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Keywords Complications Iodine treatment...

Complications Iodine treatment hyperthyroidism

https://read.qxmd.com/read/38453358/the-accomplishments-and-legacy-of-saul-hertz-md
#1
JOURNAL ARTICLE
Bennett S Greenspan, Michael S Hofman, John Buscombe
The early history of the use of radioactive iodine (RAI) is complicated and interesting, and also difficult to discover, especially since several histories have presented inaccurate content. This article is a comprehensive review of the accomplishments of Saul Hertz. Extensive use of primary-source verification has clarified several issues, including the question of whether Hertz alone conceived and asked the pivotal question: "Could iodine be made radioactive artificially?"; on what date RAI was first used to treat hyperthyroidism; and why 2 articles on the first use of RAI for treatment of hyperthyroidism, from 2 different sets of authors from the same department of the same institution, appeared adjacent to each other in the same issue of the Journal of the American Medical Association in 1946...
March 7, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38229163/thyroid-storm-in-pregnancy-a-review
#2
REVIEW
Vidhu Vadini, Prabhav Vasistha, Almog Shalit, Spyridoula Maraka
BACKGROUND: Thyroid storm is a state of circulating thyroid hormone excess leading to multiorgan dysfunction and systemic decompensation. It typically occurs in the setting of poorly controlled hyperthyroidism and a precipitating illness or event. Management of thyroid storm in pregnancy poses unique diagnostic and therapeutic challenges. MAIN BODY: Thyroid storm is a clinical diagnosis characterized by hyperpyrexia, tachyarrhythmias, congestive heart failure, gastrointestinal and neuropsychiatric disturbances...
January 17, 2024: Thyroid Research
https://read.qxmd.com/read/38098934/mechanisms-and-treatment-options-for-hyperthyroid-induced-osteoporosis-a-narrative-review
#3
REVIEW
Robert M Branstetter, Rahib K Islam, Collin A Toups, Amanda N Parra, Zachary Lee, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D Kaye
Normal thyroid hormone levels are crucial for the homeostasis of many metabolic cycles and processes throughout the human body. Thyroid dysfunction, such as thyrotoxicosis, can result from many different etiologies, including Graves' disease (GD), toxic multinodular goiter (MNG), and toxic adenoma. These hyperthyroid disease states can cause devastating complications and disease, including the disruption of the bone remodeling cycle and skeletal development, which can result in osteoporosis. Osteoporosis is characterized by a decrease in bone mineral density and a propensity for fragility fractures...
November 2023: Curēus
https://read.qxmd.com/read/38098552/atypical-presentation-of-hyperthyroidism-complicated-complete-hydatidiform-mole-in-a-24-year-old-female-a-case-report
#4
Marah Mansour, Rania Almasri, Noura Amin, George Hamwi, Rawdah Attoum, Ilda Moafak Kanbour, Sara Mohammad Talal Jeniat, Samar AlKhrait
INTRODUCTION AND IMPORTANCE: Molar pregnancy is the most common type of gestational trophoblastic disease. It manifests as vaginal bleeding, accompanied by high levels of β-human chorionic gonadotropin (β-HCG). This case aims to highlight the importance of considering gestational trophoblastic disease as a potential diagnosis and its serious complications. CASE PRESENTATION: A 24-year-old female presented with vomiting, nausea, and no complaint of vaginal bleeding...
December 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/38046703/advancing-preoperative-strategies-for-thyroidectomy-in-graves-disease-a-narrative-review
#5
REVIEW
David Elkhoury, Pruthvi Patel, Saalini Sastry, Alireza Tajik, Christina Elkhoury, Michael Montalbano
Graves' disease is an autoimmune disorder characterized by thyroid-stimulating antibodies that can potentially lead to thyrotoxicosis, goiter, skin disease, and eye disease. Available treatment options for Graves' disease include management with antithyroid drugs (ATDs), thyroid ablation with radioactive iodine (RAI), and surgical thyroid gland removal. For individuals unable to reach a normal thyroid hormone level, promptly considering a thyroidectomy is essential. Preoperative strategies to achieve a euthyroid state prevent thyroid storms and minimize postoperative complications and are therefore crucial...
