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Liver and contrast and perfusion and HCC

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https://www.readbyqxmd.com/read/30297310/dual-port-versus-mono-port-implantation-for-intra-arterial-chemoinfusion-therapy-for-treatment-of-hepatocellular-carcinoma-in-patients-with-anatomic-hepatic-artery-variation
#1
Su Ho Kim, Jung Suk Oh, Ho Jong Chun, Byung Gil Choi, Hae Giu Lee
PURPOSE: To compare the feasibility and safety of mono-port catheter system and dual-port catheter system for advanced hepatocellular carcinoma (HCC) in patients with anatomic hepatic artery variation and portal vein tumor thrombosis. MATERIALS AND METHODS: This retrospective study consisted of 22 patients with infiltrative or multiple HCC with unilateral or bilateral portal vein thrombosis who had hepatic artery variation. A mono-port or dual-port catheter system was determined according to the degree of blood supply to the entire tumor through the common hepatic and variant hepatic arteries...
October 5, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/30140622/ct-features-of-hepatic-epithelioid-angiomyolipoma-differentiation-from-hepatocellular-carcinoma-in-patients-with-noncirrhotic-livers
#2
Weihai Liu, Wenjie Liang
Background: Hepatic epithelioid angiomyolipoma (HEA) shares some similarities with other hepatic tumors, such as hepatocellular carcinoma (HCC). Thus, establishing a definite diagnosis of HEA based on medical imaging is often difficult. In this study, we evaluated multiphasic computed tomography (CT) imaging to differentiate HEA from HCC in patients with noncirrhotic livers. Methods: We retrospectively analyzed the clinical and imaging data of both contrast and non-contrast enhanced CT scans from 25 patients with HEA and 50 patients with HCC in noncirrhotic livers...
July 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/30103307/savitzky-golay-filter-based-contrast-enhanced-ultrasound-quantification-in-hepatic-tumors-methodology-and-its-correlation-with-tumor-angiogenesis
#3
Shiyun Peng, Hong Ding, Tiantian Fu, Bengang Wang, Wenping Wang, Jinzhu Zhou
BACKGROUND: Savitzky-Golay filter is a digital filter used in data smoothing, we introduced a contrast-enhanced ultrasound (CEUS) quantification software based on the filter (SGCQ). OBJECTIVE: To explore the methodology of analyzing hepatic tumors hemodynamics applying SGCQ software and the correlation between SGCQ parameters and hepatocellular carcinoma (HCC) angiogenesis. METHODS: Nighty-seven right-lobe located hepatic mass cases (15 females and 82 males, mean age 58±10y, mean lesion size: 39...
August 4, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/30042980/ultra-low-dose-sparse-view-quantitative-ct-liver-perfusion-imaging
#4
Esmaeil Enjilela, Ting-Yim Lee, Jiang Hsieh, Amol Murjoomdar, Errol Stewart, Mark Dekaban, Feng Su, Aaron So
Radiation dose of computed tomography liver perfusion imaging can be reduced by collecting fewer x-ray projections in each gantry rotation, but the resulting aliasing artifacts could affect the hepatic perfusion measurement. We investigated the effect of projection undersampling on the assessment of hepatic arterial blood flow (HA BF) in hepatocellular carcinoma (HCC) when dynamic contrast-enhanced (DCE) liver images were reconstructed with filtered backprojection (FBP) and compressed sensing (CS). DCE liver images of a patient with HCC acquired with a 64-row CT scanner were reconstructed from all the measured projections (984-view) with the standard FBP and from one-third (328-view) and one-fourth (246-view) of all available projections with FBP and CS...
December 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29951363/hepatocellular-carcinoma-diagnosis-treatment-algorithms-and-imaging-appearance-after-transarterial-chemoembolization
#5
REVIEW
Patrick Vande Lune, Ahmed K Abdel Aal, Sergio Klimkowski, Jessica G Zarzour, Andrew J Gunn
Hepatocellular carcinoma (HCC) is a common cause of cancer-related death, with incidence increasing worldwide. Unfortunately, the overall prognosis for patients with HCC is poor and many patients present with advanced stages of disease that preclude curative therapies. Diagnostic and interventional radiologists play a key role in the management of patients with HCC. Diagnostic radiologists can use contrast-enhanced computed tomography (CT), magnetic resonance imaging, and ultrasound to diagnose and stage HCC, without the need for pathologic confirmation, by following established criteria...
