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https://www.readbyqxmd.com/read/28212536/targeting-the-stress-oncoprotein-ledgf-p75-to-sensitize-chemoresistant-prostate-cancer-cells-to-taxanes
#1
Leslimar Ríos-Colón, Christina K Cajigas-Du Ross, Anamika Basu, Catherine Elix, Ivana Alicea-Polanco, Tino W Sanchez, Vinodh Radhakrishnan, Chien-Shing Chen, Carlos A Casiano
Prostate cancer (PCa) is associated with chronic prostate inflammation resulting in activation of stress and pro-survival pathways that contribute to disease progression and chemoresistance. The stress oncoprotein lens epithelium-derived growth factor p75 (LEDGF/p75), also known as DFS70 autoantigen, promotes cellular survival against environmental stressors, including oxidative stress, radiation, and cytotoxic drugs. Furthermore, LEDGF/p75 overexpression in PCa and other cancers has been associated with features of tumor aggressiveness, including resistance to cell death and chemotherapy...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209994/reversal-of-the-apoptotic-resistance-of-non-small-cell-lung-carcinoma-towards-trail-by-natural-product-toosendanin
#2
Xin Li, Ming You, Yong-Jian Liu, Lin Ma, Pei-Pei Jin, Ri Zhou, Zhao-Xin Zhang, Baojin Hua, Xiao-Jun Ji, Xiao-Ying Cheng, Fangzhou Yin, Yan Chen, Wu Yin
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively triggers cancer cell death via its association with death receptors on the cell membrane, but exerts negligible side effects on normal cells. However, some non-small-cell lung carcinoma (NSCLC) patients exhibited resistance to TRAIL treatment in clinical trials, and the mechanism varies. In this study, we described for the first time that toosendanin (TSN), a triterpenoid derivative used in Chinese medicine for pain management, could significantly sensitize human primary NSCLC cells or NSCLC cell lines to TRAIL-mediated apoptosis both in vitro and in vivo, while showing low toxicity against human primary cells or tissues...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208423/modeling-angiogenesis-a-discrete-to-continuum-description
#3
Samara Pillay, Helen M Byrne, Philip K Maini
Angiogenesis is the process by which new blood vessels develop from existing vasculature. During angiogenesis, endothelial tip cells migrate via diffusion and chemotaxis, loops form via tip-to-tip and tip-to-sprout anastomosis, new tip cells are produced via branching, and a vessel network forms as endothelial cells follow the paths of tip cells. The latter process is known as the snail trail. We use a mean-field approximation to systematically derive a continuum model from a two-dimensional lattice-based cellular automaton model of angiogenesis in the corneal assay, based on the snail-trail process...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208109/stability-against-backward-balance-loss-age-related-modifications-following-slip-like-perturbations-of-multiple-amplitudes
#4
Dario Martelli, Federica Aprigliano, Peppino Tropea, Guido Pasquini, Silvestro Micera, Vito Monaco
Falls are one of the most serious problems in the elderly. Although previous studies clearly link the increased risk of falls with ageing, the mechanisms responsible for the modifications of reactive motor behaviours in response to external perturbations are not yet fully understood. This study investigated how the stability against backward balance loss is affected by aging and intensity of perturbations. The Margin of Stability (MoS) was estimated while eight young and eight elderly adults managed three slip-like perturbations of different intensities while walking at the same normalized speed...
