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Surinder Singh Rana, Pankaj Gupta, Ravi Sharma, Anmol Bhatia, Rajesh Gupta
No abstract text is available yet for this article.
August 15, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Swati Sachdev, Anupriya Singh, Rana Pratap Singh
Use of agro-waste for production of value added products is a good alternative for developing low-cost carriers for formulation of Trichoderma -based bio-products. It provides avenues for safe utilization of wastes, while reducing cost and environment pollution load of waste disposal. The present study was undertaken to find suitable agro-waste for economical and higher mass production of Trichoderma lixii TvR1 under solid-state fermentation, optimizing culture conditions using mathematical model and assessing effect of formulated bio-product on growth of Spinach ( Spinacia oleracea )...
August 2018: 3 Biotech
David J Mathew, Rana A Greene, Yousaf Jamal Mahsood, Numan Hallaji, Ana Maria B Vargas, Ya-Ping Jin, Antonio Finelli, Matteo Parotto, Avner Belkin, Graham E Trope, Yvonne M Buys
PURPOSE: This study evaluated the effect of preoperative brimonidine tartrate 0.2% on intraocular pressure (IOP) during robotic-assisted laparoscopic radical prostatectomy (RALP) in steep Trendelenburg position (sTBURG). METHODS: In this prospective randomized controlled masked interventional trial, eligible patients scheduled for RALP in sTBURG at the Toronto General Hospital had one eye randomized to placebo (artificial tears) or drug (brimonidine tartrate 0.2%) preoperatively...
August 7, 2018: Journal of Glaucoma
Yao Gao, Chenhao Yang, Huihui Gao, Liqing Wang, Changming Yang, Hong Ji, Wuzi Dong
The aim of this study was to characterise the molecular structure of the oestrogen receptor ERα and to evaluate the effect of bisphenol A (BPA) on ERα expression during sexual development of the Chinese giant salamander (Andrias davidianus). The ERα cDNA of A. davidianus includes an open reading frame of 1755 bp (encoding 584 amino acids), a 219-bp 5' untranslated region (UTR) and a 611-bp 3'UTR. A polyadenylation signal was not found in the 3'UTR. Amino acid sequence analysis showed high homology between ERα of A...
August 10, 2018: Reproduction, Fertility, and Development
Henrik Holtmann, Julian Lommen, Norbert R Kübler, Christoph Sproll, Majeed Rana, Patrick Karschuck, Rita Depprich
Objective This study was performed to determine whether the results of prevailing in vivo and in vitro studies offer a reliable model for investigation of medication-related osteonecrosis of the jaw (MRONJ). Methods Embase, Medline, and the Cochrane Library were searched for articles published from September 2003 to June 2017 involving experimental approaches to the pathogenesis of MRONJ. In vivo and in vitro trials were analyzed with respect to the scientific question, study design, methodology, and results...
August 9, 2018: Journal of International Medical Research
Shaylika Chauhan, Priya Jaisinghani, Jaivir Rathore, Hassan Tariq, Yesenia Galan, Arjun Madhavan, Haris Rana, Douglas Frenia
We present a rare case report of a patient diagnosed with primary plasma cell leukemia (PCL) who presented with atypical signs and symptoms which acutely evolved into life-threatening multi-organ failure. This case raises questions regarding the latest diagnostic guidelines and therapeutic options in the management of acute PCL and reinforces the need for prompt treatment after diagnosis.
March 2018: Journal of Family Medicine and Primary Care
Hajar Oghbaei, Mohammad Reza Alipour, Gholamreza Hamidian, Mahdi Ahmadi, Vajihe Ghorbanzadeh, Rana Keyhanmanesh
NEW FINDINGS: What is the central question of this study? Whether a low dose of inorganic nitrate supplementation can prevent the testicular functional and structural alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months had protective effects on male reproductive system. Improved body weight loss, sperm and testis parameters, spermatogenesis index, and testis histology as well as increased serum testosterone levels in diabetic rats...
August 8, 2018: Experimental Physiology
Jishan Wu, Anup Rana, Yongseok Hong, Tullimilli Y Gopalakrishna, Hoa Phan, Tun Seng Herng, Priya Yadav, Jun Ding, Dongho Kim
We report the synthesis of a bithiophene bridged 34π conjugated aromatic expanded porphycene 1 and a cyclopentabithiophene bridged 32π conjugated anti-aromatic expanded porphycene 2 by a McMurry coupling strategy. Magnetic measurements and theoretical calculations reveal that both 1 and 2 exhibit open-shell singlet ground state with significant radical character (y0 = 0.63 for 1; y0 = 0.68, y1 = 0.18 for 2; y0: diradical character, y1: tetraradical character) and small singlet-triplet energy gap (ΔES-T= - 3...
August 8, 2018: Angewandte Chemie
Rana Keyhanmanesh, Reza Rahbarghazi, Mahdi Ahmadi
Achieving the optimal clinical outcome of mesenchymal stem cells (MSCs) is particularly dependent on fundamental understanding of therapeutic mechanisms. The current study was focused on the possible mechanisms by which rat bone marrow-derived mesenchymal stem cells (rBMMSCs) and/or conditioned media (CM) display broad immunomodulatory properties for ameliorating of asthma-related pathological changes. Male rats were divided equally into four experimental groups (n = 6): healthy rats received 50 μl PBS intravenously (group C), sensitized rats received 50 μl PBS intravenously (group OVA), sensitized rats received 50 μl CM intravenously (group OVA + CM), and sensitized rats received 50 μl PBS intravenously containing 2 × 106 rBMMSCs (group OVA + MSCs)...
