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https://www.readbyqxmd.com/read/30513787/non-invasive-diagnosis-of-diabetes-by-volatile-organic-compounds-in-urine-using-faims-and-fox4000-electronic-nose
#1
Siavash Esfahani, Alfian Wicaksono, Ella Mozdiak, Ramesh P Arasaradnam, James A Covington
The electronic nose (eNose) is an instrument designed to mimic the human olfactory system. Usage of eNose in medical applications is more popular than ever, due to its low costs and non-invasive nature. The eNose sniffs the gases and vapours that emanate from human waste (urine, breath, and stool) for the diagnosis of variety of diseases. Diabetes mellitus type 2 (DM2) affects 8.3% of adults in the world, with 43% being underdiagnosed, resulting in 4.9 million deaths per year. In this study, we investigated the potential of urinary volatile organic compounds (VOCs) as novel non-invasive diagnostic biomarker for diabetes...
December 1, 2018: Biosensors
https://www.readbyqxmd.com/read/30509300/machine-learned-models-using-hematological-inflammation-markers-in-the-prediction-of-short-term-acute-coronary-syndrome-outcomes
#2
Konrad Pieszko, Jarosław Hiczkiewicz, Paweł Budzianowski, Janusz Rzeźniczak, Jan Budzianowski, Jerzy Błaszczyński, Roman Słowiński, Paweł Burchardt
BACKGROUND: Increased systemic and local inflammation play a vital role in the pathophysiology of acute coronary syndrome. This study aimed to assess the usefulness of selected machine learning methods and hematological markers of inflammation in predicting short-term outcomes of acute coronary syndrome (ACS). METHODS: We analyzed the predictive importance of laboratory and clinical features in 6769 hospitalizations of patients with ACS. Two binary classifications were considered: significant coronary lesion (SCL) or lack of SCL, and in-hospital death or survival...
December 3, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/30508651/type-of-pelvic-disease-as-a-risk-factor-for-surgical-site-infection-in-women-undergoing-hysterectomy
#3
Innie Chen, Abdul Jamil Choudhry, David Schramm, D William Cameron, Victor Leung, Sukhbir S Singh, Laura Hopkins, Kristina Arendas, Ranjeeta Mallick
STUDY OBJECTIVE: To quantify the relationship between type of benign pelvic disease and risk of surgical site infection (SSI) after hysterectomy DESIGN: Retrospective Cohort (Classification II-2) SETTING: Hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) PATIENT(S): Women who underwent hysterectomy from 2006-2015 and recorded in NSQIP database INTERVENTION: None MEASUREMENTS AND MAIN RESULTS: SSI risk was compared for type of benign pelvic diseases, patient characteristics (age, race and selected comorbidities) and process of care variables (admission status, type of hysterectomy, and operative time)...
November 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/30507949/is-sj%C3%A3-gren-s-syndrome-dry-eye-similar-to-dry-eye-caused-by-other-etiologies-discriminating-different-diseases-by-dry-eye-tests
#4
Denny Marcos Garcia, Fabiola Reis de Oliveira, Carolina Maria Módulo, Jacqueline Faustino, Amanda Pires Barbosa, Monica Alves, Eduardo Melani Rocha
PURPOSE: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS. METHODS: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK)...
2018: PloS One
https://www.readbyqxmd.com/read/30501817/improvement-of-glibenclamide-water-solubility-by-nanoparticle-preparation
#5
Eliska Vaculikova, Aneta Pokorna, Daniela Placha, Martin Pisarcik, Katerina Dedkova, Pavlina Peikertova, Ferdinand Devinsky, Josef Jampilek
Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0...
May 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30500579/predictors-of-discharge-disposition-following-laminectomy-for-intradural-extramedullary-spinal-tumors
#6
Amy Ahn, Kevin Phan, Zoe B Cheung, Samuel Jw White, Jun S Kim, Samuel K Cho
OBJECTIVE: To identify independent risk factors for non-home discharge in patients undergoing laminectomy for intradural extramedullary (IDEM) spinal tumors. METHODS: We performed a retrospective cohort analysis of data from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) from 2011 to 2014. Adult patients undergoing laminectomy for the excision of IDEM spinal tumors were included and divided into 2 groups based on home or non-home discharge disposition...
November 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30496929/predictors-of-30-day-postoperative-pulmonary-complications-following-open-reduction-and-internal-fixation-of-vertebral-fractures
#7
Ivan Ye, Ray Tang, Samuel J White, Zoe B Cheung, Samuel K Cho
OBJECTIVE: The purpose of this study was to identify predictors of 30-day postoperative pulmonary complications following open reduction and internal fixation (ORIF) of vertebral fractures. METHODS: We performed a retrospective study using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2010 to 2014. Adult patients who underwent ORIF of vertebral fractures were included and divided into 2 groups based on the occurrence of 30-day postoperative pulmonary complications...
