keyword
https://read.qxmd.com/read/38057728/clinical-effectiveness-of-pharmacological-interventions-for-managing-chronic-migraine-in-adults-a-systematic-review-and-network-meta-analysis
#21
JOURNAL ARTICLE
Seyran Naghdi, Martin Underwood, Jason Madan, Anna Brown, Callum Duncan, Manjit Matharu, Aiva Aksentyte, Natasha Davies, Sophie Rees, Andrew Cooklin, Amy Grove, Hema Mistry
BACKGROUND: Chronic migraine can be a profoundly disabling disorder that may be treated with preventive medications. However, uncertainty remains as to which preventive medication is the most effective. We present a network meta-analysis to determine the effectiveness and rank of preventive drugs for chronic migraine in adults. METHODS: We identified, reviewed, and extracted data from randomised controlled trials (RCTs) of preventive drugs for chronic migraine with at least 200 participants...
December 6, 2023: Journal of Headache and Pain
https://read.qxmd.com/read/38021912/treatment-of-psychogenic-polydipsia-and-hyponatremia-a-case-report
#22
Alyse A Hurwit, Jonathan M Parker, Stepan Uhlyar
Psychogenic polydipsia occurs during water or fluid intoxication and can lead to electrolyte disturbances, such as hyponatremia. Hyponatremia can give rise to signs and symptoms, including lethargy, psychosis, seizures, or death. Psychogenic, or primary polydipsia, can be compared to other medical conditions that cause excessive thirst. This case report will focus on the symptoms, disease, and treatment involved in the care and hospitalization of a 30-year-old male patient who reported ingesting up to 40 liters of water a day for the last three years...
October 2023: Curēus
https://read.qxmd.com/read/38014703/solusomes-novel-soluplus%C3%A2-enriched-nano-vesicular-carriers-for-improving-the-oral-bioavailability-of-candesartan-cilexetil
#23
JOURNAL ARTICLE
Mohammed Abdallah, Aysha Sayed Mohamed, Mina Ibrahim Tadros, Mohamed El-Nabarawi, Mai Ahmed Tawfik
Candesartan cilexetil (CAN) is administered for treating hypertension and heart failure. CAN suffers poor oral bioavailability, owing to limited aqueous solubility, and first-pass metabolism. Solusomes (novel Soluplus® enriched nano-vesicular carriers) combine the merits of Soluplus® , and the traditional liposomes. They were explored to increase CAN solubility, allow a high drug release rate, and improve the oral drug bioavailability. Solusomes were developed via thin film hydration technique utilizing lipid (phosphatidylcholine; PC) and polymeric solubilizer (Soluplus® ; Solu)...
November 28, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37969233/role-of-common-antihypertensives-in-the-growth-of-abdominal-aortic-aneurysm-at-the-presurgical-stage
#24
JOURNAL ARTICLE
Toko Mitsui, Yasuko K Bando, Akihiro Hirakawa, Kenji Furusawa, Ryota Morimoto, Eiji Taguchi, Akira Kimura, Haruo Kamiya, Naomichi Nishikimi, Kimihiro Komori, Kazuhiro Nishigami, Toyoaki Murohara
Background: Whether drug therapy slows the growth of abdominal aortic aneurysms (AAAs) in the Japanese population remains unknown. Methods and Results: In a multicenter prospective open-label study, patients with AAA at the presurgical stage (mean [±SD] AAA diameter 3.27±0.58 cm) were randomly assigned to treatment with candesartan (CAN; n=67) or amlodipine (AML; n=64) considering confounding factors (statin use, smoking, age, sex, renal function), with effects of blood pressure control minimized setting a target control level...
November 10, 2023: Circulation reports
https://read.qxmd.com/read/37946621/uptake-and-metabolization-of-four-sartan-drugs-by-eight-different-plants-targeted-and-untargeted-analyses-by-hplc-drift-tube-ion-mobility-quadrupole-time-of-flight-mass-spectrometry
#25
JOURNAL ARTICLE
Laura Zellner, Thomas Schiefer, Markus Himmelsbach, Franz Mlynek, Christian W Klampfl
In this study, we investigated the uptake and metabolization of four drugs (plus the associated prodrugs) from the sartan family by eight edible plants. Growing the plants hydroponically in a medium containing the respective drug, more than 40 phases I and II metabolites derived from the four sartan drugs could be tentatively identified. To demonstrate the suitability of the proposed analytical approach for actual environmental samples, garden cress (Lepidium sativum) selected as a model plant was grown in water drawn from the effluent of two local wastewater treatment plants...
