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https://www.readbyqxmd.com/read/30106601/the-metabolic-syndrome-and-health-behaviors-in-school-children-aged-13-16-years-in-ubon-ratchathani-umesia-project
#1
Phalakorn Suebsamran, Taksin Pimpak, Patnapa Thani, Parinya Chamnan
BACKGROUND: Although metabolic syndrome (MetS) has become a significant public health problem worldwide, little evidence exists to describe the prevalence of MetS in school children using MetS different classifications, and its association with health-related behaviors. METHODS: Using data on 393 children and adolescents aged 13-16 years participating in the Ubon Ratchathani Metabolic Syndrome in Adolescent (UMeSIA) Project, the prevalence of MetS was determined using the International Diabetes Federation (IDF) 2007 definition and other three classifications reported in the previous literature...
August 14, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/30105373/association-between-sodium-glucose-cotransporter-2-inhibitors-and-lower-extremity-amputation-among-patients-with-type-2-diabetes
#2
Hsien-Yen Chang, Sonal Singh, Omar Mansour, Sheriza Baksh, G Caleb Alexander
Importance: Results of clinical trials suggest that canagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor for treating type 2 diabetes, may be associated with lower extremity amputation. Objective: To quantify the association between the use of oral medication for type 2 diabetes and 5 outcomes (lower extremity amputation, peripheral arterial disease, critical limb ischemia, osteomyelitis, and ulcer). Design, Setting, and Participants: A retrospective cohort study was conducted using Truven Health MarketScan Commercial Claims and Encounters data on new users between September 1, 2012, and September 30, 2015...
August 13, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/30103423/retinoid-x-receptor-antagonists
#3
REVIEW
Masaki Watanabe, Hiroki Kakuta
Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.
August 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30103106/docking-and-qsar-analysis-of-tetracyclic-oxindole-derivatives-as-%C3%AE-glucosidase-inhibitors
#4
M Asadollahi-Baboli, S Dehnavi
The α-glucosidase inhibitors are considered as important agents in drug discovery against diabetes mellitus. Molecular docking and quantitative structure-activity relationship (QSAR) were performed based on a series of tetracyclic oxindole derivatives to elucidate key structural properties affecting inhibitory activity and support the design of new α-glucosidase inhibitors. The molecular docking results demonstrate that at least two hydrogen bonds between Thr681 and Arg676 residues and the oxygen atoms in amid groups have an important role in the optimum binding of inhibitors...
July 31, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30101924/diabetic-nephropathy-a-comparison-of-the-clinical-and-pathological-features-between-the-ckd-risk-classification-and-the-classification-of-diabetic-nephropathy-2014-in-japan
#5
Kengo Furuichi, Miho Shimizu, Akinori Hara, Tadashi Toyama, Takashi Wada
Diabetic kidney disease is the main cause of end-stage kidney disease. However, the clinical manifestations of diabetic kidney disease are diverse. Therefore, the clinical classification of diabetic kidney disease is clinically important and valuable. In Japan, two clinical staging systems divided by the estimated glomerular filtration rate (eGFR) and albuminuria can be used for diabetic kidney disease: the CKD risk classification and the Japanese classification of diabetic nephropathy. The Japanese classification of diabetic nephropathy and the CKD risk classification are similar; however, these two classification systems show different frequencies of outcomes...
