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https://www.readbyqxmd.com/read/30114535/demonstration-of-infectious-transgression-through-the-skull-base-occurring-9-years-after-pituitary-adenoma-resection
#1
Jingyi Liu, David L Penn, Ethan Katznelson, Mina G Safain, Ian F Dunn, Edward R Laws
BACKGROUND: Sellar infections represent less than 1% of all sellar lesions and can be life-threatening. These infections occur de novo in up to 70% of patients, or can less commonly develop after surgical treatment of another primary lesion, such as a pituitary adenoma. CASE DESCRIPTION: We report a unique case of a 27 year-old woman with a recurrent pituitary adenoma treated with two prior transsphenoidal resections. She ultimately presented with hypopituitarism, followed by headaches, malaise, chills, and visual field and acuity deficits nine years after her second transsphenoidal resection...
August 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30114356/surface-functionalized-model-contact-lenses-with-a-bioinspired-proteoglycan-4-prg4-grafted-layer
#2
Myrto Korogiannaki, Michael Samsom, Tannin A Schmidt, Heather Sheardown
Ocular dryness and discomfort is the primary reason for the discontinuation of contact lens wear. This is mainly due to poorly hydrated contact lens surfaces and increased friction, particularly at the end of the day and can potentially cause reduced vision or even inflammation. Proteoglycan 4 (PRG4) is a mucinous glycoprotein with boundary lubricating properties, naturally found in the eye, able to prevent tear film evaporation and protect the ocular surface during blinking. Aiming to improve the interfacial interactions between the ocular surface and the contact lens, the synthesis and characterization of surface modified model contact lenses with PRG4 is described...
August 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30113934/radiation-induced-optic-neuropathy-clinical-and-imaging-profile-of-twelve-patients
#3
Erica L Archer, Eric A Liao, Jonathan D Trobe
BACKGROUND: Radiation-induced optic neuropathy (RON) is a form of delayed radionecrosis of the anterior visual pathways, which develops within months to years after external cranial irradiation and causes severe and irreversible vision loss. Small series reports have adequately documented its clinical features, but imaging characteristics have been less completely described. METHODS: We accrued cases from the University of Michigan Neuro-Ophthalmology Clinic files and from cases coded as "radiation optic neuropathy" at the University of Michigan Medical Center between 1994 and 2017...
August 15, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/30113489/association-between-serum-vitamin-d-deficiency-and-age-related-macular-degeneration-in-koreans-clinical-case-control-pilot-study
#4
Kyoung Lae Kim, Sung Pyo Park
The objective of this study was to evaluate the association between serum vitamin D deficiency and age-related macular degeneration (AMD) in Koreans through a clinical case-control pilot study. The study included 96 patients: 30 with late AMD, 32 with early AMD, and 34 normal controls. The patients with late AMD were divided into 2 subgroups based on the presence or absence of subretinal fibrosis on optical coherence tomography (OCT) images. We measured 25-hydroxyvitamin D levels in the serum of all patients during the same season to rule out seasonal variation of serum vitamin D level...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30113390/remote-photoplethysmographic-assessment-of-the-peripheral-circulation-in-critical-care-patients-recovering-from-cardiac-surgery
#5
Stefan Rasche, Alexander Trumpp, Martin Schmidt, Katrin Plötze, Frederik Gätjen, Hagen Malberg, Klaus Matschke, Matthias Rudolf, Fabian Baum, Sebastian Zaunseder
PURPOSE: Camera-based photoplethysmography (cbPPG) remotely detects the volume pulse of cardiac ejection in the peripheral circulation. The cbPPG signal is sourced from the cutaneous microcirculation, yields a two-dimensional intensity map and is therefore an interesting monitoring technique. In this study we investigated, whether cbPPG is in general sufficiently sensitive to discern hemodynamic conditions. METHODS: cbPPG recordings of seventy patients recovering from cardiac surgery were analyzed...
