keyword
Keywords vascular remodeling and hypert...

vascular remodeling and hypertension

https://read.qxmd.com/read/38518236/morphometric-aspects-of-remodeling-of-the-arterial-bed-of-the-testicles-in-post-resection-portal-and-pulmonary-hypertensions
#1
JOURNAL ARTICLE
Michailo S Hnatjuk, Serhiy O Konovalenko, Myroslav Yu Kritsak, Tetiana I Gargula, Oleh B Yasinovskyi
OBJECTIVE: Aim: To perform a morphometric analysis of the features of vascular remodeling of the arterial bed of the testicles in post-resection portal and pulmonary hypertension. PATIENTS AND METHODS: Materials and Methods: The testes of 54 white rats were studied, which were divided into groups: 1st included 16 intact animals, 2nd - 20 rats with pulmonary hypertension, 3rd - 18 individuals with post-resection portal hypertension. Postresection pulmonary hypertension was modeled by right-sided pulmonectomy...
2024: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38518230/changes-in-the-indicators-of-stiffness-and-remodeling-of-magistral-arteries-in-young-patients-at-the-early-stage-of-essential-hypertension-under-conditions-of-syntropy-with-obesity
#2
JOURNAL ARTICLE
Tatiana A Ivanytska, Yurii M Kazakov, Yevhen Ye Petrov, Yuriі H Burmak, Ihor V Ivanytskyi, Nataliia I Chekalina, Svitlana V Shut
OBJECTIVE: Aim: The study and analysis of indicators of remodeling and rigidity of magistral vessels in young essential hypertension patients with abdominal obesity and determination of the detected changes as a possible criterion for their remodeling.. PATIENTS AND METHODS: Materials and Methods: 98 young people with essential hypertension and obesity were included in the study. The structure of the carotid artery and its stiffness were assessed using the ultrasound method, and the level of abdominal fat was determined using dual-energy X-ray absorptiometry...
2024: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38517365/phoenixin-20-ameliorates-pulmonary-arterial-hypertension-via-inhibiting-inflammation-and-oxidative-stress
#3
JOURNAL ARTICLE
Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen
Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application. Rats were treated with normal saline, PHN-20 (100 ng/g body weight daily), hypoxia, hypoxia+PHN-20 (100 ng/g body weight daily), respectively...
March 19, 2024: Aging
https://read.qxmd.com/read/38515647/early-postnatal-moderate-catch%C3%A2-up-growth-in-rats-with-nutritional-intrauterine-growth-restriction-preserves-pulmonary-vascular-and-cognitive-function-in-adulthood
#4
JOURNAL ARTICLE
Lixia Ye, Yajie Huang, Kewei Chen, Chengcheng Hang, Yuhan Ying, Lu Zu, Xiaofei Luo, Lizhong Du
Intrauterine growth restriction (IUGR) with rapid postnatal catch-up growth is strongly associated with pulmonary vascular dysfunction in adulthood, whereas IUGR with delayed growth in early postnatal life results in long-term brain deficits. In the present study, it was hypothesized that IUGR with early moderate catch-up growth may alleviate pulmonary vascular remodeling in adulthood without affecting memory function. An IUGR model was established by restricting maternal nutrition during pregnancy. Different growth patterns were achieved by adjusting the litter size in each group during lactation...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38510938/a-central-arteriovenous-fistula-reduces-systemic-hypertension-in-a-mouse-model
#5
JOURNAL ARTICLE
Anand Brahmandam, Rafael Alves, Hao Liu, Luis Gonzalez, Yukihiko Aoyagi, Yuichi Ohashi, John T Langford, Carly Thaxton, Ryosuke Taniguchi, Weichang Zhang, Hualong Bai, Bogdan Yatsula, Alan Dardik
OBJECTIVE: A central arteriovenous fistula (AVF) has been proposed as a potential novel solution to treat patients with refractory hypertension. We hypothesized that venous remodeling after AVF creation in the hypertensive environment reduces systemic blood pressure but results in increased AVF wall thickness compared with remodeling in the normotensive environment. METHODS: A central AVF was performed in C57BL6/J mice previously made hypertensive with angiotensin II (Ang II); mice were sacrificed on postoperative day 7 or 21...
2024: Journal of vascular surgery. Vascular science
https://read.qxmd.com/read/38508664/the-nitric-oxide-soluble-guanylate-cyclase-cgmp-pathway-in-pulmonary-hypertension-from-pde5-to-soluble-guanylate-cyclase
#6
REVIEW
Raymond L Benza, Ekkehard Grünig, Peter Sandner, Johannes-Peter Stasch, Gérald Simonneau
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH). Targeted treatments include phosphodiesterase type 5 inhibitors (PDE5i) and sGC stimulators. The sGC stimulator riociguat is approved for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). sGC stimulators have a dual mechanism of action, enhancing the sGC response to endogenous NO and directly stimulating sGC, independent of NO...