June 28, 2018: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29916772/triple-arterial-phase-ct-of-the-liver-with-radiation-dose-equivalent-to-that-of-single-arterial-phase-ct-initial-experience
#6
Katharina Brehmer, Torkel B Brismar, Fabian Morsbach, Anders Svensson, Per Stål, Antonios Tzortzakakis, Nikolaos Voulgarakis, Michael A Fischer
Purpose To develop and evaluate a triple arterial phase CT liver protocol with a similar radiation dose to that of standard single arterial phase CT in study subjects suspected of having hepatocellular carcinoma (HCC). Materials and Methods The study consisted of a retrospective part A for protocol development (n = 15) and a prospective part B to evaluate diagnostic accuracy (n = 38). All 53 participants underwent perfusion CT with 50 mL contrast material between August 2013 and September 2014. Group B underwent an additional standard multiphasic liver CT examination with 120 mL of contrast material (range, 70-143 mL)...
October 2018: Radiology
https://www.readbyqxmd.com/read/29904242/noninvasive-imaging-of-hepatocellular-carcinoma-from-diagnosis-to-prognosis
#7
REVIEW
Han-Yu Jiang, Jie Chen, Chun-Chao Xia, Li-Kun Cao, Ting Duan, Bin Song
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Hepatocarcinogenesis is a complex multistep process at molecular, cellular, and histologic levels with key alterations that can be revealed by noninvasive imaging modalities. Therefore, imaging techniques play pivotal roles in the detection, characterization, staging, surveillance, and prognosis evaluation of HCC. Currently, ultrasound is the first-line imaging modality for screening and surveillance purposes...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29865043/differentiation-of-malignant-liver-tumors-by-software-based-perfusion-quantification-with-dynamic-contrast-enhanced-ultrasound-dceus
#8
Dane Wildner, Barbara Schellhaas, Daniel Strack, Ruediger S Goertz, Lukas Pfeifer, Cornelia Fießler, Markus F Neurath, Deike Strobel
BACKGROUNDEnhancement patterns on contrast-enhanced ultrasound (CEUS) help to distinguish different liver tumors. OBJECTIVE: Assessing the diagnostic value of dynamic contrast-enhanced ultrasound (DCEUS) for the discrimination of different malignant liver lesions. METHODS: 148 malignant focal liver lesions were assessed prospectively with DCEUS (hepatocellular carcinoma = HCC; cholangiocellular carcinoma = CCC; pancreatic adenocarcinoma = PCA; breast cancer = BC; colorectal cancer = CRC; melanoma = MM)...
May 25, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29758936/evaluation-of-integrated-color-coded-perfusion-analysis-for-contrast-enhanced-ultrasound-ceus-after-percutaneous-interventions-for-malignant-liver-lesions-first-results
#9
I Wiesinger, L P Beyer, N Zausig, N Verloh, P Wiggermann, C Stroszczynski, E M Jung
BACKGROUND:  With the rising number of percutaneous ablation therapies in malignant liver lesions there is a need of reliable diagnostics after the intervention to differentiate between reactive changes and tumor. PURPOSE: To assess the success of percutaneous ablation therapies for malignant liver lesions using CEUS with perfusion analysis. MATERIAL AND METHODS: Retrospective analysis of perfusion analysis for 67 patients with 94 malignant liver lesions, treated with ablation therapies...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29563601/quantitative-perfusion-imaging-of-neoplastic-liver-lesions-a-multi-institution-study
#10
Shivani Pahwa, Hao Liu, Yong Chen, Sara Dastmalchian, Gregory O'Connor, Ziang Lu, Chaitra Badve, Alice Yu, Katherine Wright, Hamid Chalian, Shengxiang Rao, Caixia Fu, Ignacio Vallines, Mark Griswold, Nicole Seiberlich, Mengsu Zeng, Vikas Gulani
We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48-72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29353652/modeling-of-normal-tissue-complications-using-imaging-and-biomarkers-after-radiation-therapy-for-hepatocellular-carcinoma
#11
Issam El Naqa, Adam Johansson, Dawn Owen, Kyle Cuneo, Yue Cao, Martha Matuszak, Latifa Bazzi, Theodore S Lawrence, Randall K Ten Haken
PURPOSE: To develop normal tissue complications (NTCP) models for hepatocellular cancer (HCC) patients who undergo liver radiation therapy (RT) and to evaluate the potential role of functional imaging and measurement of blood-based circulating biological markers before and during RT to improve the performance of these models. METHODS AND MATERIALS: The data from 192 HCC patients who had undergone RT from 2005 to 2014 were evaluated. Of the 192 patients, 146 had received stereotactic body RT (SBRT) and 46 had received conventional RT to a median physical tumor dose of 49...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29279500/hepatic-angiomyolipoma-staining-in-the-post-vascular-phase-of-contrast-enhanced-ultrasound-due-to-the-presence-of-macrophages
#12
Kei Endo, Hidekatsu Kuroda, Keisuke Kakisaka, Takayoshi Oikawa, Kei Sawara, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
A 47-year-old Japanese man was referred to hospital after the detection of a liver tumor. Dynamic computed tomography and gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging were consistent with a diagnosis of hepatocellular carcinoma (HCC). No perfusion defect was observed in the post-vascular phase of contrast-enhanced ultrasound (CEUS). Histopathological staining of the tumor cells was positive for antibodies against HMB-45 and cluster of differentiation (CD) 68, confirming the diagnosis of hepatic angiomyolipoma (HAML)...