August 14, 2018: Shock
https://www.readbyqxmd.com/read/30113081/mobile-phone-based-uv-fluorescence-microscopy-for-the-identification-of-fungal-pathogens
#6
Chhavi Goenka, William Lewis, Lee Roger Chevres-Fernández, Antonio Ortega-Martínez, Esmeralda Ibarra-Silva, Maura Williams, Walfre Franco
BACKGROUND AND OBJECTIVE: Dermatophytes are fungi that cause infections in hair, skin, and nails. Potassium Hydroxide (KOH) microscopy is the most frequently used method for identifying dermatophytes. KOH helps in the visualization of the hyphae as it clears the debris present in the specimen but needs a trained eye for final diagnosis of the infection. Fluorescence microscopy using staining agents, such as calcofluor white (CFW) or blankophor, is a better method for identification of dermatophytes but is not used in clinics due to the cost and complexity of fluorescence microscopes...
August 16, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/30112881/clinical-lymphocytes-construction-for-light-scattering-inversion-study-a-three-dimensional-morphology-constructed-method-from-defective-confocal-images
#7
Lu Zhang, Yunhao Xie, Yingzhe Tu, Lele Luo, Kaixing Li, Li Yuan, Wei Chen, Hong Zhao, Zhenxi Zhang
Constructing models of cells' realistic internal and external morphology is vital for correlation between light scattering and morphology of the scattering structure. The image stack obtained from fluorescent confocal microscopy is at present used to construct the cell's three-dimensional (3-D) morphology. However, due to the poor labeling quality and unavoidable optical noise present in the image stacks, 3-D morphologies are difficult to construct and are an impediment to the statistical analyses of cell structures...
August 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/30112279/all-optical-dual-photoacoustic-and-optical-coherence-tomography-intravascular-probe
#8
Sunish J Mathews, Callum Little, Christopher D Loder, Roby D Rakhit, Wenfeng Xia, Edward Z Zhang, Paul C Beard, Malcolm C Finlay, Adrien E Desjardins
Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging...
September 2018: Photoacoustics
https://www.readbyqxmd.com/read/30112269/optic-discs-swelling-procrastinates-wernicke-s-encephalopathy-associated-with-hyperemesis-gravidarum-a-case-report-and-review-of-literature
#9
Lam Mun-Wei, Govindasamy Gayathri, Goh Kwang Hwee, Kanesalingam Ruban, Vasudevan Suresh Kumar, Ismail Shatriah
Wernicke's encephalopathy following severe hyperemesis gravidarum is an uncommon clinical entity. We describe a rare manifestation of optic discs swelling in a pregnant woman that has caused a diagnostic dilemma. With high index of suspicion of clinical manifestations and radiological evidences, a clinical diagnosis of Wernicke's encephalopathy was made. Intravenous thiamine therapy was instituted, and prompt improvement of clinical signs was observed. The association of optic discs swelling and Wernicke's encephalopathy after hyperemesis gravidarum is discussed...
June 12, 2018: Curēus
https://www.readbyqxmd.com/read/30112048/diagnostic-implications-of-mog-aqp4-antibodies-in-recurrent-optic-neuritis
#10
Ying Peng, Lei Liu, Yuanchu Zheng, Zhixin Qiao, Kai Feng, Jiawei Wang
The present study aimed to detect myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies in serum specimens of patients with recurrent optic neuritis (RON) through establishing 293 cells with stable expression of MOG and the complete genomic sequence as the substrate using a cell-based assay (CBA). Furthermore, the clinical features of MOG antibody-positive recurrent optic neuritis (MOG-RON) were assessed. A total of 43 RON patients admitted to Beijing Tongren Hospital from December 2014 to May 2015 were enrolled, including 11 males and 32 females...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30111337/validation-of-wearable-visual-feedback-for-retraining-foot-progression-angle-using-inertial-sensors-and-an-augmented-reality-headset
#11
Angelos Karatsidis, Rosie E Richards, Jason M Konrath, Josien C van den Noort, H Martin Schepers, Giovanni Bellusci, Jaap Harlaar, Peter H Veltink
BACKGROUND: Gait retraining interventions using real-time biofeedback have been proposed to alter the loading across the knee joint in patients with knee osteoarthritis. Despite the demonstrated benefits of these conservative treatments, their clinical adoption is currently obstructed by the high complexity, spatial demands, and cost of optical motion capture systems. In this study we propose and evaluate a wearable visual feedback system for gait retraining of the foot progression angle (FPA)...