January 31, 2024: European Respiratory Review: An Official Journal of the European Respiratory Society
https://read.qxmd.com/read/38503401/functions-and-novel-regulatory-mechanisms-of-key-glycolytic-enzymes-in-pulmonary-arterial-hypertension
#7
REVIEW
Jia Wang, Chao Liu, Shen-Shen Huang, Hui-Fang Wang, Chun-Yan Cheng, Jing-Si Ma, Ruo-Nan Li, Tian-Yu Lian, Xian-Mei Li, Yue-Jiao Ma, Zhi-Cheng Jing
Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by remodeling of the pulmonary vasculature and elevated pulmonary arterial pressure, ultimately leading to right heart failure and death. Despite its clinical significance, the precise molecular mechanisms driving PAH pathogenesis warrant confirmation. Compelling evidence indicates that during the development of PAH, pulmonary vascular cells exhibit a preference for energy generation through aerobic glycolysis, known as the "Warburg effect", even in well-oxygenated conditions...
March 17, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38503152/salidroside-protects-pulmonary-artery-endothelial-cells-against-hypoxia-induced-apoptosis-via-the-ahr-nf-%C3%AE%C2%BAb-and-nrf2-ho-1-pathways
#8
JOURNAL ARTICLE
Wei Lei, Mei-Hong Chen, Zu-Feng Huang, Xiao-Ying Chen, Jin-Xia Wang, Jing Zheng, Yi-Zhun Zhu, Xiao-Zhong Lan, Yuan He
BACKGROUND: The apoptosis of pulmonary artery endothelial cells (PAECs) is an important factor contributing to the development of pulmonary hypertension (PH), a serious cardio-pulmonary vascular disorder. Salidroside (SAL) is a bioactive compound derived from an herb Rhodiola, but the potential protective effects of SAL on PAECs and the underlying mechanisms remain elusive. PURPOSE: The objective of this study was to determine the role of SAL in the hypoxia-induced apoptosis of PAECs and to dissect the underlying mechanisms...
January 18, 2024: Phytomedicine
https://read.qxmd.com/read/38497483/circalms1-alleviates-pulmonary-microvascular-endothelial-cell-dysfunction-in-pulmonary-hypertension
#9
JOURNAL ARTICLE
Xiaoyi Hu, Yuanyuan Sun, Shang Wang, Hui Zhao, Yaqin Wei, Jiaqi Fu, Yuxia Huang, Wenhui Wu, Jinling Li, Jinming Liu, Sugang Gong, Qinhua Zhao, Lan Wang, Rong Jiang, Xiao Song, Ping Yuan
BACKGROUND: Circular RNAs can serve as regulators influencing the development of pulmonary hypertension (PH). However, their function in pulmonary vascular intimal injury remains undefined. Thus, we aimed to identify specifically expressed circular RNAs in pulmonary microvascular endothelial cells (PMECs) under hypoxia and PH. METHODS AND RESULTS: Deep RNA sequencing and quantitative real-time polymerase chain reaction revealed that circALMS1 (circular RNA Alstrom syndrome protein 1) was reduced in human PMECs under hypoxia ( P <0...
March 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38495631/forsythoside-b-mitigates-monocrotaline-induced-pulmonary-arterial-hypertension-via-blocking-the-nf-%C3%AE%C2%BAb-signaling-pathway-to-attenuate-vascular-remodeling
#10
JOURNAL ARTICLE
Jiying Liu, Guangyao Fang, Cong Lan, Chenming Qiu, Li Yao, Qian Zhang, Jingtang Hu, Yaolei Zhang, Yongjian Yang, Yan Zhang
PURPOSE: Pulmonary arterial hypertension (PAH) is a devastating disease with little effective treatment. The proliferation of pulmonary artery smooth muscle cells (PASMCs) induced by the nuclear factor-κB (NF-κB) signaling activation plays a pivotal role in the pathogenesis of PAH. Forsythoside B (FTS•B) possesses inhibitory effect on NF-κB signaling pathway. The present study aims to explore the effects and mechanisms of FTS•B in PAH. METHODS: Sprague-Dawley rats received monocrotaline (MCT) intraperitoneal injection to establish PAH model, and FTS•B was co-treated after MCT injection...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38486163/mechanical-stretch-leads-to-increased-caveolin-1-content-and-mineralization-potential-in-extracellular-vesicles-from-vascular-smooth-muscle-cells
#11
JOURNAL ARTICLE
Mohammad Shaver, Kassandra Gomez, Katherine Kaiser, Joshua D Hutcheson
BACKGROUND: Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural component of plasma membrane invaginations, is a mechanosensitive protein that is required for the formation of calcifying extracellular vesicles (EVs). However, the role of mechanics in Cav-1-induced EV formation from VSMCs has not been reported. RESULTS: Exposure of VSMCs to 10% mechanical stretch (0...
