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Wei-Feng Zheng, Pranjal Protim Bora, Gui-Jun Sun, Qiang Kang
A highly regio- and stereoselective Rh-catalyzed intermolecular head-to-head [2 + 2] cycloaddition of allenamides was developed. The intermolecular cycloadducts, trans-dimethylenecyclobutane-1,2-diamine derivatives, were achieved in good yields with high regioselectivity and stereoselectivity.
August 5, 2016: Organic Letters
S Braham, C Novembrino, M Moia, E Torresani, A Tripodi
INTRODUCTION: Patients on anticoagulant therapy with vitamin K antagonists (VKA) need frequent INR monitoring. Reliability of point-of-care (POC) devices for measuring INR needs rigorous evaluation, particularly in patient with the antiphospholipid syndrome (APS). The aim of this study was to evaluate the accuracy of the ProTime InRhythm(™) System (here called device) for INR measurement in patients with APS on VKA. METHODS: We compared the device INR vs. the laboratory INR measurement for blood samples from 29 APS-positive and 31 APS-negative patients consecutively enrolled...
October 2016: International Journal of Laboratory Hematology
Anju Barhai Teli, Rumi Deori, Sidhartha Protim Saikia, Kalyani Pathak, Rita Panyang, Rashmi Rajkakati
INTRODUCTION: β-Thalassaemias are common genetic disorders in the Indian subcontinent and its status has not been well studied in the Upper Assam region of North Eastern India. AIM: The aim of the study was to show the prevalence of β- thalassaemias and its co-existence with Haemoglobin E and Haemoglobin S in the Upper Assam region of North Eastern India. MATERIALS AND METHODS: A total of 1200 anaemic patients were investigated for β- thalassaemias...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Manash Protim Borpuzari, Abhijit Boruah, Rahul Kar
Recently, the range-separated density functionals have been reported to reproduce gas phase orbital and excitation energies with good accuracy. In this article, we have revisited the ionisation potential theorem in the presence of external electric field. Numerical results on six linear molecules are presented and the performance of the range-separated density functionals in reproducing highest occupied molecular orbital (HOMO) energies, LUMO energies, HOMO-LUMO gaps in the presence of the external electric field is assessed...
April 28, 2016: Journal of Chemical Physics
Eramoni Saikia, Manash Protim Borpuzari, Bolin Chetia, Rahul Kar
Two new anion receptors 1,1-(4-nitro-1,2-phenylene) bis(3-phenylurea) (1) and 1,1-(4-nitro-1,2-phenylene) bis(3-phenylthiourea) (2) have been reported here. The binding and colorimetric sensing properties of receptors 1 and 2 with different anions were investigated by naked-eye, (1)H-NMR and UV-Vis spectroscopy. They showed effective and selective binding with two biologically important anions F(-) and CH3COO(-), in presence of other anions, such as Cl(-), Br(-), I(-), NO2(-), ClO4(-), HSO4(-), H2PO4(-), N3(-), CN(-) in acetonitrile...
January 5, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Laura V Tsu, Andrew Berry, Erin Wald, Cassandra Ehrlich
OBJECTIVE: To determine if a modified HAS-BLED score (hypertension, abnormal renal/liver dysfunction, stroke, bleeding history, elderly, drugs) predicts risk for major bleeding in patients prescribed dabigatran or rivaroxaban. DESIGN: A retrospective, case-control study. SETTING: Two inpatient medical centers. PATIENTS: Patients prescribed dabigatran or rivaroxaban who experienced a major bleed from June 1, 2011, to August 31, 2013...
July 2015: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Pawana Sharma, Graham Scotland, Moira Cruickshank, Emma Tassie, Cynthia Fraser, Chris Burton, Bernard Croal, Craig R Ramsay, Miriam Brazzelli
BACKGROUND: Self-monitoring (self-testing and self-management) could be a valid option for oral anticoagulation therapy monitoring in the NHS, but current evidence on its clinical effectiveness or cost-effectiveness is limited. OBJECTIVES: We investigated the clinical effectiveness and cost-effectiveness of point-of-care coagulometers for the self-monitoring of coagulation status in people receiving long-term vitamin K antagonist therapy, compared with standard clinic monitoring...
