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Lymphedema cancer

Andrea L Cheville, Sarah A McLaughlin, Tufia Haddad, Kathleen D Lyons, Robin Newman, Kathryn J Ruddy
The physical and psychological side effects of breast cancer therapies can have substantial impact on survivors' physical and social functioning. Roughly half of the more than 3 million Americans alive with a history of breast cancer report adverse, function-degrading sequelae related to their oncologic treatments. Care delivery models for the timely delivery of rehabilitation services have been proposed yet limitedly vetted or implemented. These include the prospective surveillance model, procedure-linked referrals, survivorship care plans and risk stratification...
August 16, 2018: American Journal of Physical Medicine & Rehabilitation
N LeVasseur, C Stober, M Ibrahim, S Gertler, J Hilton, A Robinson, S McDiarmid, D Fergusson, S Mazzarello, B Hutton, A A Joy, M McInnes, M Clemons
Background: The choice of vascular access for systemic therapy administration in breast cancer remains an area of clinical equipoise, and patient preference is not consistently acknowledged. Using a patient survey, we evaluated the patient experience with vascular access during treatment for early-stage breast cancer and explored perceived risk factors for lymphedema. Methods: Patients who had received systemic therapy for early-stage breast cancer were surveyed at 2 Canadian cancer centres...
August 2018: Current Oncology
N LeVasseur, C Stober, K Daigle, A Robinson, S McDiarmid, S Mazzarello, B Hutton, A Joy, D Fergusson, J Hilton, M McInnes, M Clemons
Background: Despite advances in systemic therapy choices for patients with early-stage breast cancer, optimal practices for intravenous (IV) access remain unknown. That lack of knowledge holds particularly true for the use of central venous access devices (cvads) such as peripherally inserted central catheters (piccs) and implanted vascular access devices (ports). Methods: Using a survey of Canadian oncologists and oncology nurses responsible for the care of breast cancer patients, we evaluated current access practices, perceptions of complications, and perceptions of risk, and we estimated complication rates and evaluated perceived risk factors for lymphedema...
August 2018: Current Oncology
B Manju, Cherian Koshy, Sibi M Ismail, O Rajasree, Rachel C Koshy
We report a case of massive upper-limb edema necessitating disarticulation, in a cancer survivor who tended to ignore instructions regarding preventive exercises since 2002 after completion of her treatment for breast cancer. However, she was in a family situation where she was constrained to physically involve in daily chores. Consequently, she presented 14 years later with a lymphedematous arm which weighed over 31 kg, necessitating disarticulation. We highlight the role of preventive exercises in postmastectomy patients and also the efficacy of continuous nerve block techniques in preventing the development of phantom limb pain in cases of disarticulation and amputation...
July 2018: Indian Journal of Palliative Care
I-Wen Penn, Yue-Cune Chang, Eric Chuang, Chi-Ming Chen, Chi-Feng Chung, Chia-Yu Kuo, Tien-Yow Chuang
PURPOSE: Breast-cancer-related lymphedema (BCRL) can be a transient or persistent condition. The aims of this study were to (1) identify and weigh the risk factors for persistent lymphedema (PLE) among all patients with BCRL and (2) establish a prediction model for the occurrence of PLE. METHODS: A cohort of 342 patients with BCRL with a median follow-up of 5 years after the onset of swelling was analyzed. PLE was defined as a hardening of the subcutaneous tissue, the persistence of the circumferential difference (CD) between arms, or a flare-up of swelling during follow-up...
August 14, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Jeffrey P Gross, Sean Sachdev, Irene B Helenowski, David Lipps, John P Hayes, Eric D Donnelly, Jonathan B Strauss
PURPOSE: The occurrence of upper extremity lymphedema after regional nodal irradiation (RNI) for breast cancer treatment varies significantly based on patient and treatment factors. The relationship between the radiation therapy (RT) field design and lymphedema risk is not well-characterized. The present study sought to correlate the variations in RT field design with lymphedema outcomes. METHODS AND MATERIALS: Women with stage II-IV breast cancer receiving RNI after breast surgery that included sentinel lymph node biopsy or axillary dissection were identified...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Pamela Liao, Kathleen Rossini, Roberts Sauls
Lymphedema is a challenging condition that occurs as a complication to many life-limiting medical conditions. It has a number of associated symptoms including pain, functional impairments, and emotional distress. Majority of treatment interventions have been studied and applied outside of the palliative care context. Subcutaneous drainage is a technique that has been used in some case reports for the lower extremity and sacrum with good results. This report describes an adapted technique of subcutaneous drainage for treating upper extremity lymphedema in the palliative setting...