August 10, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30100760/cross-national-health-care-database-utilization-between-spain-and-france-results-from-the-epichronic-study-assessing-the-prevalence-of-type-2-diabetes-mellitus
#6
Guillaume Moulis, Berta Ibañez, Aurore Palmaro, Felipe Aizpuru, Eduardo Millan, Maryse Lapeyre-Mestre, Laurent Sailler, Koldo Cambra
Aim: The EPICHRONIC (EPIdemiology of CHRONIC diseases) project investigated the possibility of developing common procedures for French and Spanish electronic health care databases to enable large-scale pharmacoepidemiological studies on chronic diseases. A feasibility study assessed the prevalence of type 2 diabetes mellitus (T2DM) in Navarre and the Basque Country (Spain) and the Midi-Pyrénées region (France). Patients and methods: We described and compared database structures and the availability of hospital, outpatient, and drug-dispensing data from 5...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/30098888/associations-between-recent-and-established-ophthalmic-conditions-and-risk-of-alzheimer-s-disease
#7
Cecilia S Lee, Eric B Larson, Laura E Gibbons, Aaron Y Lee, Susan M McCurry, James D Bowen, Wayne C McCormick, Paul K Crane
INTRODUCTION: Identifying ophthalmic diseases associated with increased risk of Alzheimer's disease (AD) may enable better screening and understanding of those at risk of AD. METHODS: Diagnoses of glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR) were based on International Classification of Diseases, 9th revision, codes for 3877 participants from the Adult Changes in Thought study. The adjusted hazard ratio for developing probable or possible AD for recent (within 5 years) and established (>5 years) diagnoses were assessed...
August 2, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/30098369/incidental-findings-on-brain-mri-in-a-cohort-of-diabetic-patients
#8
D Vázquez-Justes, J Sanahuja, J Diez, E Rubinat, R Begué, C Salas, C Vicandi, M I Gil, F Purroy, D Mauricio
OBJECTIVE: To study the frequency and management of incidental findings in nonenhanced brain MRI of a middle-aged population of type 2 diabetic patients. METHODS: We retrospectively analyzed the results of 289 brain MRI obtained from subjects between 40-75 years recruited from a previous study. Incidental findings were classified into three categories: 1) Vascular findings; 2) neoplastic findings; and 3) others. On the other side, we made a classification of referral findings...
August 8, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/30097043/using-appropriate-pre-pregnancy-body-mass-index-cut-points-for-obesity-in-the-chinese-population-a-retrospective-cohort-study
#9
Yanxin Wu, Wai-Kit Ming, Dongyu Wang, Haitian Chen, Zhuyu Li, Zilian Wang
BACKGROUND: Appropriate classification of obesity is vital for risk assessment and complication prevention during pregnancy. We aimed to explore which pre-pregnancy BMI cut-offs of obesity, either BMI ≥ 25 kg/m2 as recommended by the WHO for Asians or BMI ≥ 28 kg/m2 as suggested by the Working Group on Obesity in China (WGOC), best predicts the risk of adverse maternal and perinatal outcomes. METHODS: We retrospectively reviewed 11,494 medical records for live singleton deliveries in a tertiary center in Guangzhou, China, between January 2013 and December 2016...
August 10, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30095652/risk-factors-for-increased-postoperative-drainage-of-calcaneal-fractures-after-open-reduction-and-internal-fixation-an-observational-study
#10
Zitao Zhang, Zhen Wang, Yan Zhang, Xusheng Qiu, Yixin Chen
Sufficient drainage is very important for preventing wound complications after open reduction and internal fixation (ORIF) of calcaneal fractures. However, the drainage amount varies among patients. The objective of this study was to identify factors associated with increased postoperative drainage after ORIF of calcaneal fractures.A retrospective study including 87 patients with 92 calcaneal fractures in our hospital was performed. Patients were divided into 2 groups based on whether they had increased drainage, which was defined as a total drainage of ≥340 mL (50th percentile)...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30090920/the-role-of-obesity-in-the-association-between-posttraumatic-stress-disorder-and-incident-diabetes
#11
Jeffrey F Scherrer, Joanne Salas, Patrick J Lustman, Carissa van den Berk-Clark, Paula P Schnurr, Peter Tuerk, Beth E Cohen, Matthew J Friedman, Sonya B Norman, F David Schneider, Kathleen M Chard
Importance: Posttraumatic stress disorder (PTSD) is associated with an increased risk of type 2 diabetes mellitus (T2DM). Existing literature has adjusted for obesity in combination with other confounders, which does not allow estimating the contribution of obesity alone on the association of PTSD with incident T2DM. Objective: The current study was designed to determine if obesity accounted for the association between PTSD and incident T2DM. Design, Setting, and Participants: This cohort study used data from Veterans Health Administration medical records collected from patients with PTSD and without PTSD from 2008 to 2015...
