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https://www.readbyqxmd.com/read/30326254/activation-of-catalase-via-co-administration-of-aspirin-and-pioglitazone-experimental-and-mlsd-simulation-approaches
#1
Yunes Panahi, Reza Yekta, Gholamreza Dehghan, Samaneh Rashtbari, Nematollah Jonaidi Jafari, Ali A Moosavi-Movahedi
Aspirin (ASP) and pioglitazone (PGL) are the most common drugs that are widely used by diabetic patients to control the blood sugar and hinder cardiovascular diseases. The interaction between PGL and ASP is one of the important medical issues to clarify the safety of co-administration of these drugs. In the present study, the effect of co-administered ASP with PGL was investigated on the structure and catalytic function of catalase as a potential target in the liver. Based on our data, co-administration of ASP-PGL significantly enhanced the catalase activity in comparison with PGL alone...
October 13, 2018: Biochimie
https://www.readbyqxmd.com/read/30306360/evidence-based-management-of-diabetes-in-older-adults
#2
REVIEW
Arshag D Mooradian
The number of older adults with diabetes is rapidly increasing worldwide. A variety of factors contribute to the age-related increase in the incidence of diabetes. The lack of empiric evidence in the field has limited the management guidelines to mostly expert opinion. Given uncertainty over the rate at which to lower blood glucose levels and the optimal method of doing so, the goals of diabetes control in older people must be individualized. If the patient requires insulin therapy, the newer insulins, with their improved pharmacodynamic consistency and reduced risk of hypoglycemia, should be preferred...
October 10, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/30293793/impact-of-diabetes-on-coronary-artery-plaque-volume-by-coronary-ct-angiography-and-subsequent-adverse-cardiac-events
#3
Simon Deseive, Ramona Straub, Maximilian Kupke, Alexander Broersen, Pieter H Kitslaar, Thomas J Stocker, Steffen Massberg, Martin Hadamitzky, Jörg Hausleiter
BACKGROUND: To investigate the impact of diabetes on coronary artery total plaque volume (TPV) and adverse events in long-term follow-up. METHODS: One-hundred-and-eight diabetic patients were matched to 324 non-diabetic patients, with respect to age, sex, body-mass index, hypertension, smoking habits, LDL and HDL cholesterol, family history for CAD as well as aspirin and statin medication. In all patients, TPV was quantified from coronary CT angiographies (CTA) using dedicated software...
October 1, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/30292611/metabolic-syndrome-is-associated-with-increased-cardiac-morbidity-after-infrainguinal-bypass-surgery-irrespective-of-the-use-of-cardiovascular-risk-modifying-agents
#4
Rebecca Sorber, Andrew Lehman, Husain N Alshaikh, Christopher J Abularrage, James H Black, Ying Wei Lum
BACKGROUND: The burden of metabolic syndrome (MetS) is increasing in the United States and is pervasive among patients with peripheral arterial disease. Whereas MetS has been implicated in the development of all types of cardiovascular disease and adverse outcomes after vascular interventions, little is known about how MetS influences perioperative outcomes of lower extremity bypass surgery and whether any negative effects can be modified by use of cardiovascular risk-modifying medications...
October 3, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30273676/significance-of-urinary-11-dehydro-thromboxane-b-2-in-age-related-diseases-focus-on-atherothrombosis
#5
REVIEW
Paola Simeone, Andrea Boccatonda, Rossella Liani, Francesca Santilli
Platelet activation plays a key role in atherogenesisis and atherothrombosis. Biochemical evidence of increased platelet activation in vivo can be reliably obtained through non-invasive measurement of thromboxane metabolite (TXM) excretion. Persistent biosynthesis of TXA2 has been associated with several ageing-related diseases, including acute and chronic cardio-cerebrovascular diseases and cardiovascular risk factors, such as cigarette smoking, type 1 and type 2 diabetes mellitus, obesity, hypercholesterolemia, hyperhomocysteinemia, hypertension, chronic kidney disease, chronic inflammatory diseases...
September 28, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/30267693/revascularization-strategies-and-survival-in-patients-with-multi-vessel-coronary-artery-disease
#6
Noam Fink, Eugenia Nikolsky, Abed Assali, Oz Shapira, Yigal Kassif, Yaron D Barac, Ariel Finkelstein, Amnon Eitan, Haim Danenberg, Doron Zahger, Gideon Sahar, Shaul Atar, Ehud Raanani, Gil Bolotin, Ilan Goldenberg, Amit Segev
BACKGROUND: We sought to assess real-world implementation of the guidelines in patients with multi-vessel coronary artery disease (CAD) using a prospective national registry in Israel. METHODS: All consecutive patients with left main and/or 2- to 3-vessel CAD involving the proximal or mid left anterior descending artery (LAD) were enrolled in a dedicated multicenter registry. Patients were managed at the discretion of the treating team at each hospital and were followed for 30 months...