June 2015: Health Technology Assessment: HTA
Prerna Khurana, Protim Bhattacharjee, Angshul Majumdar
This work addresses the problem of estimating T2 maps from very few (two) echoes. Existing multi-parametric non-linear curve fitting techniques require a large number (16 or 32) of echoes to estimate T2 values. We show that our method yields very accurate and robust results from only two echoes, where as the curve-fitting techniques require about 16 echoes to achieve the same level of accuracy. We model T2 maps as a rank-deficient matrix. Since the relationship between T2 values and intensity values/K-space samples is not linear, estimating the T2 values requires recovering a low-rank matrix from non-linear projections...
September 2015: Magnetic Resonance Imaging
Dallas Swendeman, Smarajit Jana, Protim Ray, Deborah Mindry, Madhushree Das, Bhumi Bhakta
This two-phase pilot study aimed to design, pilot, and refine an automated interactive voice response (IVR) intervention to support antiretroviral adherence for people living with HIV (PLH), in Kolkata, India. Mixed-methods formative research included a community advisory board for IVR message development, 1-month pre-post pilot, post-pilot focus groups, and further message development. Two IVR calls are made daily, timed to patients' dosing schedules, with brief messages (<1-min) on strategies for self-management of three domains: medical (adherence, symptoms, co-infections), mental health (social support, stress, positive cognitions), and nutrition and hygiene (per PLH preferences)...
June 2015: AIDS and Behavior
A M H P van den Besselaar, F J M van der Meer, C F Abdoel, E Witteveen
BACKGROUND: Portable point-of-care (POC) instruments for determination of the whole blood prothrombin time (PT) have been available for the last three decades. Recently, two novel POC instruments for PT and International Normalized Ratio (INR) determination in whole blood have been manufactured. The purpose of this study was to compare INR values obtained with the novel instruments (microINR® and ProTime InRhythm™) to the INR determined with the international standard for thromboplastin rTF/09...
March 2015: Thrombosis Research
Young-Wook Won, Partho Protim Adhikary, Kwang Suk Lim, Hyung Jin Kim, Jang Kyoung Kim, Yong-Hee Kim
Commercial anti-obesity drugs acting in the gastrointestinal tract or the central nervous system have been shown to have limited efficacy and severe side effects. Anti-obesity drug development is thus focusing on targeting adipocytes that store excess fat. Here, we show that an adipocyte-targeting fusion-oligopeptide gene carrier consisting of an adipocyte-targeting sequence and 9-arginine (ATS-9R) selectively transfects mature adipocytes by binding to prohibitin. Injection of ATS-9R into obese mice confirmed specific binding of ATS-9R to fat vasculature, internalization and gene expression in adipocytes...
December 2014: Nature Materials
David B Matchar, Sean R Love, Alan K Jacobson, Robert Edson, Lauren Uyeda, Ciaran S Phibbs, Rowena J Dolor
Anticoagulation (AC) is effective in reducing thromboembolic events for individuals with atrial fibrillation (AF) or mechanical heart valve (MHV), but maintaining patients in target range for international normalized ratio (INR) can be difficult. Evidence suggests increasing INR testing frequency can improve time in target range (TTR), but this can be impractical with in-clinic testing. The objective of this study was to test the hypothesis that more frequent patient-self testing (PST) via home monitoring increases TTR...
July 2015: Journal of Thrombosis and Thrombolysis
Jagannath Dev Sharma, Manoj Kalit, Tulika Nirmolia, Sidhartha Protim Saikia, Arpita Sharma, Debanjana Barman
BACKGROUND: Cancer is becoming the most important public health burden around the globe. As per the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths were estimated to have occurred in 2008. The burden of cancer cases for India in the year 2020 is calculated to be 1,148,757 (male 534,353; female 614,404) compared to 979,786 in 2010. The pattern of cancer incidence is varying among geographical regions, esophageal cancer for example being high in China, lung cancer in USA, and gallbladder cancer in Chile...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Anton M H P van den Besselaar, Charmane F Abdoel, Davina Ardanary, Gert van de Kamp, Fanny A C Versluijs
OBJECTIVES: The aim of this study was to prepare control blood for an external quality assessment scheme (EQAS) for international normalized ratio (INR) point-of-care testing (POCT) in the Netherlands and to assess the performance of the participants. METHODS: Control blood was prepared from dialyzed pooled patient plasma and washed human erythrocytes. Samples of control blood were mailed to participants of the Netherlands EQAS from October 2006 through December 2012...
