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Rana Attalla, Erin Puersten, Nidhi Jain, P Ravi Selvaganapathy
One of the primary focuses in recent years in tissue engineering has been the fabrication and integration of vascular structures into artificial tissue constructs. However, most available methodologies lack the ability to create multi-layered concentric conduits inside natural extracellular matrices (ECMs) and gels that replicate more accurately the hierarchical architecture of biological blood vessels. In this work, we present a new microfluidic nozzle design capable of multi-axial extrusion in order to 3D print and pattern bi- and tri-layered hollow channel structures...
December 11, 2018: Biofabrication
Manal Ali, Madi Jaghbir, Mahmoud Salam, Ghada Al-Kadamany, Rana Damsees, Nedal Al-Rawashdeh
Plastic made with bisphenol A (BPA) produces trans-generational changes in genes and behavior. It has been positively linked to obesity and thyroid dysfunction. This study aimed to detect the presence of BPA in polycarbonate plastic (PC) baby bottles. Fifteen PC baby bottles with a clear indication of BPA free/safe/clear were randomly selected. High-performance liquid chromatography (HPLC) tests were used to detect residual or migrating BPA post three stress tests. An estimated intake of BPA among children was calculated then compared to the universal tolerable daily intake (TDI)...
December 7, 2018: Environmental Monitoring and Assessment
Mahtab Babadi, Ahmad Khorshidi, Esmat Aghadavood, Mansooreh Samimi, Elham Kavossian, Fereshteh Bahmani, Alireza Mafi, Rana Shafabakhsh, Mahbobeh Satari, Zatollah Asemi
This study was carried out to evaluate the effects of probiotic supplementation on genetic and metabolic profiles in patients with gestational diabetes mellitus (GDM) who were not on oral hypoglycemic agents. This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 patients with GDM. Participants were randomly divided into two groups to intake either probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, Lactobacillus fermentum (2 × 109  CFU/g each) (n = 24) or placebo (n = 24) for 6 weeks...
December 8, 2018: Probiotics and Antimicrobial Proteins
Pankaj Bahuguna, Indranil Mukhopadhyay, Akashdeep Singh Chauhan, Saroj Kumar Rana, Sakthivel Selvaraj, Shankar Prinja
INTRODUCTION: Public health spending in India has been traditionally one of the lowest globally. Punjab is one of the states with highest proportion of out-of-pocket expenditures for healthcare in India. We undertook this study to produce the sub-national health accounts (SNHA) for Punjab state in India. METHODOLOGY: We used System of Health Accounts (SHA) 2011 framework for preparing health accounts for Punjab state. Data on health spending by government was obtained from concerned public sector departments both at state and central level...
2018: PloS One
Camilo Rojas, Elena Barnaeva, Ajit G Thomas, Xin Hu, Noel Southall, Juan Marugan, Amrita Datta Chaudhuri, Seung-Wan Yoo, Niyada Hin, Ondrej Stepanek, Ying Wu, Sarah C Zimmermann, Alexandra G Gadiano, Takashi Tsukamoto, Rana Rais, Norman Haughey, Marc Ferrer, Barbara S Slusher
Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles reach the liver, they stimulate the secretion of cytokines that mobilize peripheral immune cell infiltration into the brain, which can cause secondary tissue damage and impair recovery. Recent studies suggest that suppression of EV biosynthesis through neutral sphingomyelinase 2 (nSMase2) inhibition may represent a new therapeutic strategy...
December 7, 2018: Scientific Reports
Natasha Nurse-Clarke, Barbara DiCicco-Bloom, Rana Limbo
PURPOSE: The purpose of this study was to determine the extent to which labor and delivery nurses used the tenets of Swanson's middle-range theory to care for women whose babies were stillborn. STUDY DESIGN AND METHODS: A secondary analysis of qualitative in-depth interview data from 20 labor and delivery nurses obtained during a recent grounded theory study was conducted using the directed content analysis method. The five caring processes as described in Swanson's theory were used as a priori codes to conduct the analysis...
January 2019: MCN. the American Journal of Maternal Child Nursing
Marianne H Hutti, Rana Limbo
Providing nursing care to perinatally bereaved women and their families is difficult, emotionally demanding, and complicated. Here we demonstrate how, through understanding the theoretical underpinnings of Guided Participation and perinatal grief intensity, nurses can significantly expand their competence and confidence in their ability to provide highly individualized, supportive, relationship-based perinatal bereavement care. The way that parents respond to a perinatal loss may range from little response to highly intense, long-lasting grief...
