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Dementia Sleep Osa

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https://www.readbyqxmd.com/read/30093262/difference-in-severity-of-sleep-apnea-in-patients-with-rapid-eye-movement-sleep-behavior-disorder-with-or-without-parkinsonism
#1
Dae Lim Koo, Jee Young Lee, Hyunwoo Nam
OBJECTIVE: Rapid eye movement sleep behavior disorder (RBD) is a common sleep disturbance in patients with neurodegenerative disorders. We aimed to compare sleep parameters among the different types of RBD patients. METHODS: A total of 122 patients with dream enactment behavior were screened. Of these, 92 patients who were diagnosed with RBD by polysomnography were included in this study. Enrolled patients with RBD were classified into four groups based on the following diagnoses: idiopathic RBD (iRBD); RBD with Parkinson disease (PD-RBD); multiple system atrophy (MSA) with RBD (MSA-RBD); and dementia with Lewy bodies (DLB) with RBD (DLB-RBD)...
June 28, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29973356/structural-brain-correlates-of-obstructive-sleep-apnoea-in-older-adults-at-risk-for-dementia
#2
Nathan E Cross, Negar Memarian, Shantel L Duffy, Casey Paquola, Haley LaMonica, Angela D'Rozario, Simon J G Lewis, Ian B Hickie, Ronald R Grunstein, Sharon L Naismith
This study aimed to investigate associations between obstructive sleep apnoea (OSA) and cortical thickness in older adults with subjective and objective cognitive difficulties, who are considered "at-risk" for dementia.83 middle-aged to older adults (51-88 years) underwent neuropsychological testing, polysomnography assessment of OSA and a structural magnetic resonance imaging brain scan. A principal components analysis was performed on OSA measures. Cortical thickness and subcortical volumes were compared to extracted components of "oxygen desaturation" and "sleep disturbance"...
July 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29727395/the-effect-of-an-educational-pamphlet-on-patient-knowledge-of-and-intention-to-discuss-screening-for-obstructive-sleep-apnea-in-the-acute-ischemic-stroke-population
#3
Ryan A Donald, Ruta Arays, John O Elliott, Kim Jordan
BACKGROUND: The relationship between obstructive sleep apnea (OSA) and stroke is well established, thus supporting the importance of secondary prevention via screening and treatment for acute ischemic stroke survivors. Educational pamphlets are commonly used for patient education; however, none currently available on OSA have evaluated. The aim of this study was to evaluate the effect of a brief educational intervention on patient knowledge and interest in OSA screening. METHODS: Adult acute ischemic stroke patients were enrolled into a nonrandomized, single-group, pretest and posttest study...
June 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29223769/obstructive-sleep-apnoea-and-alzheimer-s-disease-in-search-of-shared-pathomechanisms
#4
REVIEW
D Polsek, N Gildeh, D Cash, R Winsky-Sommerer, S C R Williams, F Turkheimer, G D Leschziner, M J Morrell, I Rosenzweig
Alzheimer's disease (AD) is a significant public health concern. The incidence continues to rise, and it is set to be over one million in the UK by 2025. The processes involved in the pathogenesis of AD have been shown to overlap with those found in cognitive decline in patients with Obstructive Sleep Apnoea (OSA). Currently, the standard treatment for OSA is Continuous Positive Airway Pressure. Adherence to treatment can, however, be an issue, especially in patients with dementia. Also, not all patients respond adequately, necessitating the use of additional treatments...
March 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28738188/sleep-characteristics-and-risk-of-dementia-and-alzheimer-s-disease-the-atherosclerosis-risk-in-communities-study
#5
Pamela L Lutsey, Jeffrey R Misialek, Thomas H Mosley, Rebecca F Gottesman, Naresh M Punjabi, Eyal Shahar, Richard MacLehose, Rachel P Ogilvie, David Knopman, Alvaro Alonso
INTRODUCTION: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. METHODS: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication...