November 9, 2023: Electrophoresis
https://read.qxmd.com/read/37931839/a-multi-arm-parallel-preclinical-study-investigating-the-potential-benefits-of-acetazolamide-candesartan-and-triciribine-in-combination-with-fluconazole-for-the-treatment-of-cryptococcal-meningoencephalitis
#26
JOURNAL ARTICLE
Abdulaziz H Alanazi, Daniel B Chastain, Madhuri Rudraraju, Varun Parvathagiri, Shengshuai Shan, Xiaorong Lin, Andrés F Henao-Martínez, Carlos Franco-Paredes, S Priya Narayanan, Payaningal R Somanath
Cryptococcus neoformans, an opportunistic fungal pathogen, primarily infects immunodeficient patients frequently causing cryptococcal meningoencephalitis (CM). Increased intracranial pressure (ICP) is a serious complication responsible for increased morbidity and mortality in CM patients. Non-invasive pharmacological agents that mitigate ICP could be beneficial in treating CM patients. The objective of the study was to investigate the efficacy of acetazolamide (AZA), candesartan (CAN), and triciribine (TCBN), in combination with the antifungal fluconazole, on C...
November 4, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37918771/proposal-for-priority-emerging-pollutants-in-the-nakdong-river-korea-application-of-eu-watch-list-mechanisms
#27
JOURNAL ARTICLE
Sangyoon Lee, Younghoon Choi, Daeho Kang, Junho Jeon
The Nakdong River, the longest in Korea, has received numerous pollutants from heavily industrialized and densely populated areas while being used as a drinking water source. A number of research have reported occurrences of emerging pollutants (EPs) in the river. The results requested efficient monitoring and systematic management strategies such as EU watch list under Water Framework Directive. The aim of this study is to propose a watch list through preliminary monitoring of the river and risk-based prioritization approach...
October 31, 2023: Environmental Pollution
https://read.qxmd.com/read/37910529/effect-of-safranal-or-candesartan-on-3-nitropropionicacid-induced-biochemical-behavioral-and-histological-alterations-in-a-rat-model-of-huntington-s-disease
#28
JOURNAL ARTICLE
Nagwa Ibrahim Shehata, Dina Mohamed Abd El-Salam, Roqaya Mahmoud Hussein, Sherine Maher Rizk
3-nitropropionic acid (3-NP) is a potent mitochondrial inhibitor mycotoxin. Systemic administration of 3-NP can induce Huntington's disease (HD)-like symptoms in experimental animals. Safranal (Safr) that is found in saffron essential oil has antioxidant, anti-inflammatory and anti-apoptotic actions. Candesartan (Cands) is an angiotensin receptor blocker that has the potential to prevent cognitive deficits. The present study aims to investigate the potential neuroprotective efficacy of Safr or Cands in 3-NP-induced rat model of HD...
2023: PloS One
https://read.qxmd.com/read/37892765/effects-of-angiotensin-receptor-blockers-on-streptozotocin-induced-diabetic-cataracts
#29
JOURNAL ARTICLE
Gaku Ishigooka, Hiroshi Mizuno, Shou Oosuka, Denan Jin, Shinji Takai, Teruyo Kida
This study aimed to determine the role of oxidative stress produced by the renin-angiotensin system (RAS) in cataract formation in streptozotocin-induced diabetic rats (STZ) using angiotensin II receptor blockers (ARBs). Rats were treated with streptozotocin and orally administered candesartan (2.5 mg/kg/day) or a normal diet for 10 weeks until sacrifice. Cataract progression was assessed through a slit-lamp examination. Animals were euthanized at 18 weeks, and the degree of cataract progression was evaluated...
October 19, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37880377/effect-of-at1-receptor-blockade-on-cardiovascular-outcome-after-cardiac-arrest-an-experimental-study-in-rats
#30
JOURNAL ARTICLE
E A F Araújo Filho, M J C Carmona, D A Otsuki, D R R Maia, L G C A Lima, M F Vane
Angiotensin II receptor 1(AT1) antagonists are beneficial in focal ischemia/reperfusion (I/R). However, in cases of global I/R, such as cardiac arrest (CA), AT1 blocker's potential benefits are still unknown. Wistar male rats were allocated into four groups: Control group (CG)-animals submitted to CA by ventricular fibrillation induced by direct electrical stimulation for 3 min, and anoxia for 5 min; Group AT1 (GAT1)-animals subjected to CA and treated with 0.2 mg/kg of candesartan diluted in dimethylsulfoxide (DMSO) (0...