November 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30485780/attention-deficit-hyperactivity-disorder-and-month-of-school-enrollment
#8
Timothy J Layton, Michael L Barnett, Tanner R Hicks, Anupam B Jena
BACKGROUND: Younger children in a school grade cohort may be more likely to receive a diagnosis of attention deficit-hyperactivity disorder (ADHD) than their older peers because of age-based variation in behavior that may be attributed to ADHD rather than to the younger age of the children. Most U.S. states have arbitrary age cutoffs for entry into public school. Therefore, within the same grade, children with birthdays close to the cutoff date can differ in age by nearly 1 year. METHODS: We used data from 2007 through 2015 from a large insurance database to compare the rate of ADHD diagnosis among children born in August with that among children born in September in states with and states without the requirement that children be 5 years old by September 1 for enrollment in kindergarten...
November 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30480776/adverse-side-effects-of-dexamethasone-in-surgical-patients
#9
REVIEW
Jorinde Aw Polderman, Violet Farhang-Razi, Susan Van Dieren, Peter Kranke, J Hans DeVries, Markus W Hollmann, Benedikt Preckel, Jeroen Hermanides
BACKGROUND: In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However, whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied...
November 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30478026/prediction-of-glucose-metabolism-disorder-risk-using-a-machine-learning-algorithm-pilot-study
#10
Katsutoshi Maeta, Yu Nishiyama, Kazutoshi Fujibayashi, Toshiaki Gunji, Noriko Sasabe, Kimiko Iijima, Toshio Naito
BACKGROUND: A 75-g oral glucose tolerance test (OGTT) provides important information about glucose metabolism, although the test is expensive and invasive. Complete OGTT information, such as 1-hour and 2-hour postloading plasma glucose and immunoreactive insulin levels, may be useful for predicting the future risk of diabetes or glucose metabolism disorders (GMD), which includes both diabetes and prediabetes. OBJECTIVE: We trained several classification models for predicting the risk of developing diabetes or GMD using data from thousands of OGTTs and a machine learning technique (XGBoost)...
November 26, 2018: JMIR diabetes
https://www.readbyqxmd.com/read/30477037/development-of-the-metabolic-syndrome-study-design-and-baseline-data-of-the-lufthansa-prevention-study-lups-a-prospective-observational-cohort-survey
#11
Dirk Müller-Wieland, Christiane Altenburg, Heiko Becher, Janine Burchard, Anett Frisch, Jan Gebhard, Jutta Haas, Volker Harth, Jörg Heeren, Johannes Hengelbrock, Maximilian von Karais, Birgit Knebel, Jörg Kotzka, Bernd Löwe, Nikolaus Marx, Hans Pinnschmidt, Alexandra Preisser, Matthias Rose, Barbara Sawitzky-Rose, Ludger Scheja, Claudia Terschüren, Monika Töller, Eik Vettorazzi, Karl Wegscheider
The Lufthansa Prevention Study (LUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The LUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25-60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Baseline assessments included anthropometric measures, blood and urine samples and medical history...
November 26, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30475382/stim-promotes-the-epithelial-mesenchymal-transition-of-podocytes-through-regulation-of-fc%C3%AE-rii-activity-in-diabetic-nephropathy
#12
Juan Jin, Meiyu Ye, Kang Hu, Jianguan Gong, Qiang He
BACKGROUND: Diabetic nephropathy (DN) is a serious complication in diabetic patients and has been considered as the main cause of end-stage renal disease. However, there are no studies on the role of stromal interaction molecule (STIM) and its two subtypes, STIM1 and STIM2, in the epithelial-to-mesenchymal transition (EMT) of podocytes induced by diabetic kidney disease (DKD). The present study suggests for the first time that STIM inhibition decreases DKD-induced EMT. METHODS: All DKD patients were diagnosed based on renal biopsies carried out at the Department of Nephrology, Zhejiang Provincial People's Hospital and selected using the Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN...
November 26, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/30475216/honey-dressing-on-a-leg-ulcer-with-tendon-exposure-in-a-patient-with-type-2-diabetes
#13
Ilaria Teobaldi, Vincenzo Stoico, Fabrizia Perrone, Massimiliano Bruti, Enzo Bonora, Alessandro Mantovani
Honey has been used as a wound dressing for hundreds of years by ancient civilizations, but only recently it has acquired scientific interest because of its relevant biological properties. In the last decade, indeed, several trials and observational studies have reported that, compared to conventional treatment (e.g. antiseptics, polyurethane film, paraffin gauze, soframycin-impregnated gauze), honey dressings seem to be better in healing time of different types of wounds, including diabetic foot ulcers. However, to date, information about a potential favorable biological effect of honey dressings on diabetic ulcers with exposed tendon are still scarce...
November 16, 2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/30474497/predicting-diabetes-related-hospitalizations-based-on-electronic-health-records
#14
Theodora S Brisimi, Tingting Xu, Taiyao Wang, Wuyang Dai, Ioannis Ch Paschalidis
OBJECTIVE: To derive a predictive model to identify patients likely to be hospitalized during the following year due to complications attributed to Type II diabetes. METHODS: A variety of supervised machine learning classification methods were tested and a new method that discovers hidden patient clusters in the positive class (hospitalized) was developed while, at the same time, sparse linear support vector machine classifiers were derived to separate positive samples from the negative ones (non-hospitalized)...