March 14, 2024: BMC molecular and cell biology
https://read.qxmd.com/read/38474074/a-novel-rat-model-of-mild-pulmonary-hypertension-associated-with-pulmonary-venous-congestion-induced-by-left-pulmonary-vein-banding
#12
JOURNAL ARTICLE
Jonas Münks, Athiththan Yogeswaran, Tobiah Kevin Antoine, Leonhard Anton Blumrich, Peter Dorfmüller, Hossein Ardeschir Ghofrani, Birgit Assmus, Ralph Theo Schermuly, Akylbek Sydykov
Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common form of PH. In PH-LHD, changes in the pulmonary vasculature are assumed to be mainly caused by pulmonary venous congestion. However, the underlying mechanisms of this form of PH are poorly understood. We aimed to establish a model of PH associated with pulmonary venous congestion. Wistar-Kyoto rats underwent partial occlusion of the left pulmonary vein to induce pulmonary venous congestion or sham surgery and were assessed at various time points post-surgery (3, 6, 9, 12 weeks)...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473847/functional-structural-and-proteomic-effects-of-ageing-in-resistance-arteries
#13
REVIEW
Lars Jørn Jensen
The normal ageing process affects resistance arteries, leading to various functional and structural changes. Systolic hypertension is a common occurrence in human ageing, and it is associated with large artery stiffening, heightened pulsatility, small artery remodeling, and damage to critical microvascular structures. Starting from young adulthood, a progressive elevation in the mean arterial pressure is evidenced by clinical and epidemiological data as well as findings from animal models. The myogenic response, a protective mechanism for the microcirculation, may face disruptions during ageing...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468630/evaluating-the-efficacy-and-safety-of-oral-triple-sequential-combination-therapy-for-treating-patients-with-pulmonary-arterial-hypertension-a-multicenter-retrospective-study
#14
JOURNAL ARTICLE
Qin-Hua Zhao, Jun Chen, Fa-Dong Chen, Hong-Yun Ruan, Wei Zhang, Yan-Li Zhou, Qi-Qi Wang, Xiao-Ling Xu, Ke-Fu Feng, Jian-Zhou Guo, Su-Gang Gong, Rui-Feng Zhang, Lan Wang
This study aimed to evaluate the effectiveness and safety of an oral sequential triple combination therapy with selexipag after dual combination therapy with endothelin receptor antagonist (ERA) and phosphodiesterase-5 inhibitor (PDE5I)/riociguat in pulmonary arterial hypertension (PAH) patients. A total of 192 PAH patients from 10 centers had received oral sequential selexipag therapy after being on dual-combination therapy with ERA and PDE5i/riociguat for a minimum of 3 months. Clinical data were collected at baseline and after 6 months of treatment...
January 2024: Pulmonary Circulation
https://read.qxmd.com/read/38464011/general-capillary-endothelial-cells-undergo-reprogramming-into-arterial-endothelial-cells-in-pulmonary-hypertension-through-hif-2%C3%AE-notch4-pathway
#15
Bin Liu, Dan Yi, Xiaomei Xia, Karina Ramirez, Hanqiu Zhao, Yanhong Cao, Ankit Tripathi, Ryan Dong, Anton Gao, Hongxu Ding, Shenfeng Qiu, Vladimir V Kalinichenko, Michael B Fallon, Zhiyu Dai
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling that result in right heart hypertrophy, failure, and premature death. The underlying mechanisms of loss of distal capillary endothelial cells (ECs) and obliterative vascular lesion formation remain unclear. Our recent single-cell RNA sequencing, spatial transcriptomics analysis, RNASCOPE, and immunostaining analysis showed that arterial ECs accumulation and loss of capillary ECs were evident in human PAH patients and pulmonary hypertension (PH) rodents...
March 10, 2024: bioRxiv
https://read.qxmd.com/read/38463394/maresin-1-ameliorates-hypertensive-vascular-remodeling-through-its-receptor-lgr6
#16
JOURNAL ARTICLE
Zheng Yin, Jishou Zhang, Mengmeng Zhao, Shanshan Peng, Jing Ye, Jianfang Liu, Yao Xu, Shuwan Xu, Wei Pan, Cheng Wei, Juan-Juan Qin, Jun Wan, Menglong Wang
Hypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin-1 (MaR1), one of metabolites from Omega-3 fatty acids, has been reported to promote inflammation resolution in several inflammatory diseases. This study aims to investigate the effect of MaR1 on hypertensive vascular remodeling. Here, we found serum MaR1 levels were reduced in hypertensive patients and was negatively correlated with systolic blood pressure (SBP). The treatment of MaR1 reduced the elevation of blood pressure and alleviated vascular remodeling in the angiotensin II (AngII)-infused mouse model...
