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https://www.readbyqxmd.com/read/30341654/c-reactive-protein-as-a-predictor-of-post-operative-complications-in-bariatric-surgery-patients
#1
Marie Ashley Villard, Melissa C Helm, Tammy L Kindel, Matthew I Goldblatt, Jon C Gould, Rana M Higgins
BACKGROUND: The primary objective of this study was to evaluate the utility of CRP in early identification of post-operative complications after bariatric surgery. The ability of this marker to acutely predict post-operative complications in bariatric surgery patients has not been determined. METHODS: A retrospective chart review was conducted of adult patients who underwent a primary and revisional laparoscopic Roux-en-Y gastric bypass (LRYGB) or sleeve gastrectomy (LSG) between 2013 and 2017 at a single institution...
October 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30340523/characterizing-palestinian-snake-melon-cucumis-melo-var-flexuosus-germplasm-diversity-and-structure-using-snp-and-dartseq-markers
#2
Salam Y Abu Zaitoun, Rana M Jamous, Munqez J Shtaya, Omar B Mallah, Imad S Eid, Mohammed S Ali-Shtayeh
BACKGROUND: Crop landraces embody a source of beneficial genes potentially providing endurance to environmental stress and other agronomic qualities including yield. Our study included 88 snake melon accessions (Cucumis melo var. flexuosus) collected from 9 districts in the Palestinian West-Bank. These accessions represent four landraces of Palestinian snake melon: Green, and White Baladi, and Green, and White Sahouri. RESULTS: This is the first report on successful application of genotyping by sequencing in snake melon...
October 19, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/30340467/transplantation-gene-therapy-and-intestinal-pathology-in-mngie-patients-and-mice
#3
Rana Yadak, Max V Boot, Niek P van Til, Dominique Cazals-Hatem, Armin Finkenstedt, Elly Bogaerts, Irenaeus F de Coo, Marianna Bugiani
BACKGROUND: Gastrointestinal complications are the main cause of death in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Available treatments often restore biochemical homeostasis, but fail to cure gastrointestinal symptoms. METHODS: We evaluated the small intestine neuromuscular pathology of an untreated MNGIE patient and two recipients of hematopoietic stem cells, focusing on enteric neurons and glia. Additionally, we evaluated the intestinal neuromuscular pathology in a mouse model of MNGIE treated with hematopoietic stem cell gene therapy...
October 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/30340207/sequential-displacement-strategy-for-selective-and-highly-sensitive-detection-of-zn-2-hg-2-and-s-2-ions-an-approach-toward-a-molecular-keypad-lock
#4
Subrata Kumar Padhan, Jitendra Palei, Punam Rana, Narayan Murmu, Satya Narayan Sahu
A thiocarbonohydrazone locked salicylidene based macrocycle ligand L has been synthesized and its ion sensing properties were examined by UV-visible and fluorescence spectroscopy. The macrocycle serves as a highly selective colorimetric sensor for Hg2+ ions while it acts as an excellent fluorescent sensor for Zn2+ ions by exhibiting a green fluorescence at 498 nm even in the presence of interfering ions. A detailed analysis of binding characteristics such as complex stoichiometry, association constant and detection limits of L toward Hg2+ and Zn2+ ions were evaluated by UV-visible and fluorescence experiments which revealed a stronger binding affinity and higher detection limit of L toward the mercury ions...