May 1, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29279169/hepatocellular-carcinoma-treated-with-sorafenib-arterial-tumor-perfusion-in-dynamic-contrast-enhanced-ct-as-early-imaging-biomarkers-for-survival
#13
Yuko Nakamura, Tomokazu Kawaoka, Toru Higaki, Wataru Fukumoto, Yukiko Honda, Makoto Iida, Chikako Fujioka, Masao Kiguchi, Hiroshi Aikata, Kazuaki Chayama, Kazuo Awai
OBJECTIVES: To investigate whether hepatic perfusion CT yields early imaging biomarkers predictive of the prognosis of hepatocellular carcinoma (HCC) patients treated with sorafenib. METHODS: We evaluated 36 HCC patients who underwent hepatic perfusion CT before- and one week after sorafenib therapy. We measured arterial and portal perfusion in the hepatic tumor and liver parenchyma [(AP)(PP)tumor ], [(AP)(PP)liver ]. The perfusion ratio was calculated by dividing the post- by the pre-sorafenib value...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/28583645/diagnostic-value-of-dynamic-contrast-enhanced-ct-with-perfusion-imaging-in-the-quantitative-assessment-of-tumor-response-to-sorafenib-in-patients-with-advanced-hepatocellular-carcinoma-a-feasibility-study
#14
Davide Ippolito, Giulia Querques, Stefano Okolicsanyi, Cammillo Talei Franzesi, Mario Strazzabosco, Sandro Sironi
PURPOSE: To investigate the feasibility of perfusion-CT (p-CT) measurements in quantitative assessment of hemodynamic changes related to sorafenib in patients with advanced hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Twenty-two patients with advanced HCC underwent p-CT study (256-MDCT scanner) before and 2 months after sorafenib administration. Dedicated perfusion software generated a quantitative map of arterial and portal perfusion and calculated the following perfusion parameters in target liver lesion: hepatic perfusion (HP), time-to-peak (TTP), blood volume (BV), arterial perfusion (AP), and hepatic perfusion index (HPI)...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28296685/computed-tomography-perfusion-following-transarterial-chemoembolization-of-hepatocellular-carcinoma-a-feasibility-study-in-the-early-period
#15
Thomas Wimmer, Juergen Steiner, Emina Talakic, Rudolf Stauber, Franz Quehenberger, Rupert Horst Portugaller, Helmut Schoellnast
OBJECTIVES: The aim of this study was to assess the feasibility of computed tomography (CT) perfusion in early follow-up after transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). METHODS: Fifteen patients with a total of 16 HCC who were referred to our institution for TACE were included in the study. Computed tomography perfusion was performed within 1 to 3 days before and 4 to 7 days after TACE. Multiphase contrast-enhanced CT was performed 35 (SD, 20) days after TACE...