September 26, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30265320/diabetes-and-platelet-response-to-low-dose-aspirin
#7
Mohammed E Al-Sofiani, Lisa R Yanek, Nauder Faraday, Brian G Kral, Rasika Mathias, Lewis C Becker, Diane M Becker, Dhananjay Vaidya, Rita R Kalyani
Context: Previous studies have suggested less cardioprotective benefit of aspirin in adults with diabetes, raising concerns about "aspirin resistance" and potentially reduced effectiveness for prevention of cardiovascular disease(CVD). Objective: To examine differences in platelet response to aspirin by diabetes status. Design, Setting, Participants: We examined platelet response before and after aspirin (81 mg/day for 14 days) in 2,113 adults(175 with diabetes, 1,938 without diabetes), in the Genetic Study of Aspirin Responsiveness(GeneSTAR) cohort, who had family history of early-onset CVD...
September 27, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30251061/dose-reduction-oral-application-and-order-of-intake-to-preserve-aspirin-antiplatelet-effects-in-dipyrone-co-medicated-chronic-artery-disease-patients
#8
Lisa Dannenberg, Tobias Petzold, Alina Achilles, David Naguib, Saif Zako, Carolin Helten, René M'Pembele, Philipp Mourikis, Yanina Podsvyadek, Maria Grandoch, Bodo Levkau, Tobias Zeus, Malte Kelm, Thomas Hohlfeld, Amin Polzin
BACKGROUND: Dipyrone comedication in aspirin-treated patients is associated with impaired pharmacodynamic response to aspirin (high on-treatment platelet reactivity [HTPR]). Additionally, in small observational studies, an association with impaired outcome has been described. In this uncontrolled, hypothesis-generating study, we aimed to investigate strategies to prevent this drug-drug interaction in patients with coronary artery disease (CAD). METHODS: We analyzed pharmacodynamic response to aspirin in 80 dipyrone co-medicated CAD patients...
September 24, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30249291/determinants-of-drug-related-problems-among-ambulatory-type-2-diabetes-patients-with-hypertension-comorbidity-in-southwest-ethiopia-a-prospective-cross-sectional-study
#9
Mohammed Yimama, Habtemu Jarso, Tigestu Alemu Desse
OBJECTIVE: The aim of this study was to assess drug-related problems and its determinants in type 2 diabetes patients with hypertension co-morbidity. RESULTS: A total of 300 type 2 diabetes patients with hypertension co-morbidity were studied. The majority of participants, 194 (64.7%), were males. Mean age of the participants was 54.44 ± 11.68 years. The mean durations of diabetes and hypertension were 5.37 ± 4.79 and 5.15 ± 4.65 years respectively...
September 24, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30240925/a-high-glucose-level-is-associated-with-decreased-aspirin-mediated-acetylation-of-platelet-cyclooxygenase-cox-1-at-serine-529-a-pilot-study
#10
Francesco Finamore, Jean-Luc Reny, Sarah Malacarne, Pierre Fontana, Jean-Charles Sanchez
Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. However, a direct effect on the critical residue (serine 529, or Ser 529) of the catalytic pocket of cyclooxygenase 1 (COX-1) has never been demonstrated...
September 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/30234774/optimal-sbp-targets-in-routine-clinical-care
#11
Lisanne A Gitsels, Elena Kulinskaya, Ilyas Bakbergenuly, Nicholas Steel
OBJECTIVE: Compare outcomes of intensive treatment of SBP to less than 120 mmHg versus standard treatment to less than 140 mmHg in the US clinical Systolic Blood Pressure Intervention Trial (SPRINT) with similar hypertensive patients managed in routine primary care in the United Kingdom. METHODS: Hypertensive patients aged 50-90 without diabetes or chronic kidney disease (CKD) were selected in SPRINT and The Health Improvement Network (THIN) database. Patients were enrolled in 2010-2013 and followed-up to 2015 (SPRINT N = 4112; THIN N = 8631)...
September 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30224843/role-of-aspirin-in-high-pulsatility-index-of-uterine-artery-a-consort-study
#12
Nidhi Sharma, Sunayana Srinivasan, K Jayashree Srinivasan, Kulasekaran Nadhamuni
Background: Preeclampsia is a heterogeneous disorder prevalent in 3-10% of pregnant women globally. The etiology is multifactorial. There is a initial stage of endothelial dysfunction and placental ischemia (Stage 1); this leads to maternal syndrome of hypertension, edema, and proteinuria (Stage 2). Drugs acting on immunomodulatory, anti-inflammatory, antioxidant and proresolving pathways can minimize the complications of preeclampsia. The therapeutic effect of aspirin is based on acetyl group and salicylate group...