October 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30337994/3d-fea-study-on-implant-threading-role-on-selection-of-implant-and-crown-materials
#5
Ahmad Mohamad Wazeh, Mohamed I El-Anwar, Rami M Galal Atia, Rana Mohammed Mahjari, Sara Abdulelah Linga, Linah Mujeeb Alhaq Al-Pakistani, Salah Abdulazim Yousief
AIM: This study deeply investigates the effect of dental implant threading and material selection on the mandibular bone under two different crown materials (Translucent Zirconia and Porcelain fused to metal). METHODS: Two different designs of single piece dental implants were supporting dummy crown above simplified bone geometry in two finite element models. Models components were created by general-purpose CAD/CAM engineering package and then assembled inside ANSYS before meshing and assigning materials...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/30337150/the-burden-and-impact-of-antibiotic-prescribing-in-ambulatory-pediatrics
#6
Alexandra B Yonts, Matthew P Kronman, Rana F Hamdy
Antibiotics are one of the most commonly prescribed classes of medication for children and adolescents. While they are arguably the most powerful tool we possess against bacterial infections, they are frequently given to children whose illnesses are due to viruses or other non-infectious etiologies. When antibiotics are not used judiciously, the consequences can be serious and accumulate over time. This review article quantifies the burden of antimicrobial use in the pediatric outpatient setting in the United States, reviews recommended first line antibiotic regimens for common outpatient pediatric and adolescent conditions, investigates the reasons for inappropriate prescribing of antibiotics in outpatient healthcare settings, and explores the range of consequences of overuse and inappropriate use of antibiotics, from adverse drug reactions to impact on the microbiome to rising rates of antimicrobial resistance in common ambulatory conditions...
October 15, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/30336431/the-influence-of-microplastics-on-trophic-interaction-strengths-and-oviposition-preferences-of-dipterans
#7
Ross N Cuthbert, Rana Al-Jaibachi, Tatenda Dalu, Jaimie T A Dick, Amanda Callaghan
Microplastic (MP) pollution continues to proliferate in freshwater, marine and terrestrial environments, but with their biotic implications remaining poorly understood. Biotic interactions such as predation can profoundly influence ecosystem structuring, stability and functioning. However, we currently lack quantitative understandings of how trophic interaction strengths and associated behaviours are influenced by MP pollution, and how transference of MPs between trophic levels relates to consumptive traits...
October 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30334765/identification-of-novel-scaffolds-with-dual-role-as-antiepileptic-and-anti-breast-cancer
#8
Shailima Rampogu, Ayoung Baek, Rohit S Bavi, Minky Son, Guang Ping Cao, Raj Kumar, Chanin Park, Amir Zeb, Rabia Mukthar Rana, Seok Ju Park, Keun Woo Lee
Aromatase inhibitors with an IC50 value ranging from 1.4 to 49.7uM are known to act as antiepileptic drugs besides being potential breast cancer inhibitors. The aim of the present study is to identify novel antiepileptic aromatase inhibitors with higher activity exploiting the ligand-based pharmacophore approach utilizing the experimentally known inhibitors. The resultant Hypo1 consists of four features and was further validated by using three different strategies. Hypo1 was allowed to screen different databases to identify lead molecules and were further subjected to Lipinski' Rule of Five and ADMET to establish their drug-like properties...
October 12, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/30328608/availability-and-safety-of-blood-transfusion-during-humanitarian-emergencies
#9
REVIEW
Yetmgeta Abdella, Rana Hajjeh, Cees Th Smit Sibinga
Background: Availability and safety of blood transfusion is a major concern in countries affected by humanitarian emergencies. These emergencies increase demand for blood transfusion and make its delivery challenging and complex. Nevertheless, there is a lack of information on emergency preparedness and response capacity of blood transfusion services and on the challenges in meeting patients' needs. Aims: To assess availability and safety of blood transfusion during humanitarian emergencies...
October 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/30325986/association-of-androgen-deprivation-therapy-with-dementia-in-men-with-prostate-cancer-who-receive-definitive-radiation-therapy
#10
Rishi Deka, Daniel R Simpson, Alex K Bryant, Vinit Nalawade, Rana McKay, J D Murphy, Brent S Rose
No abstract text is available yet for this article.
