keyword
https://read.qxmd.com/read/38711887/the-importance-of-attentive-primary-care-in-the-early-identification-of-mild-cognitive-impairment-case-series
#1
Waseem Jerjes
BACKGROUND: Mild cognitive impairment (MCI) is a condition often preceding Alzheimer's disease and other dementias, characterized by subtle changes in cognitive function. While the importance of early detection is recognised, MCI is frequently underdiagnosed, especially when patients consult primary care physicians for non-cognitive health concerns. The case series aims to investigate the incidental identification of MCI in older patients who visit primary care settings for reasons unrelated to memory issues...
2024: AME Case Reports
https://read.qxmd.com/read/38710093/diagnostic-strategy-using-color-doppler-ultrasound-of-temporal-arteries-in-patients-with-high-clinical-suspicion-of-giant-cell-arteritis-a-prospective-cohort-study
#2
JOURNAL ARTICLE
Guillaume Denis, Olivier Espitia, Caroline Allix-Béguec, Céline Dieval, Fanny Lorcerie, Bruno Gombert, Xavier Pouget-Abadie, Claire Toquet, Christian Agard, Alizée Raimbeau, Giovanni Gautier, Jean-Michel Goujon, Géraldine Durand, Cécile Thollot-Karolewicz, Christian Lormeau, Aurélie Grados, Anne Grenot-Mercier, Rony El-Khoury, Agnès Riche, Florence Hospital, Sebastien Visee, Marie-Luce Auriault, Cédric Landron, Mickaël Martin, Christophe Roncato
BACKGROUND: Giant cell arteritis (GCA) is the most prevalent systemic vasculitis in people older than 50 years. Any delay in diagnosis impairs patients' quality of life and can lead to permanent damage, particularly vision loss. OBJECTIVE: To evaluate a diagnostic strategy for GCA using color Doppler ultrasound of the temporal artery as a first-line diagnostic test, temporal artery biopsy (TAB) as a secondary test, and physician expertise as the reference method...
May 7, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38708457/non-cardiac-comorbid-health-outcomes-and-prevalence-after-myocardial-infarction-an-umbrella-review
#3
REVIEW
H Jeon, H Lee, H Yang, M Rahmati, M S Kim, Y Choi, J M Cho, D K Yon
OBJECTIVE: There exists limited comprehensive evidence on the potential association between non-cardiac comorbidities and myocardial infarction (MI). Thus, we conducted an umbrella review of existing meta-analyses to provide a broad understanding of non-cardiac health outcomes associated with MI. MATERIALS AND METHODS: The primary focus on the prevalence of related health outcomes in patients with MI was systemically searched. Each original meta-analysis that was included had its methodological quality evaluated by a Measurement Tool Assessment Systematic Reviews 2 (AMSTAR2)...
April 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38708124/associations-among-tremor-amplitude-activities-of-daily-living-and-quality-of-life-in-patients-with-essential-tremor
#4
JOURNAL ARTICLE
Margaret E Gerbasi, Rodger J Elble, Eddie Jones, Alexander Gillespie, John Jarvis, Elizabeth Chertavian, Zachary Smith, Mina Nejati, Ludy C Shih
BACKGROUND: Essential tremor (ET) is a disabling syndrome consisting of tremor, primarily in the upper limbs. We assessed the correlation of The Essential Tremor Rating Assessment Scale (TETRAS) Performance Item 4 ratings of upper limb tremor with the TETRAS activities of daily living (ADL) subscale and with 2 quality of life (QoL) scales. METHODS: This noninterventional, cross-sectional, point-in-time survey of neurologists(n = 60), primary care physicians (n = 38), and their patients with ET (n = 1,003) used real-world data collected through the Adelphi ET Disease Specific Programme™...
2024: Tremor and Other Hyperkinetic Movements
https://read.qxmd.com/read/38706273/multiomics-blood-based-biomarkers-predict-alzheimer-s-predementia-with-high-specificity-in-a-multicentric-cohort-study
#5
MULTICENTER STUDY
B Souchet, A Michaïl, M Heuillet, A Dupuy-Gayral, E Haudebourg, C Pech, A A Berthemy, F Autelitano, B Billoir, K Domoto-Reilly, C Fowler, T Grabowski, S Jayadev, C L Masters, J Braudeau
BACKGROUND: The primary criteria for diagnosing mild cognitive impairment (MCI) due to Alzheimer's Disease (AD) or probable mild AD dementia rely partly on cognitive assessments and the presence of amyloid plaques. Although these criteria exhibit high sensitivity in predicting AD among cognitively impaired patients, their specificity remains limited. Notably, up to 25% of non-demented patients with amyloid plaques may be misdiagnosed with MCI due to AD, when in fact they suffer from a different brain disorder...
