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Kari Remes, Pekka Anttila, Raija Silvennoinen, Mervi Putkonen, Hanna Ollikainen, Venla Terävä, Marjatta Sinisalo, Kristiina Kananen, Frida Schain, Päivi Castren-Kortegangas, Tiina M Järvinen, Marta Pisini, Felix Wahl, Tricia Dixon, Amy Leval
Outcomes for patients with multiple myeloma (MM) have improved with the advent of novel therapies, however, real-world evidence of outcomes in clinical practice is scarce. We conducted a multi-center registry study to build a reliable picture of treatment and patient outcomes in Finland. The aim of this study was also to understand any methodological challenges in assessing treatment outcomes using disease registry data. METHODS: We carried out a retrospective, observational study using data from the national Finnish Hematology Registry (FHR) to provide real-world evidence of outcomes for all adult patients diagnosed with and treated for MM between 2009-2013 at one of the six regional hospitals, with at least six months of recorded follow-up...
2018: PloS One
Ilona Luoma, Marie Korhonen, Kaija Puura, Raili K Salmelin
Loneliness has potentially adverse effects on health and is often connected with depression, while maternal depression has been shown to have a harmful effect on many indicators of children's socioemotional outcomes. The prevalence of loneliness among first-time mothers and its associations with depressive symptoms, background factors, and child outcomes in middle childhood and adolescence were investigated in this longitudinal study. A sample of 122 mother-child dyads was collected from maternal health clinics in Tampere, Finland...
December 5, 2018: Psychology, Health & Medicine
Risto Uusitalo, Riitta Lemola, Eila Turtola
No-till as a water protection measure is highly efficient in controlling erosion and particulate P (PP) loss but tends to increase dissolved reactive P (DRP) concentrations in runoff water. In a 9-yr field study on a clay soil in Southwest Finland, the effects of no-till and autumn plowing on surface runoff and subsurface drainage water quality were compared. The site had a 2% slope and was under spring cereal cropping, with approximately replacement fertilizer P rates. Vertical stratification of soil-test P that had developed during a preceding 6-yr grass ley was undone by plowing but continued to develop under no-till...
November 2018: Journal of Environmental Quality
Jenni Ervasti, Olli Pietiläinen, Ossi Rahkonen, Eero Lahelma, Anne Kouvonen, Tea Lallukka, Minna Mänty
PURPOSE: We developed a job exposure matrix (JEM) to study the association between long-term exposure to heavy physical effort or heavy lifting and carrying at work with disability pension due to musculoskeletal disorders and premature all-cause mortality. METHODS: Exposure to heavy physical effort at work during 1996-2005 was estimated with JEM developed for this study population, where the exposure was based on occupational titles of the participants. We included all employees of the City of Helsinki, Finland, who had annual data of exposure for 8-10 years (1996-2005, n = 18387)...
December 3, 2018: International Archives of Occupational and Environmental Health
Anna-Riia Holmström, Riina Järvinen, Raisa Laaksonen, Timo Keistinen, Persephone Doupi, Marja Airaksinen
BACKGROUND: Medication errors are common in healthcare. Medication error reporting systems can be established for learning from medication errors and risk prone processes, and their data can be analysed and used for improving medication processes in healthcare organisations. However, data reliability testing is crucial to avoid biases in data interpretation and misleading findings informing patient safety improvement. OBJECTIVE: To assess the inter-rater reliability of medication error classifications in a voluntary patient safety incident reporting system (HaiPro) widely used in Finland, and to explore reported medication errors and their contributing factors...
November 28, 2018: Research in Social & Administrative Pharmacy: RSAP
Samuel Asumadu Sarkodie, Vladimir Strezov
Adaptation strategies have become critical in climate change mitigation and impact reduction, to safeguard population and the ecosystem from irreparable damage. While developed countries have integrated adaptation plans and policies into their developmental agenda, developing countries are facilitating or yet to initiate adaptation policies in their development. This study examines the nexus between climate change vulnerability and adaptation readiness in 192 UN countries using mapping and panel data models...
November 24, 2018: Science of the Total Environment
U Mattila, T Tokola
Since one purpose of forestry laws and certification standards is to guide loggers to minimize the damage caused by forest operations, information regarding internal variations in site trafficability is needed for both economic and ecological reasons. The aim of this work was to test the prediction of terrain mobility from open data sources in Finland. New Lidar-based data sources were available for calculating terrain features and a gamma-ray-based soil wetness parameter. Rut depths were measured and can bus data were collected from a forwarder in two logging areas...