November 2023: Curēus
https://read.qxmd.com/read/38044176/autoimmune-thyroid-diseases
#6
REVIEW
Petra Petranović Ovčariček, Rainer Görges, Luca Giovanella
Autoimmune thyroid diseases (AITDs) include a wide spectrum of thyroid diseases affecting more commonly women than men. The most frequent forms are Graves' Disease (GD) and Hashimoto's thyroiditis / Autoimmune Thyroiditis (AIT), but there are also other immunogenic destructive forms of thyroiditis, that is, silent and postpartum thyroiditis. In the last decade, AITDs and other inflammatory thyroid diseases related to anti-tumor molecular drugs are more frequently seen due to the widespread use of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICPIs)...
December 2, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38028251/therapeutic-plasma-exchange-as-a-bridging-therapy-for-the-definitive-treatment-of-a-patient-with-graves-disease-and-methimazole-induced-liver-injury
#7
Dyah Purnamasari, Ardy Wildan, Juferdy Kurniawan, Nadia Ayu Mulansari, Birry Karim, Erwin Danil Yulian
INTRODUCTION: Graves' disease (GD) is an autoimmune condition affecting the thyroid gland. The aim of treating GD is to control the symptoms of hyperthyroidism and achieve long-term remission. Antithyroid drugs (ATDs) are the medications of choice among newly-diagnosed GD patients as they are easy to be delivered and cause remission in more than 50% of patients. However, ATDs increase the risk of hepatotoxicity, especially among patients with liver abnormalities. Patients who cannot tolerate ATDs should receive definitive therapy such as radioactive iodine (RAI) or surgery...
July 2023: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/37487349/a-giant-toxic-multinodular-goiter-extending-into-the-retropharyngeal-space-a-case-report
#8
Gutu Ganati Tola, Birhanu Abdisa Tesso, Wongel Tena Shale
INTRODUCTION: In areas with iodine deficiency, multinodular goiter is a prevalent cause of hyperthyroidism. If left untreated, it can grow until it is noticeably huge in size. Although it is a rare clinical phenomenon, thyroid swelling extending into the retro-pharyngeal space presents a substantial difficulty for the surgeon. In this article, we report a giant thyroid mass that had extended to the retro-pharyngeal space and how it posed a challenge during surgery. CASE PRESENTATION: Female, 30-year-old, presented with a huge goiter of 15 years duration which extended to retro-visceral space and completely encircled them without extension to retro-sternal space...
July 20, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37180180/acute-myeloid-leukemia-following-radioactive-iodine-therapy-for-metastatic-follicular-carcinoma-of-the-thyroid
#9
Komal Bishnoi, Ralph Emerson, Girish Kumar Parida, Prapti Acharya, Somanath Padhi, Kanhaiyalal Agrawal
Radioactive iodine (RAI) therapy is widely used and has an important role in the management of hyperthyroidism and thyroid malignancies. The development of acute or chronic leukemia is a very rare complication of RAI therapy. We report a case of metastatic Follicular thyroid cancer (FTC) who underwent total thyroidectomy followed by treatment with a cumulative dose of 1600 mCi of RAI (for 4 years) and by palliative radiotherapy for L4 spinal metastasis, later on, developed acute myeloid leukemia. Thus, all patients with thyroid carcinoma treated with RAI should undergo periodic hematological examinations irrespective of RAI dose...
2023: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://read.qxmd.com/read/37051708/gestational-and-postpartum-complications-in-patients-with-first-trimester-thyrotoxicosis-a-prospective-multicenter-cohort-study-from-northeast-china
#10
MULTICENTER STUDY
Yingxi Xu, Chenyan Li, Weiwei Wang, Xiaohui Yu, Aihua Liu, Yang Shi, Xiaochen Xie, Jiashu Li, Yongze Li, Zhongyan Shan, Weiping Teng, Yushu Li
Objective: Gestational transient thyrotoxicosis (GTT) and Graves' disease (GD) are the most common causes of hyperthyroidism during pregnancy. However, few studies have compared pregnancy outcomes of patients who had GTT with those who had GD in the first trimester of pregnancy. Methods: We conducted a prospective multicenter cohort study in China. Participants received questionnaires, physical examinations, and underwent measurements of thyrotropin (TSH), free thyroxine (fT4), thyroid peroxidase antibody (TPOAb), TSH receptor antibody (TRAb), and urinary iodine in the first trimester...