November 25, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30474144/the-unmet-need-for-better-risk-stratification-of-non-proliferative-diabetic-retinopathy
#15
REVIEW
S Sivaprasad, E Pearce
Diabetic retinopathy is a common microvascular complication of diabetes and remains one of the leading causes of preventable blindness in working-age people. Non-proliferative diabetic retinopathy is the earliest stage of diabetic retinopathy and is typically asymptomatic. Currently, the severity of diabetic retinopathy is assessed using semi-quantitative grading systems based on the presence or absence of retinal lesions. These methods are well validated, but do not predict those at high risk of rapid progression to sight-threatening diabetic retinopathy; therefore, new approaches for identifying these people are a current unmet need...
November 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30471658/occurrence-impact-analysis-and-treatment-of-metformin-and-guanylurea-in-coastal-aquatic-environments-of-canada-usa-and-europe
#16
Yunwen Tao, Bing Chen, Baiyu Helen Zhang, Zhiwen Joy Zhu, Qinhong Cai
This review discusses the occurrence, impact, analysis and treatment of metformin and guanylurea in coastal aquatic environments of Canada, USA and Europe. Metformin, a biguanide in chemical classification, is widely used as one of the most effective first-line oral drugs for type 2 diabetes. It is difficult to be metabolized by the human body and exists in both urine and faeces samples in these regions. Guanylurea is metformin's biotransformation product. Consequently, significant concentrations of metformin and guanylurea have been reported in wastewater treatment plants (WWTPs) and coastal aquatic environments...
2018: Advances in Marine Biology
https://www.readbyqxmd.com/read/30467801/glomerular-basement-membrane-duplication-is-a-predictor-of-the-prognosis-of-diabetic-nephropathy-in-patients-with-type-2-diabetes
#17
Takafumi Yamakawa, Takehiko Kawaguchi, Hiroshi Kitamura, Moritoshi Kadomura, Motonobu Nishimura, Takashi Yokoo, Toshiyuki Imasawa
BACKGROUND: Several clinical parameters and pathological findings are known to be predictors of the deterioration of diabetic nephropathy (DN). Glomerular basement membrane duplication (GBM-DP) is a pathological feature representing endothelial injury, which is commonly observed in DN. In the present study, we investigated the association between GBM-DP and the renal prognosis in DN. METHODS: The study enrolled 80 patients with renal biopsy-proven DN who were managed at Chiba-East Hospital from 2005 to 2012...
November 22, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/30465036/clinical-and-ct-analysis-of-lumbar-spine-arthrodesis-%C3%AE-tricalcium-phosphate-versus-demineralized-bone-matrix
#18
Pedro Hoffiz Ricart, Sapan D Gandhi, Jonathon Geisinger, Kevin Baker, Daniel K Park
Background: Bone graft substitutes have been developed to circumvent donor site morbidity associated with iliac crest bone graft, but sparse literature compares the efficacy of various substitutes. Two commonly used bone graft substitutes used in lumbar fusion are β-tricalcium phosphate (BTP) and demineralized bone matrix (DBM). Methods: A retrospective review of patients who underwent instrumented posterolateral lumbar fusion was conducted by a single surgeon from January 2013 to December 2016...
September 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
https://www.readbyqxmd.com/read/30463754/preoperative-hypoglycemia-and-hyperglycemia-are-related-to-postoperative-infection-rates-in-implant-based-breast-reconstruction
#19
Tsun Yee Law, Ellie Moeller, Zachary S Hubbard, Samuel Rosas, Anthony Andreoni, Harvey W Chim
OBJECTIVES: Diabetic patients undergoing surgery are known to have a higher risk for infection. However, current literature does not adequately investigate the effects of preoperative hypoglycemia or hyperglycemia on postoperative infection risk. METHODS: A retrospective review of a national private payer database within the PearlDiver Supercomputer application (Warsaw, IN) for patients undergoing breast reconstruction with implant/expander (BR) was conducted. These patients were identified by Current Procedural Terminology (CPT) and International Classification of Disease (ICD-9) ninth revision codes...
December 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/30459853/frequency-of-ischemic-stroke-subtypes-based-on-toast-classification-at-a-tertiary-care-center-in-pakistan
#20
Faleha Zafar, Waseem Tariq, Raja Farhat Shoaib, Ahmed Shah, Maimoona Siddique, Abdullah Zaki, Salman Assad
Background: The purpose of this study was to determine the frequency of ischemic stroke subtypes based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification at a tertiary care center in Pakistan. Materials and Methods: A cross-sectional study was conducted in Stroke Unit of Shifa International Hospital, Islamabad. We included 145 patients who presented to us from November 2015 to February 2016 with radiological confirmed neurological deficits consistent with ischemic stroke...
October 2018: Asian Journal of Neurosurgery
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