January 2019: MCN. the American Journal of Maternal Child Nursing
Jintao Guo, Marc Giovannini, Anand V Sahai, Adrian Saftoiu, Christoph F Dietrich, Erwin Santo, Pietro Fusaroli, Ali A Siddiqui, Manoop S Bhutani, Anthony Yuen Bun Teoh, Atsushi Irisawa, Brenda Lucia Arturo Arias, Chalapathi Rao Achanta, Christian Jenssen, Dong-Wan Seo, Douglas G Adler, Evangelos Kalaitzakis, Everson Artifon, Fumihide Itokawa, Jan Werner Poley, Girish Mishra, Khek Yu Ho, Hsiu-Po Wang, Hussein Hassan Okasha, Jesse Lachter, Juan J Vila, Julio Iglesias-Garcia, Kenji Yamao, Kenjiro Yasuda, Kensuke Kubota, Laurent Palazzo, Luis Carlos Sabbagh, Malay Sharma, Mitsuhiro Kida, Mohamed El-Nady, Nam Q Nguyen, Peter Vilmann, Pramod Kumar Garg, Praveer Rai, Shuntaro Mukai, Silvia Carrara, Sreeram Parupudi, Subbaramiah Sridhar, Sundeep Lakhtakia, Surinder S Rana, Takeshi Ogura, Todd H Baron, Vinay Dhir, Siyu Sun
Background and Objectives: EUS-guided biliary drainage (EUS-BD) was shown to be useful for malignant biliary obstruction (MBO). However, there is lack of consensus on how EUS-BD should be performed. Methods: This was a worldwide multi-institutional survey among members of the International Society of EUS conducted in February 2018. The survey consisted of 10 questions related to the practice of EUS-BD. Results: Forty-six endoscopists of them completed the survey...
November 2018: Endoscopic Ultrasound
Joseph R Mihaljevic, Jason T Hoverman, Pieter T J Johnson
Multiple pathogens commonly co-occur in animal populations, yet few studies demonstrate how co-exposure of individual hosts scales up to affect transmission. Although viruses in the genus Ranavirus are globally widespread, and multiple virus species or strains likely co-occur in nature, no studies have examined how co-exposure affects infection dynamics in larval amphibians. We exposed individual northern red-legged frog Rana aurora larvae to 2 species of ranavirus, namely Ambystoma tigrinum virus (ATV), frog virus 3 (FV3), or an FV3-like strain isolated from a frog-culturing facility in Georgia, USA (RCV-Z2)...
December 11, 2018: Diseases of Aquatic Organisms
Samir Rana, Phyllis C Pugh, J Michael Wyss, Sarah M Clinton, Ilan A Kerman
We previously demonstrated independent effects of early-life experience (ELE) and trait aggression (TA) on resting heart rate (HR) and mean arterial pressure (MAP) in rats. The present study examined the effects of TA and ELE on stress-evoked cardiovascular reactivity and recovery. Pups born to Wistar-Kyoto dams were exposed to daily 180-min periods of maternal separation (MS) during the first two weeks of life, and aggression was assessed in adult offspring using the resident-intruder test. Radiotelemetry was then used to record stress-evoked HR and MAP responses in response to: strobe light, novel environment, intruder rat, or restraint...
December 4, 2018: Physiology & Behavior
Angie Docherty, Patti Warkentin, Judy Borgen, KellyAnn Garthe, Katherine L Fischer, Rana Halabi Najjar
AIM: This paper presents four innovative teaching modalities conceptually designed and adherent to National Survey of Student Engagement (NSSE) indicators. BACKGROUND: Nurse education has received 'calls' for transformation, demanding a pedagogical refocus that better equips the future workforce. A key aspect is the need to actively engage students in learning, an approach shown to improve outcomes. METHOD: Four innovative teaching modalities were incorporated into a baccalaureate curriculum, aligned to the NSSE indicators, and targeted an area of the curriculum where active student participation had the potential to improve the learning experience...
November 2018: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
Ruby Minhas, Danielle Young, Rabab Naseem, Ariel Mueller, Sireesha Chinthala, Joana Lopes Perdigao, Kiang-Teck J Yeo, Siaw Li Chan, Avery Tung, Julia Bregand White, Sajid Shahul, Sarosh Rana
BACKGROUND: Angiogenic factors have been implicated in the pathogenesis of preeclampsia. This pilot study explored the association between antenatal blood pressure levels and angiogenic biomarkers (sFlt1 and PlGF) among women with chronic hypertension (cHTN). METHODS: Blood samples were collected from women with cHTN (with/without superimposed preeclampsia) within 96 h prior to delivery. Subjects were stratified by mean outpatient BP as controlled (cBP < 140/90) or uncontrolled (uBP ≥ 140/90)...
October 2018: Pregnancy Hypertension
Atay Vural, Serhat Okar, Aslı Kurne, Güliz Sayat-Gürel, Nazire Pınar Acar, Erdem Karabulut, Kader Karlı Oğuz, Sibel Kadayıfçılar, Rana Karabudak
BACKGROUND: The extent of neurodegeneration in the earliest stages of central nervous system (CNS) demyelination is not known. Optical coherence tomography (OCT) is a powerful tool to study neurodegeneration in demyelinating disorders. OBJECTIVES: To study neuroaxonal loss in the retina of individuals with radiologically isolated syndrome (RIS) and investigate whether OCT measurements are associated with brain volumetrics and clinical conversion to multiple sclerosis (MS)...