June 2023: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/37038339/a-30-year-old-woman-with-a-history-of-autoimmune-hyperthyroidism-presenting-with-fever-and-oral-ulcers-diagnosed-with-discoid-lupus-erythematosus
#11
JOURNAL ARTICLE
Jing Chen, Yulei Gao, Yanfen Chai, Hua Gao
BACKGROUND Lupus erythematosus (LE) is mainly clinically divided into cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) depending on the presence of multi-system manifestations. The most common subtype of CLE is discoid lupus erythematosus (DLE). Graves' disease (GD) is immunologically characterized by lymphocytic infiltration of the thyroid gland and the presence of thyroid-stimulating hormone (TSH) receptor antibodies (TSH-R-Ab), and is the most common autoimmune pathogenic cause of hyperthyroidism...
April 11, 2023: American Journal of Case Reports
https://read.qxmd.com/read/37036479/efficacy-of-single-session-radiofrequency-ablation-rfa-in-rendering-euthyroidism-for-persistent-relapsed-graves-disease-a-pilot-study
#12
JOURNAL ARTICLE
Man Him Matrix Fung, Brian Hung Hin Lang
OBJECTIVES: Graves' disease (GD) is the most common cause of hyperthyroidism. Antithyroid drug (ATD) is often the first-line treatment but  > 50% patients suffer a relapse when ATD is discontinued. Surgery or radioiodine remains the current options of definitive treatment in these patients. This pilot study examined the short-term efficacy of single-session thyroid radiofrequency ablation (RFA) as a novel definitive treatment for persistent/relapsed GD. METHODS: Consecutive patients with persistent/relapsed GD requiring ATD were considered...
September 2023: European Radiology
https://read.qxmd.com/read/36963758/iatrogenic-endocrine-complications-of-lithium-therapy
#13
JOURNAL ARTICLE
Marie-Christine Vantyghem
Lithium is a cation, similar to sodium and potassium, affecting ion transport. It is used in the medical field as a treatment of bipolar disorders. The main endocrine complications of lithium treatment affect thyroid and parathyroid glands, in association with renal complications. Thyroid adverse effects, which are more frequent in women, comprise hypothyroidism, goiter, or sometimes hyperthyroidism, through interference with the iodine symporter. The increase in thyroid volume is early. Prevalence of goiter is 4 times higher than in the general population and hypothyroidism (8-20%) more frequent in case of pre-existing thyroid autoimmunity...
March 22, 2023: Annales D'endocrinologie
https://read.qxmd.com/read/36761477/efficacy-evaluation-and-influencing-factor-analysis-of-postoperative-131-i-for-the-treatment-of-primary-hyperthyroidism-combined-with-differentiated-thyroid-cancer-dtc-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Zilong Zhao, Na Han, Chenghui Lu, Congcong Wang, Yingying Zhang, Xinfeng Liu, Guoqiang Wang, Jiao Li, Zenghua Wang, Zengmei Si, Fengqi Li, Xufu Wang
BACKGROUND: 131 I treatment is one of the important methods of comprehensive postoperative treatment for patients with hyperthyroidism complicated with differentiated thyroid cancer (DTC). Early identification of patients with poor treatment efficacy of 131 I is particularly important. Current studies mainly focus on the relationship between hyperthyroidism and the occurrence and development of DTC, and there are few studies on the factors affecting the curative effect. The purpose of this study was to find the influencing factors of efficacy evaluation and provide evidence for early identification of patients with poor efficacy in DTC combined with primary hyperthyroidism patients...
January 1, 2023: Gland Surgery
https://read.qxmd.com/read/36727115/cardiothyreosis-epidemiological-clinical-and-therapeutic-approach
#15
JOURNAL ARTICLE
Elleuch Mouna, Ben Bnina Molka, Ben Teber Sawssan, Ben Salah Dhoha, Boujelbene Khouloud, Charfi Nadia, Mnif Fatma, Mnif Fatma, Mnif Mouna, Rekik Nabila, Hadj Kacem Faten, Abid Mohamed
INTRODUCTION: Cardiothyreosis corresponds to the cellular effects of free thyroid hormones on the vascular wall and the myocardium. We aim to describe the clinical, para-clinical and therapeutic aspects of cardiothyreosis and to detail prognostic factors. METHODS: We conducted a descriptive retrospective study at the Endocrinology-Diabetology Department of the Hedi Chaker University Hospital in Sfax-Tunisia. We collected medical records of 100 patients with cardiothyreosis between January 1999 and December 2019...
