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https://www.readbyqxmd.com/read/29684275/a-self-assembled-coumarin-anchored-dendrimer-for-efficient-gene-delivery-and-light-responsive-drug-delivery
#1
Hui Wang, Wujun Miao, Fei Wang, Yiyun Cheng
The assembly of low molecular weight polymers into highly efficient and non-toxic nanostructures has broad applicability in gene delivery. In this study, we reported the assembly of coumarin-anchored low generation dendrimers in aqueous solution via hydrophobic interactions. The synthesized material showed significantly improved DNA binding and gene efficacy, and minimal toxicity on the transfected cells. Moreover, the coumarin moieties in the assembled nanostructures endow the materials with light-responsive drug delivery behaviors...
April 23, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29683777/relationship-between-posturography-clinical-balance-and-executive-function-in-parkinson%C3%A2-s-disease
#2
Carolina de Oliveira Souza, Mariana Callil Voos, Alessandra Ferreira Barbosa, Janini Chen, Debora Cristina Valente Francato, Matija Milosevic, Milos Popovic, Erich Talamoni Fonoff, Hsin Fen Chien, Egberto Reis Barbosa
This study aimed to evaluate the relationship between posturography, clinical balance, and executive function tests in Parkinson´s disease (PD). Seventy-one people participated in the study. Static posturography evaluated the center of pressure fluctuations in quiet standing and dynamic posturography assessed sit-to-stand, tandem walk, and step over an obstacle. Functional balance was evaluated by Berg Balance Scale, MiniBESTest, and Timed Up and Go test. Executive function was assessed by Trail Making Test (TMT) and semantic verbal fluency test...
April 23, 2018: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29682185/stat5-inhibition-induces-trail-dr4-dependent-apoptosis-in-peripheral-t-cell-lymphoma
#3
Haley M Simpson, Aki Furusawa, Kavitha Sadashivaiah, Curt I Civin, Arnob Banerjee
Peripheral T-cell lymphoma (PTCL) is a rare, aggressive, heterogeneous, Non-Hodgkin's lymphoma with poor prognosis and inadequate response to current therapies. Recent sequencing studies indicate a prevalence of activating mutations in the JAK/STAT signaling pathway. Oncogenic mutations in STAT5B, observed in approximately one third of cases of multiple different PTCL subtypes, correlate with inferior patient outcomes. Therefore, interest in the development of therapeutic strategies for targeting STAT5 in PTCL is warranted...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680270/regulation-of-cancer-cell-signaling-pathways-by-mushrooms-and-their-bioactive-molecules-overview-of-the-journey-from-benchtop-to-clinical-trials
#4
Aliye Aras, Sumbul Khalid, Saima Jabeen, Ammad Ahmad Farooqi, Baojun Xu
Mushrooms represent a tremendous source of biologically useful and pharmacologically active molecules. Recent breakthroughs in cancer genetics, genomics, proteomics and translational research have helped us to develop a better understanding of the underlying mechanisms which are contributory in cancer development and progression. Different signaling pathways particularly, Wnt, SHH, TGF/SMAD and JAK/STAT have been shown to modulate cancer progression and development. Increasingly it is being realized that genetic/epigenetic mutations and loss of apoptosis also mandate a 'multi-molecular' perspective for the development of therapies to treat cancer...
April 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679197/neuropsychological-impacts-of-indirect-revascularization-for-pediatric-moyamoya-disease
#5
WooHyun Kim, Eun-Young Lee, Seong-Eun Park, Eun-Kyung Park, Ju-Seong Kim, Dong-Seok Kim, Kyu-Won Shim
PURPOSE: Moyamoya disease (MMD) commonly leads to neurocognitive impairment. This study was carried out to show that temporal encephaloduroarteriosynangiosis (EDAS) has a positive neuropsychological impact on pediatric MMD patients. METHODS: Fifty-five participants diagnosed with MMD from 2008 to 2014 were included in this retrospective study. The mean age at the preoperative evaluation was 9.5 years and the mean age at postoperative evaluation was 10.4. The average interval of initial and follow-up test was 10 months...
April 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29678784/feasibility-safety-and-efficacy-of-a-novel-pre-shaped-nitinol-esophageal-deviator-to-successfully-deflect-the-esophagus-and-ablate-left-atrium-without-esophageal-temperature-rise-during-atrial-fibrillation-ablation-the-deflect-gut-study
#6
Valay Parikh, Vijay Swarup, Jacob Hantla, Venkat Vuddanda, Tawseef Dar, Bharath Yarlagadda, Luigi Di Biase, Amin Al-Ahmad, Andrea Natale, Dhanunjaya Lakkireddy
BACKGROUND: Esophageal thermal injury is a feared complication of radiofrequency ablation (RFA) for atrial fibrillation (AF). Rise in luminal esophageal temperature (LET) limits the ability to deliver RF energy on posterior wall of LA. OBJECTIVE: The aim of this registry was to evaluate feasibility, safety and efficacy of a mechanical esophageal deviation (ED) tool during AF ablation. METHODS: We evaluated 687 patients who underwent RFA for AF...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29678621/activation-of-the-non-canonical-nf-%C3%AE%C2%BAb-p52-pathway-in-vascular-endothelial-cells-by-rankl-elicits-pro-calcific-signalling-in-co-cultured-smooth-muscle-cells
#7
Emma Harper, Keith D Rochfort, Hannah Forde, Colin Davenport, Diarmuid Smith, Philip M Cummins
BACKGROUND: The intimal endothelium is known to condition the underlying medial smooth muscle cell (SMC) layer of the vessel wall, and is highly responsive to receptor-activator of nuclear factor-κB ligand (RANKL) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), pro-calcific and anti-calcific agents, respectively. In this paper, we tested the hypothesis that RANKL-induced activation of endothelial NF-κB signalling is essential for pro-calcific activation of the underlying SMCs...