August 15, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/30110705/the-progression-of-the-stargardt-disease-type-4-progstar-4-study-design-and-baseline-characteristics-progstar-4-report-no-1
#12
Rupert W Strauss, Beatriz Muñoz, Mohamed I Ahmed, Millena Bittencourt, Etienne M Schönbach, Michel Michaelides, David Birch, Eberhart Zrenner, Ann-Margret Ervin, Peter Charbel Issa, Jun Kong, Yulia Wolfson, Mahmood Shah, Saghar Bagheri, Sheila West, Hendrik P N Scholl
BACKGROUND/AIMS: To describe the design and baseline characteristics of patients enrolled in the multicenter, prospective natural history study of Stargardt disease type 4. METHODS: Fifteen eligible patients aged 6 years and older at baseline, harboring disease-causing variants in the PROM1 gene, and with specified ocular lesions were enrolled. They were examined at baseline using a standard protocol, with 6 monthly follow-up visits for a 2-year period including best-corrected ETDRS visual acuity, spectral-domain optical coherence tomography, fundus autofluorescence (FAF), mesopic and scotopic microperimetry (MP)...
August 15, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/30110074/prevalence-of-entamoeba-histolytica-and-other-enteral-parasitic-diseases-in-the-metropolitan-region-of-belo-horizonte-brazil-a-cross-sectional-study
#13
Juliana de Oliveira Costa, José Adão Resende, Frederico Ferreira Gil, Joseph Fabiano Guimarães Santos, Maria Aparecida Gomes
BACKGROUND: Enteral parasitic diseases are a public health problem in nations with low economic development and in settings with poor sanitation. Amebiasis is the second most frequent form of parasitosis, with a high burden of disease. Knowledge of the prevalence of enteroparasitoses in a given region is useful for planning clinical decision-making. Thus, the aim of this study was to estimate the prevalence of enteral parasitic diseases, especially amebiasis, through analysis on stool samples from public and private laboratories in a metropolitan area in southeastern Brazil...
August 13, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/30109995/a-key-point-based-real-time-tracking-of-lung-tumor-in-x-ray-image-sequence-by-using-difference-of-gaussians-filtering-and-optical-flow
#14
Kei Ichiji, Yusuke Yoshida, Noriyasu Homma, Xiaoyong Zhang, Ivo Bukovsky, Yoshihiro Takai, Makoto Yoshizawa
In radiation therapy, for accurate radiation dose delivery to a target tumor and reduction of the extra exposure of normal tissues, real-time tumor tracking is an important technique typically for a lung cancer treatment since the lung tumor moves with patient's respiration. To observe the tumor motion in real time, X-ray fluoroscopic devices can be employed, and various tracking techniques have been proposed to track the tumor. However, development of an accurate and fast-tracking method for clinical use is still a challenging task since the obscureness can cause the decreased tracking accuracy and additional processing time for improving the accuracy...
August 15, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/30109878/single-gold-bipyramids-on-a-silanized-substrate-as-robust-plasmonic-sensors-for-liquid-environments
#15
Jan-Michael Rye, Christophe Bonnet, Frédéric Lerouge, Michel Pellarin, Jean Lermé, Stéphane Parola, Emmanuel Cottancin
Sensitive, robust and stable sensors are required to bring biosensing techniques from the forefront of research to clinical and commercial settings. To this end, we report on the development of new robust plasmonic sensors consisting of gold nano-bipyramids (BPs) grafted to a glass substrate via silanization, associated with a novel setup based on Spatial Modulation Spectroscopy allowing the measurement of the optical response of individual nano-objects in a liquid environment. We thereby show that changes in the refractive index of the medium around individual silanized BPs can be detected by measuring their plasmonic shift with sensitivities comparable to values reported elsewhere and in good agreement with theoretical calculations...