August 7, 2018: Inflammation
Hang Cheng, Jeffrey W Clymer, Rana A Qadeer, Nicole Ferko, Behnam Sadeghirad, Chris G Cameron, Joseph F Amaral
Background: As compared to conventional techniques, recent meta-analyses have reported cost savings with Harmonic devices; however, only in thyroidectomy. Thus, the aim of this study was to evaluate the costs associated with Harmonic devices versus conventional techniques across a range of surgical procedures. Methods: A systematic search of MEDLINE, EMBASE, and Cochrane Library was conducted from inception to October 01, 2016 without language restrictions to identify randomized controlled trials comparing Harmonic devices to conventional techniques and reporting procedure costs (operating time plus operating equipment/consumables/device costs)...
2018: ClinicoEconomics and Outcomes Research: CEOR
Sudhir Jain, Anita Rana, Kavita Jain, Sravan K Perla, Nitin Puri, Ashok Kumar
Background: The contribution of single nucleotide polymorphisms in transcriptional regulation of the human angiotensin receptor type I (hAT1R) gene in age related chronic pathologies such as hypertension and associated renal disorders is not well known. The hAT1R gene has SNPs in its promoter that forms two haplotypes (Hap), Hap-I and Hap-II. Hap-I of AT1R gene is associated with hypertension in Caucasians. We have hypothesized here that age will alter the transcriptional environment of the cell and will regulate the expression of hAT1R gene in a haplotype-dependent manner...
August 1, 2018: American Journal of Hypertension
Wenyan Zhang, Guocheng Shu, Yulong Li, Shan Xiong, Chunping Liang, Cheng Li
Roadkill has gradually become a common factor that has contributed to the decline of amphibians, and traffic volume is an important parameter that can be used to determine the impacts of roads. However, few researchers have studied the effects of either daily or nightly traffic volume on amphibian roadkill in China. Hence, as an essential step for implementing mitigation measures, we conducted 77 road surveys along 10 km of road in the Wanglang National Nature Reserve (NNR) to determine the temporal and spatial distribution patterns of amphibian road mortality...
2018: PeerJ
Vandana Roy, Proteesh Rana
No abstract text is available yet for this article.
May 2018: Indian Journal of Medical Research
Adebanjo Adegbola, Rana Abutaima, Adeniyi Olagunju, Omotade Ijarotimi, Marco Siccardi, Andrew Owen, Julius Soyinka, Oluseye Bolaji
Background: Artemether-lumefantrine is often co-administered with efavirenz-based antiretroviral therapy for malaria treatment in HIV-infected women during pregnancy. Previous studies showed changes in lumefantrine pharmacokinetics due to interaction with efavirenz in non-pregnant adults. The influence of pregnancy on this interaction has not been reported. Method: This pharmacokinetic study involved 35 pregnant and 34 non-pregnant HIV-malaria co-infected women receiving efavirenz-based antiretroviral therapy and was conducted in four health facilities in Nigeria...
August 6, 2018: Antimicrobial Agents and Chemotherapy
Ritika Rana, Ruchika Sharma, Anoop Kumar
Today's, microbial infections, resistance to approved drugs, the emergence of new infectious diseases and lack of vaccines, create a huge threat to human health. Thus, there is an urgent need to create novel antimicrobial agents, but the high cost and prolonged timeline of novel drug discovery and development is major barrier to make new drugs. Therefore, there is a need for specific cost effective approaches in order to identify new drugs for the treatment of various microbial infections. Drug repurposition is an alternative technique to find existing clinically approved drugs for other indications...
August 6, 2018: Infectious Disorders Drug Targets
Rana Ahmed Youness, Reem Amr Assal, Amira Abdel Motaal, Mohamed Zakaria Gad
Hydrogen sulphide (H2 S) gas has been recognized as an intracellular mediator influencing an array of signaling pathways. Yet, the role of H2 S in cancer progression has been controversial. This study aims to unravel the role of exogenous H2 S in triple negative breast cancer (TNBC) and to further investigate any possible association of H2 S mediated actions with the endogenous production of nitric oxide (NO) gas. A wide concentration range of NaHS (20-2000 μM) and a variable reaction time (2-72 h) were probed...
August 3, 2018: Nitric Oxide: Biology and Chemistry
Maged Hassan, Maaz Rana, Najib M Rahman
No abstract text is available yet for this article.
August 2018: Chest
Krzysztof Nawara, Anup Rana, Pradeepta K Panda, Jacek Waluk
The determination of luminescence quantum yields by means of relative methods requires setting identical experimental conditions for both, sample and reference compounds. This requirement has a critical impact on the applicability of these protocols, as it does not allow for the precise determination of low quantum yield values using well-characterized high quantum yield standards. We show that using the SAFE approach (Simultaneous Absorption and Fluorescence Emission measurement, Anal. Chem. 2017, 89 (17), 8650-8655), the sample and reference compounds can be effectively measured with different excitation slit spectral bandpass or integration times, separately optimized for each chromophore...
August 6, 2018: Analytical Chemistry
Margaret N Holme, Subinoy Rana, Hanna M G Barriga, Ulrike Kauscher, Nicholas J Brooks, Molly M Stevens
The enzyme sphingomyelinase (SMase) is an important biomarker for several diseases such as Niemann Pick's, atherosclerosis, multiple sclerosis, and HIV. We present a two-component colorimetric SMase activity assay that is more sensitive and much faster than currently available commercial assays. Herein, SMase-triggered release of cysteine from a sphingomyelin (SM)-based liposome formulation with 60 mol % cholesterol causes gold nanoparticle (AuNP) aggregation, enabling colorimetric detection of SMase activities as low as 0...
August 6, 2018: ACS Nano
Yetmgeta Abdella, Gabriele Riedner, Rana Hajjeh, Cees Th Smit Sibinga
No abstract text is available yet for this article.
July 29, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
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