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https://www.readbyqxmd.com/read/29231784/feet-kinematics-upon-slipping-discriminate-between-recoveries-and-three-types-of-slip-induced-falls
#1
Leigh J Allin, Maury A Nussbaum, Michael L Madigan
This study investigated the relationship between feet kinematics upon slipping while walking and the outcome of the slip. Seventy-one slips (induced by walking over an unexpectedly slippery surface) were analysed, which included 37 recoveries, 16 feet-split falls, 11 feet-forward falls, and seven lateral falls. Feet kinematics differed between these four slip outcomes, and a discriminant model including six measures of feet kinematics correctly predicted 87% of slip outcomes. Two potentially modifiable characteristics of the feet kinematics upon slipping that can improve the likelihood of successfully averting a fall were identified: (1) quickly arresting the motion of the slipping foot; and (2) a recovery step that places the trailing toe approximately 0-10% body height anterior to the sacrum...
December 12, 2017: Ergonomics
https://www.readbyqxmd.com/read/29231584/-electrothermal-acupuncture-in-the-prevention-and-treatment-of-chemotherapy-induced-nausea-and-vomiting-a-randomized-controlled-trial
#2
Dianrong Lu, Dianxiang Lu, Dapeng Bai, Shengqi He, Fang Wang, Yin Gao, Yanlin Du, Ningjun Wang, Zhenglong Jiang, Zemin Wang, Shijie Zhu
OBJECTIVE: To observe the effectiveness and safety of electrothermal acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in the cancerous patients of phlegm-stasis interaction in cisplatin-containing chemotherapy. METHODS: Sixty cases of phlegm-stasis interaction in cisplatin-containing chemotherapy were randomized into a trial group and a control group, 30 cases in each one. In the control group, the intravenous drip of granisetron hydrochloride injection was adopted, 3 mg before and after cisplatin-containing chemotherapy 30 min, continuously for 3 days...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231538/-establishing-the-acupuncture-moxibustion-clinical-trial-registry-and-improving-the-transparence-of-clinical-trials-of-acupuncture-and-moxibustion
#3
Yali Liu, Liyun He, Jia Liu, Xingyue Yang, Dongning Yan, Xin Wang, Lin Luo, Hongjiao Li, Shiyan Yan, Tiancai Wen, Wenjing Bai, Taixiang Wu, Baoyan Liu
As a kind of intervention measures of traditional Chinese medicine, acupuncture-moxibustion is highly adopted on global clinical practice. Even though the global clinical trial registration system was established more than 10 years ago, the proportion of acupuncture-moxibustion clinical trial registration is still very low; and it is very problematic on the methodological quality and report quality in the published acupuncture-moxibustion clinical trials. In order to manage particularly the acupuncture-moxibustion clinical trials, China Academy of Chinese Medical Sciences, collaborated with China Association of Acupuncture and Moxibustion and World Federation of Acupuncture Societies, established the Acupuncture-Moxibustion Clinical Trail Registry (AMCTR)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228637/sorafenib-improves-lipiodol-deposition-in-transarterial-chemoembolization-of-chinese-patients-with-hepatocellular-carcinoma-a-long-term-retrospective-study
#4
Lin Zheng, Chen-Yang Guo, Cheng-Shi Chen, Jin-Cheng Xiao, Hong-Tao Hu, Hong-Tao Cheng, Deng-Wei Zong, Li Jiang, Hai-Liang Li
Objective: Though synergy of sorafenib and transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) is well discussed in previous reports, association of lipiodol retention by sorafenib addition to TACE with the survival outcomes remain elusive. Therefore, we studied the impact of sorafenib addition to TACE on survival outcomes mediated by lipiodol retention. Materials and Methods: This is a long-term, retrospective, single-center study using medical records of patients diagnosed with HCC at the Department of Interventional Radiology of Zhengzhou University Affiliated Cancer Hospital (China) between April 2004 and March 2012...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228204/decreased-resting-state-interhemispheric-functional-connectivity-correlated-with-neurocognitive-deficits-in-drug-naive-first-episode-adolescent-onset-schizophrenia
#5
Yi Liu, Yan Zhang, Luxian Lv, Feihu Hu, Renrong Wu, Jingping Zhao, Wenbin Guo
Background: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia (AOS), particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previous resting-state functional magnetic resonance imaging (fMRI) studies have shown abnormal functional connectivity in separate hemispheres in patients with adult-onset schizophrenia. Our aim to study AOS can provide clues for the early aetiology of schizophrenia...