November 29, 2018: Journal of Environmental Management
Juha Suuronen, Samu Sjöblom, Marjo Tuppurainen, Risto Honkanen, Toni Rikkonen, Heikki Kröger, Joonas Sirola
OBJECTIVE: The aim of this cross-sectional study was to determine the association of hormonal contraception and other life-style factors and habits affecting body composition (BC) and muscle strength. STUDY DESIGN: We measured the body composition of 400 healthy Finnish women (aged 20-40 years) using total body dual energy x-ray absorptiometry (TB-DXA) as well as grip strength (GS [kPa]) with a hand-held dynamometer and knee extension strength (KES [kg]) between 2011 and 2014...
November 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Ann Ojala, Kalevi Korpela, Liisa Tyrväinen, Pekka Tiittanen, Timo Lanki
In this experiment we investigated how individual differences in orientation towards built vs. nature environment as well as noise sensitivity affect psychological and physiological restoration in a constructed urban park, urban woodland and city centre of Helsinki, Finland. The participants, 30-61-year-old healthy women (N = 83), visited each study site once. The experiment consisted of a 15-min viewing session, followed by a 30-min walking session in each environment. We measured restorative effects: perceived restorative outcomes, vitality, and blood pressure in these three environments...
November 27, 2018: Health & Place
M V Budzinskaya, I A Bubnova, A G Kurguzova, E I Fettser
Numerous studies have demonstrated the efficacy of anti-VEGF medications for exudative (wet) age-related macular degeneration (AMD). Significant IOP elevation is one of the side effects of anti-VEGF intravitreal injection. PURPOSE: To study the changes in the parameters of anterior segment of the eyeball against acute IOP elevation after repeated intravitreal injections (IVI) of anti-VEGF medication. MATERIAL AND METHODS: The study was conducted on a random sample of 45 patients (45 eyes) diagnosed with exudative (wet) form of AMD...
2018: Vestnik Oftalmologii
Marketta Fredriksson
Higher education institutions (HEIs) have a growing interest in establishing International joint degree programmes in developing countries. A Master's degree in global health care is an international joint degree programme run by two Finnish Universities of Applied Sciences and one Kenyan University. To provide students and staff members who live in Finland with an authentic experience of the circumstances in the developing countries, part of the programme involves delivering a two-week intensive course in Kenya...
December 2018: Health Information and Libraries Journal
Mikaela Sauvala, Sauli Laaksonen, Riikka Laukkanen-Ninios, Katri Jalava, Roger Stephan, Maria Fredriksson-Ahomaa
Hunting is currently a very popular activity, and interest in game meat is increasing. However, only limited research is available on the bacterial quality and safety of moose (Alces alces) and white-tailed deer (Odocoileus virginianus) harvested by hunters. Poor hunting hygiene can spread bacteria onto the carcasses, and inadequate chilling of the carcasses may increase the bacterial load on the carcass surface. We studied the bacterial contamination level on carcasses of 100 moose and 100 white-tailed deer shot in southern Finland...
April 2019: Food Microbiology
Karmela Liebkind, Viivi Mäkinen, Inga Jasinskaja-Lahti, Tuuli Anna Renvik, Erling F Solheim
Despite the urgent need for promoting positive intergroup relations in schools, research on intergroup relations is not systematically translated into prejudice-reduction interventions. Although prejudice-reduction interventions in schools based on indirect contact have been conducted for decades, they have all been carried out by researchers themselves. In a field experiment in Finland in autumn 2015, we tested for the first time a vicarious contact prejudice-reduction intervention for its effectiveness among adolescents (N = 639) when implemented independently by school teachers instead of researchers...
November 29, 2018: Scandinavian Journal of Psychology
Lauri Vähämurto, Katja Pahkala, Costan G Magnussen, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen, Leena Taittonen, Päivi Tossavainen, Terho Lehtimäki, Eero Jokinen, Risto Telama, Tapani Rönnemaa, Jorma Viikari, Markus Juonala, Olli T Raitakari
BACKGROUND AND AIMS: In the 1960s and 1970s, Finland, mortality due to coronary heart disease (CHD) was over 30% higher among Finns residing in the east of the country compared with those residing in the west. Today, CHD mortality remains 20% higher among eastern Finns. The higher incidence of CHD mortality among eastern Finns has largely been explained by higher risk factor levels. Using a unique longitudinal cohort, we aimed to determine if participants who resided in eastern Finland during childhood had higher CHD risk factors in adulthood and from childhood to adulthood...
