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Emmi Alakärppä, Heikki M Salo, Luis Valledor, Maria Jesús Cañal, Hely Häggman, Jaana Vuosku
Long-lived conifers are vulnerable to climate change because classical evolutionary processes are slow in developing adaptive responses. Therefore, the capacity of a genotype to adopt different phenotypes is important. Gene expression is the primary mechanism to convert genome-encoded information into phenotypes, and further, DNA methylation is employed in epigenetic regulation of gene expression. We investigated variation in global DNA methylation and gene expression between three Scots pine (Pinus sylvestris L...
August 3, 2018: Journal of Experimental Botany
Sofia Visuri, Timo Jahnukainen, Reetta Kivisaari, Seppo Taskinen
AIM: A top-down approach is widely used for detecting vesicoureteral reflux (VUR) in children with febrile urinary tract infections. We evaluated the diagnostic value of renal scintigraphy in predicting VUR in children with antenatal hydronephrosis (AHN). METHODS: The voiding cystourethrogram (VCUG) and renal scintigraphy results of 125 AHN patients (76% male) admitted to the Children's Hospital of Helsinki University, Finland, from 2003-2013 were analysed. Of those, 94 had non-refluxing hydronephrosis, nine had low-grade VUR and 22 had high-grade VUR...
August 16, 2018: Acta Paediatrica
Annakaisa Haapasalo, Mikko Hiltunen
The international Kuopio Alzheimer Symposium was organized by the University of Eastern Finland in Kuopio, Finland on June 6-8, 2018 for the 8th time. Approximately 300 researchers in the fields of neuroscience and neurology from 12 different countries around the world gathered to Kuopio to hear and discuss about the latest insights into the mechanisms and comorbidities and novel approaches for diagnosis, prediction, prevention and therapies of Alzheimer's disease and other neurodegenerative diseases. The 2-day international program on June 7-8 included a keynote session, five oral scientific sessions and a poster session...
August 16, 2018: Neurodegenerative Disease Management
Kaarina Matilainen, Ismo Strandén, Gert Pedersen Aamand, Esa A Mäntysaari
Joint Nordic (Denmark, Finland, Sweden) genetic evaluation of female fertility is currently based on the multiple trait multilactation animal model (BLUP). Here, single step genomic model (ssGBLUP) was applied for the Nordic Red dairy cattle fertility evaluation. The 11 traits comprised of nonreturn rate and days from first to last insemination in heifers and first three parities, and days from calving to first insemination in the first three parities. Traits had low heritabilities (0.015-0.04), but moderately high genetic correlations between the parities (0...
August 16, 2018: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
Pirjo-Liisa Rantanen, Ilkka Mellin, Minna M Keinänen-Toivola, Merja Ahonen, Riku Vahala
We studied the seasonal variation of nitrite exposure in a drinking water distribution system (DWDS) with monochloramine disinfection in the Helsinki Metropolitan Area. In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure. Our data included both the obligatory monitoring and a sampling campaign data from a sampling campaign. Seasonality was evaluated by comparing a nitrite time series to temperature and by calculating the seasonal indices of the nitrite time series...
August 15, 2018: International Journal of Environmental Research and Public Health
Marjo H Kervinen, Seppo Lehto, Jaakko Helve, Carola Grönhagen-Riska, Patrik Finne
BACKGROUND: Type 2 diabetic (T2DM) patients on renal replacement therapy (RRT) seldom receive a kidney transplant, which is partly due to age and comorbidities. Adjusting for case mix, we investigated whether T2DM patients have equal opportunity for renal transplantation compared to other patients on dialysis, and whether survival after transplantation is comparable. METHODS: Patients who entered RRT in Finland in 2000-2010 (n = 5419) were identified from the Finnish Registry for Kidney Diseases and followed until the end of 2012...
2018: PloS One
Eerik Ee Santala, Antti Rannikko, Teemu J Murtola
Antihypertensive (anti-HT) drugs targeting renin-angiotensin-aldosterone (RAA)- system have been associated with improved prostate cancer (PCa)-specific survival. Challenge is that often multiple drugs are used simultaneously. We evaluated the association between use of anti-HT drugs and PCa survival among 14,422 surgically treated Finnish PCa patients. Information on drug purchases was obtained from a national prescription database. We used Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for risk of PCa death and initiation of androgen deprivation therapy (ADT) with adjustment for age, tumor extent, use of statins and for Charlson Comorbidity Index...
