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Carlos Rp Dechandt, Tatiane M Vicentini, Guilherme Pauperio Lanfredi, Rui M P da Silva, Enilza Maria Espreafico, José A C de Oliveira, Vitor Marcel Faça, Norberto Garcia-Cairasco, Luciane C Alberici
The Wistar Audiogenic Rat (WAR) is an animal model of tonic-clonic epileptic seizures, developed after genetic selection by sister x brother inbreeding of Wistar rats susceptible to sound stimuli. Although metabolic changes have been described in this strain, nothing, however, is known about its mitochondrial metabolism. Here, we addressed mitochondrial aspects of OXPHOS, oxidative stress, biogenesis and dynamics in liver, skeletal muscle and heart of male WAR, correlating then to physiological aspects of body metabolism...
December 5, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Michael A Benvenuti, Thomas J An, Megan E Mignemi, Jeffrey E Martus, Gregory A Mencio, Stephen A Lovejoy, Jonathan G Schoenecker, Derek J Williams
OBJECTIVE: There are currently no algorithms for early stratification of pediatric musculoskeletal infection (MSKI) severity that are applicable to all types of tissue involvement. In this study, the authors sought to develop a clinical prediction algorithm that accurately stratifies infection severity based on clinical and laboratory data at presentation to the emergency department. METHODS: An IRB-approved retrospective review was conducted to identify patients aged 0 to 18 who presented to the pediatric emergency department at a tertiary care children's hospital with concern for acute MSKI over a 5-year period (2008 to 2013)...
March 7, 2018: Journal of Pediatric Orthopedics
Lecticia Barbosa Jorge, Fernanda Oliveira Coelho, Talita Rojas Sanches, Denise M A C Malheiros, Leandro Ezaquiel de Souza, Fernando Dos Santos, Larissa de Sá Lima, Cristóforo Scavone, Maria Claudia Irigoyen, Makoto Kuro-O, Lucia Andrade
Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Klotho has also been shown to protect the kidneys in ischemia-reperfusion injury and to have antioxidant properties. To analyze the role of Klotho in sepsis-related organ dysfunction and AKI, we used a cecal ligation and puncture (CLP) model of sepsis in heterozygous Klotho-haploinsufficient mice and their wild-type littermates (CLP-Kl+/- and CLP-WT mice, respectively)...
December 5, 2018: American Journal of Physiology. Renal Physiology
Anne-Josée Guimond, Hans Ivers, Josée Savard
OBJECTIVES: This study examined the cross-sectional and prospective relationships between subjective (cognitive reappraisal, expressive suppression and experiential avoidance) and objective (high-frequency heart rate variability [HF-HRV]) measures of emotion regulation (ER) and a set of psychological symptoms (anxiety, depression, fear of cancer recurrence [FCR], insomnia, fatigue, pain, and cognitive impairments) among women receiving radiation therapy for non-metastatic breast cancer...
December 5, 2018: Psychology & Health
J Huggins, Mark Rakobowchuk
PURPOSE: Physiological markers that estimate sympathetic activation may be used to infer pain and stress in humans. To date, effective reproducible methods are invasive and pose an undesired risk to participants. Previous work in animal models has used infrared thermography to measure the temperature of the lacrimal caruncle region and may be a promising method for measuring stress and pain non-invasively. The current study aimed to determine whether this method is useful in humans. METHODS: Sixteen young healthy participants (age: 18-35) were recruited and underwent sympathetic activation using a cold pressor test (CPT) and a muscle chemoreflex (MCR), and completed a control trial...
December 4, 2018: European Journal of Applied Physiology
Hyun Bin Kwon, Heenam Yoon, Sang Ho Choi, Jae-Won Choi, Yu Jin Lee, Kwang Suk Park
We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Time- and frequency-domain, and fractal HRV parameters were derived from 5-min electrocardiogram segments during light sleep, deep sleep, rapid eye movement (REM) sleep, and the pre- and post-sleep wake periods...
November 12, 2018: Psychiatry Research
Stefano Palma, Mohammad Keilani, Timothy Hasenoehrl, Richard Crevenna
PURPOSE: To systematically review literature for interventional studies and their impact on autonomic dysfunction assessed by heart rate variability in cancer patients. METHODS: Research was conducted using the databases Medline/Pubmed, Scopus, and Web of science from their inception to October 2017. Original articles with an interventional design that reported changes in at least one heart rate variability parameter as outcome parameter were included and described...
