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https://www.readbyqxmd.com/read/28811393/analysis-of-geographical-variations-in-the-epidemiology-and-management-of-non-valvular-atrial-fibrillation-results-from-the-ramses-registry
#1
Volkan Doğan, Özcan Başaran, Murat Biteker, Fatma Özpamuk Karadeniz, Ahmet İlker Tekkesin, Yasin Çakıllı, Ceyhan Türkkan, Mehmet Hamidi, Vahit Demir, Mustafa Ozan Gürsoy, Müjgan Tek Öztürk, Gökhan Aksan, Sabri Seyis, Mehmet Ballı, Mehmet Hayri Alıcı, Serdar Bozyel, Cevat Kırma
OBJECTIVE: This study aimed to determine the differences in terms of demographic characteristics and preferred stroke prevention strategies for patients with non-valvular atrial fibrillation living in seven geographical regions of Turkey. METHODS: In total, 6273 patients were enrolled to this prospective, observational RAMSES study. The patients were divided into seven groups based on the geographical region of residence. RESULTS: In terms of the geographical distribution of the overall Turkish population, the highest number of patients were enrolled from Marmara (1677, 26...
August 11, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28776688/mosaics-often-outperform-pyramids-insights-from-a-model-comparing-strategies-for-the-deployment-of-plant-resistance-genes-against-viruses-in-agricultural-landscapes
#2
Ramses Djidjou-Demasse, Benoît Moury, Frédéric Fabre
The breakdown of plant virus resistance genes is a major issue in agriculture. We investigated whether a set of resistance genes would last longer when stacked into a single plant cultivar (pyramiding) or when deployed individually in regional mosaics (mosaic strategy). We modeled the genetic and epidemiological processes shaping the demogenetic dynamics of viruses under a multilocus gene-for-gene system, from the plant to landscape scales. The landscape consisted of many fields, was subject to seasonality, and of a reservoir hosting viruses year-round...
August 4, 2017: New Phytologist
https://www.readbyqxmd.com/read/28742120/virus-induced-asthma-attack-the-importance-of-allergic-inflammation-in-response-to-viral-antigen-in-an-animal-model-of-asthma
#3
Christopher Skappak, Ramses Ilarraza, Ying-Qi Wu, Matthew G Drake, Darryl J Adamko
Asthma exacerbation can be a life-threatening condition, and is most often triggered by common respiratory viruses. Poor asthma control and worsening of respiratory function is associated with increased airway inflammation, including eosinophilia. Prevention of asthma exacerbation relies on treatment with corticosteroids, which preferentially inhibit allergic inflammation like eosinophils. Human studies demonstrate that inactivated virus can trigger eosinophil activation in vitro through antigen presentation and memory CD4+ lymphocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28732240/constitutive-transgene-expression-of-stem-cell-antigen-1-in-the-hair-follicle-alters-the-sensitivity-to-tumor-formation-and-progression
#4
Rikke Christensen, David M Owens, Annette C Füchtbauer, Anders Gunnarsson, Mette Ramsing, Ernst-Martin Füchtbauer, Uffe Birk Jensen
The cell surface protein Stem Cell Antigen-1 (Sca-1) marks stem or progenitor cells in several murine tissues and is normally upregulated during cancer development. Although the specific function of Sca-1 remains unknown, Sca-1 seems to play a role in proliferation, differentiation and cell migration in a number of tissues. In the skin epithelium, Sca-1 is highly expressed in the interfollicular epidermis but is absent in most compartments of the hair follicle; however, the function of Sca-1 in the skin has not been investigated...