August 15, 2018: International Journal of Cancer. Journal International du Cancer
Sol P Juárez, Sven Drefahl, Andrea Dunlavy, Mikael Rostila
Background: A mortality advantage has been observed among recently arrived immigrants in multiple national contexts, even though many immigrants experience more social disadvantage compared to natives. This is the first study to investigate the combined influence of duration of residence and age at arrival on the association between region of origin and all-cause mortality among the adult immigrant population in Sweden. Methods: Using population-based registers, we conducted a follow-up study of 1,363,429 individuals aged 25-64 years from 1990 to 2008...
December 2018: SSM—Population Health
Outi Jolanki, Liina-Kaisa Tynkkynen
Recent health reforms in many European countries have emphasised patient choice as a tool for patient participation, and for the improved efficiency of services. Little attention has been paid to experiences of the nurses in these reforms, even though the reforms directly concern all health care personnel and cannot be implemented without their contribution. This study looks at patient choice from the perspective of the nurses working in primary health care clinics in Finland. In Finnish primary care, nurses have a central role in coordinating patient care and advising patients...
August 10, 2018: Health Policy
Lotta Schepel, Lasse Lehtonen, Marja Airaksinen, Raimo Ojala, Jouni Ahonen, Outi Lapatto-Reiniluoto
BACKGROUND: 10- 30% of hospital stays by older patients are drug-related. The admission phase is important for identifying drug-related problems, but taking an incorrect medication history often leads to medication errors. OBJECTIVES: To enhance medication history recording and identify drug-related problems (DRPs) of older patients admitted to emergency departments (EDs). METHODS: DRPs were identified by pharmacists-led medication reconciliation and review procedures in two EDs in Finland; Helsinki University Hospital (HUS), and Kuopio University Hospital (KUH)...
August 6, 2018: International Journal of Risk & Safety in Medicine
Kim Orsel, Heidi Taipale, Sami Raatikainen, Pasi Lampela, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Helga Gardarsdottir, Sirpa Hartikainen
BACKGROUND: Antipsychotics (APs) are known to exacerbate symptoms of benign prostate hyperplasia (BPH) and may even cause urinary retention. The anticholinergic effects of APs and their dopamine D2- and α-receptor blockade may lead to voiding dysfunction of BPH patients. The objective of our study was to investigate whether the use of APs is associated with an increased risk of initiating medication for BPH in men with Alzheimer disease (AD). METHODS: Data from the nationwide MEDALZ (MEDication use and ALZheimer's disease) cohort, including all community-dwelling persons diagnosed with AD in Finland, were utilized...
August 10, 2018: Journal of Clinical Psychopharmacology
Ronen Hady-Cohen, Hila Ben-Pazi, Vardit Adir, Keren Yosovich, Luba Blumkin, Tally Lerman-Sagie, Dorit Lev
In 2003, a new syndrome was described in the Sephardi Jewish population, named progressive cerebello-cerebral atrophy (PCCA) based on the typical neuroradiological findings. Following the identification of the causal genes in 2010 and 2014, two types were defined: PCCA type 1 due to SEPSECS mutations and PCCA type 2 due to VPS53 mutations. Progressive encephalopathy with edema, hypsarrhythmia and optic atrophy (PEHO) was described in 1991 in Finland. The clinical and radiological phenotype resembles PCCA. The genetic background has been elusive for many years...
July 26, 2018: European Journal of Paediatric Neurology: EJPN
Elsi Autio, Petteri Oura, Jaro Karppinen, Markus Paananen, Jaakko Niinimäki, Juho-Antti Junno
Previous studies have shown that vertebral height increases until the early twenties, but very few studies have been conducted on other vertebral dimensions. Growth in vertebral size is believed to take place in elderly age but not in early adulthood. In this study, we wanted to clarify the potential changes in the dimensions of the lumbar vertebrae during early adulthood. We used the Northern Finland Birth Cohort 1986 as our study material, with a final sample size of 375 individuals. We performed lumbar magnetic resonance imaging (MRI) when the participants were 20 and 30 years of age (baseline and follow-up, respectively)...