April 17, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29677927/hs-register-an-audit-trail-tool-to-respond-to-the-general-data-protection-regulation-gdpr
#8
Duarte Gonçalves-Ferreira, Mariana Leite, Cátia Santos-Pereira, Manuel E Correia, Luis Antunes, Ricardo Cruz-Correia
Introduction The new General Data Protection Regulation (GDPR) compels health care institutions and their software providers to properly document all personal data processing and provide clear evidence that their systems are inline with the GDPR. All applications involved in personal data processing should therefore produce meaningful event logs that can later be used for the effective auditing of complex processes. Aim This paper aims to describe and evaluate HS.Register, a system created to collect and securely manage at scale audit logs and data produced by a large number of systems...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677664/age-induced-changes-in-the-lower-limb-muscle-activities-during-uphill-walking-at-steep-grades
#9
Sonja Th Kwee-Meier, Alexander Mertens, Sabina Jeschke
BACKGROUND: Uphill walking is particularly challenging for elderly persons. However, there is a lack of age-differentiated studies investigating the underlying differences in muscle activation when walking on sloped surfaces. These studies are needed, e.g., for planning of evacuations of large modern cruise ships with long walking distances on often inclined surfaces. METHODS: An age-differentiated, gender-balanced study with 26 young (20-30 years) and 26 elderly people (60-77 years) was therefore conducted, investigating uphill walking at 7° and at 14° contrasted to level walking on a treadmill...
April 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29675945/epigenetically-enhanced-pdt-epdt-induces-significantly-higher-levels-of-multiple-extrinsic-pathway-apoptotic-factors-than-standard-pdt-resulting-in-greater-extrinsic-and-overall-apoptosis-of-ctcl
#10
Katrin A Salva, Youn H Kim, Ziba Rahbar, Gary S Wood
Aminolevulinate-based photodynamic therapy (ALA-PDT) selectively eliminates diseased tissues primarily through the induction of intrinsic apoptotic pathway. ALA-PDT is a first-line therapy for actinic keratosis, however, it is less effective for cutaneous T-cell lymphoma (CTCL). We have previously demonstrated that the resistance of CTCL to apoptosis correlates with decreased expression of death receptors such as FAS, and that methotrexate functions as an epigenetic regulator that re-establishes the susceptibility of CTCL to extrinsic pathway apoptosis...
April 20, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29674187/lower-maternal-serum-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-levels-in-early-preeclampsia-a-retrospective-study
#11
Danila Morano, Alessandro Rolfo, Veronica Tisato, Antonio Farina, Erika Rimondi, Gennaro Scutiero, Pantaleo Greco, Gloria Bonaccorsi, Tullia Todros
OBJECTIVE: To determine whether maternal serum concentrations of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a cytokine with anti-inflammatory activity, also involved in cardiovascular morbidity, differ between women with early preeclampsia (<34 weeks) and those with uncomplicated pregnancies. STUDY DESIGN: This nested case control study included 40 women carrying a single fetus with an uncomplicated pregnancy and 20 women with early preeclampsia (<34 weeks)...
February 7, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29672672/mri-and-neuropsychological-correlates-in-african-americans-with-hypertension-and-left-ventricular-hypertrophy
#12
B Waldron-Perrine, J E Kisser, A Brody, E M Haacke, R Dawood, S Millis, P Levy
Background: African Americans (AA) are at high risk for hypertension (HTN) and poor blood pressure (BP) control. Persistently elevated BP contributes to cardiovascular morbidity. White matter hyperintensities (WMH) are a definable magnetic resonance imaging (MRI) marker of cerebrovascular injury linked to impairments in higher level thinking (i.e., executive functions), memory formation and speed of perceptual-motor processing. Methods: This sub-investigation evaluated neuropsychological functioning in association with WMH on brain MRIs in 23 otherwise healthy hypertensive AAs participating in an NIH-funded study of the effects of Vitamin D on BP and cardiac remodeling in AA patients 30-74 years of age with HTN and left ventricular hypertrophy...
