keyword
https://read.qxmd.com/read/38355138/potential-role-of-dietary-salmon-nasal-cartilage-proteoglycan-on-uvb-induced-photoaged-skin
#1
JOURNAL ARTICLE
Hae Ran Lee, Seong-Min Hong, Kyohee Cho, Seon Hyeok Kim, Eunji Ko, Eunyoo Lee, Hyun Jin Kim, Se Yeong Jeon, Seon Gil Do, Sun Yeou Kim
New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti-wrinkle effects on dorsal mouse skin and keratinocytes and dermal fibroblasts cell lines. These results showed that SPG restored the levels of filaggrin, involucrin, and AQP3 in the epidermis of UVB-irradiated dorsal skin and keratinocytes, thereby enhancing the keratinization process and water flow...
February 15, 2024: Biomolecules & Therapeutics
https://read.qxmd.com/read/38342436/loss-of-function-and-reduced-levels-of-sphingolipid-desaturase-degs1-variants-are-both-relevant-in-disease-mechanism
#2
JOURNAL ARTICLE
Michele Dei Cas, Linda Montavoci, Claudia Pasini, Anna Caretti, Sara Penati, Carla Martinelli, Umberto Gianelli, Sara Casati, Francesca Nardecchia, Annalaura Torella, Nicola Brunetti-Pierri, Marco Trinchera
The last step of ex novo ceramide biosynthesis consists of the conversion of dihydroceramide into ceramide catalyzed by sphingolipid Δ4-desaturase DEGS1. DEGS1 variants were found to be responsible for heterogeneous clinical pictures belonging to the family of hypomyelinating leukodystrophies. To investigate the mechanisms making such variants pathogenic, we designed a procedure for the efficient detection of desaturase activity in vitro using LC-MS/MS and prepared a suitable cell model knocking-out DEGS1 in HEK-293T cells through CRISPR-Cas9 genome editing (KO-DES-HEK)...
February 9, 2024: Journal of Lipid Research
https://read.qxmd.com/read/38339798/metabolism-fibrosis-and-apoptosis-the-effect-of-lipids-and-their-derivatives-on-keloid-formation
#3
REVIEW
Chen-Yu Li, Ru-Xin Xie, Shi-Wei Zhang, Jiao Yun, Ai Zhong, Ying Cen, Jun-Jie Chen
Keloids, pathological scars resulting from skin trauma, have traditionally posed significant clinical management challenges due to their persistence and high recurrence rates. Our research elucidates the pivotal roles of lipids and their derivatives in keloid development, driven by underlying mechanisms of abnormal cell proliferation, apoptosis, and extracellular matrix deposition. Key findings suggest that abnormalities in arachidonic acid (AA) synthesis and non-essential fatty acid synthesis are integral to keloid formation...
February 2024: International Wound Journal
https://read.qxmd.com/read/38329128/inhibition-of-cysteine-protease-cathepsin-lincreases-the-level-and-activity-of-lysosomal-glucocerebrosidase
#4
JOURNAL ARTICLE
Myung Jong Kim, Soojin Kim, Thomas Reinheckel, Dimitri Krainc
The glucocerebrosidase (GCase) encoded by the GBA1 gene hydrolyzes glucosylceramide (GluCer) to ceramide and glucose in lysosomes. Homozygous or compound heterozygous GBA1 mutations cause the lysosomal storage disease Gaucher disease (GD) due to severe loss of GCase activity. Loss-of-function variants in the GBA1 gene are also the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Restoring lysosomal GCase activity represents an important therapeutic approach for GBA1-associated diseases...