July 8, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28642813/corrigendum-to-association-of-nuclear-factor-erythroid-2-related-factor-2-thioredoxin-interacting-protein-and-heme-oxygenase-1-gene-polymorphisms-with-diabetes-and-obesity-in-mexican-patients
#5
Angélica Saraí Jiménez-Osorio, Susana González-Reyes, Wylly Ramsés García-Niño, Hortensia Moreno-Macías, Martha Eunice Rodríguez-Arellano, Gilberto Vargas-Alarcón, Joaquín Zúñiga, Rodrigo Barquera, José Pedraza-Chaverri, Juan Pablo Meza-Espinoza, Evelia Leal-Ugarte, Valeria Peralta-Leal
[This corrects the article DOI: 10.1155/2016/7367641.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28627046/donor-specific-antibodies-are-associated-with-micro-and-macrovascular-coronary-disease-restrictive-myocardial-damage-and-poor-outcome-in-heart-transplanted-patients
#6
Tor Skibsted Clemmensen, Pernille Koefoed-Nielsen, Lis-Ann Jensen, Steen Hvitfeldt Poulsen, Niels Ramsing Holm, Brian Bridal Løgstrup, Evald Høj Christiansen, Jouke Dijkstra, Kamilla Pernille Bjerre Valen, Hans Eiskjaer
AIMS: We examined the relationship between donor-specific HLA antibody (DSA) presence and graft function, hemodynamics, cardiac allograft vasculopathy (CAV), and major adverse cardiac events (MACE) in stable long-term heart-transplanted (HTx) patients. METHODS: Sera from 79 patients (median 7.5 years after HTx) were analyzed for DSA presence. Graft function was evaluated by echocardiography and right heart catheterization. CAV-burden was determined by coronary angiography, optical coherence tomography (OCT), and coronary flow velocity reserve (CFVR)...
June 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28583948/lysinibacillus-fusiformis-m5-induces-increased-complexity-in-bacillus-subtilis-168-colony-biofilms-via-hypoxanthine
#7
Ramses Gallegos-Monterrosa, Stefanie Kankel, Sebastian Götze, Robert Barnett, Pierre Stallforth, Ákos T Kovács
In recent years, biofilms have become a central subject of research in the fields of microbiology, medicine, agriculture, or systems biology amongst others. The sociomicrobiology of multispecies biofilms, however, is still poorly understood. Here, we report a screening system that allowed us to identify soil bacteria, which induce architectural changes in biofilm colonies when cocultured with B. subtilis We identified the soil bacterium Lysinibacillus fusiformis M5 as inducer of wrinkle-formation in B. subtilis colonies mediated by a diffusible signaling molecule...
June 5, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28492474/fabrication-of-silicon-nanobelts-and-nanopillars-by-soft-lithography-for-hydrophobic-and-hydrophilic-photonic-surfaces
#8
Estela Baquedano, Ramses V Martinez, José M Llorens, Pablo A Postigo
Soft lithography allows for the simple and low-cost fabrication of nanopatterns with different shapes and sizes over large areas. However, the resolution and the aspect ratio of the nanostructures fabricated by soft lithography are limited by the depth and the physical properties of the stamp. In this work, silicon nanobelts and nanostructures were achieved by combining soft nanolithography patterning with optimized reactive ion etching (RIE) in silicon. Using polymethylmethacrylate (PMMA) nanopatterned layers with thicknesses ranging between 14 and 50 nm, we obtained silicon nanobelts in areas of square centimeters with aspect ratios up to ~1...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28469860/first-reported-case-of-simpson-golabi-behmel-syndrome-in-a-female-fetus-diagnosed-prenatally-with-chromosomal-microarray
#9
Heidi Kristine Støve, Naja Becher, Vibike Gjørup, Mette Ramsing, Ida Vogel, Else Marie Vestergaard
Simpson-Golabi-Behmel syndrome (SGBS) is a rare X-linked syndrome. Female carriers may have mild manifestations. Macrosomia, polyhydramnios, and kidney and urinary tract anomalies are common findings in male fetuses. We present the first case of a severely affected female fetus with stigmata of SGBS and a deletion involving the GPC3 gene.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28462716/treatment-of-bifurcation-lesions-by-bail-out-tap-or-culotte-lost-in-translation
#10
Francesco Burzotta, Thierry Lefèvre, Jens Flensted Lassen, Niels Ramsing Holm, Goran Stankovic
BACKGROUND: Coronary bifurcated lesions (CBL) represent a hot topic of interventional cardiology. Provisional stenting, i.e. implantation of a drug-eluting (DES) in the main branch followed by side-branch (SB) intervention in case of suboptimal SB result, represents the gold standard to treat the vast majority of CBL undergoing percutaneous coronary interventions (PCI). The best technique for bail-out SB stenting has not been established. Prospective randomized trials comparing different stenting techniques may help provide important insights regarding the best way to conduct PCI in patients with CBL...
