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https://www.readbyqxmd.com/read/29050285/high-dose-atorvastatin-reduces-the-risk-of-cardiovascular-events-in-patients-with-percutaneous-coronary-intervention
#1
Changqing Lu, Helei Jia, Zhentao Wang
We systematically searched in PubMed, Web of Science, Embase and China National Knowledge Infrastructure from the inception to March 31, 2017, identified relevant trials about efficacy of high-does Atorvastatin for patients with percutaneous coronary intervention. Twelve studies with the number of 2801 patients were included in the meta-analysis. Compared with control group, high-does Atorvastatin significantly reduced the risk of myocardial infarction in patients with percutaneous coronary intervention (Relative risk =0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048428/dual-role-of-dr5-in-death-and-survival-signaling-leads-to-trail-resistance-in-cancer-cells
#2
Yelyzaveta Shlyakhtina, Valeria Pavet, Hinrich Gronemeyer
Besides its tumor-selective apoptotic activity, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes pro-survival, proliferative or migratory signaling (NF-κB, PI3K/Akt, MAPK and JNK; referred to as 'non-apoptotic' cascades). Indeed, apoptosis and non-apoptotic signaling can be activated in clonal populations of cancer cells in response to treatment and, as a result, only a part of the initial cellular population dies while a fraction survives and develops resistance to TRAIL-induced apoptosis (referred to as 'fractional survival')...
August 31, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29047155/maduramicin-induces-apoptosis-and-necrosis-and-blocks-autophagic-flux-in-myocardial-h9c2-cells
#3
Xin Chen, Long Chen, Shanxiang Jiang, Shile Huang
Maduramicin, a polyether ionophore antibiotic, is widely used as an anticoccidial agent in the poultry industry. It has been reported that maduramicin may cause heart and skeletal muscle cell damage, resulting in heart failure, skeletal muscle degeneration and even death in animals and humans, if improperly used. However, the molecular mechanism behind its capability to cause death of cardiac cells is not known. Here, we show that maduramicin induced apoptosis and necrosis in rat myocardial cells (H9c2). Maduramicin did not apparently upregulate the expression of pro-apoptotic proteins (e...
October 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29047030/representational-momentum-and-anisotropies-in-nearby-visual-space
#4
Timothy L Hubbard, Susan E Ruppel
The possibility of anisotropies in visual space in and near the final location of a moving target was examined. Experiments 1 and 2 presented a moving target, and after the target vanished, participants indicated the final location of the leading or trailing edge of the target. Memory for both edges was displaced forward from the actual final locations, and the magnitude of displacement was smaller for the leading edge. Experiments 3 and 4 also presented stationary objects in front of and behind the final location of the target, and participants indicated the location of the nearest or farthest edge of one of the stationary objects...
October 18, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29046648/the-relationships-among-tryptophan-kynurenine-indoleamine-2-3-dioxygenase-depression-and-neuropsychological-performance
#5
Knut A Hestad, Knut Engedal, Jon E Whist, Per G Farup
It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan (TRP) metabolic pathway, resulting in reduced Serotonin. In this study, we examined KYN, TRP, and the ratio of KYN to TRP concentrations × 10(3) (KT Ratio) in serum and cerebrospinal fluid (CSF) in (a) a group of depressed patients and (b) a control group of patients referred to a neurologic outpatient clinic for whom no specific diagnosis could be established...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29045826/a-cell-migration-tracking-tool-supports-coupling-of-tissue-rotation-to-elongation
#6
Dong-Yuan Chen, Justin Crest, David Bilder
Cell migration is indispensable to morphogenesis and homeostasis. Live imaging allows mechanistic insights, but long-term observation can alter normal biology, and tools to track movements in vivo without perturbation are lacking. We develop here a tool called M-TRAIL (matrix-labeling technique for real-time and inferred location), which reveals migration histories in fixed tissues. Using clones that overexpress GFP-tagged extracellular matrix (ECM) components, motility trajectories are mapped based on durable traces deposited onto basement membrane...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045478/camera-trap-placement-and-the-potential-for-bias-due-to-trails-and-other-features
#7
Joseph M Kolowski, Tavis D Forrester
Camera trapping has become an increasingly widespread tool for wildlife ecologists, with large numbers of studies relying on photo capture rates or presence/absence information. It is increasingly clear that camera placement can directly impact this kind of data, yet these biases are poorly understood. We used a paired camera design to investigate the effect of small-scale habitat features on species richness estimates, and capture rate and detection probability of several mammal species in the Shenandoah Valley of Virginia, USA...
