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https://www.readbyqxmd.com/read/29444104/shdcr3-sensitizes-trail-resistant-hcc-cells-by-inducing-caspase-dependent-apoptosis-while-suppressing-nf-%C3%AE%C2%BAb-dependent-cflipl-expression
#1
Dong-Yu Liang, Wei Huang, Qing Chang, Yan-Qiang Hou
Evidence has shown that most hepatocellular carcinoma (HCC) cells are resistant to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. However, the molecular mechanisms underlying TRAIL-mediated apoptosis resistance are not well understood. In this study, we reported that downregulation of Decoy receptor 3 (DcR3) expression by lentiviral vectors carrying shRNA against DcR3 (LV-ShDcR3, shDcR3) in Huh7 both greatly enhanced TRAIL-mediated apoptosis and reduced cell proliferation capability...
2018: PloS One
https://www.readbyqxmd.com/read/29441343/construct-validity-of-the-movement-assessment-battery-for-children-second-edition-test-in-preschool-children-with-respect-to-age-and-gender
#2
Jakub Kokštejn, Martin Musálek, James J Tufano
Background: The Movement Assessment Battery for Children-second edition (MABC-2) Age Band 1 is widely used to identify preschoolers with motor difficulties. Despite unsatisfactory construct validity of the original three-factor model, MABC-2 (manual dexterity, aiming and catching, and balance), previous research has not considered possible age and gender differences throughout the entire preschool period. Aim: The aim of this study was to verify the construct validity of the MABC-2 Age Band 1 in a population of Czech preschoolers with respect to age and gender...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29441012/a-modified-reading-the-mind-in-the-eyes-test-predicts-behavioral-variant-frontotemporal-dementia-better-than-executive-function-tests
#3
Matthias L Schroeter, Sarah Pawelke, Sandrine Bisenius, Jana Kynast, Katharina Schuemberg, Maryna Polyakova, Sarah Anderl-Straub, Adrian Danek, Klaus Fassbender, Holger Jahn, Frank Jessen, Johannes Kornhuber, Martin Lauer, Johannes Prudlo, Anja Schneider, Ingo Uttner, Angelika Thöne-Otto, Markus Otto, Janine Diehl-Schmid
Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those neuropsychological and behavioral parameters best discriminating between bvFTD and healthy controls. Eighty six patients were diagnosed with possible or probable bvFTD according to Rascovsky et al. (2011) and compared with 43 healthy age-matched controls...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29438112/executive-functioning-and-daily-living-of-individuals-with-chronic-stroke-measurement-and-implications
#4
Lena Lipskaya-Velikovsky, Gabi Zeilig, Harold Weingarden, Clara Rozental-Iluz, Debbie Rand
Deficits in executive functioning (EF) are often still present at the chronic stage after stroke, which may negatively impact independent living. The objectives of this study were (a) to characterize the EF and independence in daily living of community-dwelling individuals with chronic stroke by using pen-and-paper and performance-based EF assessments, (b) to explore correlations between scores detected by different EF assessments and (c) to assess the correlations between EF and independence in basic activities of daily living (BADL) and instrumental activities of daily living (IADL)...
February 12, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29435731/using-crowd-sourced-photos-to-assess-seasonal-patterns-of-visitor-use-in-mountain-protected-areas
#5
Chelsey Walden-Schreiner, Sebastian Dario Rossi, Agustina Barros, Catherine Pickering, Yu-Fai Leung
Managing protected areas effectively requires information about patterns of visitor use, but these data are often limited. We explore how geotagged photos on Flickr, a popular photo-sharing social-media site, can generate hotspot maps and distribution models of temporal and spatial patterns of use in two mountain-protected areas of high conservation value. In Aconcagua Provincial Park (Argentina), two routes to the summit of Aconcagua were used in summer, but most visitors stayed close to the main road, using formal and informal walking trails and the Visitor Centre, while in winter, there was very limited visitation...