April 26, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28407526/the-impact-of-antidepressants-on-seizure-frequency-and-depressive-and-anxiety-disorders-of-patients-with-epilepsy-is-it-worth-investigating
#11
Ramses Ribot, Bichun Ouyang, Andres M Kanner
PURPOSE: Depression and anxiety disorders in patients with epilepsy (PWE) remain under-recognized and under-treated, despite being the most common psychiatric co-morbidities. Selective serotonin re-uptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are considered first-line treatment for primary depression and anxiety disorders. We performed this study to investigate if SSRIs and SNRIs could affect the seizure frequency of PWE and to assess whether such effect is independent of the response of the mood and anxiety disorders to these drugs...
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28407216/real-world-stroke-prevention-strategies-in-nonvalvular-atrial-fibrillation-in-patients-with-renal-impairment
#12
Kadir U Mert, Gurbet Ö Mert, Özcan Başaran, Osman Beton, Volkan Dogan, Mehmet Tekinalp, Ahmet Ç Aykan, Ezgi Kalaycıoğlu, Ismail Bolat, Onur Taşar, Özgen Şafak, Macit Kalçık, Mehmet Yaman, Cevat Kırma, Murat Biteker
BACKGROUND: The data regarding stroke prevention strategies in nonvalvular atrial fibrillation (NVAF) are limited especially in patients with renal impairment (RI). We sought to evaluate management dilemmas in patients with concurrent NVAF and RI in RAMSES (ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies inTurkey) study. METHODS: We conducted a prospective, multicenter, nation-wide registry in NVAF patients in outpatient cardiology clinics. All consecutive patients with NVAF were enrolled in RAMSES study (ClinicalTrials...
April 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28363123/the-implications-of-shedder-status-and-background-dna-on-direct-and-secondary-transfer-in-an-attack-scenario
#13
Ane Elida Fonneløp, Merete Ramse, Thore Egeland, Peter Gill
In court questions are often raised related to how trace DNA was deposited, directly during the crime or innocently for instance by secondary transfer. It is therefore of interest to have knowledge of the probability of transfer or secondary transfer in different situations. Factors that could influence transfer probabilities are background DNA and the shedder status of the involved persons. In this study, we have classified participants as high or low DNA shedders. We observed DNA transfer in a simulated attack scenario, and demonstrated that shedder status has a significant influence of transfer rates...
July 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28359668/the-anterolateral-ligament-has-similar-biomechanical-and-histologic-properties-to-the-inferior-glenohumeral-ligament
#14
Kristof Smeets, Josh Slane, Lennart Scheys, Ramses Forsyth, Steven Claes, Johan Bellemans
PURPOSE: To characterize the tensile and histologic properties of the anterolateral ligament (ALL), inferior glenohumeral ligament (IGHL), and knee capsule. METHODS: Standardized samples of the ALL (n = 19), anterolateral knee capsule (n = 15), and IGHL (n = 13) were isolated from fresh-frozen human cadavers for uniaxial tensile testing to failure. An additional 6 samples of the ALL, capsule, and IGHL were procured for histologic analysis and determination of elastin content...
March 27, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28340232/a-proposed-set-of-metrics-to-reduce-patient-safety-risk-from-within-the-anatomic-pathology-laboratory
#15
Peter Banks, Richard Brown, Alex Laslowski, Yvonne Daniels, Phil Branton, John Carpenter, Richard Zarbo, Ramses Forsyth, Yan-Hui Liu, Shane Kohl, Joachim Diebold, Shinobu Masuda, Tim Plummer, Eslie Dennis
Background: Anatomic pathology laboratory workflow consists of 3 major specimen handling processes. Among the workflow are preanalytic, analytic, and postanalytic phases that contain multistep subprocesses with great impact on patient care. A worldwide representation of experts came together to create a system of metrics, as a basis for laboratories worldwide, to help them evaluate and improve specimen handling to reduce patient safety risk. Method: Members of the Initiative for Anatomic Pathology Laboratory Patient Safety (IAPLPS) pooled their extensive expertise to generate a list of metrics highlighting processes with high and low risk for adverse patient outcomes...
May 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28330670/layered-fibrotic-plaques-are-the-predominant-component-in-cardiac%C3%A2-allograft-vasculopathy-systematic-findings-and-risk-stratification-by-oct
#16
Tor Skibsted Clemmensen, Niels Ramsing Holm, Hans Eiskjær, Brian Bridal Løgstrup, Evald Høj Christiansen, Jouke Dijkstra, Trine Ørhøj Barkholt, Christian Juhl Terkelsen, Michael Maeng, Steen Hvitfeldt Poulsen
OBJECTIVES: The aims of this study were to characterize cardiac allograft vasculopathy (CAV) phenotypes using optical coherence tomography (OCT) and to evaluate the prognostic significance of OCT-determined CAV severity. BACKGROUND: Intravascular OCT enables in vivo characterization of CAV microstructure after heart transplantation. METHODS: Sixty-two patients undergoing heart transplantation were enrolled at routine angiography from September 2013 through October 2015 and prospectively followed until censoring on May 27, 2016...