2024: Journal of Prevention of Alzheimer's Disease
https://read.qxmd.com/read/38704227/reactive-oxygen-species-and-their-role-in-the-andrological-factor-of-couple-fertility
#6
REVIEW
P Turčan, P Pokorný, P Kepič, J Hambálek, P Entnerová, J Kvintová, M Sigmund, E Jurásková Sedlatá, T Fait
Reactive oxygen species play a significant role in male fertility and infertility. They are essential for physiological processes, but when their concentration becomes excessive, they can be a cause of various sperm pathologies. Seminal leukocytes and pathologically abnormal sperm are the primary sources of oxygen radicals in ejaculate. They negatively affect sperm quality, including DNA fragmentation and sperm motility impairment. Addressing increased concentrations of reactive oxygen species involves various appropriate lifestyle modifications and measures, including the use of antioxidants, treatment of urogenital infections, management of varicocele, weight reduction, and others...
2024: Ceská Gynekologie
https://read.qxmd.com/read/38702871/acute-eye-tracking-changes-correlated-with-vestibular-symptom-provocation-following-mild-traumatic-brain-injury
#7
JOURNAL ARTICLE
Caroline Uyeno, Rachel Zhang, Jordan Cornwell, Masaru Teramoto, Marie Boo, Angela Lumba-Brown
OBJECTIVES: To quantify norms and changes in eye-tracking proficiency, and determine vestibular symptom correlations in varsity college athletes following acute mild traumatic brain injury (mTBI). We hypothesized that mTBI impacts central coordination between the vestibular and oculomotor systems with resultant changes in eye-tracking proficiency that are correlated with vestibular symptom provocation. DESIGN: Retrospective cohort study. SETTING: Sports medicine care at a single institution...
May 2, 2024: Clinical Journal of Sport Medicine
https://read.qxmd.com/read/38701951/predictors-of-stool-deoxyribonucleic-acid-test-use-in-the-united-states-implications-for-outreach-to-under-resourced-populations
#8
JOURNAL ARTICLE
Kathleen A Fairman, Sarah Lira
OBJECTIVE: Although colorectal cancer screening (CRCS) is a public health priority, uptake is suboptimal in under-resourced groups. Noninvasive modalities, including stool deoxyribonucleic acid (sDNA) testing, may mitigate economic, geographic, cultural, or impairment-related barriers to CRCS. We assessed use of sDNA testing and other CRCS modalities in U.S. residents, comparing subgroups defined by several social determinants of health (SDOH). METHODS: A nationally representative sample of community-dwelling respondents aged 50-75 years self-reported use of CRCS modalities in the 2020 Behavioral Risk Factor Surveillance System Survey...
May 1, 2024: Preventive Medicine
https://read.qxmd.com/read/38698912/euthanasia-and-physician-assisted-suicide-in-people-with-an-accumulation-of-health-problems-related-to-old-age-a-cross-sectional-questionnaire-study-among-physicians-in-the-netherlands
#9
JOURNAL ARTICLE
Frédérique W M Kraak-Steenken, Sophie C Renckens, H Roeline W Pasman, Fenne Bosma, Agnes van der Heide, Bregje D Onwuteaka-Philipsen
Objectives: We explored characteristics of people with an accumulation of health problems related to old age requesting euthanasia or physician-assisted suicide (EAS) and identified characteristics associated with granting EAS requests. Methods: We conducted a cross-sectional questionnaire study among Dutch physicians on characteristics of these people requesting EAS ( n = 123). Associations between characteristics and granting a request were assessed using logistic regression analyses. Results: People requesting EAS were predominantly >80 years old (82...
2024: International Journal of Public Health
https://read.qxmd.com/read/38698738/effects-of-thiazides-and-new-findings-on-kidney-stones-and-dysglycemic-side-effects
#10
REVIEW
Matteo Bargagli, Manuel A Anderegg, Daniel G Fuster
Thiazide and thiazide-like diuretics (thiazides) belong to the most frequently prescribed drugs worldwide. By virtue of their natriuretic and vasodilating properties, thiazides effectively lower blood pressure and prevent adverse cardiovascular outcomes. In addition, through their unique characteristic of reducing urine calcium, thiazides are also widely employed for the prevention of kidney stone recurrence and reduction of bone fracture risk. Since their introduction into clinical medicine in the early 1960s, thiazides have been recognized for their association with metabolic side effects, particularly impaired glucose tolerance, and new-onset diabetes mellitus...