2017: PloS One
https://www.readbyqxmd.com/read/29045430/the-association-between-herpes-virus-infections-and-functional-somatic-symptoms-in-a-general-population-of-adolescents-the-trails-study
#8
Iris Jonker, Robert Schoevers, Hans Klein, Judith Rosmalen
BACKGROUND: FSS have been suggested to follow activation of the immune system, triggered by herpes virus infections. The aim of this study was to find out whether herpes virus infections were associated with the experience of FSS in adolescents, and whether this association was mediated by hsCRP, as a general marker of immune activation. METHODS: This study was performed in TRAILS, a large prospective population cohort of 2230 adolescents (mean age: 16.1 years, SD = ...
2017: PloS One
https://www.readbyqxmd.com/read/29045376/drug-therapy-on-the-treatment-trail-for-als
#9
Andrew Scott
No abstract text is available yet for this article.
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29044596/angelicin-potentiates-trail-induced-apoptosis-in-renal-carcinoma-caki-cells-through-activation-of-caspase-3-and-down-regulation-of-c-flip-expression
#10
Kyoung-Jin Min, Hee Jung Um, Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Sang Hyun Kim, Yung Hyun Choi, Tae-Jin Lee, Taeg Kyu Kwon
Preclinical Research & Development Angelicin is a furocoumarin derived from Psoralea corylifolia L. fruit that has anti-inflammatory and anti-tumor activity. In the present study, the effect of angelicin in enhancing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptotic cell death was studied in Caki (renal carcinoma) cells. Angelicin alone and TRAIL alone had no effect on apoptosis, but in combination these compounds markedly induced apoptosis in the cancer cell lines while not inducing apoptosis in normal cells...
October 16, 2017: Drug Development Research
https://www.readbyqxmd.com/read/29044145/myosin-v-chemomechanical-coupling-ratchet-with-load-induced-mechanical-slip
#11
Tomonari Sumi
A chemomechanical-network model for myosin V is presented on the basis of both the nucleotide-dependent binding affinity of the head to an actin filament (AF) and asymmetries and similarity relations among the chemical transitions due to an intramolecular strain of the leading and trailing heads. The model allows for branched chemomechanical cycles and takes into account not only two different force-generating mechanical transitions between states wherein the leading head is strongly bound and the trailing head is weakly bound to the AF but also load-induced mechanical-slip transitions between states in which both heads are strongly bound...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042386/effectiveness-of-an-electronic-patient-centred-self-management-tool-for-gout-sufferers-a-cluster-randomised-controlled-trail-protocol
#12
Richard O Day, Lauren J Frensham, Amy D Nguyen, Melissa T Baysari, Eindra Aung, Annie Y S Lau, Nicholas Zwar, Jennifer Reath, Tracey Laba, Ling Li, Andrew McLachlan, William B Runciman, Rachelle Buchbinder, Robyn Clay-Williams, Enrico Coiera, Jeffrey Braithwaite, H Patrick McNeil, David J Hunter, Kevin J Pile, Ian Portek, Kenneth Mapson WIlliams, Johanna I Westbrook
INTRODUCTION: Gout is increasing despite effective therapies to lower serum urate concentrations to 0.36 mmol/L or less, which, if sustained, significantly reduces acute attacks of gout. Adherence to urate-lowering therapy (ULT) is poor, with rates of less than 50% 1 year after initiation of ULT. Attempts to increase adherence in gout patients have been disappointing. We aim to evaluate the effectiveness of use of a personal, self-management, 'smartphone' application (app) to achieve target serum urate concentrations in people with gout...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042081/peritoneal-dialysis-is-associated-with-better-cognitive-function-than-hemodialysis-over-a-one-year-course
#13
Denise Neumann, Wilfried Mau, Andreas Wienke, Matthias Girndt
Impaired cognitive functioning in patients with end-stage renal disease may reduce their capabilities to adhere to complex medical or dietary regimens and to fully participate in medical decisions. With decreasing renal function, cognitive abilities are likely to decline, with cognitive dysfunction improving after initiation of dialysis and even being generally reversible after successful renal transplantation. However, little is known about cognitive changes particularly regarding different treatment modalities...