December 4, 2018: Disability and Rehabilitation
Theodore K Marras, Christopher Vinnard, Quanwu Zhang, Keith Hamilton, Jennifer Adjemian, Gina Eagle, Raymond Zhang, Engels Chou, Kenneth N Olivier
RATIONALE: The risk of all-cause mortality of nontuberculous mycobacterial lung disease (NTMLD) in the United States (US) population is not well established. OBJECTIVES: This study aims to assess the public health burden of NTMLD in the US by comparing the relative risk of all-cause mortality in the NTMLD population with an age- and sex-matched cohort from the general population. METHODS: Patients with physician claims for NTMLD (ICD-9 0.031; ICD-10 A31...
December 2018: Respiratory Medicine
Konrad Pieszko, Jarosław Hiczkiewicz, Paweł Budzianowski, Janusz Rzeźniczak, Jan Budzianowski, Jerzy Błaszczyński, Roman Słowiński, Paweł Burchardt
BACKGROUND: Increased systemic and local inflammation play a vital role in the pathophysiology of acute coronary syndrome. This study aimed to assess the usefulness of selected machine learning methods and hematological markers of inflammation in predicting short-term outcomes of acute coronary syndrome (ACS). METHODS: We analyzed the predictive importance of laboratory and clinical features in 6769 hospitalizations of patients with ACS. Two binary classifications were considered: significant coronary lesion (SCL) or lack of SCL, and in-hospital death or survival...
December 3, 2018: Journal of Translational Medicine
Daniel Bunout, Gladys Barrera, Sandra Hirsch, Teresa Jimenez, María Pia de la Maza
BACKGROUND: Sedentariness may be an important risk factor for sarcopenia. The aim of this work was to assess the association between muscle mass and strength and markers of usual physical activity such as activity energy expenditure and peak oxygen uptake. METHODS: Young and old participants were assessed measuring body composition by DEXA (double beam X ray absorptiometry), handgrip strength, peak oxygen consumption and workload during an exercise calorimetry in a braked cycle ergometer and a 72 h activity energy expenditure using Actiheart actigraphs...
December 3, 2018: BMC Geriatrics
L Hunakova, M Zvarik, K Majerova, M Mestanik, V Bella, I Tonhajzerova
Vagal activity of patients with metastatic or recurrent breast cancer can predict their survival and can be altered by behavioral, pharmacological, and surgical interventions. Tumor oxygenation is important in defining the cellular metabolic microenvironment of human malignancies, O2-depleted areas coincide with nutrient and energy deprivation and with a hostile metabolic microenvironment. In our work we simultaneously measured two oxygen-sensitive parameters in breast cancer patients, blood oxygen saturation (SpO2) and transcutaneous O2 partial pressure (tcpO2) in breast tissue...
October 13, 2018: Neoplasma
Jarren C Kay, Gerald C Claghorn, Zoe Thompson, Thomas G Hampton, Theodore Garland
Changes in cardiac function that occur with exercise training have been studied in detail, but those accompanying evolved increases in the duration or intensity of physical activity are poorly understood. To address this gap, we studied electrocardiograms (ECGs) of mice from an artificial selection experiment in which four replicate lines are bred for high voluntary wheel running (HR) while four non-selected lines are maintained as controls (C). ECGs were recorded using an ECGenie (Mouse Specifics, Inc.) both before and after six days of wheel access (as used in the standard protocol to select breeders)...
November 30, 2018: Physiology & Behavior
Eduardo Frio Marins, Leo Cabistany, Charles Farias, Jay Dawes, Fabrício Boscolo Del Vecchio
Marins, EF, Cabistany, L, Farias, CB, Dawes, J, and Del Vecchio, FB. Effects of personal protective equipment on metabolism and performance during an Occupational Physical Ability Test for Federal Highway Police officers. J Strength Cond Res XX(X): 000-000, 2018-Federal Highway Police (FHP) officers perform their duties while wearing personal protective equipment (PPE). Given the need for officers to wear PPE, it is important to understand the effects this additional load can have on occupational performance...
November 29, 2018: Journal of Strength and Conditioning Research
Carolina Varon, Jesus Lazaro, Juan Bolea, Alberto Hernando, Jordi Aguilo, Eduardo Gil, Sabine Van Huffel, Raquel Bailon
OBJECTIVE: This paper proposes an approach to better estimate the sympathovagal balance (SB) and the respiratory sinus arrhythmia (RSA) after separating respiratory influences from the heart rate (HR). METHODS: The separation is performed using orthogonal subspace projections and the approach is first tested using simulated HR and respiratory signals with different spectral properties. Then, RSA and SB are estimated during autonomic blockade and stress using the proposed approach and the classical heart rate variability (HRV) analysis...