February 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28207976/does-increased-physical-activity-in-school-affect-children-s-executive-function-and-aerobic-fitness
#5
Silje Eikanger Kvalø, Edvin Bru, Kolbjørn Brønnick, Sindre M Dyrstad
This study seeks to explore if increased PA in school affects children's executive function and aerobic fitness. The "Active school" study was a 10-month randomized controlled trial. The sample included 449 children (10-11 years old) in five intervention and four control schools. The weekly interventions were 2x45 min physically active academic lessons, 5x10 min physically active breaks and 5x10 min physically active homework. Aerobic fitness was measured using a 10-min interval running test. Executive function was tested using four cognitive tests (Stroop, verbal fluency, digit span and Trail Making)...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28202653/argentine-ants-linepithema-humile-use-adaptable-transportation-networks-to-track-changes-in-resource-quality
#6
Tanya Latty, Michael J Holmes, James C Makinson, Madeleine Beekman
Transportation networks play a crucial role in human and animal societies. For a transportation network to be efficient, it must have adequate capacity to meet traffic demand. Network design becomes increasingly difficult in situations where traffic demand can change unexpectedly. In humans, network design is often constrained by path dependency because it is difficult to move a road once it is built. A similar issue theoretically faces pheromone-trail-laying social insects; once a trail has been laid, positive feedback makes re-routing difficult because new trails cannot compete with continually reinforced pre-existing trails...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28202521/ex-vivo-explant-cultures-of-non-small-cell-lung-carcinoma-enable-evaluation-of-primary-tumor-responses-to-anticancer-therapy
#7
Ellie Karekla, Wen-Jing Liao, Barry Sharp, John Pugh, Helen Reid, John Pc Le Quesne, David Moore, Catrin A Pritchard, Marion MacFarlane, J Howard Pringle
To improve treatment outcomes in non-small cell lung cancer (NSCLC), preclinical models that can better predict individual patient response to novel therapies are urgently needed. Using freshly resected tumor tissue, we describe an optimized ex vivo explant culture model that enables concurrent evaluation of NSCLC response to therapy while maintaining the tumor microenvironment. We found that ~70% of primary NSCLC specimens were amenable to explant culture with tissue integrity intact for up to 72 hours after explant...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28202415/glutamine-deprivation-sensitizes-human-breast-cancer-mda-mb-231-cells-to-trial-mediated-apoptosis
#8
Matharage Gayani Dilshara, Jin-Woo Jeong, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Ilandarage Menu Neelaka Molagoda, Seungheon Lee, Sang Rul Park, Yung Hyun Choi, Gi-Young Kim
Tumor cell metabolism is a promising target for various cancer treatments. Apart from aerobic glycolysis, cancer cell growth is dependent on glutamine (Gln) supply, leading to their survival and differentiation. Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). Gln deprivation decreased cell proliferation as expected, but did not induce remarkable cell death. TRAIL/Gln deprivation, however, significantly increased growth inhibition and morphological shrinkage of MDA-MB-231 cells compared to those induced by treatment with either Gln deprivation or TRAIL alone...
February 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28199994/association-between-montreal-cognitive-assessment-sub-item-scores-and-corresponding-cognitive-test-performance-in-patients-with-frontotemporal-dementia-and-related-disorders
#9
Kristy K L Coleman, Brenda L Coleman, Julia D MacKinley, Stephen H Pasternak, Elizabeth C Finger
The Montreal Cognitive Assessment (MoCA), a brief screening test developed to detect patients with mild cognitive impairment, is used in clinical settings across North America [Nasreddine et al.: J Am Geriatr Soc 2005;53:695-699]. The MoCA has been demonstrated to be sensitive to cognitive deficits in frontotemporal dementias (FTD) and related disorders [Coleman et al.: Alzheimer Dis Assoc Disord 2016;30:258-263]. Given attentional impairments in patients with FTD, whether and to what extent the abbreviated items on the MoCA may predict performance on corresponding assessments is not known...
February 16, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28197810/a-wrist-sensor-and-algorithm-to-determine-instantaneous-walking-cadence-and-speed-in-daily-life-walking
#10
Benedikt Fasel, Cyntia Duc, Farzin Dadashi, Flavien Bardyn, Martin Savary, Pierre-André Farine, Kamiar Aminian
In daily life, a person's gait-an important marker for his/her health status-is usually assessed using inertial sensors fixed to lower limbs or trunk. Such sensor locations are not well suited for continuous and long duration measurements. A better location would be the wrist but with the drawback of the presence of perturbative movements independent of walking. The aim of this study was to devise and validate an algorithm able to accurately estimate walking cadence and speed for daily life walking in various environments based on acceleration measured at the wrist...