September 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27812781/ct-perfusion-for-early-response-evaluation-of-radiofrequency-ablation-of-focal-liver-lesions-first-experience
#16
Herman P Marquez, Gilbert Puippe, Rishi Philip Mathew, Hatem Alkadhi, Thomas Pfammatter, Michael A Fischer
PURPOSE: To investigate the value of perfusion CT (P-CT) for early assessment of treatment response in patients undergoing radiofrequency ablation (RFA) of focal liver lesions. METHODS AND MATERIALS: 20 consecutive patients (14 men; mean age 64 ± 14) undergoing P-CT within 24 h after RFA of liver metastases (n = 10) or HCC (n = 10) were retrospectively included. Two readers determined arterial liver perfusion (ALP, mL/min/100 mL), portal liver perfusion (PLP, mL/min/100 mL), and hepatic perfusion index (HPI, %) in all post-RFA lesions by placing a volume of interest in the necrotic central (CZ), the transition (TZ), and the surrounding parenchymal (PZ) zone...
January 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27776657/vegfr-2-expression-in-hcc-dysplastic-and-regenerative-liver-nodules-and-correlation-with-pre-biopsy-dynamic-contrast-enhanced-ct
#17
W M Thaiss, S Kaufmann, C Kloth, K Nikolaou, H Bösmüller, M Horger
PURPOSE: To evaluate whether VEGFR-2-expression in hepatocellular carcinoma (HCC), dysplastic (DLN) and regenerative liver nodules (RLN) correlates with pre-histology, in vivo Dynamic Contrast Enhanced-Computed Tomography (DCE-CT) data as VEGFR-2-expression affects prognosis and therapeutic options. MATERIALS AND METHODS: 34 patients (63.6±8.9years, 7 females) underwent liver biopsy or surgery due to suspected HCC or dysplastic nodules after DCE-CT between 2009 and 2015 with no previous chemo- or interventional therapy...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27728840/quantitative-analysis-of-microcirculation-blood-perfusion-in-patients-with-hepatocellular-carcinoma-before-and-after-transcatheter-arterial-chemoembolisation-using-contrast-enhanced-ultrasound
#18
Hui Tian, Qi Wang
To conduct a quantitative analysis of microcirculation blood perfusion in patients with hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolisation (TACE) using contrast-enhanced ultrasound (CEUS). From 2013 June to 2105 October, a total of 106 HCC patients undergoing TACE were recruited. CEUS was performed before and after TACE to determine time-intensity curve (TIC) and perfusion quantitative parameters of the HCC lesions and surrounding liver parenchyma. Quantitative perfusion parameters were obtained using the region of interest method...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27551338/correlation-of-magnetic-resonance-signal-characteristics-and-perfusion-parameters-assessed-by-volume-perfusion-computed-tomography-in-hepatocellular-carcinoma-impact-on-lesion-characterization
#19
Gerd Grözinger, Michael Bitzer, Roland Syha, Dominik Ketelsen, Konstantin Nikolaou, Ulrich Lauer, Marius Horger
AIM: To find out if magnetic resonance (MR)-signal characteristics of hepatocellular carcinomas (HCC) correlate with perfusion parameters assessed by volume perfusion computed tomography (VPCT). METHODS: From October 2009 to January 2014, 26 (mean age, 69.3 years) patients with 36 HCC lesions who underwent both VPCT and MR liver imaging were analysed. We compared signal intensity in the T1w- and T2w-images and wash-in/wash-out kinetics on post-contrast MR images with mean values of blood flow (BF, mL/100 mL per minute), blood volume (BV, mL/100 mL), k-trans (mL/100 mL per minute), arterial liver perfusion (mL/100 mL per minute), portal venous perfusion and hepatic perfusion index (HPI, %) obtained by VPCT...
July 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27258196/parametric-imaging-with-contrast-enhanced-ultrasound-for-differentiating-hepatocellular-carcinoma-from-metastatic-liver-cancer
#20
Wen-Wen Yue, Shuo Wang, Hui-Xiong Xu, Li-Ping Sun, Le-Hang Guo, Xiao-Wan Bo, Xiao-Long Li, Chong-Ke Zhao, Dan Wang, Bo-Ji Liu
AIM: To evaluate the diagnostic performance of parametric imaging with contrast-enhanced ultrasound(CEUS) for differentiating hepatocellular carcinoma(HCC) from metastatic liver cancer(MLC). METHODS: 30 HCCs (mean diameter, 3.6±1.3 cm; range, 2.1-5.0 cm) and 30 MLCs (mean diameter, 2.8±1.5 cm; range, 1.2-5.0 cm) pathologically diagnosed or confirmed by clinical criteria that underwent CEUS were randomly included. CEUS was carried out using a multifrequency transducer (2-4 MHz) and a bolus injection of 2...
November 25, 2016: Clinical Hemorheology and Microcirculation
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