November 15, 2018: Atherosclerosis
A Herpain, S Bouchez, M Girardis, F Guarracino, J Knotzer, B Levy, T Liebregts, P Pollesello, S-E Ricksten, H Riha, A Rudiger, F Sangalli
Levosimendan is an inodilator that promotes cardiac contractility primarily via calcium sensitization of cardiac troponin C and vasodilatation via opening of adenosine triphosphate-sensitive potassium (KATP) channels in vascular smooth muscle cells; the drug also exerts organ-protective effects via a similar effect on mitochondrial KATP channels.This pharmacological profile identifies levosimendan as a drug that may have applications in a wide range of critical illness situations encountered in intensive care unit medicine: hemodynamic support in cardiogenic or septic shock; weaning from mechanical ventilation or from extracorporeal membrane oxygenation; and in the context of cardiorenal syndrome...
November 22, 2018: Journal of Cardiovascular Pharmacology
Justin D Salciccioli, Dominic C Marshall, Joseph Shalhoub, Mahiben Maruthappu, Giuseppe De Carlo, Kian Fan Chung
OBJECTIVE: To compare age standardised death rates for respiratory disease mortality between the United Kingdom and other countries with similar health system performance. DESIGN: Observational study. SETTING: World Health Organization Mortality Database, 1985-2015. PARTICIPANTS: Residents of the UK, Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, the Netherlands, Portugal, Spain, Sweden, Australia, Canada, the United States, and Norway (also known as EU15+ countries)...
November 28, 2018: BMJ: British Medical Journal
Anna E Heino, Mika Gissler, Maili Malin, Heini VÄisÄnen
AIMS: Understanding the differences in reproductive-health behaviours between native and migrant populations helps provide good reproductive-health services. We investigate the differences in induced abortion rates, pregnancy histories and use of contraceptives between native and migrant populations in Finland. METHODS: The Finnish Register on Induced Abortions was linked with Population Register data from years 2001-2014 to identify first- and second-generation immigrants...
November 29, 2018: Scandinavian Journal of Public Health
Jari Mällinen, Tero Rautio, Juha Grönroos, Tuomo Rantanen, Pia Nordström, Heini Savolainen, Pasi Ohtonen, Saija Hurme, Paulina Salminen
Importance: The step after conservative treatment of periappendicular abscess arouses controversy, ranging from recommendations to abandon interval appendectomy based on low recurrence rates of the precipitating diagnosis to performing routine interval appendectomy owing to novel findings of increased neoplasm risk at interval appendectomy. To our knowledge, there are no randomized clinical trials with sufficient patient numbers comparing these treatments. Objective: To compare interval appendectomy and follow-up with magnetic resonance imaging after initial successful nonoperative treatment of periappendicular abscess...
November 28, 2018: JAMA Surgery
Jani Jukka Sormunen, Tero Klemola, Jari Hänninen, Satu Mäkelä, Ilppo Vuorinen, Ritva Penttinen, Ilari Eerikki Sääksjärvi, Eero Juhani Vesterinen
Ticks (Acari: Ixodoidea) are among the most common vectors of zoonotic pathogens worldwide. While research on tick-borne pathogens is abundant, few studies have thoroughly investigated small-scale spatial differences in their occurrence. Here, we used long-term cloth-dragging data of Ixodes ricinus and its associated, known and putative pathogens (Borrelia burgdorferi s.l., Borrelia miyamotoi, Anaplasma phagocytophilum, Rickettsia spp., Candidatus Neoehrlichia mikurensis, Bartonella spp., Babesia spp., and tick-borne encephalitis virus, TBEV) from a small, well-studied island in southwestern Finland to analyze potential temporal and spatial differences in pathogen prevalence and diversity between and within different biotopes...
November 28, 2018: Emerging Microbes & Infections
Noora Kanerva, Tea Lallukka, Ossi Rahkonen, Olli Pietiläinen, Jouni Lahti
Physical inactivity has been associated with both insomnia symptoms and smoking. Further, they are all independently associated with increased sickness absence (SA) from work. However, joint contribution of either physical activity (PA) with insomnia symptoms or with smoking to SA and, especially, their direct cost for the employer, are poorly understood. Therefore, we aimed to examine these joint associations with short-term (<15 days) SA cost. The Helsinki Health Study is a cohort of midlife employees of the City of Helsinki, Finland (baseline n=8960, response rate 67%)...
November 27, 2018: Scandinavian Journal of Medicine & Science in Sports
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