March 2024: MedComm
https://read.qxmd.com/read/38461659/portal-hypertension-like-pattern-in-coronavirus-disease-2019-acute-respiratory-distress-syndrome
#17
JOURNAL ARTICLE
Daniele Dondossola, Caterina Lonati, Alessia Pini, Daniela Bignamini, Alberto Zanella, Rosa Lombardi, Vittorio Scaravilli, Vincenzo La Mura, Laura Forzenigo, Pierpaolo Biondetti, Giacomo Grasselli, Anna Fracanzani, Chiara Paleari, Annalisa Cespiati, Serena Todaro, Emanuele Cattaneo, Marianna Di Feliciantonio, Giordano Sigon, Carlo Valsecchi, Amedeo Guzzardella, Michele Battistin, Federica Iuculano
OBJECTIVES: Although respiratory failure is the most common feature in coronavirus disease 2019 (COVID-19), abdominal organ involvement is likewise frequently observed. To investigate visceral and thoracic circulation and abdominal organ damage in COVID-19 patients. MATERIALS AND METHODS: A monocentric observational study was carried on. In COVID-19 patients affected by acute respiratory distress syndrome (ARDS) (n = 31) or mild pneumonia (n = 60) thoracoabdominal circulation was evaluated using Doppler-ultrasound and computed tomography...
March 9, 2024: Journal of Critical Care
https://read.qxmd.com/read/38451018/ercc1-dna-repair-deficiency-results-in-vascular-aging-characterized-by-vsmc-phenotype-switching-ecm-remodeling-and-an-increased-stress-response
#18
JOURNAL ARTICLE
Janette van der Linden, Sanne J M Stefens, José María Heredia-Genestar, Yanto Ridwan, Renata M C Brandt, Nicole van Vliet, Isa de Beer, Bibi S van Thiel, Herman Steen, Caroline Cheng, Anton J M Roks, A H Jan Danser, Jeroen Essers, Ingrid van der Pluijm
Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the aging process, and mice with a DNA repair defect caused by Ercc1 deficiency display hypertension, vascular stiffening, and loss of vasomotor control. To determine the underlying cause, we compared important hallmarks of vascular aging in aortas of both Ercc1Δ/- and age-matched wildtype mice...
March 7, 2024: Aging Cell
https://read.qxmd.com/read/38445498/ovariectomy-induced-arterial-stiffening-differs-from-vascular-aging-and-is-reversed-by-gper-activation
#19
JOURNAL ARTICLE
Isabella M Kilanowski-Doroh, Alexandra B McNally, Tristen Wong, Bruna Visniauskas, Sophia A Blessinger, Ariane Imulinde Sugi, Chase Richard, Zaidmara Diaz, Alec Horton, Christopher A Natale, Benard O Ogola, Sarah H Lindsey
BACKGROUND: Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether a mouse model of menopause increases arterial stiffness in a similar manner to aging and whether activation of the G-protein-coupled estrogen receptor could reverse stiffness. METHODS: Female C57Bl/6J mice were ovariectomized at 10 weeks of age or aged to 52 weeks, and some mice were treated with G-protein-coupled estrogen receptor agonists...
March 6, 2024: Hypertension
https://read.qxmd.com/read/38444129/-effects-of-human-umbilical-cord-mesenchymal-stem-cells-mscs-derived-exosomes-on-pulmonary-vascular-remodeling-in-hypoxic-pulmonary-hypertension
#20
JOURNAL ARTICLE
Hong Liu, Yu-Wei Zhang, Qing-Qing Zhang, Yu-Xiang Wang, Ri-Li Ge, Lan Ma
The present study aimed to investigate the effect of human umbilical cord mesenchymal stem cells (MSCs)-derived exosomes (MSCs-Exo) on mice with hypoxic pulmonary hypertension (HPH). MSCs were isolated and cultured from human umbilical cords under aseptic conditions, and exosomes were extracted from the supernatants and identified. Healthy SPF C57BL/6 mice were randomly divided into three groups: normoxic group, hypoxic group, and hypoxic+MSCs-Exo group. Mice in the hypoxic group and the hypoxic+MSCs-Exo group were maintained for 28 d at an equivalent altitude of 5 000 m in a hypobaric chamber to establish HPH mouse model...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
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