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https://www.readbyqxmd.com/read/29674373/study-protocol-quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-2-uk-prospective-cohort-study
#1
Sarah Jane Stock, Lisa M Wotherspoon, Kathleen Anne Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben Mol, Richard D Riley, John Norrie, Jane Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (fFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts, USA) which quantifies fFN in a vaginal swab. In QUIDS part 2, we will perform a prospective cohort study in at least eight UK consultant-led maternity units, in women with symptoms of preterm labour at 22+0  to 34+6 weeks gestation to externally validate a prognostic model developed in QUIDS part 1...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29673669/rupture-of-the-scarred-and-unscarred-gravid-uterus-outcomes-and-risk-factors-analysis
#2
Shu-Han You, Yao-Lung Chang, Chih-Feng Yen
OBJECTIVE: To study the maternal and fetal outcomes and assess the risk factors in patients with rupture at the lower-segment or non-lower-segment scarred, or unscarred gravid uterus. MATERIALS AND METHODS: Gravid patients with uterine rupture were retrospectively collected in Chang-Gung Memorial Hospital from November 2004 to July 2017. The rupture timing and location in association with maternal and fetal outcomes were collected as well as the possible risk factors including surgical history and interval prior to conception were analyzed...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29668022/follow-up-care-for-high-risk-preterm-infants
#3
Stephannie M B Voller
Preterm infants continue to have complex medical and developmental issues after discharge from the neonatal intensive care unit. Over the past few decades there has been an increase in preterm births and a decrease in preterm mortality. Many infants are referred to follow-up clinics that specialize in neurodevelopmental assessment. Often, a community pediatrician or family practitioner provides both the medical management and observes developmental milestones of the high-risk neonate. Intense medical management, early identification of delay, and referral for developmental services may improve preterm infant outcomes...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29664499/ambulatory-blood-pressure-monitoring-in-school-children-with-a-history-of-extreme-prematurity
#4
Andrea Solís, Jaime Cerda, Claudia González
INTRODUCTION: Extremely premature children have a higher incidence of High Blood Pressure (HBP) and risk of renal damage due to decreased glomerular count with consequent hyperfiltration of the remnants. OBJECTIVES: To assess the prevalence of altered blood pressure values in outpatient measurement and ambulatory blood pressure monitoring (ABPM) in preterm infants ≤ 32 weeks and/ or ≤ 1,500 g birth weight between 5 and 7 years of age, as well as the presence of early renal damage markers...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29663524/early-echocardiography-does-not-predict-subsequent-treatment-of-symptomatic-pda-in-extremely-preterm-infants
#5
Sujith S Pereira, Stephen T Kempley, Divyen K Shah, Joan K Morris, Ajay K Sinha
AIM: To determine whether early echocardiographic ductal parameters identified infants who subsequently received medical or surgical treatment of the patent ductus arteriosus (PDA). METHODS: Infants <29 weeks had PDA size in 2-D and colour, flow velocity and patterns obtained on day 1 and 3. Infants were followed up to identify those subsequently receiving treatment for symptomatic PDA by clinicians who were unaware of scan results. Receiver operator characteristics curves and logistic regression were performed...
April 16, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29663314/prediction-models-for-the-risk-of-spontaneous-preterm-birth-based-on-maternal-characteristics-a-systematic-review-and-independent-external-validation
#6
Linda Je Meertens, Pim van Montfort, Hubertina Cj Scheepers, Sander Mj van Kuijk, Robert Aardenburg, Josje Langenveld, Ivo Ma van Dooren, Iris M Zwaan, Marc Ea Spaanderman, Luc Jm Smits
INTRODUCTION: Prediction models may contribute to personalized risk-based management of women at high risk of spontaneous preterm delivery. Although prediction models are published frequently, often with promising results, external validation generally lacks. We performed a systematic review of prediction models for the risk of spontaneous preterm birth based on routine clinical parameters. Additionally, we externally validated and evaluated the clinical potential of the models. MATERIAL AND METHODS: Prediction models based on routinely collected maternal parameters obtainable during first 16 weeks of gestation were eligible for selection...
April 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29663112/extramucosal-pyriplasty-without-stenting-for-management-of-pyriform-aperture-stenosis
#7
Remon Bazak, Ahmed Aly Ibrahim, Wael K A Hussein, Mustafa Mohamed Abdelnaby, Samy Elwany
PURPOSE: The current management options of congenital pyriform aperture stenosis (CNPAS) are either conservative measures awaiting further growth of the bony nasal framework or surgical intervention that focuses on bone removal from the margin of the pyriform aperture (PA) without exposure of the nasolacrimal duct (NLD) followed by stenting. Recently, CT measurements of the nasal cavity in CNPAS have shed light that the site of maximal bony obstruction corresponds to the bony buttress encasing the NLD rather than the margin of the PA as initially thought...