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36529758/incidence-and-treatment-outcomes-of-graves-disease-in-thailand-a-single-center-retrospective-observational-study
#16
JOURNAL ARTICLE
Wasit Kanokwongnuwat, Nawarat Penpong, Chaninporn Sangsri
BACKGROUND: Treatment patterns and outcomes of Graves' disease (GD) are variable around the world. However, studies on treatment outcomes of GD from the Asian populations are limited. We aimed to evaluate treatment outcomes of GD in Thailand. METHODS: Patients with new diagnoses of GD in a single center between 2014-2018 were retrospectively reviewed. The diagnosis of GD was based on clinical features, which included diffuse goiter, Graves' orbitopathy (GO), pretibial myxedema and acropachy...
December 19, 2022: Thyroid Research
https://read.qxmd.com/read/36437195/executive-summary-of-the-seen-sociedad-espa%C3%A3-ola-de-endocrinolog%C3%A3-a-y-nutrici%C3%A3-n-spanish-society-of-endocrinology-and-nutrition-sego-sociedad-espa%C3%A3-ola-deginecolog%C3%A3-a-y-obstetricia-spanish-society-of-gynaecology-and-obstetrics-consensusdocument-on-the-management
#17
Inés Velasco, Lluís Vila, Maria Goya, Amelia Oleaga, Maria de la Calle, Fco Javier Santamaria
During pregnancy, thyroid function disorders are associated with multiple complications, both maternal and foetal. In recent years, numerous Clinical Practice Guidelines have been developed to facilitate the identification and correct management of thyroid disease in pregnant women. However, this proliferation of guidelines has led to confusion by proposing different cut-off points for reference values and different recommendations for similar situations. For this reason, the Sociedad Española de Endocrinología y Nutrición and the Sociedad Española de Ginecología y Obstetricia have prepared this Consensus Document, with the aim of creating a framework for joint action to unify criteria for the diagnosis and treatment of thyroid dysfunction in these patients...
March 2023: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/36370147/abnormal-tsh-prior-to-surgery-in-children-with-graves-disease-predicts-abnormal-tsh-following-thyroidectomy
#18
JOURNAL ARTICLE
Inbal Hazkani, Eli Stein, Evan Edwards, John Maddalozzo, Douglas Johnston, Jill Samis, Jami Josefson, Jeffrey Rastatter
OBJECTIVE: To identify variables that are associated with poor compliance to thyroid hormone replacement therapy in children after total thyroidectomy. METHOD: A retrospective cohort study of children who underwent total thyroidectomy by high-volume pediatric otolaryngologists between 1/2014 and 9/2021. Postoperative poor compliance was characterized by at least three separate measurements of high TSH levels not associated with radioactive iodine treatment. RESULTS: There were 100 patients, ages 3-20 years old who met inclusion criteria; 44 patients underwent thyroidectomy for cancer diagnosis, and 56 for Graves' disease...
November 12, 2022: Laryngoscope
https://read.qxmd.com/read/36118802/clinical-review-and-update-on-the-management-of-thyroid-storm
#19
REVIEW
Reuben De Almeida, Sean McCalmon, Peminda K Cabandugama
Thyroid storm is a severe manifestation of thyrotoxicosis. Thyroid storm is diagnosed as a combination of thyroid function studies showing low to undetectable thyroid stimulating hormone (TSH) (<0.01mU/L) with elevated free thyroxine (T4) and/or triiodothyronine (T3), positive thyroid receptor antibody (TRab) (if Graves' disease is the underlying etiology), and with clinical signs and symptoms of end organ damage. Treatment involves bridging to a euthyroid state prior to total thyroidectomy or radioactive iodine ablation to limit surgical complications such as excessive bleeding from highly vascular hyperthyroid tissue or exacerbation of thyrotoxicosis...
2022: Missouri Medicine
https://read.qxmd.com/read/35985711/update-on-pediatric-hyperthyroidism
#20
REVIEW
Priya Vaidyanathan
Typical symptoms which should lead to suspicion of hyperthyroidism are unintentional weight loss, tachycardia, and palpitations, heat intolerance, and hyperactivity. It is diagnosed by suppressed thyroid-stimulating hormone (TSH) with elevated thyroid hormone (TH) levels. Graves' disease (GD) due to antibodies stimulating the TSH receptor is the leading cause, and first-line treatment is with methimazole (MMI). Emerging data suggest MMI treatment, up to 8 years is effective and safe in improving the rate of remission...
August 2022: Advances in Pediatrics
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