November 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29227498/elastic-particle-deformation-in-rectangular-channel-flow-as-a-measure-of-particle-stiffness
#6
Margaret Y Hwang, Seo Gyun Kim, Heon Sang Lee, Susan J Muller
In this study, we experimentally observed and characterized soft elastic particle deformation in confined flow in a microchannel with a rectangular cross-section. Hydrogel microparticles of pNIPAM were produced using two different concentrations of crosslinker. This resulted in particles with two different shear moduli of 13.3 ± 5.5 Pa and 32.5 ± 15.7 Pa and compressive moduli of 66 ± 10 Pa and 79 ± 15 Pa, respectively, as measured by capillary micromechanics. Under flow, the particle shapes transitioned from circular to egg, triangular, arrowhead, and ultimately parachute shaped with increasing shear rate...
December 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/29225439/exploring-the-obesity-paradox-as-a-correlate-of-cognitive-and-physical-function-in-community-dwelling-black-and-white-older-adults
#7
Jeannine S Skinner, Willie Mae Abel, Katryna McCoy, Consuelo H Wilkins
Objective: The obesity paradox has been documented in aged populations, yet it remains unclear if this paradox persists for physical and cognitive outcomes in community-dwelling older adult populations. Our study examines associations between body mass index (BMI) classification, cognitive function, and physical function. We also investigate whether these associations are modified by race or age. Design: Cross-sectional study. Setting: Senior residential sites and community centers in Saint Louis, Missouri...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29219008/powered-off-road-wheelchair-for-the-transportation-of-tetraplegics-along-mountain-trails
#8
Michele Gabrio Antonelli, Stefano Alleva, Pierluigi Beomonte Zobel, Francesco Durante, Terenziano Raparelli
PURPOSE: For off-road mobility, some manual or power assisted devices were conceived to be self-driven by paraplegics while for tetraplegics non power-assisted devices were conceived. These devices require one or more conductors who are subjected to a high physical demand thus potentially creating: precarious safety condition for the user an elevated physical demand of conductors could reduce the care and the attention to give to the user; the time of the outdoor adventure experience of the user could be limited...
December 8, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29218684/feasibility-of-arthroscopic-autologous-chondrocyte-implantation-in-the-hip-using-an-injectable-hydrogel
#9
Steffen Thier, Florian Baumann, Christel Weiss, Stefan Fickert
INTRODUCTION: In the long term the treatment of articular cartilage defects of the hip has the most direct impact on the postoperative outcome and should diminish degenerative changes caused by different pathologies. The purpose of this prospective feasibility study is to describe technical aspects of arthroscopic, injectable autologous chondrocyte implantation in the hip and to report the short-term outcome. METHODS: Full-thickness cartilage defects of 13 patients were treated arthroscopically with an injectable autologous chondrocyte transplantation product (Novocart Inject, Tetec) in a 2-step surgical procedure...
December 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29218574/tracking-long-distance-atmospheric-deposition-of-trace-metal-emissions-from-smelters-in-the-upper-columbia-river-valley-using-pb-isotope-analysis-of-lake-sediments
#10
Andrew Wright Child, Barry C Moore, Jeffrey D Vervoort, Marc W Beutel
Heavy metal discharge from mining and smelting operations into aquatic ecosystems can cause long-term biological and ecological impacts. The upper Columbia River is highly contaminated with heavy metal wastes from nearby smelting operations in Trail, British Columbia, Canada, and to a lesser extent, Northport (Le Roi smelter), Washington, USA. Airborne emissions from the Trail operations were historically and are currently transported by prevailing winds down the Columbia River canyon, where particulate metals can be deposited into lakes and watersheds...