February 8, 2024: JCI Insight
https://read.qxmd.com/read/38244710/identification-of-cers5-as-a-molecular-biomarker-in-pan-cancer-through-multiple-omics-integrative-analysis
#5
JOURNAL ARTICLE
Shengyu Wang, Jian Yang, Weijia Huang, Zhu Yu, Yuantian Mao, Yue Feng, Junqiang Chen
Cancer is a devastating disease that presents a major threat to human health. The protein CERS5 is responsible for synthesizing C16-ceramide, but its role in cancer is poorly understood. In this study, we examined the connection between CERS5 expression and pan-cancer prognosis, diagnosis, and the molecular mechanism involved. Kaplan-Meier survival analysis revealed variations among different cancer types. Functional enrichment analysis was conducted using gene set enrichment analysis (GSEA), and a network of protein-protein interaction (PPI) was constructed...
January 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38104072/correlation-between-secondary-metabolites-of-iris-confusa-sealy-and-iris-pseudacorus-l-and-their-newly-explored-antiprotozoal-potentials
#6
JOURNAL ARTICLE
Passent M Abdel-Baki, Moshera M El-Sherei, Amal E Khaleel, Essam Abdel-Sattar, Mohamed A Salem, Mona M Okba
BACKGROUND: In the last few decades, the use of plant extracts and their phytochemicals as candidates for the management of parasitic diseases has increased tremendously. Irises are aromatic and medicinal plants that have long been employed in the treatment of different infectious diseases by traditional healers in many cultures. This study aims to explore the potential of three common Iris species (I. confusa Sealy, I. pseudacorus L. and I. germanica L.) against infectious diseases. Their in vitro antiprotozoal potency against Plasmodium falciparum, Trypanosoma brucei brucei, T...
December 16, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/38075064/pfos-elicited-metabolic-perturbation-in-liver-and-fatty-acid-metabolites-in-testis-of-adult-mice
#7
JOURNAL ARTICLE
Wang Ka Lee, Thomas Ka Yam Lam, Hiu Ching Tang, Tsz Chun Ho, Hin Ting Wan, Chris Kong Chu Wong
INTRODUCTION: Multiple factors can contribute to sub-fecundity, including genetics, lifestyle, and environmental contaminants. PFASs are characterized as "forever chemicals" due to their ubiquitous contamination and their persistence in the environment, wildlife, and humans. Numerous studies have demonstrated that PFAS exposure adversely affects multiple bodily functions, including liver metabolism and gonadal function. It is unclear, however, how the disruption of hepatic fatty acid metabolism affects testicular function...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38041679/recurrent-de-novo-sptlc2-variant-causes-childhood-onset-amyotrophic-lateral-sclerosis-als-by-excess-sphingolipid-synthesis
#8
JOURNAL ARTICLE
Safoora B Syeda, Museer A Lone, Payam Mohassel, Sandra Donkervoort, Pinki Munot, Marcondes C França, Juan Eli Galarza-Brito, Matthias Eckenweiler, Alexander Asamoah, Kenneth Gable, Anirban Majumdar, Anke Schumann, Sita D Gupta, Arpita Lakhotia, Perry B Shieh, A Reghan Foley, Kelly E Jackson, Katherine R Chao, Thomas L Winder, Francesco Catapano, Lucy Feng, Janbernd Kirschner, Francesco Muntoni, Teresa M Dunn, Thorsten Hornemann, Carsten G Bönnemann
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motor neurons with varying ages of onset, progression and pathomechanisms. Monogenic childhood-onset ALS, although rare, forms an important subgroup of ALS. We recently reported specific SPTLC1 variants resulting in sphingolipid overproduction as a cause for juvenile ALS. Here, we report six patients from six independent families with a recurrent, de novo, heterozygous variant in SPTLC2 c...