August 13, 2018: American Journal of Hospice & Palliative Care
Tae-Hun Kim, Jung Won Kang, Myeong Soo Lee
BACKGROUND: Breast cancer survivors experience various symptoms associated with their cancer interventions, and the benefits of acupuncture for these symptoms have been evaluated in clinical trials worldwide. The purpose of this review was to discuss the current status of clinical research regarding the use of acupuncture as a part of traditional Korean medicine (KM) for various symptoms associated with breast cancer therapies. METHODS: We conducted a systematic review of the literature regarding the use of acupuncture as a part of traditional KM to treat symptoms associated with breast cancer therapies...
August 2018: Medicine (Baltimore)
Reishi Toshiyama, Masamitsu Konno, Hidetoshi Eguchi, Hiroyasu Takemoto, Takehiro Noda, Ayumu Asai, Jun Koseki, Naotsugu Haraguchi, Yuji Ueda, Katsunori Matsushita, Kei Asukai, Tomofumi Ohashi, Yoshifumi Iwagami, Daisaku Yamada, Daisuke Sakai, Tadafumi Asaoka, Toshihiro Kudo, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Taroh Satoh, Yuichiro Doki, Nobuhiro Nishiyama, Masaki Mori, Hideshi Ishii
Previous studies highlighted that aminopeptidase N (APN)/CD13 acts as a scavenger in the survival of hepatocellular carcinoma (HCC) stem cells by reducing reactive oxygen species (ROS) levels. Hence, it has been proposed that APN/CD13 inhibition can increase cellular ROS levels and sensitize cells to chemotherapeutic agents. Although ubenimex, also known as bestatin, competitively inhibits proteases such as APN/CD13 on the cellular membrane and it is clinically used for patients with acute myeloid leukemia and lymphedema, research has demonstrated that higher concentrations of the agent induce the death of APN/CD13+ HCC stem cells...
August 8, 2018: Oncogene
L Vergara de la Campa, E R Martínez Lorenzo, E Molina Figuera
No abstract text is available yet for this article.
July 31, 2018: Revista Clínica Española
Adriano Rodríguez-Trujillo, Pere Fusté, Pilar Paredes, Eduard Mensión, Núria Agustí, Blanca Gil-Ibáñez, Marta Del Pino, Eduardo González-Bosquet, Aureli Torné
INTRODUCTION: To compare oncological outcomes and morbidity in patients with early-stage vulvar cancer with negative sentinel lymph node (SLN) biopsy vs. negative inguinofemoral lymphadenectomy (IFL). MATERIAL AND METHODS: Study with retrospective collected data in patients with squamous cell vulvar carcinomas ≤ 4 cm without suspected inguinofemoral lymph node metastases. Only patients with negative nodes after histopathology procedure were followed. Patients who underwent only SLN were compared with patients who underwent IFL +/- SLN in order to compare recurrences and survival rates and morbidity...
July 31, 2018: Acta Obstetricia et Gynecologica Scandinavica
Fangdi Sun, Alexander Hall, Megan P Tighe, Cheryl L Brunelle, Hoda E Sayegh, Tessa C Gillespie, Kayla M Daniell, Alphonse G Taghian
PURPOSE: Despite increasing emphasis on screening and early intervention for breast cancer-related lymphedema (BCRL), there is marked heterogeneity in diagnostic methodology, including for volumetric measures. This retrospective study compared two volumetric modalities, perometry and simulated circumferential tape measurement (anatomic- and interval-based), for BCRL detection. METHODS: Between 2005 and 2017, 287 female patients with unilateral breast cancer were prospectively screened for BCRL by perometry and the relative volume change (RVC) formula...
July 30, 2018: Breast Cancer Research and Treatment
Hung Chun Fu, Jen Ruei Chen, Min Yu Chen, Keng Fu Hsu, Wen Fang Cheng, An Jen Chiang, Yu Min Ke, Yu Chieh Chen, Yin Yi Chang, Chia Yen Huang, Chieh Yi Kang, Yuan Yee Kan, Sheng Mou Hsiao, Ming Shyen Yen
OBJECTIVE: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. METHODS: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated...
September 2018: Journal of Gynecologic Oncology
Jonas Gustafsson, Sung-Yu Chu, Wen-Hui Chan, Ming-Huei Cheng
BACKGROUND: Vascularized lymph node transfer (VLNT) has shown promising results in the treatment of lower limb lymphedema, but little is known about the number of lymph nodes needed for the transfer to achieve optimal results. This study investigated the correlation between number of transferred lymph nodes in submental VLNT and outcomes regarding limb circumference reduction and cellulitis incidence. METHODS: Thirty-five patients who had received submental VLNT to an ankle for lower limb lymphedema, post-gynecological cancer treatment, were included in the study...