August 8, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30090730/prevalence-of-pediatric-metabolic-syndrome-and-associated-risk-factors-among-school-age-children-of-10-16-years-living-in-district-shimla-himachal-pradesh-india
#12
Anmol Gupta, Amit Sachdeva, Narender Mahajan, Aakriti Gupta, Neha Sareen, Ravindra Mohan Pandey, Lakshmy Ramakrishnan, Hem Chandra Sati, Brij Sharma, Neetu Sharma, Umesh Kapil
Introduction: Recently, an increasing trend in the prevalence of pediatric metabolic syndrome (PMS) among school-age children has been documented in different parts of India. There is lack of data on the prevalence of PMS and its associated risk factors among school-age children living in district Shimla, Himachal Pradesh. Hence, to fill in the gap in the existing knowledge, the present study was conducted. Methodology: A cross-sectional study was conducted during 2015-2016...
May 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30088631/training-in-diabetes-education-meanings-attributed-by-primary-care-nurses
#13
Magda Coeli Vitorino Sales Coêlho, Camila Aparecida Pinheiro Landim Almeida, Ana Roberta Vilarouca da Silva, Luana Kelle Batista Moura, Lucíola Galvão Gondim Corrêa Feitosa, Laura Barbosa Nunes
OBJECTIVE: seize meanings attributed by primary care nurses to training in diabetes education. METHOD: exploratory and descriptive study, with a qualitative approach, with twenty primary care nurses; semistructured interview script, with interviews processed in the IRaMuTeQ software and analyzed through the Descending Hierarchical Classification. The results were subsidized in the Representational Theory of Meaning. RESULTS: nurse training in diabetes education is insufficient for holistic action, although it allows the community to be instrumentalized in specific issues about the disease, using the limited tools available, especially lectures...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/30086044/risk-factors-for-kidney-dysfunction-with-the-use-of-gentamicin-in-open-fracture-antibiotic-treatment
#14
Jacob Folse, Charles E Hill, Matthew L Graves, George V Russell, Josie Hydrick, LaRita C Jones, William H Replogle, Patrick F Bergin, Clay A Spitler
OBJECTIVES: To evaluate all patients who received gentamicin for open fracture treatment and determine the incidence of, and risk factors for, kidney injury in this population. DESIGN: Retrospective, Case Control SETTING:: Single institution; Level 1 trauma center PATIENTS/PARTICIPANTS:: A retrospective chart review identified patients who received gentamicin for open fracture antibiotic treatment from January 2008-December 2012. Overall, 371 patients met inclusion criteria and were categorized into 2 groups using RIFLE criteria: normal kidney function (74...
July 30, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/30085245/renal-albumin-excretion-in-healthy-young-adults-and-its-association-with-mortality-risk-in-the-us-population
#15
Jiehan Chong, James Fotheringham, Charles Tomson, Timothy Ellam
Background: Current classification systems do not specify a healthy normal range for urinary albumin excretion. Occult microvascular disease induced by a Western lifestyle may mean that normal values for apparently healthy adults exceed optimal levels defined by mortality risk. Methods: Using a national population sample [the US Third National Health and Nutrition Examination Survey (NHANES III) cohort; n = 11 887], the distributions of albumin:creatinine ratio (ACR) and fractional excretion of albumin (FEalb) were studied in healthy young adults [ages 20-40 years, without cardiovascular disease (CVD) or risk factors]...