April 16, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29662962/the-relation-of-maternal-hypothyroidism-and-hypothyroxinemia-during-pregnancy-on-preterm-birth-an-updated-systematic-review-and-meta-analysis
#8
REVIEW
Marzieh Parizad Nasirkandy, Gholamreza Badfar, Masoumeh Shohani, Shoboo Rahmati, Mohammad Hossein YektaKooshali, Shamsi Abbasalizadeh, Ali Soleymani, Milad Azami
Background: The clinical consequences of hypothyroidism and hypothyroxinemia during pregnancy such as preterm birth are not still clear. Objective: The aim of this meta-analysis was to estimate the relation of clinical and subclinical hypothyroidism and hypothyroxinemia during pregnancy and preterm birth. Materials and Methods: In this meta-analysis, Preferred Reporting Items for Systematic review and Meta-Analysis were utilized. Searching the cohort studies were done by two researchers independently without any restrictions on Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO and Google Scholar databases up to 2017...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29661565/fetal-growth-restriction-in-twins
#9
REVIEW
R Townsend, A Khalil
Twin pregnancies are more likely to be affected by fetal growth restriction (FGR), preterm birth and perinatal loss. The management of fetal growth restriction in multiple pregnancy, particularly where only one fetus is affected is complicated by the need to consider the interests of both twins. Selective growth restriction in monochorionic (MC) twins is a pathophysiological process distinct from FGR in dichorionic (DC) pregnancies and management demands an understanding of the monochorionic placental structure and interdependent fetal circulations...
February 24, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29660833/selenium-deficiency-and-pregnancy-outcome-in-pregnant-women-with-hiv-in-lagos-nigeria
#10
Kehinde S Okunade, Olusola F Olowoselu, Gbemisola E Osanyin, Sarah John-Olabode, Sulaimon A Akanmu, Rose I Anorlu
OBJECTIVE: To investigate the prevalence of maternal selenium deficiency and its effects on pregnancy outcomes in pregnant women with HIV in Lagos, Nigeria. METHODS: The present descriptive cross-sectional study enrolled women aged 15-49 years with HIV who were at 14-26 weeks of a singleton pregnancy and were attending Lagos University Teaching Hospital, Lagos, Nigeria, between August 1, 2016, and April 30, 2017. Participants were selected by consecutive sampling and baseline data were collected through interviews...
April 16, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29656287/respiratory-management-of-extremely-preterm-infants-an-international-survey
#11
Marc Beltempo, Tetsuya Isayama, Máximo Vento, Kei Lui, Satoshi Kusuda, Liisa Lehtonen, Gunnar Sjörs, Stellan Håkansson, Mark Adams, Akihiko Noguchi, Brian Reichman, Brian A Darlow, Naho Morisaki, Dirk Bassler, Simone Pratesi, Shoo K Lee, Abhay Lodha, Neena Modi, Kjell Helenius, Prakesh S Shah
BACKGROUND: There are significant international variations in chronic lung disease rates among very preterm infants yet there is little data on international variations in respiratory strategies. OBJECTIVE: To evaluate practice variations in the respiratory management of extremely preterm infants born at < 29 weeks' gestational age (GA) among 10 neonatal networks participating in the International Network for Evaluating Outcomes (iNeo) of Neonates collaboration...
April 13, 2018: Neonatology
https://www.readbyqxmd.com/read/29649290/the-contribution-of-gestational-age-area-deprivation-and-mother-s-country-of-birth-to-ethnic-variations-in-infant-mortality-in-england-and-wales-a-national-cohort-study-using-routinely-collected-data
#12
Yangmei Li, Maria A Quigley, Nirupa Dattani, Ron Gray, Hiranthi Jayaweera, Jennifer J Kurinczuk, Alison Macfarlane, Jennifer Hollowell
OBJECTIVES: We aimed to describe ethnic variations in infant mortality and explore the contribution of area deprivation, mother's country of birth, and prematurity to these variations. METHODS: We analyzed routine birth and death data on singleton live births (gestational age≥22 weeks) in England and Wales, 2006-2012. Infant mortality by ethnic group was analyzed using logistic regression with adjustment for sociodemographic characteristics and gestational age...