July 10, 2018: Plastic and Reconstructive Surgery
Benoit Ayestaray, Theodoros Chrelias
BACKGROUND: Breast lymphedema is a common issue after breast cancer surgery but remains understudied because it is difficult to be quantified. Untreated breast lymphedema may lead to severe form of delayed breast cellulitis. Supermicrosurgical lymphaticovenular anastomosis is one option for the treatment of breast cancer-related lymphedema but has not been described for the treatment of breast lymphedema. METHODS: This report presented a rare case of male breast lymphedema secondary to axillary lymph node dissection for the treatment of a forearm melanoma...
July 10, 2018: Annals of Plastic Surgery
Mads Gustaf Jørgensen, Navid Mohammadpour Toyserkani, Christian Rønn Hansen, Svend Hvidsten, Christina Baun, Eva Kildall Hejbøl, Henrik Daa Schrøder, Jens Ahm Sørensen
BACKGROUND: Lymphedema is a common and debilitating complication following cancer treatment with surgical lymph node excision and radiotherapy. Currently there are no curative treatments for lymphedema. Animal models that intended to replicate the disease have been inadequate, making a troublesome transition from experimental therapeutic studies into the clinic. It is therefore imperative to establish an experimental animal model that can reliably replicate clinical lymphedema. METHODS: To discover the optimal method of lymphedema induction, surgical lymph ablation and irradiation or silicone splint emplacement were combined in 8 experimental groups (n = 4)...
July 10, 2018: Annals of Plastic Surgery
Lyndsey J Kilgore, Sabrina S Korentager, Amanda N Hangge, Amanda L Amin, Christa R Balanoff, Kelsey E Larson, Melissa P Mitchell, John G Chen, Emily Burgen, Qamar J Khan, Anne P O'Dea, Lauren Nye, Priyanka Sharma, Jamie L Wagner
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a chronic progressive disease that results from breast cancer treatment and nodal surgery. NCCN guidelines support baseline measurements with prospective assessment for early diagnosis and treatment. We sought to determine if baseline measurement with bioimpedance spectroscopy (BIS) and serial postoperative evaluations provide early detection amenable to conservative interventions that reduce BCRL. METHODS: Breast cancer patients with unilateral disease high-risk for BCRL from a single institution were evaluated from November 2014 to December 2017...
July 9, 2018: Annals of Surgical Oncology
Jane M Armer, Karla V Ballman, Linda McCall, Nathan C Armer, Yuanlu Sun, Tipparat Udmuangpia, Kelly K Hunt, Elizabeth A Mittendorf, David R Byrd, Thomas B Julian, Judy C Boughey
PURPOSE: Lymphedema is a potential complication of breast cancer treatment. This longitudinal substudy aimed to prospectively assess arm measurements and symptoms following neoadjuvant chemotherapy and axillary dissection in the ACOSOG/Alliance Z1071 trial to characterize the optimal approach to define lymphedema. METHODS: Z1071 enrolled patients with cT0-4, N1-2, M0 disease treated with neoadjuvant chemotherapy. All patients underwent axillary dissection. Bilateral limb volumes, circumferences, and related symptoms were assessed pre-surgery, 1-2 weeks post-surgery, and semiannually for 36 months...
July 6, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Susan J Doh, Michael Yamakawa, Samuel M Santosa, Mario Montana, Kai Guo, Joseph R Sauer, Nicholas Curran, Kyu-Yeon Han, Charles Yu, Masatsugu Ema, Mark I Rosenblatt, Jin-Hong Chang, Dimitri T Azar
The study of lymphangiogenesis is an emerging science that has revealed the lymphatic system as a central player in many pathological conditions including cancer metastasis, lymphedema, and organ graft rejection. A thorough understanding of the mechanisms of lymphatic growth will play a key role in the development of therapeutic strategies against these conditions. Despite the known potential of this field, the study of lymphatics has historically lagged behind that of hemangiogenesis. Until recently, significant strides in lymphatic studies were impeded by a lack of lymphatic-specific markers and suitable experimental models compared to those of the more immediately visible blood vasculature...
July 3, 2018: Angiogenesis
Ines Gruber, Maja Henzel, Birgitt Schönfisch, Annette Stäbler, Florin-Andrei Taran, Markus Hahn, Carmen Röhm, Gisela Helms, Ernst Oberlechner, Benjamin Wiesinger, Konstantin Nikolaou, Christian LA Fougère, Diethelm Wallwiener, Andreas Hartkopf, Natalia Krawczyk, Tanja Fehm, Sara Brucker
BACKGROUND/AIM: Only 30-50% of patients with sentinel lymph node (SLN) metastases present with further axillary lymph node metastases. Therefore, up to 70% of patients with positive SLN are overtreated by axillary dissection (AD) and may suffer from complications such as sensory disturbances or lymphedema. According to the current S3 guidelines, AD can be avoided in patients with a T1/T2 tumor if breast-conserving surgery with subsequent tangential irradiation is performed and no more than two SLNs are affected...
July 2018: Anticancer Research
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