November 24, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/37889115/neutral-sphingomyelinase-regulates-mechanotransduction-in-human-engineered-cardiac-tissues-and-mouse-hearts
#9
JOURNAL ARTICLE
Daniel G P Turner, Willem J De Lange, Yanlong Zhu, Christopher L Coe, Judith Simcox, Ying Ge, Timothy J Kamp, J Carter Ralphe, Alexey V Glukhov
Cardiovascular disease is the leading cause of death in the USA and is known to be exacerbated by elevated mechanical stress from hypertension. Caveolae are plasma membrane structures that buffer mechanical stress but have been found to be reduced in pathological conditions associated with chronically stretched myocardium. To explore the physiological implications of the loss of caveolae, we used human engineered cardiac tissue (ECT) constructs, composed of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and hiPSC-derived cardiac fibroblasts, to develop a long-term cyclic stretch protocol that recapitulates the effects of hypertension on caveolae expression, membrane tension, and the β-adrenergic response...
October 27, 2023: Journal of Physiology
https://read.qxmd.com/read/37840567/taurine-accelerates-the-synthesis-of-ceramides-and-hyaluronic-acid-in-cultured-epidermis-and-dermal-fibroblasts
#10
JOURNAL ARTICLE
Tomohisa Yoshimura, Chika Manabe, Jun-Ichiro Nagumo, Tohru Nagahama, Takashi Sato, Shigeru Murakami
Taurine is a sulfur-containing amino acid derivative that can be found in the majority of mammalian tissues. Taurine is also present in the skin and is involved in maintaining skin homeostasis by exerting osmoregulatory and antioxidant effects. Previous studies have indicated that taurine treatment is effective against age-, ultraviolet- or detergent-induced skin dysfunction. To determine the mechanism responsible for the beneficial actions of taurine in the skin, the present study aimed to evaluate the effects of taurine on epidermal components (ceramides and filaggrin) and on the dermal extracellular matrix, in three-dimensionally (3D) cultured epidermis and dermal fibroblasts, respectively...
November 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/37676252/neural-specific-alterations-in-glycosphingolipid-biosynthesis-and-cell-signaling-associated-with-two-human-ganglioside-gm3-synthase-deficiency-variants
#11
JOURNAL ARTICLE
Michelle Dookwah, Shannon K Wagner, Mayumi Ishihara, Seok-Ho Yu, Heidi Ulrichs, Michael J Kulik, Nadja Zeltner, Stephen Dalton, Kevin A Strauss, Kazuhiro Aoki, Richard Steet, Michael Tiemeyer
GM3 Synthase Deficiency (GM3SD) is a neurodevelopmental disorder resulting from pathogenic variants in the ST3GAL5 gene, which encodes GM3 synthase, a glycosphingolipid (GSL)-specific sialyltransferase. This enzyme adds a sialic acid to the terminal galactose of lactosylceramide (LacCer) to produce the monosialylated ganglioside GM3. In turn, GM3 is extended by other glycosyltransferases to generate nearly all the complex gangliosides enriched in neural tissue. Pathogenic mechanisms underlying the neural phenotypes associated with GM3SD are unknown...
September 7, 2023: Human Molecular Genetics
https://read.qxmd.com/read/37653044/a-defect-in-mitochondrial-fatty-acid-synthesis-impairs-iron-metabolism-and-causes-elevated-ceramide-levels
#12
JOURNAL ARTICLE
Debdeep Dutta, Oguz Kanca, Seul Kee Byeon, Paul C Marcogliese, Zhongyuan Zuo, Rishi V Shridharan, Jun Hyoung Park, Guang Lin, Ming Ge, Gali Heimer, Jennefer N Kohler, Matthew T Wheeler, Benny A Kaipparettu, Akhilesh Pandey, Hugo J Bellen
In most eukaryotic cells, fatty acid synthesis (FAS) occurs in the cytoplasm and in mitochondria. However, the relative contribution of mitochondrial FAS (mtFAS) to the cellular lipidome is not well defined. Here we show that loss of function of Drosophila mitochondrial enoyl coenzyme A reductase (Mecr), which is the enzyme required for the last step of mtFAS, causes lethality, while neuronal loss of Mecr leads to progressive neurodegeneration. We observe a defect in Fe-S cluster biogenesis and increased iron levels in flies lacking mecr, leading to elevated ceramide levels...