October 11, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30325682/regulatory-t-cells-and-their-association-with-serum-markers-and-symptoms-in-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#11
Vikas Kailashiya, Usha Singh, Ranjan Rana, Nand Kumar Singh, Debabrata Dash, Jyotsna Kailashiya
PURPOSE: Impairment in number and functions of regulatory T cells (Treg) has been found to be associated with many autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study was conducted to identify and compare Treg by flow cytometry using two different staining approaches. METHODS: Treg were identified by using CD4+CD25+high and CD4+CD25+CD127dim staining approaches in SLE and RA patients and healthy controls. Association of both identified Treg levels with various serum markers and clinical presentation was also examined...
October 16, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/30322711/from-paper-to-practice-strategies-for-improving-antibiotic-stewardship-in-the-pediatric-ambulatory-setting
#12
Michael J Bozzella, Nada Harik, Jason G Newland, Rana F Hamdy
Antibiotic stewardship aims to better patient outcomes, reduce antibiotic resistance, and decrease unnecessary health care costs by improving appropriate antibiotic use. More than half of annual antibiotic expenditures for antibiotics in the United States are prescribed in the ambulatory setting. This review provides a summary of evidence based strategies shown to improve antibiotic prescribing in ambulatory care settings including: providing education to patients and their families, providing education to clinicians regarding best practices for specific conditions, providing communications training to clinicians, implementing disease-specific treatment algorithms, implementing delayed prescribing for acute otitis media, supplying prescribing feedback to providers with peer comparisons, using commitment letters, and prompting providers to justify antibiotic prescribing for diagnoses for which antibiotics are not typically recommended...
October 13, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/30322303/degloving-the-feet-a-severe-case-of-hand-foot-syndrome-after-induction-chemotherapy
#13
Rana Kasht, Sarbajit Mukherjee, Sami Ibrahimi
No abstract text is available yet for this article.
November 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/30322120/evaluating-the-bioactivity-of-a-novel-broad-spectrum-antimicrobial-peptide-brevinin-1gha-from-the-frog-skin-secretion-of-hylarana-guentheri-and-its-analogues
#14
Qi Chen, Peng Cheng, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, Huimin Bian, Tianbao Chen
Many antimicrobial peptides (AMPs) have been identified from the skin secretion of the frog Hylarana guentheri ( H.guentheri ), including Temporin, Brevinin-1, and Brevinin-2. In this study, an antimicrobial peptide named Brevinin-1GHa was identified for the first time by using 'shotgun' cloning. The primary structure was also confirmed through mass spectral analysis of the skin secretion purified by reversed-phase high-performance liquid chromatography (RP-HPLC). There was a Rana-box (CKISKKC) in the C-terminal of Brevinin-1GHa, which formed an intra-disulfide bridge...
October 13, 2018: Toxins
https://www.readbyqxmd.com/read/30321957/radiological-outcome-of-calcaneo-cuboid-cuneiform-osteotomies-for-planovalgus-feet-in-cerebral-palsy-children-relationship-with-pedobarography
#15
Rana El-Hilaly, Mostafa H El-Sherbini, Mohamed M Abd-Ella, Ahmed A Omran
BACKGROUND: Calcaneo-cuboid-cuneiform (triple C) osteotomies correct all levels of deformity of flexible planovalgus feet (PVF) in patients with cerebral palsy (CP). The objective was assessing short term results and the hypothesis was that static pedobarography correlates with radiological parameters as outcome measures. METHODS: A prospective case series of consecutive skeletally immature ambulatory spastic CP patients above the age of 4 years who underwent triple C for PVF...
March 26, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/30320192/anti-endothelial-cell-antibody-rich-sera-from-rheumatic-heart-disease-patients-induces-proinflammatory-phenotype-and-methylation-alteration-in-endothelial-cells
#16
Mukul Rastogi, Subendu Sarkar, Ankita Makol, Rana Sandip Singh, Uma Nahar Saikia, Dibyajyoti Banerjee, Seema Chopra, Anuradha Chakraborti
Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in developing nations like India. RHD commonly affects the mitral valve which is lined by a single layer of endothelial cells (ECs). The role of ECs in mitral valve damage during RHD is not well elucidated. In here, anti-endothelial cell antibody from RHD patients has been used to stimulate the ECs (HUVECs and HMVECs). ECs proinflammatory phenotype with increased expression of TNFα, IL-6, IL-8, IFNγ, IL-1β, ICAM1, VCAM1, E-selectin, laminin B, and vimentin was documented in both ECs...