February 12, 2018: Ambio
https://www.readbyqxmd.com/read/29435468/the-impact-of-workload-on-the-evolution-of-hip-internal-and-external-rotation-in-professional-baseball-players-over-the-course-of-the-season
#6
Christopher L Camp, John M Zajac, Dave Pearson, Dean Wang, Alec S Sinatro, Anil S Ranawat, Joshua S Dines, Struan H Coleman
Background: Although restricted hip range of motion (ROM) is associated with an increased risk for injuries in baseball players, the evolution of hip ROM over the season remains undefined. Hypothesis: Hip ROM profiles would be symmetric between hips and positions (pitchers vs position players) but would decrease from preseason to postseason. Additionally, it was hypothesized that this decrease in motion would correlate with workload. Study Design: Cohort study; Level of evidence, 2...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29434699/neuroprotective-effect-of-epigallocatechin-3-gallate-on-autoimmune-thyroiditis-in-a-rat-model-by-an-anti-inflammation-effect-anti-apoptosis-and-inhibition-of-trail-signaling-pathway
#7
Junfeng Li
(-)-Epigallocatechin-3-gallate (EGCG) is a polyphenol monomer compound extracted and separated from green tea, and is a key catechin in green tea. Recent research has identified that EGCG is equipped with important biological activities, including antitumor, antioxidant, anti-inflammation, blood fat reduction and radiation protection abilities. In the current study, it was investigated whether EGCG exerts a neuroprotective effect on AIT and examined the possible underlying mechanism. The present study sought to establish an experimental autoimmune thyroiditis (AIT) rat model and to investigate the neuroprotective effect of EGCG in this model...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434473/trail-induced-apoptosis-in-trail-resistant-breast-carcinoma-through-quercetin-cotreatment
#8
Jasmine M Manouchehri, Katherine A Turner, Michael Kalafatis
Breast cancer is the most commonly diagnosed cancer in women. There is a continued interest for the development of more efficacious treatment regimens for breast carcinoma. Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) shows potential as a potent anticancer therapeutic for the treatment of breast cancer, whereas displaying minimal toxicity to normal cells. However, the promise of rhTRAIL for the treatment of breast cancer is dismissed by the resistance to rhTRAIL-induced apoptosis exhibited by many breast cancers...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29434187/glutamine-metabolism-regulates-flip-expression-and-sensitivity-to-trail-in-triple-negative-breast-cancer-cells
#9
Marta Mauro-Lizcano, Abelardo López-Rivas
Glutamine plays an important role in the metabolism of tumor cells through its contribution to redox homeostasis, bioenergetics, synthesis of macromolecules, and signaling. Triple-negative breast cancers (TNBC) are highly metastatic and associated with poor prognosis. TNBC cells show a marked dependence on extracellular glutamine for growth. Herein we demonstrate that TNBC cells are markedly sensitized to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis upon glutamine deprivation...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29433577/gaps-and-strategies-in-developing-health-research-capacity-experience-from-the-nigeria-implementation-science-alliance
#10
Echezona E Ezeanolue, William Nii Ayitey Menson, Dina Patel, Gregory Aarons, Ayodotun Olutola, Michael Obiefune, Patrick Dakum, Prosper Okonkwo, Bola Gobir, Timothy Akinmurele, Anthea Nwandu, Hadiza Khamofu, Bolanle Oyeledun, Muyiwa Aina, Andy Eyo, Obinna Oleribe, Ikoedem Ibanga, John Oko, Chukwuma Anyaike, John Idoko, Muktar H Aliyu, Rachel Sturke
BACKGROUND: Despite being disproportionately burdened by preventable diseases than more advanced countries, low- and middle-income countries (LMICs) continue to trail behind other parts of the world in the number, quality and impact of scholarly activities by their health researchers. Our strategy at the Nigerian Implementation Science Alliance (NISA) is to utilise innovative platforms that catalyse collaboration, enhance communication between different stakeholders, and promote the uptake of evidence-based interventions in improving healthcare delivery...