2018: PloS One
https://www.readbyqxmd.com/read/29630015/maternal-pyrexia-and-villitis-of-unknown-etiology
#13
Dorothy F Graham, Eileen Sung, Bligh Berry
BACKGROUND: Villitis of unknown etiology is an inflammatory placental condition associated with adverse pregnancy outcomes, including fetal growth restriction and preterm birth. CASE: We describe maternal pyrexia with daily rigors in the third trimester of two consecutive pregnancies in the same woman. In her second pregnancy, we found no evidence of infection despite an extensive antenatal investigation (blood and urine cultures, serologies, chest X-ray, abdominal ultrasonogram, echocardiogram)...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29627817/quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-1-individual-participant-data-meta-analysis-and-health-economic-analysis
#14
Sarah J Stock, Lisa M Wotherspoon, Kathleen A Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben W Mol, Richard D Riley, John Norrie, Jane E Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (qfFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts) which quantifies fFN in a vaginal swab. In part 1 of the study, we will develop and internally validate a prognostic model using an individual participant data (IPD) meta-analysis of existing studies containing women with symptoms of preterm labour alongside fFN measurements and pregnancy outcome...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29626976/chronic-histiocytic-intervillositis-clinical-biochemical-and-radiological-findings-an-observational-study
#15
Lawrence Koby, Sarah Keating, Ann Kinga Malinowski, Rohan D'Souza
INTRODUCTION: Chronic histiocytic intervillositis (CHI) of the placenta although rare, has a high recurrence rate, is associated with serious adverse pregnancy outcomes and has no available treatment. This study aims to determine clinical, biochemical and radiological factors associated with CHI, to guide management of subsequent pregnancies. METHODS: This retrospective observational study included consecutive cases with a histopathologic diagnosis of CHI after 18 weeks of gestation, between 2001 and 2014, and no controls...
April 2018: Placenta
https://www.readbyqxmd.com/read/29626275/antenatal-management-for-women-with-inflammatory-bowel-disease-experience-from-our-ibd-mom-clinic
#16
Ariella Bar-Gil Shitrit, Yael Cohen, Ori Hassin, Ami Ben Ya'acov, Rivkah Farkash, Benjamin Koslowsky, Yael Milgrom, Dan Meir Livovsky, Arnon Samueloff, Eran Goldin, Sorina Grisaru-Granovsky
BACKGROUND: Inflammatory bowel disease affects women during their reproductive years and thus pregnancy outcomes. IBD MOM is a multidisciplinary, single-center clinic established to benefit women with IBD and their neonates. AIM: The aim of this study was to evaluate the perinatal outcomes of the IBD MOM clinic patients compared to patients who attended antenatal and gastrointestinal disease community clinics (IBD CC). METHODS: This single-center, prospective study was conducted from 2011 to 2015...
April 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29625857/decrease-of-premature-mothers-stress-levels-in-the-intensive-care-unit
#17
B Villamizar-Carvajal, C Vargas-Porras, J R García-Corzo
OBJECTIVE: To determine the effectiveness of the 'Creating Opportunities for Parent Empowerment' (COPE) programme in reducing stress levels in mothers of preterm infants in the neonatal intensive care unit (NICU). METHODS: Clinical trial performed in Colombia, including mothers of infants younger than 34 weeks of gestation, hospitalized, without a history of premature delivery. The mothers with psychiatric illnesses, language disorders, history of use of psychoactive substances and whose newborns had a congenital malformation were excluded...
April 3, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/29621826/cognitive-functions-of-the-fetus
#18
Aida Salihagic Kadic, Asim Kurjak
The human brain is intricately designed to execute cognitive functions, such as perception, attention, action, memory and learning. The complete nervous system is active during prenatal development and the aim of this review is to present data on fetal cognitive functions. The fetus processes sensory stimuli at a cortical level, including painful stimulus, from about 25 weeks of gestation onwards. At gestational week 34, the fetus is able not only to perceive complex acoustic external sounds but also to discriminate between different sounds...
April 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29618272/does-fortification-of-pasteurized-donor-human-milk-increase-the-incidence-of-necrotizing-enterocolitis-among-preterm-neonates-a-randomized-controlled-trial
#19
Bethou Adhisivam, Dilesh Kohat, Vasanthan Tanigasalam, Vishnu Bhat, Nishad Plakkal, C Palanivel
OBJECTIVE: To compare the effect of fortified pasteurized donor human milk (PDHM) versus unfortified PDHM on the incidence of necrotizing enterocolitis (NEC) and immediate outcome among preterm neonates. METHODS: This randomized controlled trial (RCT) conducted in a tertiary care teaching hospital, south India included 80 healthy preterm neonates randomized to two groups (Group A and B). Neonates in Group A and B were fed with fortified PDHM and unfortified PDHM respectively...
April 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29614278/progestogens-in-singleton-gestations-with-preterm-prelabor-rupture-of-membranes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Johanna Quist-Nelson, Pamela Parker, Neggin Mokhtari, Rossana Di Sarno, Gabriele Saccone, Vincenzo Berghella
BACKGROUND: Preterm prelabor rupture of membranes (PROM) occurs in 3% of all pregnancies. Neonatal benefit is seen in uninfected women that do not deliver immediately after preterm PROM. OBJECTIVE: To evaluate if administration of progestogens in singleton pregnancies prolongs pregnancy after preterm PROM. STUDY DESIGN: Searches were performed in MEDLINE, OVID, Scopus, EMBASE, ClinicalTrials.gov and the Cochrane Central Register of Controlled Trials with the use of a combination of keywords and text words related to "progesterone," "progestogen," "prematurity" and "preterm premature rupture of membranes" from inception of databases until January 2018...
March 31, 2018: American Journal of Obstetrics and Gynecology
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