August 31, 2023: Nature metabolism
https://read.qxmd.com/read/37620957/ceramide-synthesis-regulates-biogenesis-and-packaging-of-exosomal-malat1-from-adipose-derived-stem-cells-increases-dermal-fibroblast-migration-and-mitochondrial-function
#13
JOURNAL ARTICLE
Xaioyuan Kong, Niketa A Patel, Charles E Chalfant, Denise R Cooper
BACKGROUND: The function of exosomes, small extracellular vesicles (sEV) secreted from human adipose-derived stem cells (ADSC), is becoming increasingly recognized as a means of transferring the regenerative power of stem cells to injured cells in wound healing. Exosomes are rich in ceramides and long noncoding RNA (lncRNA) like metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). We identified putative ceramide responsive cis-elements (CRCE) in MALAT1. We hypothesized that CRCE respond to cellular ceramide levels to regulate sEV MALAT1 packaging...
August 24, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37400950/the-small-molecule-fgfr-inhibitor-infigratinib-exerts-anti-inflammatory-effects-and-remyelination-in-a-model-of-multiple-sclerosis
#14
JOURNAL ARTICLE
Ranjithkumar Rajendran, Vinothkumar Rajendran, Gregor Böttiger, Christine Stadelmann, Kian Shirvanchi, Laureen von Au, Sudhanshu Bhushan, Natascha Wallendszus, Darja Schunin, Victor Westbrock, Gerhard Liebisch, Süleyman Ergün, Srikanth Karnati, Martin Berghoff
BACKGROUND AND PURPOSE: Fibroblast growth factors (FGF) and receptors (FGFR) have been shown to modulate inflammation and neurodegeneration in multiple sclerosis (MS). The selective FGFR inhibitor infigratinib has been shown efficient in models of cancers. Herein, we aimed to investigate the effects of infigratinib on prevention and suppression of first clinical episodes in MOG35-55 -induced EAE. EXPERIMENTAL APPROACH: The oral FGFR inhibitor infigratinib was applied over 10 days either from the time of EAE induction or the onset of symptoms...
July 3, 2023: British Journal of Pharmacology
https://read.qxmd.com/read/37305575/-medicago-sativa-defensin1-as-a-tumor-sensitizer-for-improving-chemotherapy-translation-from-anti-fungal-agent-to-a-potential-anti-cancer-agent
#15
JOURNAL ARTICLE
Raghu Pandurangi, Amol Karwa, Uma Shankar Sagaram, Katherine Henzler-Wildman, Dilip Shah
Plant defensins including Medicago Sativa defensin 1 (MsDef1) are cysteine-rich antifungal peptides which are known for potent broad-spectrum antifungal activity against bacterial or fungal pathogens of plants. The antimicrobial activities of these cationic defensins are attributed to their capacity to bind to cell membranes to create potentially structural defects tin the cell membranes to interact with intracellular target (s) and mediates cytotoxic effects. Our earlier work identified Glucosylceramide (GlcCer) of fungus F...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37082124/sphingolipids-in-thyroid-eye-disease
#16
REVIEW
Anne Gulbins, Gina-Eva Görtz, Erich Gulbins, Anja Eckstein
Graves' disease (GD) is caused by an autoimmune formation of autoantibodies and autoreactive T-cells against the thyroid stimulating hormone receptor (TSHR). The autoimmune reaction does not only lead to overstimulation of the thyroid gland, but very often also to an immune reaction against antigens within the orbital tissue leading to thyroid eye disease, which is characterized by activation of orbital fibroblasts, orbital generation of adipocytes and myofibroblasts and increased hyaluronan production in the orbit...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37016912/inhibitory-effect-of-porphyromonas-gingivalis-derived-phosphoethanolamine-dihydroceramide-on-acid-ceramidase-expression-in-oral-squamous-cells
#17
JOURNAL ARTICLE
Chiaki Yamada, Anny Ho, Amilia Nusbaum, Ruijuan Xu, Mary Ellen Davey, Frank Nichols, Cungui Mao, Alexandru Movila
The maintenance of diminished acid ceramidase (ASAH1) gene expression leading to the accumulation of antiproliferative intracellular ceramides in oral squamous cell carcinoma (OSCC) has emerged as a prospective oral cancer therapeutic regimen. Our published study demonstrated that the key periodontal pathogen Porphyromonas gingivalis downregulates the expression patterns of ASAH1 mRNA in normal epithelial cells in vitro. Therefore, P. gingivalis may also beneficially diminish the expression of ASAH1 in OSCC...