December 11, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Rana Ahmed Youness, Reem Amr Assal, Shahira Mohamed Ezzat, Mohamed Zakaria Gad, Amira Abdel Motaal
This study focused on studying the impact of flavonoids isolated from Cleome droserifolia on HCC cell lines and to further unveil their possible impact on TP53 and its downstream tumor suppressor miRNAs. Three flavonol glycosides were isolated from C. droserifolia namely, Isorhamnetin-3-O-β-D-glucoside (1), Quercetin-3`-methoxy-3-O-(4``-acetylrhamnoside)-7-O-α-rhamnoside (2), and Kaempferol-4`-methoxy-3,7-O-dirhamnoside (3). They showed a concentration and time dependent reduction in cellular viability and anchorage-independent growth of HCC cells...
December 11, 2018: Natural Product Research
Payal Rana, Michael D Aleo, Mark Gosink, Yvonne Will
Mitochondrial toxicity has been shown to contribute to a variety of organ toxicities such as liver, cardiac and kidney. In the past decades, two high throughput applicable screening assays (isolated rat liver mitochondria; glucose-galactose grown HepG2 cells) to assess mitochondrial toxicity have been deployed in many pharmaceutical companies and numerous publications have demonstrated its usefulness for mechanistic investigations. However, only two publications have demonstrated the utility of these screens as a predictor of human drug induced liver injury...
December 10, 2018: Chemical Research in Toxicology
Stanzin Angmo, Shilpa Rana, Kamalendra Yadav, Rajat Sandhir, Nitin Kumar Singhal
Hepcidin, master regulator of iron homeostasis, causes anemia under infectious and inflammatory conditions by reducing intestinal absorption of iron with decreased release of iron from macrophages and liver despite adequate iron stores leading to Anemia of Inflammation (AI). Many therapeutic trials have been carried out but none have been effective due to its adverse effects. In present study, we discover that Guanosine 5'-diphosphate (GDP) encapsulated in lipid vesicle (NH+) was found to inhibit NF-ҝB activation by limiting phosphorylation and degradation of IҝBα, thus, attenuating IL-6 secretion from macrophage cells...
December 6, 2018: Scientific Reports
Rana Shafabakhsh, Esmat Aghadavod, Majid Ghayour-Mobarhan, Gordon Ferns, Zatollah Asemi
Retinopathy, characterized by an alteration of the retinal microvasculature, is a common complication of diabetes mellitus. These changes can cause increased permeability and alter endothelial cell proliferation, edema, and abnormal neovascularization and eventually result in blindness. The pathogenesis of diabetic retinopathy (DR) is complicated, involving many factors/mediators such as genetic susceptibility, microRNAs, and cytokines. One of the factors involved in DR pathogenesis is epigenetic changes that can have a key role in the regulation of gene expression; these include microRNAs, histone modifications, and methylation of DNA...
December 4, 2018: Journal of Cellular Physiology
Lakhwinder Singh, Surbhi Rana, Sidharth Mehan
The present study aimed to investigate the role of adenylyl cyclase activator in preventing diabetic nephropathy in rats. Renal function parameters, renal hypertrophy, lipid profile, markers of oxidative stress and free radical scavenging activities were assessed. Histopathology was performed to confirm Streptozotocin induced renal morphological changes in diabetic rats. Male Wistar rats were used in the present study to reduce the effect of estrogen. Rats were subjected to high fat diet (HFD) for two weeks followed by low dose of Streptozotocin (STZ) [35 mg/kg, i...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
Susiane S Moreira-Oliveira, Lucas Amaral-Machado, Wógenes Nunes de Oliveira, Éverton N Alencar, Kelly Cristine Zatta, Luanda B F C de Souza, Aldo da Cunha Medeiros, Guilherme Maranhão Chaves, Eryvaldo S T Egito
Oral candidiasis (OC) is an infectious disease caused by microorganisms of the genus Candida , leading to lesions in the buccal cavity. Its treatment consists of the administration of topical or systemic antifungal agents, which may compromise the patient compliance due to its side effects, highlighting the need for alternative treatments. In this scenario, bullfrog oil, an animal oil composed of a pool of saturated and unsaturated fatty acids, is introduced as a potential antifungal raw material. Thus, the aim of this work was to produce a mucoadhesive emulsified system able to deliver the bullfrog oil in the buccal cavity to treat the OC...
December 3, 2018: Pharmaceutics
Kriti Gupta, Arun Dadwal, Shammi Rana, Plawan Kumar Jha, Anil Jain, S M Yusuf, Pattayil A Joy, Nirmalya Ballav
Herein, we have synthesized at room-temperature two-dimensional nanosheets of a MOF comprised of cobalt(II) ion with benzenedicarboxylic acid  ligand, which exhibited unusual magnetic properties. Direct-current magnetic susceptibility revealed an antiferromagnetic (AFM) transition at 26 K (Néel temperature,  TN ) followed by a canting of the spin moments along with the concomitant appearance of a sigmoidal-shaped magnetization versus field ( M- H) curve at 15 K. Such a canted AFM ordering led to nonzero remnant magnetization with a remarkably high coercive field of ∼10 kOe at 5 K...
December 4, 2018: Inorganic Chemistry
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