December 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29218092/hsp90-inhibitor-sensitizes-trail-mediated-apoptosis-via-chop-dependent-dr5-upregulation-in-colon-cancer-cells
#11
Zhicheng Yao, Ang Chen, Xin Li, Zhiyong Zhu, Xin Jiang
Heat shock protein 90 (Hsp90), a molecular chaperone, is involved in a variety of physiological and pathological processes. Targeting Hsp90 by small molecules has been developed as an attractive strategy of anticancer therapy. In this study, we investigated the mechanism of Hsp90 inhibitor suppresses CRC growth and potentiates effects of other chemotherapeutic drugs. We found that Hsp90 inhibitor induces chop-dependent DR5 upregulation regardless of p53 status. Furthermore, DR5 is required for Hsp90 inhibitor-induced apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29216597/role-of-dopamine-receptors-in-the-anticancer-activity-of-onc201
#12
Christina Leah B Kline, Marie B Ralff, Amriti R Lulla, Jessica M Wagner, Phillip H Abbosh, David T Dicker, Joshua E Allen, Wafik S El-Deiry
ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early activation of the integrated stress response. Its promising safety profile and broad-spectrum efficacy in vitro have been confirmed in Phase I/II trials in several advanced malignancies. Binding and reporter assays have shown that ONC201 is a selective antagonist of the dopamine D2-like receptors, specifically, DRD2 and DRD3. We hypothesized that ONC201's interaction with DRD2 plays a role in ONC201's anticancer effects. Using cBioportal and quantitative reverse-transcription polymerase chain reaction analyses, we confirmed that DRD2 is expressed in different cancer cell types in a cell type-specific manner...
December 4, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29215900/apoe-e4-genotype-and-lifestyle-interaction-on-cognitive-performance-results-of-the-life-adult-study
#13
Francisca S Rodriguez, Matthias L Schroeter, Katrin Arélin, A Veronica Witte, Ronny Baber, Ralph Burkhardt, Christoph Engel, Markus Löffler, Joachim Thiery, Arno Villringer, Tobias Luck, Steffi G Riedel-Heller
OBJECTIVE: Previous studies have shown that the e4-allele of the APOE gene is associated with a higher risk of developing dementia. Our study investigated whether well-known associations between lifestyle factors and cognitive functioning may be stronger in individuals who carry the dementia risk variant of the APOE gene and whether this association is amplified with older age. METHOD: Data analysis comprised 7,526 participants (aged 40- to 79-years-old) from the population-based LIFE-Adult-study...
December 7, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29213506/symptoms-of-depression-in-patients-with-mild-cognitive-impairment-in-parkinson-s-disease
#14
Ana Lara Soares Blum Malak, Luiz Felipe Vasconcellos, João Santos Pereira, Denise Vieira Greca, Manuela Cruz, Heloisa Veiga Dias Alves, Mariana Sptiz, Helenice Charchat-Fichman
Objective: To investigate the most frequent depressive symptoms and their association with cognition in Parkinson's disease (PD) patients with mild cognitive impairment (MCI). Methods: 48 patients with PD and 44 controls (CG), aged between 50 and 80 years and with at least 4 years of formal education, all with MCI and none diagnosed with depression, were assessed. Patients and controls were matched for age, education, and Mini-Mental State Examination (MMSE) score...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29212196/juglanin-inhibits-lung-cancer-by-regulation-of-apoptosis-ros-and-autophagy-induction
#15
Liang Chen, Ya-Qiong Xiong, Jing Xu, Ji-Peng Wang, Zi-Li Meng, Yong-Qing Hong
Juglanin (Jug) is obtained from the crude extract of Polygonum aviculare, exerting suppressive activity against cancer cell progression in vitro and in vivo. Juglanin administration causes apoptosis and reactive oxygen species (ROS) in different types of cells through regulating various signaling pathways. In our study, the effects of juglanin on non-small cell lung cancer were investigated. A significant role of juglanin in suppressing lung cancer growth was observed. Juglanin promoted apoptosis in lung cancer cells through increasing Caspase-3 and poly ADP-ribose polymerase (PARP) cleavage, which is regulated by TNF-related apoptosis-inducing ligand/Death receptors (TRAIL/DRs) relied on p53 activation...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212182/oncogenic-p95her2-611ctf-primes-human-breast-epithelial-cells-for-metabolic-stress-induced-down-regulation-of-flip-and-activation-of-trail-r-caspase-8-dependent-apoptosis