August 9, 2018: Bone
Noora Berg, Olli Kiviruusu, Christopher G Bean, Taina Huurre, Tomi Lintonen, Anne Hammarström
BACKGROUND: Applying the Process-Person-Context-Time (PPCT) model of the bioecological theory, this study considers whether proximal processes between the individual and the microsystem (social relationships within family, peer group and school) during adolescence are associated with heavy episodic drinking (HED), from youth to midlife, and whether the macro level context (country) plays a role in these associations. METHODS: Participants of two prospective cohort studies from Finland and Sweden, recruited in 1983/1981 at age 16 (n = 2194/1080), were followed-up until their forties using postal questionnaires...
August 10, 2018: BMC Public Health
Suvi T Itkonen, Maijaliisa Erkkola, Christel J E Lamberg-Allardt
Fluid milk products are systematically, either mandatorily or voluntarily, fortified with vitamin D in some countries but their overall contribution to vitamin D intake and status worldwide is not fully understood. We searched the PubMed database to evaluate the contribution of vitamin D-fortified fluid milk products (regular milk and fermented products) to vitamin D intake and serum or plasma 25-hydroxyvitamin D (25(OH)D) status in observational studies during 1993⁻2017. Twenty studies provided data on 25(OH)D status ( n = 19,744), and 22 provided data on vitamin D intake ( n = 99,023)...
August 9, 2018: Nutrients
Emmelie Barenfeld, Synneve Dahlin-Ivanoff, Lars Wallin, Susanne Gustafsson
The aim was to evaluate the 6-month and 1-year effects of a person-centered group-based health-promoting intervention on independence in daily activities and self-rated health. The study was an RCT with follow-ups at 6 months and 1 year. A total of 131 independent living people (70+) who have migrated to Sweden from Finland or Western Balkan region were included. Participants were independent in activities of daily living and cognitively intact. They were randomized to an intervention group receiving four weekly group-meetings and a follow-up home visit, or a control group (no intervention)...
2018: AIMS Public Health
Judith Klostermann, Kaj van de Sandt, Mike Harley, Mikael Hildén, Timo Leiter, Jelle van Minnen, Nico Pieterse, Leendert van Bree
Adaptation is increasingly recognised as essential when dealing with the adverse impacts of climate change on societies, economies and the environment. However, there is insufficient information about the effectiveness of adaption policies, measures and actions. For this reason, the establishment of monitoring programmes is considered to be necessary. Such programmes can contribute to knowledge, learning and data to support adaptation governance. In the European Union (EU), member states are encouraged to develop National Adaptation Strategies (NASs)...
2018: Mitigation and adaptation strategies for global change
Mäkinen Hanna, Kaseva Janne, Virkajärvi Perttu, Kahiluoto Helena
The within-species diversity in response to weather and the gaps in the response diversity in the modern set of forage crop cultivars were determined using an approach that assessed the adaptive capacity under global climate change. The annual dry matter (DM) yields were recorded in multi-location MTT (Maa- ja elintarviketalouden tutkimuskeskus) Agrifood Research Official Variety Trials in Finland for modern forage crop cultivars from 2000 to 2012, as a response to agroclimatic variables critical to yield based on the year-round weather data...
2018: Mitigation and adaptation strategies for global change
Linghua Kong, Gunnar Norstedt, Martin Schalling, Mika Gissler, Catharina Lavebratt
BACKGROUND: Prenatal exposure to metabolic disturbances is associated with increased risk of offspring neurodevelopmental impairment and autism spectrum disorder, while little is known about the joint effect of maternal obesity and diabetes. With this study, we aim to assess the joint effect of maternal obesity and diabetes on the risk for offspring psychiatric and mild neurodevelopmental disorders. METHODS: Nationwide registries were used to link data of all live births in Finland between 2004 and 2014 ( n = 649 043)...
August 9, 2018: Pediatrics
Vivian Visnapuu, Sirkku Peltonen, Lotta Alivuotila, Risto-Pekka Happonen, Juha Peltonen
Neurofibromatosis type 1 (NF1) is one of the most common inherited syndromes. The literature on craniofacial alterations associated with NF1 has been limited and partially contradictory. This review is based on literature search and the results of the clinical study "Craniofacial and Oral Alterations and Speech in patients with Neurofibromatosis 1", carried out at the University of Turku and Turku University Hospital, Finland in 2006-2012. By the end of 2012, a total of 110 NF1 patients, 54 female and 56 male patients, were examined...
August 9, 2018: Orphanet Journal of Rare Diseases
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