July 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28262624/a-novel-four-dimensional-angiographic-approach-to-assess-dynamic-superficial-wall-stress-of-coronary-arteries-in-vivo-initial-experience-in-evaluating-vessel-sites-with-subsequent-plaque-rupture
#17
Xinlei Wu, Clemens von Birgelen, Takashi Muramatsu, Yingguang Li, Niels Ramsing Holm, Johan H C Reiber, Shengxian Tu
AIMS: Repetitive and fluctuating stress is one important biomechanical mechanism that underlies the rupture of atherosclerotic plaques. We developed a novel coronary angiography-based method for in vivo 4-dimensional analysis of dynamic superficial wall stress (SWS) in coronary plaques and applied it for the first time in two clinical cases to investigate the potential relationship between dynamic stress concentration at baseline and plaque rupture during acute coronary syndrome (ACS) several months later...
March 7, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28257543/free-lung-cancer-screening-trends-toward-a-twofold-increase-in-lung-cancer-prevalence-in-the-underserved-southeastern-united-states
#18
Erika L Simmerman, Norman B Thomson, Thomas A Dillard, Zhonglin Hao, Ramses F Sadek, Samir N Khleif, Carsten Schroeder
OBJECTIVES: The National Lung Screening Trial (NLST) reported that the prevalence of lung cancer in individuals at high risk for the disease is 1%, and that screening these individuals using low-dose helical computed tomography of the chest saves lives. To increase screening accessibility in the underserved southeastern United States, we developed a free lung screening program, modeled after the Lahey Hospital & Medical Center Free Lung Screening Program, for individuals meeting National Comprehensive Cancer Network high-risk criteria...
March 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28244590/laser-thermal-ablation-for-mesiotemporal-epilepsy-analysis-of-ablation-volumes-and-trajectories
#19
Walter J Jermakowicz, Andres M Kanner, Samir Sur, Christina Bermudez, Pierre-Francois D'Haese, John Paul G Kolcun, Iahn Cajigas, Rui Li, Carlos Millan, Ramses Ribot, Enrique A Serrano, Naymee Velez, Merredith R Lowe, Gustavo J Rey, Jonathan R Jagid
OBJECTIVE: To identify features of ablations and trajectories that correlate with optimal seizure control and minimize the risk of neurocognitive deficits in patients undergoing laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE). METHODS: Clinical and radiographic data were reviewed from a prospectively maintained database of all patients undergoing LiTT for the treatment of mTLE at the University of Miami Hospital. Standard preoperative and postoperative evaluations, including contrast-enhanced magnetic resonance imaging (MRI) and neuropsychological testing, were performed in all patients...
May 2017: Epilepsia
https://www.readbyqxmd.com/read/28238569/guideline-adherent-therapy-for-stroke-prevention-in-atrial-fibrillation-in-different-health-care-settings-results-from-ramses-study
#20
Özcan Başaran, Volkan Dogan, Murat Biteker, Fatma Özpamuk Karadeniz, Ahmet İlker Tekkesin, Yasin Çakıllı, Ceyhan Türkkan, Mehmet Hamidi, Vahit Demir, Mustafa Ozan Gürsoy, Müjgan Tek Öztürk, Gökhan Aksan, Sabri Seyis, Mehmet Ballı, Mehmet Hayri Alıcı, Serdar Bozyel, Cevat Kırma
OBJECTIVE: No studies have been conducted in Turkey to compare the quality of stroke prevention therapies provided in different healthcare settings in patients with atrial fibrillation (AF). Therefore, we aimed to evaluate possible differences between secondary (SH) and tertiary hospital (TH) settings in the effectiveness of implementing AF treatment strategies. METHODS: Baseline characteristics of 6273 patients with non-valvular AF enrolled in the RAMSES (ReAl-life Multicentre Survey Evaluating Stroke Prevention Strategies in Turkey) study were compared...
May 2017: European Journal of Internal Medicine
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