April 5, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/36951944/sphingolipid-desaturase-degs1-is-essential-for-mitochondria-associated-membrane-integrity
#18
JOURNAL ARTICLE
Laura Planas-Serra, Nathalie Launay, Leire Goicoechea, Bénédicte Heron, Cristina Jou, Natalia Juliá-Palacios, Montserrat Ruiz, Stéphane Fourcade, Carlos Casasnovas, Carolina De La Torre, Antoinette Gelot, Maria Marsal, Pablo Loza-Alvarez, Àngels García-Cazorla, Ali Fatemi, Isidre Ferrer, Manel Portero-Otin, Estela Area-Gómez, Aurora Pujol
Sphingolipids function as membrane constituents and signaling molecules, with crucial roles in human diseases, from neurodevelopmental disorders to cancer, best exemplified in the inborn errors of sphingolipid metabolism in lysosomes. The dihydroceramide desaturase Δ4-dihydroceramide desaturase 1 (DEGS1) acts in the last step of a sector of the sphingolipid pathway, de novo ceramide biosynthesis. Defects in DEGS1 cause the recently described hypomyelinating leukodystrophy-18 (HLD18) (OMIM #618404). Here, we reveal that DEGS1 is a mitochondria-associated endoplasmic reticulum membrane-resident (MAM-resident) enzyme, refining previous reports locating DEGS1 at the endoplasmic reticulum only...
May 15, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/36928060/the-role-of-bile-acids-in-regulating-glucose-and-lipid-metabolism
#19
JOURNAL ARTICLE
Hengcai Yu, Ruifang Nie, Chengwu Shen
In recent years, bile acids (BAs) are increasingly being appreciated as signaling molecules beyond their involvement in bile formation and fat absorption. The farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) are two dominating receptors through which BAs modulate glucose and lipid metabolism. FXR is highly expressed in the intestine and liver. GPBAR1 is highly expressed in the intestine. The present study reviews the metabolism and regulation of BAs, especially the effects of BAs on glucose and lipid metabolism by acting on FXR in the liver and intestine, and GPBAR1 in the intestine...
March 15, 2023: Endocrine Journal
https://read.qxmd.com/read/36791476/the-effects-of-size-and-surface-functionalization-of-polystyrene-nanoplastics-on-stratum-corneum-model-membranes-an-experimental-and-computational-study
#20
JOURNAL ARTICLE
Shiqiang Cheng, Jiajie Hu, Chen Guo, Zhicheng Ye, Yazhuo Shang, Cheng Lian, Honglai Liu
Nanoplastics are mainly generated from the decomposition of plastic waste and artificial production and have attracted much attention due to their wide distribution in the environment and the potential risk for humans. As the largest organ of the human body, the skin is inevitably in contact with nanoplastics. Stratum corneum is the first barrier when the skin is exposed to nanoplastics. However, little is known about the interactions between nanoplastics and stratum corneum. Here, the effects of particle size and surface functionalization (amino-modified and carboxy-modified) of polystyrene nanoplastics on the stratum corneum models were studied by Langmuir monolayer and molecular dynamics simulations...
February 4, 2023: Journal of Colloid and Interface Science
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