February 12, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29432906/hepatitis-b-virus-x-protein-and-proinflammatory-cytokines-synergize-to-enhance-trail-induced-apoptosis-of-renal-tubular-cells-by-upregulation-of-dr4
#11
Yitong Yang, Xuan Wang, Yueyue Zhang, Weijie Yuan
Persistent infection with hepatitis B virus (HBV) may lead to HBV-associated glomerulonephritis (HBV-GN). Presence of HBV-DNA and -RNA in renal tubular epithelial cells (RTECs) suggests direct virus-induced injury. Increase in proinflammatory cytokines is also observed under these conditions. Apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a significant role in the pathogenesis of HBV-infections. However, the effects of HBV X protein (HBx) on TRAIL-induced apoptosis of RTECs especially under certain inflammatory conditions remain obscure...
February 9, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29432778/-looking-at-nothing-during-sequential-sensorimotor-actions-long-term-memory-based-eye-scanning-of-remembered-target-locations
#12
Rebecca M Foerster
Before acting humans saccade to a target object to extract relevant visual information. Even when acting on remembered objects, locations previously occupied by relevant objects are fixated during imagery and memory tasks - a phenomenon called "looking-at-nothing". While looking-at-nothing was robustly found in tasks encouraging declarative memory built-up, results are mixed in the case of procedural sensorimotor tasks. Eye-guidance to manual targets in complete darkness was observed in a task practiced for days beforehand, while investigations using only a single session did not find fixations to remembered action targets...
February 9, 2018: Vision Research
https://www.readbyqxmd.com/read/29432613/circulating-dkk1-and-trail-are-associated-with-cognitive-decline-in-community-dwelling-older-adults-with-cognitive-concerns
#13
Ryan D Ross, Raj C Shah, Sue Leurgans, Teodoro Bottligieri, Robert S Wilson, D Rick Sumner
Background: Osteoporosis and Alzheimer's disease (AD) are common diseases of aging that would seem to be unrelated, but may be linked through the influence of bone-derived signals on brain function. The current study aimed to investigate the relationship between circulating levels of bone-related biomarkers and cognition. Methods: The population included 103 community-dwelling older individuals with memory concerns but without cognitive impairment. A global cognition summary measure was collected at baseline and 6, 12, and 18-months post-enrollment by converting raw scores from 19 cognitive function tests to z-scores and averaging...
February 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29430117/trails-on-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-leading-to-diagnosis-of-testicular-adrenal-rest-tumor
#14
Raghava Kashyap
Testicular adrenal rest tumors (TARTs) are secondary to hypertrophy of adrenal rest cells in the rete testis in settings of hypersecretion of androgens. We present a case of congenital adrenal hyperplasia with TART with clues to the diagnosis on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT). To the best of our knowledge, this is the first reported case on the role of 18 F-FDG PET/CT in TART.
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29428957/associations-of-near-miss-traffic-incidents-with-attention-and-executive-function-among-older-japanese-drivers
#15
Hyuma Makizako, Hiroyuki Shimada, Ryo Hotta, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Keitaro Makino
BACKGROUND: Attention and executive function may play an important role in ensuring safe driving as they involve paying attention to complex information and making an instantaneous judgment during driving. We hypothesized that poor performance in attention and executive function may increase the risk of near-miss incidents among older drivers. OBJECTIVE: The aim of this study was to examine associations of current experience of near-miss traffic incidents with attention and executive function among older Japanese drivers...