February 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28291701/obstructive-sleep-apnea-exaggerates-cognitive-dysfunction-in-stroke-patients
#6
Yan Zhang, Wanhua Wang, Sijie Cai, Qi Sheng, Shenggui Pan, Fang Shen, Qing Tang, Yang Liu
BACKGROUND: Obstructive sleep apnea (OSA) is very common in stroke survivors. It potentially worsens the cognitive dysfunction and inhibits their functional recovery. However, whether OSA independently damages the cognitive function in stroke patients is unclear. A simple method for evaluating OSA-induced cognitive impairment is also missing. METHODS: Forty-four stroke patients six weeks after onset and 24 non-stroke patients with snoring were recruited for the polysomnographic study of OSA and sleep architecture...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28057621/interaction-of-obstructive-sleep-apnoea-and-cognitive-impairment-with-slow-gait-speed-in-middle-aged-and-older-adults
#7
Sunghee Lee, Chol Shin
Objective: to investigate whether slow gait speed is associated with cognitive impairment and further whether the association is modified by obstructive sleep apnoea (OSA). Methods: in total, 2,222 adults aged 49-80 years, free from dementia, stroke and head injury were asked to walk a 4-m course at fast and usual gait speeds. The time taken to walk was measured. All participants completed the Korean Mini-Mental State Examination, which was validated in the Korean language, to assess cognitive function...
July 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/27415826/sleep-apnea-sleep-duration-and-brain-mri-markers-of-cerebral-vascular-disease-and-alzheimer-s-disease-the-atherosclerosis-risk-in-communities-study-aric
#8
Pamela L Lutsey, Faye L Norby, Rebecca F Gottesman, Thomas Mosley, Richard F MacLehose, Naresh M Punjabi, Eyal Shahar, Clifford R Jack, Alvaro Alonso
BACKGROUND: A growing body of literature has suggested that obstructive sleep apnea (OSA) and habitual short sleep duration are linked to poor cognitive function. Neuroimaging studies may provide insight into this relation. OBJECTIVE: We tested the hypotheses that OSA and habitual short sleep duration, measured at ages 54-73 years, would be associated with adverse brain morphology at ages 67-89 years. METHODS: Included in this analysis are 312 ARIC study participants who underwent in-home overnight polysomnography in 1996-1998 and brain MRI scans about 15 years later (2012-2013)...
2016: PloS One
https://www.readbyqxmd.com/read/27350397/cerebral-hypoperfusion-and-glucose-hypometabolism-key-pathophysiological-modulators-promote-neurodegeneration-cognitive-impairment-and-alzheimer-s-disease
#9
REVIEW
Mak Adam Daulatzai
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative-nitrosative stress that in turn decrease nitric oxide and enhance endothelin, Amyloid-β deposition, cerebral amyloid angiopathy, and blood-brain barrier disruption. Proinflammatory cytokines, endothelin-1, and oxidative-nitrosative stress trigger several pathological feedforward and feedback loops...
April 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27322475/changes-in-neurocognitive-architecture-in-patients-with-obstructive-sleep-apnea-treated-with-continuous-positive-airway-pressure
#10
Ivana Rosenzweig, Martin Glasser, William R Crum, Matthew J Kempton, Milan Milosevic, Alison McMillan, Guy D Leschziner, Veena Kumari, Peter Goadsby, Anita K Simonds, Steve C R Williams, Mary J Morrell
BACKGROUND: Obstructive sleep apnea (OSA) is a chronic, multisystem disorder that has a bidirectional relationship with several major neurological disorders, including Alzheimer's dementia. Treatment with Continuous Positive Airway Pressure (CPAP) offers some protection from the effects of OSA, although it is still unclear which populations should be targeted, for how long, and what the effects of treatment are on different organ systems. We investigated whether cognitive improvements can be achieved as early as one month into CPAP treatment in patients with OSA...
