sectional study included 184 kidney transplant recipients. Blood samples were obtained from all patients to detect anti-HEV immunoglobulin (Ig)A, IgM, and IgG by enzyme-linked immunosorbent assay and HEV RNA by reverse transcription-polymerase chain reaction...
November 27, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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