February 9, 2018: Gerontology
https://www.readbyqxmd.com/read/29428344/the-effects-of-timing-and-intensity-of-neurorehabilitation-on-functional-outcome-after-traumatic-brain-injury-a-systematic-review-meta-analysis
#16
REVIEW
Marsh Königs, Eva A Beurskens, Lian Snoep, Erik J A Scherder, Jaap Oosterlaan
OBJECTIVE: To systematically review evidence on the effects of timing and intensity of neurorehabilitation on the functional recovery of patients with moderate to severe traumatic brain injury (TBI) and aggregate the available evidence using meta-analytic methods. DATA SOURCES: Pubmed, Embase, PsycINFO and Cochrane Database. DATA SELECTION: Electronic databases were searched for prospective controlled clinical trials assessing the effect of timing or intensity of multidisciplinary neurorehabilitation programs on functional outcome of patients with moderate or severe TBI...
February 8, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29428192/expanding-access-to-primary-healthcare-for-women-through-a-microfinance-institution-a-case-study-from-rural-guatemala
#17
Marcela Colom, Kirsten Austad, Neftali Sacuj, Karen Larson, Peter Rohloff
The utilization of existing social networks is increasingly being recognized as a powerful strategy for delivering healthcare services to underserved populations in low- and middle-income countries. In Guatemala, multiple barriers prevent access to healthcare services for rural and indigenous populations, and strategies for delivering healthcare in more efficient ways are needed. The case study we describe here is a unique collaboration between a microfinance institution (Friendship Bridge) and a primary care organization (Wuqu' Kawoq | Maya Health Alliance) to scale up healthcare through an existing lending-borrowing social network...
February 7, 2018: Healthcare
https://www.readbyqxmd.com/read/29427703/safety-and-clinical-efficacy-of-tenvermectin-a-novel-antiparasitic-16-membered-macrocyclic-lactone-antibiotics
#18
Chenzhong Fei, Rufeng She, Guiyu Li, Lifang Zhang, Wushun Fan, Suhan Xia, Feiqun Xue
Tenvermectin (TVM) is a novel 16-membered macrocyclic lactone antibiotics, which contains component TVM A and TVM B. However there is not any report on safety and clinical efficacy of TVM for developing as a potential drug. In order to understand the part of safety and clinical efficacy of TVM, we conducted the acute toxicity test, the standard bacterial reverse mutation (Ames) test and the clinical deworming test. In the acute toxicity studies, TVM, TVM A and ivermectin (IVM) were administrated once by oral gavage to mice and rats...
February 7, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29426384/development-of-internet-based-tasks-for-the-executive-function-performance-test
#19
Debbie Rand, Keren Lee Ben-Haim, Rachel Malka, Sigal Portnoy
OBJECTIVE: The Executive Function Performance Test (EFPT) is a reliable and valid performance-based tool to assess executive functions (EFs). This study's objective was to develop and verify two Internet-based tasks for the EFPT. METHOD: A cross-sectional study assessed the alternate-form reliability of the Internet-based bill-paying and telephone-use tasks in healthy adults and people with subacute stroke (Study 1). It also sought to establish the tasks' criterion reliability for assessing EF deficits by correlating performance with that on the Trail Making Test in five groups: healthy young adults, healthy older adults, people with subacute stroke, people with chronic stroke, and young adults with attention deficit hyperactivity disorder (Study 2)...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29423112/ophiopogonin-b-sensitizes-trail-induced-apoptosis-through-activation-of-autophagy-flux-and-downregulates-cellular-flice-like-inhibitory-protein
#20
Uddin Md Nazim, Jae-Kyo Jeong, Sang-Youel Park
Tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a type II transmembrane protein, belongs to the TNF superfamily. Compared to other family members, TRAIL is a promising anti-cancer agent that can selectively induce apoptosis of various types of transformed cells and xenografts, with negligible cytotoxicity against normal tissues. Ophiopogonin B is a bioactive ingredient of Radix Ophiopogon japonicus , which is frequently used in traditional Chinese medicine to treat cancer. In this study, we report that Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is the key determinant mediating TRAIL resistance in A549 cells and Ophiopogonin B downregulates c-FLIP and enhances TRAIL-induced apoptosis by activating autophagy flux...
January 9, 2018: Oncotarget
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