October 25, 2023: Scientific Reports
https://read.qxmd.com/read/37867501/atypical-adpkd-due-to-a-dnajb11-pathogenic-variant-an-educational-case-report
#31
Jessica Kachmar, Zaki El-Haffaf, Guillaume Bollée
RATIONALE: Due to next-generation sequencing, variants in new genes such as DNAJB11 are recently being identified as causing atypical autosomal dominant polycystic kidney disease (ADPKD). It is important to describe phenotypes associated with these variants in order to increase awareness among clinicians, especially since genetic variability affects ADPKD severity. PRESENTING CONCERNS OF THE PATIENT: We describe a 55-year-old female patient of Haitian origin who presented with slowly deteriorating kidney function, microscopic hematuria, proteinuria, enlarged kidneys with innumerable small cysts, and a family history of chronic kidney disease and cysts...
2023: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/37842366/a-case-of-significant-improvement-of-heart-failure-with-reduced-ejection-fraction-with-a-small-dose-of-candesartan-in-a-hemodialysis-patient-with-hypertensive-heart-disease-and-nephrosclerosis
#32
Haruhito Harada, Yoshiteru Higa, Daisuke Wakasugi, Yoshifumi Wada
Hypertension induces vascular damage followed by organ damage, including heart failure in hypertensive heart disease (HHD) and nephrosclerosis (the resultant renal pathologic change from long-standing hypertension affecting renal vascular supply), ultimately causing renal failure. Renin-angiotensin-aldosterone system (RAAS) inhibitors are well known as effective drugs for the treatment of hypertension and the anti-remodeling of affected organs. A 52-year-old male was evaluated. Right atrophic kidney and proteinuria were noted in his high school years; however, he had no symptoms for about 35 years...
September 2023: Curēus
https://read.qxmd.com/read/37831115/telmisartan-and-candesartan-promote-browning-of-white-adipose-tissue-and-reverse-fatty-liver-changes-in-high-fat-diet-fed-male-albino-rats
#33
JOURNAL ARTICLE
Noha A T Abbas, Fawkia A Fayed, Rabab Saber El Sebaey, Heba A Hassan
UNLABELLED: Obesity is a key risk factor for many diseases, as cardiovascular disorders, diabetes, infertility, osteoarthritis, sleep apnea, non-alcoholic fatty liver disease (NAFLD) as well as increased risk for many cancers. Telmisartan and Candesartan cilexetil are angiotensin II receptor blockers which had proven to involve in pathogenesis of obesity and NAFLD. AIMS: This work is designed to explore the possible mitigated effects of Telmisartan and Candesartan cilexetil on weight gain and fatty liver in high fat diet (HFD) fed rats...
October 13, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37805247/a-68-year-old-patient-with-dyspnea-and-hypoxemia-after-total-hip-arthroplasty
#34
Vasilios Tzilas, Ioannis Roussis, Katianna Sakellaropoulou, Serafeim Chrysikos, Georgios Hillas, Jay H Ryu
A 68-year-old patient with obesity (BMI, 4 7 kg/m2 ) was transferred to the ED of our hospital because of dyspnea and pronounced hypoxemia. The patient underwent total right hip arthroplasty in an outside hospital because of osteoarthritis; there was no history of trauma. After 48 h, she experienced dyspnea with severe hypoxemia. The next day she was transferred to our hospital. Her history was notable for arterial hypertension and depression, but not heart failure. Her medications included candesartan (16 mg once daily) and sertraline (100 mg once daily)...
October 2023: Chest
https://read.qxmd.com/read/37801970/therapeutic-effects-of-candesartan-in-inflammatory-skin-disorders-by-suppressing-th17-differentiation
#35
JOURNAL ARTICLE
So-Eun Son, Dong-Soon Im
As angiotensin II is associated with inflammation, type I angiotensin II receptor blockers (ARBs) exibit anti-inflammatory effects in patients with hypertension as well as inflammatory disease animal models including arthritis models. The present study aimed to investigate whether ARBs exert anti-inflammatory effects in vivo in skin disorders. We tested effects of ARBs on 1-chloro-2,4-dinitrobenzene(CDNB)-induced atopic dermatitis-like and imiquimod-induced psoriasis-like skin models. CDNB-induced atopic dermatitis-like skin lesions were suppressed by administration of candesartan or telmisartan...
October 4, 2023: International Immunopharmacology
https://read.qxmd.com/read/37797493/novel-aspects-of-taxifolin-pharmacokinetics-dose-proportionality-cumulative-effect-metabolism-microemulsion-dosage-forms
#36
JOURNAL ARTICLE
Alexander P Lakeev, Elena A Yanovskaya, Vyacheslav A Yanovsky, Galina A Frelikh, Mikhail O Andropov
Taxifolin (TFL) is a small drug molecule with a broad therapeutic potential limited by its poor aqueous solubility and excessive metabolism. Despite comprehensive research, some aspects of the TFL pharmacokinetics, e.g., dose proportionality and possible cumulative effect, remain unexplored. In the current study, we have tried to fill this gap. Our results revealed that the TFL pharmacokinetics in rats had nonlinear character in the dose range of 10-50 mg/kg after its single oral administration (AUC). For Cmax , the data are ambiguous: linearity was confirmed via the equivalence criterion and was disproved using the power model approach...