December 3, 2018: IEEE Journal of Biomedical and Health Informatics
Carine Jasseron, Camille Legeai, Christian Jacquelinet, Karine Nubret-Le Coniat, Erwan Flécher, Christelle Cantrelle, Benoît Audry, Olivier Bastien, Richard Dorent
The new French heart allocation system is designed to minimize waitlist mortality and extend the donor pool without a detrimental effect on post-transplant survival. This study was designed to construct a 1-year post-transplant graft-loss risk score incorporating recipient and donor characteristics. The study included all adult first single-organ recipients transplanted between 2010 and 2014 (N=1776). This population was randomly divided in a 2:1 ratio into derivation and validation cohorts. The association of variables with 1-year graft-loss was determined with a mixed Cox model with center as random effect...
December 2, 2018: American Journal of Transplantation
Marianne Six Dijkstra, Remko Soer, André Bieleman, Rollin McCraty, Frits Oosterveld, Douglas Gross, Michiel Reneman
Low heart rate variability (HRV) is related to health problems that are known reasons for sick-leave or early retirement. A 1-minute-protocol could allow large scale HRV measurement for screening of health problems and, potentially, sustained employability. Our objectives were to explore the association of HRV with measures of health. Cross-sectional design with 877 Dutch employees assessed during a Workers' Health Assessment. Personal and job characteristics, workability, psychological and mental problems, and lifestyle were measured with questionnaires...
December 1, 2018: Applied Psychophysiology and Biofeedback
Roger D Dias, Heather M Conboy, Jennifer M Gabany, Lori A Clarke, Leon J Osterweil, David Arney, Julian M Goldman, Giuseppe Riccardi, George S Avrunin, Steven J Yule, Marco A Zenati
Procedural flow disruptions secondary to interruptions play a key role in error occurrence during complex medical procedures, mainly because they increase mental workload among team members, negatively impacting team performance and patient safety. Since certain types of interruptions are unavoidable, and consequently the need for multitasking is inherent to complex procedural care, this field can benefit from an intelligent system capable of identifying in which moment flow interference is appropriate without generating disruptions...
September 2018: OR 2.0 context-aware operating theaters, computer assisted robotic endoscopy, clinical image-based procedures, and skin image analysis: first International Workshop, OR 2.0 2018, 5th International Workshop, CARE 2018, 7th International Workshop, CLIP 201
Başar Erdivanlı, Özlem Çelebi Erdivanlı, Ahmet Şen, Abdullah Özdemir, Ersagun Tuğcugil, Engin Dursun
Objective: Controlled hypotension is commonly induced during functional endoscopic sinus surgery to limit mucosal bleeding. This may be detrimental to elderly patients and patients with arterial stenosis. The aim of this pilot study was to determine if a normotensive anaesthetic technique with sufficient analgesia and without profound vasodilation may reduce intraoperative bleeding and incidence of adverse haemodynamic effects associated with vasodilation and variable rate continuous infusions...
December 2018: Turkish Journal of Anaesthesiology and Reanimation
Chiara Scopa, Elisabetta Palagi, Claudio Sighieri, Paolo Baragli
To manage a stressful stimulus animals react both behaviorally and physiologically to restore the homeostasis. In stable horses, a stressful stimulus can be represented by social separation, riding discomfort or the presence of novel objects in their environment. Although Heart Rate Variability is a common indicator of stress levels in horses, the behavioral mechanisms concurrently occurring under stressful conditions are still unknown. The sudden inflation of a balloon was administered to 33 horses. Video-recording of self-directed behaviors (snore, vacuum chewing, snort, head/body shaking) and monitoring of heart activity (HR and SDRR) were conducted for five minutes before (Pre-test) and after the stimulus administration (Stress-test)...
November 30, 2018: Scientific Reports
Luis Montesinos, Rossana Castaldo, Francesco P Cappuccio, Leandro Pecchia
Acute sleep deprivation is known to affect human balance and posture control. However, the effects of variations in sleep quality and pattern over consecutive days have received less attention. This study investigated the associations between day-to-day variations in sleep quality and standing balance in healthy subjects. Twenty volunteers (12 females and 8 males; age: 28.8 ± 5.7 years, body mass index: 23.4 ± 3.4 kg/m2 , resting heart rate: 63.1 ± 8.7 bpm) with no history of sleep disorders or balance impairments participated in the study...
November 30, 2018: Scientific Reports
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