#16
Rosa Martín-Pérez, Rosario Yerbes, Rocío Mora-Molina, Ana Cano-González, Joaquín Arribas, Massimiliano Mazzone, Abelardo López-Rivas, Carmen Palacios
Oncogenic transformation triggers reprogramming of cell metabolism, as part of the tumorigenic process. However, metabolic reprogramming may also increase the sensitivity of transformed cells to microenvironmental stress, at the early stages of tumor development. Herein, we show that transformation of human breast epithelial cells by the p95HER2/611CTF oncogene markedly sensitizes these cells to metabolic stress induced by the simultaneous inhibition of glucose and glutamine metabolism. In p95HER2/611CTF-transformed cells, metabolic stress activates a TNF related apoptosis-inducing ligand (TRAIL)-R and caspase-8-dependent apoptotic process that requires prior down-regulation of cellular FLICE-like inhibitor protein (c-FLIP) levels...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211397/efficacy-of-targeted-therapy-for-advanced-renal-cell-carcinoma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Chao Wei, Shen Wang, Zhangqun Ye, Zhiqiang Chen
We conducted a systematic review and meta-analysis of the literature on the efficacy of the targeted therapies in the treatment of advanced RCC and, via an indirect comparison, to provide an optimal treatment among these agents. A systematic search of Medline, Scopus, Cochrane Library and Clinical Trials unpublished was performed up to Jan 1, 2015 to identify eligible randomized trials. Outcomes of interest assessing a targeted agent included progression free survival (PFS), overall survival (OS) and objective response rate (ORR)...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29209876/mentalization-deficit-in-bipolar-patients-during-an-acute-depressive-and-manic-episode-association-with-cognitive-functions
#18
Anna Bodnar, Janusz K Rybakowski
BACKGROUND: A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective mentalization in well-defined groups of depressed and manic bipolar patients, compared to healthy control subjects, using a battery of tests measuring mentalization processes. The second aim was to investigate a possible relationship between cognitive and affective mentalization and cognitive functions in bipolar patients during a depressive and manic episode...
December 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29209781/age-dependent-cognitive-dysfunction-in-untreated-hereditary-transthyretin-amyloidosis
#19
Ana Martins da Silva, Sara Cavaco, Joana Fernandes, Raquel Samões, Cristina Alves, Márcio Cardoso, Jeffery W Kelly, Cecília Monteiro, Teresa Coelho
Central nervous system (CNS) involvement in hereditary transthyretin (TTR) amyloidosis has been described in patients whose disease course was modified by liver transplant. However, cognitive dysfunction has yet to be investigated in those patients. Moreover, CNS involvement in untreated patients or asymptomatic mutation carriers remains to be studied. A series of 340 carriers of the TTRVal30Met mutation (180 symptomatic and 160 asymptomatic) underwent a neuropsychological assessment, which included the Dementia Rating Scale-2 (DRS-2), auditory verbal learning test, semantic fluency, phonemic fluency, and trail making test...
December 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29207641/a-small-molecule-e-2-methoxy-4-3-4-methoxyphenyl-prop-1-en-1-yl-phenol-suppresses-tumor-growth-via-inhibition-of-ikappab-kinase-%C3%AE-in-colorectal-cancer-in-vivo-and-in-vitro
#20
Jie Zheng, Mi Hee Park, Hee Pom Lee, Byung Kook Hyun, Hyung Ok Chun, Sung Hee Jung, Hyun Ok Seo, Young Wan Ham, Sang-Bae Han, Jin Tae Hong
Here we report that a novel synthesized compound (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol (MMPP) which exhibits better stability, drug-likeness and anti-cancer effect than (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB) that we previously reported. Of all newly synthesized BHPB analogues, MMPP showed the most significant inhibitory effect on colon cancer cell growth. Thus, we evaluated the anti-cancer effects and possible mechanisms of MMPP in vitro and in vivo. MMPP treatment (0-15 μg/mL) induced apoptotic cell death and enhanced the expression of cleaved caspase-3 and cleaved caspase-8 in a concentration dependent manner...
October 31, 2017: Oncotarget
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