November 30, 2023: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/37796134/nanotechnology-based-strategies-for-extended-release-delivery-of-angiotensin-receptor-blockers-arbs-a-comprehensive-review
#37
JOURNAL ARTICLE
Bahareh Haji Ali, Milad Shirvaliloo, Sonia Fathi-Karkan, Shekoufeh Mirinejad, Fulden Ulucan-Karnak, Saman Sargazi, Sara Sargazi, Roghayeh Sheervalilou, Mohammed M Rahman
There has been a significant shift in the perception of hypertension as an important contributor to the global disease burden. Approximately 6% and 8% of pregnancies are affected by hypertension, which can adversely affect the mother and the fetus. Furthermore, a hypertensive individual is at increased risk of developing kidney disease, arterial hardening, eye damage, and strokes. Using angiotensin receptor blockers (ARBs) is widespread in treating hypertension, heart failure, coronary artery disease, and diabetic nephropathy...
October 5, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37746692/multicenter-prospective-randomized-controlled-trial-of-high-sensitivity-cardiac-troponin-i-guided-combination-angiotensin-receptor-blockade-and-beta-blocker-therapy-to-prevent-anthracycline-cardiotoxicity-the-cardiac-care-trial
#38
RANDOMIZED CONTROLLED TRIAL
Peter A Henriksen, Peter Hall, Iain R MacPherson, Shruti S Joshi, Trisha Singh, Morag Maclean, Steff Lewis, Aryelly Rodriguez, Alex Fletcher, Russell J Everett, Harriet Stavert, Angus Broom, Lois Eddie, Lorraine Primrose, Heather McVicars, Pam McKay, Annabel Borley, Clare Rowntree, Simon Lord, Graham Collins, John Radford, Amy Guppy, Michelle C Williams, Alan Japp, John R Payne, David E Newby, Nicholas L Mills, Olga Oikonomidou, Ninian N Lang
BACKGROUND: Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac troponin concentrations. Beta-adrenergic receptor blocker and renin-angiotensin system inhibitor therapies have been associated with modest cardioprotective effects in unselected patients receiving anthracycline chemotherapy. METHODS: In a multicenter, prospective, randomized, open-label, blinded end-point trial, patients with breast cancer and non-Hodgkin lymphoma receiving anthracycline chemotherapy underwent serial high-sensitivity cardiac troponin testing and cardiac magnetic resonance imaging before and 6 months after anthracycline treatment...
November 21, 2023: Circulation
https://read.qxmd.com/read/37665450/cost-utility-analysis-of-valsartan-enalapril-and-candesartan-in-patients-with-heart-failure-in-iran
#39
JOURNAL ARTICLE
Ramin Ravangard, Farideh Sadat Jalali, Marjan Hajahmadi, Abdosaleh Jafari
BACKGROUND: Today, heart failure is one of the leading causes of death and disability in most developed and developing countries. By 2030, more than 23.3 million people are projected to die of cardiovascular diseases each year, and the prevalence of heart failure is expected to increase by 25%. One of the preventive interventions is pharmacological interventions which can be used to reduce the complications of cardiovascular diseases such as heart failure. One of the most important pharmacological interventions in patients with heart failure is the use of antihypertensive drugs such as candesartan, enalapril, and valsartan...
September 4, 2023: Health Economics Review
https://read.qxmd.com/read/37652238/sex-dependent-effects-of-angiotensin-ii-type-1-receptor-blocker-on-molecular-and-behavioral-changes-induced-by-single-prolonged-stress
#40
JOURNAL ARTICLE
Emily Ortiz Nazario, Carla M Denton Ortiz, Lawry D M Soto Escobar, Zaira Mateo Mayol, Maria Colon Romero, Anixa Hernandez Lopez, James T Porter
Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that not only entails alterations in fear behavior and anxiety but also includes neuroendocrine dysfunctions involving the hypothalamic pituitary adrenal (HPA) axis and the renin-angiotensin system. Recent preclinical studies demonstrate that activation of the angiotensin type 1 receptor (AT1R) in the paraventricular region of the hypothalamus (PVR) promotes anxiety-like behaviors and enables microglia proliferation. An increase in microglia and anxiety-like behavior also occurs in the PTSD animal model single-prolonged stress (SPS)...
August 29, 2023: Behavioural Brain Research
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