August 6, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30082571/correlation-of-obesity-comorbid-conditions-with-chronic-venous-insufficiency-results-of-a-single-centre-study
#16
Sandeep Mahapatra, Pinjala Ramakrishna, Bhumika Gupta, Arumalla Anusha, Muneer Ahmad Para
Background & objectives: Chronic venous insufficiency (CVI) is a common clinical problem among obese patients. This study was conducted to evaluate the impact of body mass index (BMI) and associated morbidities such as diabetes, hypertension and hypothyroidism on venous disease clinical scores as per Clinical, Etiological, Anatomical, Pathological (CEAP) classification. Methods: In this study, adult patients with BMI more than 30 kg/m2 with signs of CVI were evaluated clinically and by using Duplex ultrasonography of venous system...
May 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/30081878/frequency-of-foot-ulcers-in-people-with-type-2-diabetes-presenting-to-specialist-diabetes-clinic-at-a-tertiary-care-hospital-lahore-pakistan
#17
Bilal Bin Younis, Adeela Shahid, Rozina Arshad, Saima Khurshid, Muhammad Ahmad, Haroon Yousaf
BACKGROUND: Diabetic foot ulceration is a serious limb-threatening complication of diabetes. It is the common cause of hospital admissions and amputations. The objective of the study was to determine the prevalence of diabetic foot ulcers (DFU) and its association with age, gender, duration of diabetes, peripheral neuropathy (PN), peripheral arterial disease (PAD) and HbA1c. METHODS: A total of 1940 people (≥ 30 years of age) with type 2 diabetes coming to the Sakina Institute of Diabetes and Endocrine Research (specialist diabetes clinic) at Shalamar Hospital, Lahore, Pakistan, were recruited over a period of 1 year from January 2016 to January 2017...
August 6, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/30081789/impaired-awareness-of-hypoglycaemia-in-insulin-treated-type-2-diabetes-mellitus
#18
Mohammad J Alkhatatbeh, Nedaa A Abdalqader, Mohammad A Y Alqudah
BACKGROUND: Patients with Type 2 Diabetes Mellitus (T2DM) may develop hypoglycemia as an adverse effect of insulin therapy. Hypoglycemia has dangerous consequences that result from neuroglycopenia and hypersecretion of counter-regulatory hormones. Patients who recognize early symptoms of hypoglycemia can initiate self-treatment and rectify the situation. Impaired awareness of hypoglycemia (IAH) predisposes patients to severe hypoglycemia and unconsciousness. OBJECTIVE: To assess prevalence of IAH, intensity of hypoglycaemic symptoms, frequency of severe hypoglycemia and factors associated with IAH in patients with insulin-treated T2DM...
August 6, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30076537/a-random-forest-classifier-based-approach-in-the-detection-of-abnormalities-in-the-retina
#19
Amrita Roy Chowdhury, Tamojit Chatterjee, Sreeparna Banerjee
Classification of abnormalities from medical images using computer-based approaches is of growing interest in medical imaging. Timely detection of abnormalities due to diabetic retinopathy and age-related macular degeneration is required in order to prevent the prognosis of the disease. Computer-aided systems using machine learning are becoming interesting to ophthalmologists and researchers. We present here one such technique, the Random Forest classifier, to aid medical practitioners in accurate diagnosis of the diseases...
August 4, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/30075532/healthcare-costs-and-utilization-of-diabetes-related-complications-in-taiwan-a-claims-database-analysis
#20
Ssu-Wei Cheng, Chin-Yuan Wang, Jin-Hua Chen, Yu Ko
To estimate the healthcare utilization and costs of major diabetes mellitus (DM)-related complications in Taiwan in the year of first occurrence and in subsequent years.This study is a retrospective claim database analysis using the longitudinal cohort of diabetes patients (LHDB) with 2012 as the base year. Occurrences of 8 DM-related complications of interest were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Annual healthcare costs and utilization of these DM-related complications in the LHDB cohorts of the years 2004 to 2009 were examined, and the generalized linear model was used to estimate annual total healthcare costs for each complication...
August 2018: Medicine (Baltimore)
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