September 2018: Genes & Diseases
https://www.readbyqxmd.com/read/30319957/creutzfeldt-jakob-disease-with-unusual-presentation-of-peripheral-neuropathy-and-ophthalmoplegia
#17
Mais Arwani, Abhishek Purohit, Abdullah Haddad, Sandeep Rana
Creutzfeldt-Jakob disease (CJD) is a well-described disease. It is characterized by rapidly progressive dementia, myoclonus, ataxia, pyramidal, and extrapyramidal signs. There are well-defined electroencephalogram and magnetic resonance imaging (MRI) findings, and markers found in the cerebrospinal fluid (CSF). The gold standard for diagnosing CJD remains brain biopsy. We present a case of a patient with a family history of biopsy-proven CJD who initially presented with symptoms of peripheral neuropathy. A month later, he developed ataxia, ophthalmoparesis, and then dysarthria...
October 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/30319196/increased-nuclear-factor-%C3%AE%C2%BAb-rela-expression-levels-in-human-colorectal-carcinoma-in-north-indian-patients
#18
Ram Rattan Negi, Satya Vati Rana, Rajesh Gupta, Vikas Gupta, Vijayta D Chadha, Devinder K Dhawan
Colorectal cancer is a major cause of cancer-related death in many countries. Inflammatory pathway is considered to play a major role in colorectal carcinogenesis. Nuclear factor kappa B (NF-κB) pathway is a link between inflammation and cancer. NF-κB is a transcription factor which belongs to the Rel family. Activation of NF-κB has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The aim of the present study was to evaluate the expression levels of NF-κB/RelA in colorectal carcinoma using Real-time PCR...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/30318976/phyllodes-tumors-of-the-breast-treated-in-a-tertiary-health-care-center-case-series-and-literature-review
#19
Hazem Assi, Rana Salem, Fares Sukhon, Jaber Abbas, Fouad Boulos, Nagi El Saghir
Objective This study was performed to determine the subtypes of phyllodes tumor (PT) in patients at a single tertiary healthcare center in Lebanon and to describe their characteristics along with a review of the literature. Methods This single-institution retrospective cohort study included all cases of PT of the breast treated at the American University of Beirut Medical Center from 1 January 2010 to 31 December 2014. The patients' demographic data, tumor characteristics, treatment data, and pathology reports were analyzed...
October 14, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30317118/toxicity-of-some-prevalent-organic-chemicals-to-tadpoles-and-comparison-with-toxicity-to-fish-based-on-mode-of-toxic-action
#20
Shuo Wang, Li C Yan, Shan S Zheng, Tian T Li, Ling Y Fan, Tao Huang, Chao Li, Yuan H Zhao
Although mode of action (MOA) plays a key role in the understanding of the toxic mechanism of chemicals, the MOAs of class-based compounds to tadpoles have not been investigated. To explore the MOAs, acute toxicity (expressed as log 1/LC50 ) to Rana chensinensis tadpoles were determined and molecular descriptors were calculated. Quantitative structure-activity relationship (QSAR) showed that toxicity to tadpoles is closely related to the chemical octanol/water partition coefficient (log KOW ), energy of the lowest unoccupied molecular orbital (ELUMO ), and number of hydrogen bond donors and acceptors (NHDA ), representing the bio-uptake potential in tadpoles, the electrophilicity and hydrogen bonding capacity with target site(s), respectively...
October 11, 2018: Ecotoxicology and Environmental Safety
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