February 14, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28197384/oncolytic-measles-virus-induces-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-mediated-cytotoxicity-by-human-myeloid-and-plasmacytoid-dendritic-cells
#11
Carole Achard, Jean-Baptiste Guillerme, Daniela Bruni, Nicolas Boisgerault, Chantal Combredet, Frédéric Tangy, Nolwenn Jouvenet, Marc Grégoire, Jean-François Fonteneau
Attenuated measles virus (MV) is currently being evaluated in clinical trials as an oncolytic therapeutic agent. Originally used for its lytic activity against tumor cells, it is now admitted that the effectiveness of MV also lies in its ability to initiate antitumor immune responses through the activation of dendritic cells (DCs). In this study, we investigated the capacity of oncolytic MV to convert human blood myeloid CD1c(+) DCs and plasmacytoid DCs (pDCs) into cytotoxic effectors. We found that MV induces the expression of the cytotoxic protein TNF-related apoptosis-inducing ligand (TRAIL) on the surface of DCs...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28197361/nkp30-isoforms-and-nkp30-ligands-are-predictive-biomarkers-of-response-to-imatinib-mesylate-in-metastatic-gist-patients
#12
Sylvie Rusakiewicz, Aurélie Perier, Michaela Semeraro, Jonathan M Pitt, Elke Pogge von Strandmann, Katrin S Reiners, Sandrine Aspeslagh, Christelle Pipéroglou, Frédéric Vély, Alexandre Ivagnes, Sarah Jegou, Niels Halama, Loic Chaigneau, Pierre Validire, Christos Christidis, Thierry Perniceni, Bruno Landi, Anne Berger, Nicolas Isambert, Julien Domont, Sylvie Bonvalot, Philippe Terrier, Julien Adam, Jean-Michel Coindre, Jean-François Emile, Vichnou Poirier-Colame, Kariman Chaba, Benedita Rocha, Anne Caignard, Antoine Toubert, David Enot, Joachim Koch, Aurélien Marabelle, Marion Lambert, Sophie Caillat-Zucman, Serge Leyvraz, Christian Auclair, Eric Vivier, Alexander Eggermont, Christophe Borg, Jean-Yves Blay, Axel Le Cesne, Olivier Mir, Laurence Zitvogel
Despite effective targeted therapy acting on KIT and PDGFRA tyrosine kinases, gastrointestinal stromal tumors (GIST) escape treatment by acquiring mutations conveying resistance to imatinib mesylate (IM). Following the identification of NKp30-based immunosurveillance of GIST and the off-target effects of IM on NK cell functions, we investigated the predictive value of NKp30 isoforms and NKp30 soluble ligands in blood for the clinical response to IM. The relative expression and the proportions of NKp30 isoforms markedly impacted both event-free and overall survival, in two independent cohorts of metastatic GIST...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28197189/does-a-combined-intervention-program-of-repetitive-transcranial-magnetic-stimulation-and-intensive-occupational-therapy-affect-cognitive-function-in-patients-with-post-stroke-upper-limb-hemiparesis
#13
Takatoshi Hara, Masahiro Abo, Kiyohito Kakita, Takeshi Masuda, Ryunosuke Yamazaki
Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) to the contralesional hemisphere and intensive occupational therapy (iOT) have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-rTMS and iOT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient's Trail-Making Test part B (TMT-B) performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28197005/p300-and-neuropsychological-measurements-in-patients-with-schizophrenia-and-their-healthy-biological-siblings
#14
D Vijaya Raghavan, Arumugam Shanmugiah, P Bharathi, Ramasamy Jeyaprakash
BACKGROUND: Patients with schizophrenia and their first-degree relatives' exhibit abnormalities in neuropsychological and electrophysiological measures especially P300. The aim was to study the P300 and neuropsychological measures together in patients with schizophrenia, their unaffected siblings, and normal controls. MATERIALS AND METHODS: Thirty patients diagnosed as schizophrenia, their unaffected biological siblings, and normal controls were included in the study...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28196435/dynamic-assessment-of-the-wrist-after-total-wrist-arthroplasty
#15
H P Singh, D Bhattacharjee, J J Dias, I Trail
Our aim was to assess the outcome in patients with total wrist arthroplasty performed for end stage wrist osteoarthritis. We analysed the ranges of motion of operated and un-operated wrists using a flexible electrogoniometer during the Sollerman hand function test. We assessed grip strength with a digital dynamometer and completed patient reported outcome scores more than one year post-operatively. We reviewed 12 patients with a mean age of 64 (range 48-82) years. The flexion-extension arc was 72% and radioulnar deviation arc was 53% of the un-operated side but the total range of motion (area of circumduction) was 43% of the un-operated side and only 20% of the circumduction in age and gender-matched normal volunteers...