May 3, 2024: Acta Physiologica
https://read.qxmd.com/read/38695500/criteria-timing-and-factors-associated-with-return-to-competitive-sport-after-rotator-cuff-surgery
#11
REVIEW
Emanuele Maggini, Mac Donald Tedah Djemetio, Isabella Husband, Luca Paganelli, Maristella F Saccomanno, Giuseppe Milano
Rotator cuff pathology in competitive athletes is common and may produce chronic symptoms and joint disability, impairing sports participation and leading to premature retirement. Athletes are a high-functioning patient population with unique characteristics. Decision-making for return to sport is a complex and multifactorial process. Literature is sparse and does not provide precise guidelines to assist physicians to make the right decision. This review aimed to highlight factors affecting outcome, timing, and criteria for return to competitive sport after rotator cuff surgery to help physicians to clearly counsel athletes and make high-quality decisions for return to sport...
March 1, 2024: Sports Medicine and Arthroscopy Review
https://read.qxmd.com/read/38695491/real-world-clinical-evaluation-of-natural-and-induced-vasomotor-symptoms-in-the-usa-and-europe
#12
JOURNAL ARTICLE
Sheryl Kingsberg, Victoria Banks, Cecilia Caetano, Cecile Janssenswillen, Carsten Moeller, Nils Schoof, Lauren Lee, Megan Scott, Rossella E Nappi
OBJECTIVE: This study aimed to examine physicians' and patients' perceptions regarding symptom burden and impact in women experiencing natural vasomotor symptoms (nVMS) or vasomotor symptoms induced by endocrine therapy for breast cancer (iVMS). METHODS: The cross-sectional survey based on real-world clinical consultations was conducted in the USA and five European countries. Obstetrician-gynecologists, primary-care physicians and oncologists provided demographic and symptom data for patients experiencing VMS; patients optionally self-reported their experiences via questionnaires, including their symptom profile and work/activity burden through the Menopause Quality of Life (MENQOL) and Work Productivity and Activity Impairment (WPAI) tools...
May 2, 2024: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/38694670/hansen-s-disease-a-practical-update-on-a-neglected-globally-significant-infection
#13
REVIEW
Soukaina Benlamkadam, Amina Errahmany, Klevor Raymond, Mohamed Chraa, Najib Kissani
Leprosy is a great mimicker. It is caused by Mycobacterium leprae and Mycobacterium lepromatosis , together termed the M. leprae complex. Leprosy can result in systemic manifestations; however, the neurocutaneous syndrome is the most classic. There is a gap in recognizing the condition leading to misdiagnosis and delays in treatment. Leprosy remains an important cause of aesthetic and functional impairment. In this paper, we provide a practical review of leprosy touching on pathophysiology, clinical manifestation, classification, diagnostic approach and management of the condition in a way that can translate into clinical practice and help physicians better identify and manage potential cases of leprosy...
April 2024: Curēus
https://read.qxmd.com/read/38693772/definition-and-management-of-arrhythmia-induced-cardiomyopathy-findings-from-the-european-heart-rhythm-association-survey
#14
JOURNAL ARTICLE
Teodor Serban, Patrick Badertscher, Jeanne du Fay de Lavallaz, Rui Providencia, Federico Migliore, Giacomo Mugnai, Diego Penela, Laura Perrotta, Michael Kühne, Christian Sticherling, Kyoung-Ryul Julian Chun
BACKGROUND: Arrhythmia-induced Cardiomyopathy (AiCM) represents a subtype of acute heart failure (HF) in the context of sustained arrhythmia. Clear definitions and management recommendations for AiCM are lacking. PURPOSE: The European Heart Rhythm Association Scientific Initiatives Committee (EHRA SIC) conducted a survey to explore the current definitions and management of patients with AiCM among European and non-European electrophysiologists. METHODS: A 25-item online questionnaire was developed and distributed among EP specialists on the EHRA SIC website and on social media between September 4th and October 5th 2023...
May 2, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38689398/2024-alzheimer-s-disease-facts-and-figures
#15
JOURNAL ARTICLE
(no author information available yet)
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The Special Report discusses the larger health care system for older adults with cognitive issues, focusing on the role of caregivers and non-physician health care professionals. An estimated 6.9 million Americans age 65 and older are living with Alzheimer's dementia today...