May 2016: EBioMedicine
https://www.readbyqxmd.com/read/27189468/obstructive-sleep-apnea-syndrome-an-emerging-risk-factor-for-dementia
#11
Laura Buratti, Simona Luzzi, Cristina Petrelli, Sara Baldinelli, Giovanna Viticchi, Leandro Provinciali, Claudia Altamura, Fabrizio Vernieri, Mauro Silvestrini
Epidemiological studies have suggested that obstructive sleep apnea syndrome (OSAS) may increase the risk of developing cognitive impairment. In patients with Alzheimer's disease (AD), the prevalence of OSAS is much higher than that expected in cognitively healthy subjects. A deeper knowledge of the pathophysiological link between OSAS and AD and the demonstration that OSAS may directly influence the development of cognitive alterations, would increase prevention and treatment strategies for AD patients. In this article, we discuss the evidence of the association between OSAS and dementia...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27139243/obstructive-sleep-apnea-is-linked-to-depression-and-cognitive-impairment-evidence-and-potential-mechanisms
#12
REVIEW
Nancy A Kerner, Steven P Roose
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is an independent risk factor for depression and cognitive impairment/dementia. Herein the authors review studies in the literature pertinent to the effects of OSA on the cerebral microvascular and neurovascular systems and present a model to describe the key pathophysiologic mechanisms that may underlie the associations, including hypoperfusion, endothelial dysfunction, and neuroinflammation. Intermittent hypoxia plays a critical role in initiating and amplifying these pathologic processes...
June 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26557104/the-role-of-sleep-and-sleep-disorders-in-the-development-diagnosis-and-management-of-neurocognitive-disorders
#13
REVIEW
Michelle A Miller
It is becoming increasingly apparent that sleep plays an important role in the maintenance, disease prevention, repair, and restoration of both mind and body. The sleep and wake cycles are controlled by the pacemaker activity of the superchiasmic nucleus in the hypothalamus but can be disrupted by diseases of the nervous system causing disordered sleep. A lack of sleep has been associated with an increase in all-cause mortality. Likewise, sleep disturbances and sleep disorders may disrupt neuronal pathways and have an impact on neurological diseases...
2015: Frontiers in Neurology
https://www.readbyqxmd.com/read/26301370/evidence-of-neurodegeneration-in-obstructive-sleep-apnea-relationship-between-obstructive-sleep-apnea-and-cognitive-dysfunction-in-the-elderly
#14
REVIEW
Mak Adam Daulatzai
The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β (Aβ) plaques and neurofibrillary tangles. The disease involves widespread synaptic loss in the neocortex and the hippocampus. Rodent and clinical studies suggest that OSA impairs the structural integrity of several brain regions, including the medial temporal lobe. Indeed, hypoxia, hypertension, hypoperfusion, endothelial dysfunction, inflammation, and oxidative stress noted in OSA patients also occur in AD patients...
December 2015: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/25070768/cognitive-impairment-in-obstructive-sleep-apnea
#15
REVIEW
K Gagnon, A-A Baril, J-F Gagnon, M Fortin, A Décary, C Lafond, A Desautels, J Montplaisir, N Gosselin
Obstructive sleep apnea (OSA) is characterised by repetitive cessation or reduction of airflow due to upper airway obstructions. These respiratory events lead to chronic sleep fragmentation and intermittent hypoxemia. Several studies have shown that OSA is associated with daytime sleepiness and cognitive dysfunctions, characterized by impairments of attention, episodic memory, working memory, and executive functions. This paper reviews the cognitive profile of adults with OSA and discusses the relative role of altered sleep and hypoxemia in the aetiology of these cognitive deficits...
October 2014: Pathologie-biologie
https://www.readbyqxmd.com/read/24551457/screening-for-sleep-apnoea-in-mild-cognitive-impairment-the-utility-of-the-multivariable-apnoea-prediction-index
#16
Georgina Wilson, Zoe Terpening, Keith Wong, Ron Grunstein, Louisa Norrie, Simon J G Lewis, Sharon L Naismith
Purpose. Mild cognitive impairment (MCI) is considered an "at risk" state for dementia and efforts are needed to target modifiable risk factors, of which Obstructive sleep apnoea (OSA) is one. This study aims to evaluate the predictive utility of the multivariate apnoea prediction index (MAPI), a patient self-report survey, to assess OSA in MCI. Methods. Thirty-seven participants with MCI and 37 age-matched controls completed the MAPI and underwent polysomnography (PSG). Correlations were used to compare the MAPI and PSG measures including oxygen desaturation index and apnoea-hypopnoea index (AHI)...