April 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29670837/assessing-the-effect-of-high-performance-inulin-supplementation-via-klf5-mrna-expression-in-adults-with-type-2-diabetes-a-randomized-placebo-controlled-clinical-trail
#13
Abed Ghavami, Neda Roshanravan, Shahriar Alipour, Meisam Barati, Behzad Mansoori, Faezeh Ghalichi, Elyas Nattagh-Eshtivan, Alireza Ostadrahimi
Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670480/the-association-between-male-circumcision-and-condom-use-behavior-a-meta-analysis
#14
Steven Ndugwa Kabwama, Derrick Ssewanyana, Gabriele Berg-Beckhoff
Introduction: The protective benefit of male circumcision against spreading HIV is well established. Aim: The objective of this Meta-analysis was to investigate behavioral risk compensation measured as the change in condom use behavior in light of knowledge of the benefits of circumcision. Material and Methods: A systematic search was conducted from 6 bibliographic databases for studies that quantitatively assessed a link between male circumcision and condom use behavior...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29670467/trail-dependent-resolution-of-pulmonary-fibrosis
#15
David M Habiel, Ana Paula Moreira, Ugur B Ismailoglu, Michael P Dunleavy, Karen A Cavassani, Nico van Rooijen, Ana Lucia Coelho, Cory M Hogaboam
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling. In the present study, the expression of tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) was key to the resolution of bleomycin-induced pulmonary fibrosis. Both in vivo and in vitro studies demonstrated that Gr-1+ TRAIL+ bone marrow-derived myeloid cells blocked the activation of lung myofibroblasts...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29670075/the-novel-trail-receptor-agonist-apg350-exerts-superior-therapeutic-activity-in-pancreatic-cancer-cells
#16
Karen Legler, Charlotte Hauser, Jan-Hendrik Egberts, Anna Willms, Carola Heneweer, Susann Boretius, Christoph Röcken, Claus-Christian Glüer, Thomas Becker, Michael Kluge, Oliver Hill, Christian Gieffers, Harald Fricke, Holger Kalthoff, Johannes Lemke, Anna Trauzold
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has raised attention as a novel anticancer therapeutic as it induces apoptosis preferentially in tumor cells. However, first-generation TRAIL-receptor agonists (TRAs), comprising recombinant TRAIL and agonistic receptor-specific antibodies, have not demonstrated anticancer activity in clinical studies. In fact, cancer cells are often resistant to conventional TRAs. Therefore, in addition to TRAIL-sensitizing strategies, next-generation TRAs with superior apoptotic activity are warranted...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29666515/effect-of-fiber-sources-on-fatty-acids-profile-glycemic-index-and-phenolic-compound-content-of-in-vitro-digested-fortified-wheat-bread
#17
Marcin Andrzej Kurek, Jarosław Wyrwisz, Sabina Karp, Agnieszka Wierzbicka
In this study, some dietary fiber (DF) sources were investigated as fortifiers of wheat bread: oat (OB), flax (FB), and apple (AB). Adding oat and flax fibers to bread significantly changed the fatty acid profiles. OB was highest in oleic acid (33.83% of lipids) and linoleic acid (24.31% of lipids). Only in FB, γ-linolenic fatty acid was present in a significant amount-18.32%. The bioaccessibility trails revealed that the DF slow down the intake of saturated fatty acids. PUFA were least bioaccessible from all fatty acids groups in the range of (72% in OB to 87% in FB)...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29665655/mir-760-enhances-trail-sensitivity-in-non-small-cell-lung-cancer-via-targeting-the-protein-foxa1
#18
Xiang Zhang, Lei Wang, Yu Liu, Weicong Huang, Dezhi Cheng
Non-small cell lung cancer (NSCLC) is one of the leading cause of death worldwide. TNF-related apoptosis-inducing ligand (TRAIL) is a promising anti-tumor agent with the ability to kill tumor cells while spare normal ones. MicroRNAs (miRNAs) are small, non-coding RNAs that play vital roles in carcinogenesis. Although miR-760 has been reported to be dysregulated in a variety of cancers, the role of miR-760 in NSCLC is not fully understood, and the relationship between miR-760 dysregulation and TRAIL sensitivity is still elusive...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665614/vo2max-testing-in-trail-runners-is-there-a-specific-exercise-test-protocol
#19
Volker Scheer, Katharina Ramme, Claus Reinsberger, Hans-Christian Heitkamp
Trail running places specific physiological demands on the human body due to its uphill and downhill running sections. We developed and investigated a more sport-specific trail exercise test protocol (inclination and speed incremental protocol), and compared it to two standard exercise test protocols (horizontal step and ramp protocol) in thirteen highly trained trail runners (age 31±6 years, height 179±6.4 cm, weight 69.2±7.9 kg, BMI 21.6±2.1 kg/m2 ). The maximum oxygen uptake (VO2 max) measured during the trail test (62...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29665124/how-does-dementia-with-lewy-bodies-start-prodromal-cognitive-changes-in-rem-sleep-behavior-disorder
#20
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
Objective We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. Methods Patients (n=109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a three-year prodromal period, and performed linear regressions for a six-year prodromal period...
April 17, 2018: Annals of Neurology
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