April 30, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38687696/does-small-talk-with-a-medical-provider-affect-chatgpt-s-medical-counsel-performance-of-chatgpt-on-usmle-with-and-without-distractions
#16
JOURNAL ARTICLE
Myriam Safrai, Amos Azaria
Efforts are being made to improve the time effectiveness of healthcare providers. Artificial intelligence tools can help transcript and summarize physician-patient encounters and produce medical notes and medical recommendations. However, in addition to medical information, discussion between healthcare and patients includes small talk and other information irrelevant to medical concerns. As Large Language Models (LLMs) are predictive models building their response based on the words in the prompts, there is a risk that small talk and irrelevant information may alter the response and the suggestion given...
2024: PloS One
https://read.qxmd.com/read/38673688/the-association-between-untreated-and-treated-hearing-loss-and-cognitive-performance-in-men-and-women-aged-60-96-years-data-from-the-swedish-good-aging-in-sk%C3%A3-ne-population-study
#17
JOURNAL ARTICLE
Paula Lundgren, Sölve Elmståhl, Henrik Ekström
Background/Objectives : Recent decades have witnessed a sharp increase in research investigating the association between hearing loss and cognitive impairment. Few previous studies have stratified for sex when investigating this issue, where results were inconsistent and require further clarification. Thus, the objective was to investigate the association between self-reported hearing loss and levels of cognitive impairment, stratified for sex. Methods : In this cross-sectional study, data were collected from 2001 to 2016...
April 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38664994/comprehensive-insights-into-pediatric-craniopharyngioma-endocrine-and-metabolic-profiles-treatment-challenges-and-long-term-outcomes-with-a-multicenter-approach
#18
JOURNAL ARTICLE
Zeynep Şıklar, Elif Özsu, Sirmen Kızılcan Çetin, Samim Özen, Filiz Çizmecioğlu-Jones, Hanife Gül Balkı, Zehra Aycan, Damla Goksen, Fatih Kilci, Sema Nilay Abseyi, Ummahan Tercan, Gözde Gürpınar, Şükran Poyrazoğlu, Feyza Darendeliler, Korcan Demir, Özge Besci, İlker Tolga Özgen, Semra Bahar Akın, Zümrüt Kocabey Sütçü, Emel Hatun Aykaç Kaplan, Emine Çamtosun, İsmail Dundar, Elif Sağsak, Hüseyin Anıl Korkmaz, Ahmet Anık, Gül Yeşiltepe Mutlu, Bahar Özcabi, Ahmet Uçar, Aydilek Dağdeviren Çakır, Beray Selver Eklioğlu, Birgül Kırel, Merih Berberoğu
INTRODUCTION: Craniopharyngiomas (CPG) have complex challenges in treatment due to their proximity to vital structures, surgical and radiotherapeutic complexities, and the tendency for recurrence. This study aims to identify the prevalence of endocrine and metabolic comorbidities observed during initial diagnosis and long-term follow-up in a nationwide cohort of pediatric CPG patients. The study also highlights the associated difficulties in their management. METHODS: Sixteen centers entered 152 patients into the ÇEDD NET data system...
April 26, 2024: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/38664724/how-family-physicians-in-singapore-recognise-complexity-during-consultations-a-qualitative-study
#19
JOURNAL ARTICLE
Jing Sheng Quek, Eng Sing Lee, Lian Leng Low, Sabrina Kay Wye Wong
BACKGROUND: The prevalence of persons with complex needs in Singapore is rising. Poor understanding of what constitutes complexity impedes the identification of care gaps and development of interventions to improve care for these individuals. We aim to identify the characteristics contributing to complexity in primary care, from the Family Physicians' (FP) perspectives. METHODS: Focus group discussions (FGDs) were conducted from January to September 2021 with experienced FPs across 14 study sites, employing a qualitative descriptive approach based on a complexity framework...
April 25, 2024: BMC Prim Care
https://read.qxmd.com/read/38664015/evaluation-of-neurodegenerative-disorders-with-amyloid-%C3%AE-tau-and-dopaminergic-pet-imaging-interpretation-pitfalls
#20
JOURNAL ARTICLE
Brian J Burkett, Derek R Johnson, Val J Lowe
Antiamyloid therapies for Alzheimer disease recently entered clinical practice, making imaging biomarkers for Alzheimer disease even more relevant to guiding patient management. Amyloid and tau PET are valuable tools that can provide objective evidence of Alzheimer pathophysiology in living patients and will increasingly be used to complement 18 F-FDG PET in the diagnostic evaluation of cognitive impairment and dementia. Parkinsonian syndromes, also common causes of dementia, can likewise be evaluated with a PET imaging biomarker,18 F-DOPA, allowing in vivo assessment of the presynaptic dopaminergic neurons...
April 25, 2024: Journal of Nuclear Medicine
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