August 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/30109755/corneal-collagen-cross-linking-following-superficial-keratectomy-as-treatment-for-corneal-endothelial-cell-dystrophy-in-dogs-preliminary-clinical-study
#16
Jury Kim, Dong-Beom Ji, Naoaki Takiyama, Jaehyun Bae, Min-Su Kim
OBJECTIVE: To describe the outcome of corneal collagen cross-linking (CXL) combined with superficial keratectomy (SK) as treatment for corneal edema due to corneal endothelial dystrophy (CED) in dogs. ANIMALS STUDIED: Four eyes of four dogs (3 Shih Tzus and 1 English Cocker Spaniel) with corneal edema due to CED were treated with SK and CXL. Two were males, and two were females. PROCEDURE: Depending on corneal thickness, 500-700 μm of edematous cornea was removed by SK...
August 15, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/30109704/optical-coherence-tomography-in-acute-optic-neuritis-a-population-based-study
#17
Kerstin Soelberg, Svenja Specovius, Hanna G Zimmermann, Jakob Grauslund, Jesper J Mehlsen, Clement Olesen, Allan S B Neve, Friedemann Paul, Alexander U Brandt, Nasrin Asgari
OBJECTIVES: To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population-based cohort. METHODS: In a prospective population-based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast letter acuity (LCLA)...
August 14, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/30109245/breast-biopsy-navigation-system-with-an-assisted-needle-holder-tool-and-2d-graphical-user-interface
#18
Jackrit Suthakorn, Narucha Tanaiutchawoot, Cholatip Wiratkapan, Songpol Ongwattanakul
Objective: This paper proposes the development of a breast biopsy navigation system with an assisted needle holder tool for a coaxial needle and a graphical user interface, which utilizes an optical tracking device to localize the needle position relative to the ultrasound image with the aim to improve performance especially for a new radiologist or an inexperienced group. Materials and methods: The system consists of an assisted needle holder tool, which as an attachment for the 2D ultrasound transducer and the graphical user interface (GUI) that shows the needle pathway, needle line and warning signs...
2018: European Journal of Radiology Open
https://www.readbyqxmd.com/read/30107658/-clinical-research-progress-of-gene-therapy-for-leber-hereditary-optic-neuropathy
#19
Y J Wu, W S Li
Leber hereditary optic neuropathy (LHON) is a mitochondria hereditary eye disease that involves with retinal ganglion cells (RGCs) resulting eventually in degeneration and atrophy of optic nerve. The three mitochondrial DNA mutations (ND4 G11778A, ND1G3460A, ND6T14484C) have been recognized as the primary mutation locus of LHON. Currently there is no effective therapy for LHON. The result of a clinical trial launched in 2007 indicated that intraocular injection of the recombination of adeno-associated virus and target gene is an effective and safe cure for Leber's Congenital Amaurosis (LCA), which brings hope of treating other hereditary eye diseases with gene therapy...
August 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/30107640/the-effect-of-corneal-infiltrates-on-densitometry-and-higher-order-aberrations
#20
Kemal Tekin, Hasan Kiziltoprak, Mustafa Koc, Yasin Sakir Goker, Ali Mert Kocer, Pelin Yilmazbas
BACKGROUND: This study aimed to measure the effects of persistent corneal subepithelial infiltrates associated with epidemic keratoconjunctivitis on corneal densitometry and total corneal higher order aberrations (HOAs), and to compare these measurements with the data obtained from their fellow unaffected healthy eyes. METHODS: This prospective cross-sectional study included those who had persistent subepithelial infiltrates in only the affected eyes for at least three months and clinically normal fellow unaffected eyes...
August 14, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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