June 2014: American Journal of Clinical Pathology
Abdullah Al-Mamun, Akhirunnessa Mily, Protim Sarker, Snigdha Tiash, Armando Navarro, Mahmuda Akter, Kaisar Ali Talukder, Mohammad Faizul Islam, Birgitta Agerberth, Gudmundur H Gudmundsson, Alejandro Cravioto, Rubhana Raqib
Treatment of shigellosis in rabbits with phenylbutyrate reduces clinical severity and counteracts down-regulation of cathelicidin (CAP-18) in the large intestinal epithelia. We aimed to further evaluate whether in a rabbit model of enteropathogenic Escherichia coli (EPEC) diarrhea, CAP-18 is down-regulated in the small intestine and if oral phenylbutyrate treatment affects CAP-18 expression, clinical recovery, shedding of EPEC in stool and virulence properties of the isolated colonies. EPEC-induced diarrhea down-regulated CAP-18 in the small intestinal epithelia as revealed by immunohistochemistry...
November 2013: Microbes and Infection
Maria Niña Banque, Ma Dulce Requiron-Sy, Maria Nerissa De Leon, Milagros Bautista, Ma Encarnita Limpin
SESSION TYPE: Post operative ICU issues PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: This is a prospective observational cohort study done to determine the risk factors associated with postoperative pulmonary complications (PPCs) following cardiothoracic surgery in children 6 years old and below who underwent cardiothoracic surgery from November 1, 2010-October 31, 2011 at the Philippine Heart CenterMETHODS: The following variables were included in the study: demographic and clinical characteristics, identified preoperative risk factors, ASA and RACHS-1 scores, surgical procedures done, bypass time, aortic cross clamp time, duration of postoperative mechanical ventilation, recovery room (RR) stay, pediatric intensive care unit (PICU) stay, overall length of postoperative hospital stay and condition on discharge...
October 1, 2012: Chest
Akhirunnesa Mily, Rokeya Sultana Rekha, S M Mostafa Kamal, Evana Akhtar, Protim Sarker, Zeaur Rahim, Gudmundur H Gudmundsson, Birgitta Agerberth, Rubhana Raqib
BACKGROUND: We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB alone or in combination with vitamin D3 for induction of LL-37 expression in immune cells and enhancement of antimycobacterial activity in monocyte-derived macrophages (MDM). METHODS: Healthy volunteers were enrolled in an 8-days open trial with three doses of PB [250 mg (Group-I), 500 mg (Group-II) or 1000 mg (Group-III)] twice daily (b...
2013: BMC Pulmonary Medicine
Rubhana Raqib, Protim Sarker, Akhirunnesa Mily, Nur Haque Alam, Abu Saleh Mohammed Arifuzzaman, Rokeya Sultana Rekha, Jan Andersson, Gudmundur H Gudmundsson, Alejandro Cravioto, Birgitta Agerberth
BACKGROUND: Treatment of shigellosis in rabbits with butyrate reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia. Here, we aimed to evaluate whether butyrate can be used as an adjunct to antibiotics in the treatment of shigellosis in patients. METHODS: A randomized, double-blind, placebo-controlled, parallel-group designed clinical trial was conducted. Eighty adult patients with shigellosis were randomized to either the Intervention group (butyrate, n = 40) or the Placebo group (normal saline, n = 40)...
2012: BMC Infectious Diseases
Kyung-Min Kim, Young-Wook Won, Partho Protim Adhikary, Yun-Mi Hwang, Yong-Hee Kim
No abstract text is available yet for this article.
November 30, 2011: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mohammad Abu Sayem, Shaikh Meshbahuddin Ahmad, Rokeya Sultana Rekha, Protim Sarker, Birgitta Agerberth, Kaisar Ali Talukder, Rubhana Raqib
Shigella dysenteriae type 1 causes devastating epidemics in developing countries with high case-fatality rates in all age-groups. The aim of the study was to compare host immune responses to epidemic (T2218) and endemic strains of S. dysenteriae type 1. Shigellacidal activity of serum from rabbits immunized with epidemic or endemic strains, S. dysenteriae type 1-infected patients, and healthy adult controls from Shigella-endemic and non-endemic regions was measured. Immunogenic cross-reactivity of antibodies against Shigella antigens was evaluated by Western blot analysis...
October 2011: Journal of Health, Population, and Nutrition
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