February 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28195953/cross-validation-of-a-classification-system-for-persons-with-traumatic-brain-injury-in-the-posthospital-period
#16
Mark Sherer, Jennie Ponsford, Amelia Hicks, Luis Leon-Novelo, Esther Ngan, Angelle M Sander
OBJECTIVE: To (1) identify groupings of persons with traumatic brain injury (TBI) in the posthospital period in a cohort recruited in Australia; (2) compare groupings from the Australian cohort to groupings previously developed for a US cohort. SETTING: Rehabilitation centers in the US and Australia. PARTICIPANTS: A total of 170 persons with TBI from Australia and 504 persons with TBI from the United States. Participants were aged 18 to 64 years, greater than 6 months postinjury, had capacity to give consent, and had definitive contemporaneous medical evidence of TBI...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28193864/ontogeny-of-collective-behavior-reveals-a-simple-attraction-rule
#17
Robert C Hinz, Gonzalo G de Polavieja
The striking patterns of collective animal behavior, including ant trails, bird flocks, and fish schools, can result from local interactions among animals without centralized control. Several of these rules of interaction have been proposed, but it has proven difficult to discriminate which ones are implemented in nature. As a method to better discriminate among interaction rules, we propose to follow the slow birth of a rule of interaction during animal development. Specifically, we followed the development of zebrafish, Danio rerio, and found that larvae turn toward each other from 7 days postfertilization and increase the intensity of interactions until 3 weeks...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193281/municipal-investment-in-off-road-trails-and-changes-in-bicycle-commuting-in-minneapolis-minnesota-over-10%C3%A2-years-a-longitudinal-repeated-cross-sectional-study
#18
Jana A Hirsch, Katie A Meyer, Marc Peterson, Le Zhang, Daniel A Rodriguez, Penny Gordon-Larsen
BACKGROUND: We studied the effect of key development and expansion of an off-road multipurpose trail system in Minneapolis, Minnesota between 2000 and 2007 to understand whether infrastructure investments are associated with increases in commuting by bicycle. METHODS: We used repeated measures regression on tract-level (N = 116 tracts) data to examine changes in bicycle commuting between 2000 and 2008-2012. We investigated: 1) trail proximity measured as distance from the trail system and 2) trail potential use measured as the proportion of commuting trips to destinations that might traverse the trail system...
February 13, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28191816/interferon-%C3%AE-inducible-dendritic-cells-matured-with-ok-432-exhibit-trail-and-fas-ligand-pathway-mediated-killer-activity
#19
Terutsugu Koya, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Shigetaka Shimodaira
Active human dendritic cells (DCs), which efficiently induce immune responses through their functions as antigen-presenting cells, exhibit direct anti-tumour killing activity in response to some pathogens and cytokines. These antigen-presenting and tumour killing abilities may provide a breakthrough in cancer immunotherapy. However, the mechanisms underlying this killer DC activity have not been fully proven, despite the establishment of interferon-α (IFN-α)-generated killer DCs (IFN-DCs). Here mature IFN-DCs (mIFN-DCs), generated from IFN-DCs primed with OK-432 (streptococcal preparation), exhibited elevated expression of CD86 and human leukocyte antigen-DR (minimum criteria for DC vaccine clinical trials) as well as antigen-presenting abilities comparable with those of mature IL-4-DCs (mIL-4-DCs)...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188962/impact-of-poor-sleep-quality-and-physical-inactivity-on-cognitive-function-in-community-dwelling-older-adults
#20
Sho Nakakubo, Hyuma Makizako, Takehiko Doi, Kota Tsutsumimoto, Sangyoon Lee, Sungchul Lee, Ryo Hotta, Seongryu Bae, Takao Suzuki, Hiroyuki Shimada
AIM: The purpose of the present study was to examine whether the combination of subjective sleep quality and physical activity is associated with cognitive performance among community-dwelling older adults. METHODS: Cross-sectional data on 5381 older adults who participated in part of the National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes were analyzed. We assessed general cognitive impairment using the Mini-Mental State Examination, and also assessed story memory, attention, executive function and processing speed using the National Center for Geriatrics and Gerontology Functional Assessment Tool...
February 11, 2017: Geriatrics & Gerontology International
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