2014: Sleep Disorders
https://www.readbyqxmd.com/read/24489679/untreated-sleep-disordered-breathing-links-to-aging-related-decline-in-sleep-dependent-memory-consolidation
#17
Ina Djonlagic, Mengshuang Guo, Paul Matteis, Andrea Carusona, Robert Stickgold, Atul Malhotra
BACKGROUND: Increasing age is associated with a decline in cognition and motor skills, while at the same time exacerbating one's risk of developing obstructive sleep apnea (OSA). OSA-related cognitive deficits are highly prevalent and can affect various memory systems including overnight memory consolidation on a motor sequence task. Thus, the aim of our study was to examine the effect of aging on sleep-dependent motor memory consolidation in patients with and without OSA. METHODS: We studied 44 patients (19-68 years) who had been referred by a physician for a baseline polysomnography (PSG) evaluation...
2014: PloS One
https://www.readbyqxmd.com/read/23886593/rapid-eye-movement-sleep-behavior-disorder-devising-controlled-active-treatment-studies-for-symptomatic-and-neuroprotective-therapy-a-consensus-statement-from-the-international-rapid-eye-movement-sleep-behavior-disorder-study-group
#18
C H Schenck, J Y Montplaisir, B Frauscher, B Hogl, J-F Gagnon, R Postuma, K Sonka, P Jennum, M Partinen, I Arnulf, V Cochen de Cock, Y Dauvilliers, P-H Luppi, A Heidbreder, G Mayer, F Sixel-Döring, C Trenkwalder, M Unger, P Young, Y K Wing, L Ferini-Strambi, R Ferri, G Plazzi, M Zucconi, Y Inoue, A Iranzo, J Santamaria, C Bassetti, J C Möller, B F Boeve, Y Y Lai, M Pavlova, C Saper, P Schmidt, J M Siegel, C Singer, E St Louis, A Videnovic, W Oertel
OBJECTIVES: We aimed to provide a consensus statement by the International Rapid Eye Movement Sleep Behavior Disorder Study Group (IRBD-SG) on devising controlled active treatment studies in rapid eye movement sleep behavior disorder (RBD) and devising studies of neuroprotection against Parkinson disease (PD) and related neurodegeneration in RBD. METHODS: The consensus statement was generated during the fourth IRBD-SG symposium in Marburg, Germany in 2011. The IRBD-SG identified essential methodologic components for a randomized trial in RBD, including potential screening and diagnostic criteria, inclusion and exclusion criteria, primary and secondary outcomes for symptomatic therapy trials (particularly for melatonin and clonazepam), and potential primary and secondary outcomes for eventual trials with disease-modifying and neuroprotective agents...
August 2013: Sleep Medicine
https://www.readbyqxmd.com/read/23633753/obstructive-sleep-apnea-as-a-risk-factor-for-cerebral-white-matter-change-in-a-middle-aged-and-older-general-population
#19
Hyun Kim, Chang-Ho Yun, Robert Joseph Thomas, Seung Hoon Lee, Hyung Suk Seo, Eo Rin Cho, Seung Ku Lee, Dae Wui Yoon, Sooyeon Suh, Chol Shin
STUDY OBJECTIVE: Obstructive sleep apnea (OSA) contributes to the development of systemic hypertension, and hypertension strongly predicts the development of white matter change (WMC). Thus, it is plausible that OSA mediates WMC. The goal of the current study is to determine whether a contextual relationship exists between OSA and cerebral WMC. DESIGN: Cross-sectional analyses conducted in a population-based study. SETTING: Korean community-based sample from the Korean Genome and Epidemiology Study (KoGES) who attended examinations in 2011 at a medical center...
May 2013: Sleep
https://www.readbyqxmd.com/read/22990657/cognitive-dysfunction-and-obstructive-sleep-apnea-from-cradle-to-tomb
#20
REVIEW
Madeleine Grigg-Damberger, Frank Ralls
PURPOSE OF REVIEW: To understand clinical characteristics and risk factors for cognitive impairment in patients with obstructive sleep apnea (OSA) syndromes. RECENT FINDINGS: Primary snoring increases the risk of neurocognitive impairment and lower intelligence quotients in infants and children. Middle-aged adults with severe OSA are at greater risk for cognitive impairment than young adults with apnea of equal severity. Older women with OSA are at increased risk for minimal cognitive impairment or dementia, 5 years later...
November 2012: Current Opinion in Pulmonary Medicine
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