Chao Huang, Shun Shi, Muyan Qin, Xiao Rong, Zichuan Ding, Xiaoxue Fu, Weinan Zeng, Lei Luo, Deping Wang, Zeyu Luo, Yiwen Li, Zongke Zhou
Critical-size bone defects pose a formidable challenge in clinical treatment, prompting extensive research efforts to address this problem. In this study, an inorganic-organic multifunctional composite hydrogel denoted as PLG-g-TA/VEGF/Sr-BGNPs is developed, engineered for the synergistic management of bone defects. The composite hydrogel demonstrated the capacity for mineralization, hydroxyapatite formation, and gradual release of essential functional ions and vascular endothelial growth factor (VEGF) and also maintained an alkaline microenvironment...
May 7, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)