October 14, 2017: Kidney International
https://www.readbyqxmd.com/read/29039600/synergism-between-%C3%AE-mangostin-and-trail-induces-apoptosis-in-squamous-cell-carcinoma-of-the-oral-cavity-through-the-mitochondrial-pathway
#14
Masakatsu Fukuda, Hide Sakashita, Hiroyasu Hayashi, Junya Shiono, Genki Miyake, Yusuke Komine, Fuyoko Taira, Hideaki Sakashita
Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reported to exert chemopreventive effects against chemically-induced colon cancer through the decrease of c-Myc expression, suppressing tumor growth in a mouse model of mammary cancer. A recent study demonstrated the inhibitive effect of α-mangostin on the growth of prostate cancer...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039580/combination-of-oncolytic-adenovirus-and-luteolin-exerts-synergistic-antitumor-effects-in-colorectal-cancer-cells-and-a-mouse-model
#15
Boduan Xiao, Yun Qin, Chang Ying, Buyun Ma, Binrong Wang, Fei Long, Ruwei Wang, Ling Fang, Yigang Wang
In recent years, oncolytic viruses have attracted increasing interest due to their potent antitumor effects. Luteolin, a natural product, has additionally been observed to exhibit various pharmacological antitumor activities. Previously, a novel dual‑targeting oncolytic adenovirus, complement decay‑accelerating factor (CD55)‑tumor necrosis factor ligand superfamily member 10 (TRAIL), was constructed, which exhibited significant growth inhibitory effects in various types of tumor cell. The present study investigated whether the combination of luteolin and CD55‑TRAIL was able to exert a synergistic antitumor effect in colorectal carcinoma (CRC) cells...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039537/juglone-potentiates-trail%C3%A2-induced-apoptosis-in-human-melanoma-cells-via-activating-the-ros%C3%A2-p38%C3%A2-p53-pathway
#16
Xiao Liu, Yan Chen, Yaohua Zhang, Juan Du, Yubao Lv, Shuming Mo, Yingchao Liu, Feng Ding, Jinfeng Wu, Ji Li
Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL)‑based cancer therapy offers promise as TRAIL can kill cancer cells without apparent toxicity towards normal cells. However, intrinsic or acquired resistance to TRAIL inseveral types of cancer cell has become a major challenge in TRAIL‑based cancer therapy. Juglone is a natural compound isolated from walnut trees. In the present study, it was demonstrated that juglone sensitized melanoma cells to TRAIL‑induced cytotoxicity by MTT and crystal violet assays...
October 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039511/trail-mutant-membrane-penetrating-peptide-alike-tmppa-trail%C3%A2-mu3-enhances-the-antitumor-effects-of-trail-in%C3%A2-vitro-and-in%C3%A2-vivo
#17
Hong Zhu, Juan Yan, Qi Xu, Lijia Wei, Xianzhou Huang, Shouchun Chen, Cheng Yi
The aim of the present study was to prepare a tumor necrosis factor ligand superfamily member 10 (TRAIL) mutant membrane penetrating peptide alike (TMPPA), TRAIL‑Mu3, and to investigate its antitumor effects in colorectal cancer in vitro and in vivo. The pMD19/TRAIL plasmid with designed primers was amplified to construct the target gene; it was ligated with an expression plasmid and the expression was confirmed. Subsequently, TRAIL‑Mu3 was purified and further confirmed by western blot analysis. Immunofluorescence analysis was used to detect the distribution of TRAIL‑Mu3 in colorectal cancer cells...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039048/sclerosing-and-obstructive-cholangiopathy-in-biliary-atresia-mechanisms-and-association-with-biliary-innate-immunity
#18
REVIEW
Kenichi Harada
Biliary atresia (BA) is histologically characterized by a progressive, sclerosing cholangitis and the obstruction of extrahepatic bile ducts. In terms of the etiology and pathogenesis of BA, several viral infections consisting of dsRNA, including Reoviridae, have been implicated. Human biliary epithelial cells (BECs) possess an innate immune system consisting of Toll-like receptors (TLRs). BECs have negative regulatory mechanisms of TLR tolerance to avoid an excessive inflammatory response to lipopolysaccharide (LPS), a TLR4 ligand; however, they lack the tolerance to poly(I:C) (a synthetic analog of viral dsRNA), a TLR3 ligand...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29038620/dengue-virus-induces-nk-cell-activation-through-trail-expression-during-infection
#19
Mariana Gandini, Fabienne Petitinga-Paiva, Cíntia Ferreira Marinho, Gladys Correa, Luzia Maria De Oliveira-Pinto, Luiz José de Souza, Rivaldo Venâncio Cunha, Claire Fernandes Kubelka, Elzinandes Leal de Azeredo
Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during dengue infection. A higher frequency of NK cell subsets and TRAIL+NK cells was found in mild DF cases when compared to that in severe cases or healthy donors. NK activation markers such as CD107a and TLR3 were upregulated in patients' cells compared to those in healthy donors...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29038485/a-versatile-pretargeting-approach-for-tumour-selective-delivery-and-activation-of-tnf-superfamily-members
#20
Yuan He, Peter E van Bommel, Douwe F Samplonius, Edwin Bremer, Wijnand Helfrich
TNFR superfamily (TNFRSF) members have important immunoregulatory functions and are of clear interest for cancer immunotherapy. Various TNFRSF agonists have been clinically evaluated, but have met with limited efficacy and/or toxicity. Recent insights indicate that 'first-generation' TNFRSF agonists lack efficacy as they do not effectively cross-link their corresponding receptor. Reversely, ubiquitous TNFRSF receptor(s) cross-linking by CD40 and Fas agonistic antibodies resulted in dose-limiting liver toxicity...
October 16, 2017: Scientific Reports
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