October 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/30218743/the-effects-of-cardiovascular-risk-factor-combined-anti-platelet-therapy-and-the-risk-of-cerebrovascular-events-in-patients-with-t2dm-in-an-urban-community-over-96-months-follow-up-the-beijing-communities-diabetes-study-19
#13
Xue-Lian Zhang, Han-Jing Fu, Guang-Ran Yang, Gang Wan, Dongmei Li, Liang-Xiang Zhu, Rong-Rong Xie, Yu-Jie Lv, Jian-Dong Zhang, Yu-Ling Li, Qin-Fang Dai, Yu Ji, Da-Yong Gao, Xue-Li Cui, De-Yuan Liu, Shen-Yuan Yuan, Ming-Xia Yuan
OBJECTIVE: We investigated the prognostic significance of metabolic risk scores and aspirin with respect to cerebrovascular events. METHODS: A total of 25 communities of diabetic patients were enrolled in Beijing Community Diabetes Study (BCDS) from 2008. 3413 patients with T2DM in BCDS have complete screening data, including blood glucose, blood pressure, lipid profiles and anti-platelet therapy, which were assigned metabolic score (MS) and add up to the total metabolic score (TMS)...
September 13, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30209868/a-systematic-review-of-risk-factors-for-cataract-in-type-2-diabetes
#14
REVIEW
Jocelyn J Drinkwater, Wendy A Davis, Timothy M E Davis
Type 2 diabetes (T2D) is a risk factor for cataract development. With T2D prevalence increasing, the burden of cataract-associated vision loss will also increase. We aimed to characterise cataract diabetes-specific risk factors to assist prevention and management strategies. As part of a systematic review, two investigators independently searched online electronic databases according to a predetermined protocol for relevant published data to end-March 2018. Studies were included if they were longitudinal with ≥100 participants, diabetes was defined, a description of cataract assessment was provided, data were from humans, and the reports were in English...
September 12, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30189792/anticoagulation-strategy-in-patients-with-atrial-fibrillation-after-carotid-endarterectomy
#15
Murat Ugurlucan, Hakki Tankut Akay, Ibrahim Erdinc, Didem Melis Oztas, Cenk Conkbayir, Erdal Aslim, Cenk Eray Yildiz, Kubilay Aydin, Ufuk Alpagut
AIM: Carotid artery stenosis and atrial fibrillation are diseases of the aging patient population. Literature lacks precise anticoagulation treatment protocols for patients with atrial fibrillation following carotid endarterectomy. We present our experiences with anticoagulation strategy in this particular patient population. PATIENTS AND METHODS: Between June 2001-September 2017, 165 patients with chronic or paroxysmal atrial fibrillation out of 1594 cases from three different institutions whom received Coumadin and aspirin and required carotid endarterectomy were reviewed, respectively...
September 6, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/30188374/pharmacogenetic-and-clinical-predictors-of-response-to-clopidogrel-plus-aspirin-after-acute-coronary-syndrome-in-egyptians
#16
Shaimaa Fathy, Mohamed H Shahin, Taimour Langaee, Basma M Khalil, Ayman Saleh, Nagwa A Sabry, Mona F Schaalan, Lamiaa L El Wakeel, Larisa H Cavallari
OBJECTIVES: Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the risk for recurrent cardiovascular events after acute coronary syndrome (ACS). However, there is significant variation in response to DAPT that may be influenced by both genetic and nongenetic factors. This study aimed to assess the effect of genetic polymorphisms in PON-1, PEAR-1, P2Y12, CES1, and CYP2C19, along with clinical, demographic, and social factors, on variation in response to DAPT in Egyptians...
September 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30173426/-risk-factors-for-early-castration-resistant-prostate-cancer-after-androgen-deprivation-therapy-for-bone-metastatic-prostate-cancer
#17
Feng-Ming Huang, Xiao-Hong Li, Yong Liang
Objective: To investigate the risk factors for early castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT) in patients primarily diagnosed with bone-metastatic prostate cancer (BMPC). METHODS: We retrospectively analyzed the clinical data on 97 cases of primarily diagnosed BMPC treated in our hospital between January 2010 and May 2016. We included the patients without CRPC in group A and those with CRPC found within 12 months after ADT in group B...
August 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/30158069/use-of-aspirin-to-reduce-risk-of-initial-vascular-events-in-patients-at-moderate-risk-of-cardiovascular-disease-arrive-a-randomised-double-blind-placebo-controlled-trial
#18
J Michael Gaziano, Carlos Brotons, Rosa Coppolecchia, Claudio Cricelli, Harald Darius, Philip B Gorelick, George Howard, Thomas A Pearson, Peter M Rothwell, Luis Miguel Ruilope, Michal Tendera, Gianni Tognoni
BACKGROUND: The use of aspirin in the primary prevention of cardiovascular events remains controversial. We aimed to assess the efficacy and safety of aspirin versus placebo in patients with a moderate estimated risk of a first cardiovascular event. METHODS: ARRIVE is a randomised, double-blind, placebo-controlled, multicentre study done in seven countries. Eligible patients were aged 55 years (men) or 60 years (women) and older and had an average cardiovascular risk, deemed to be moderate on the basis of the number of specific risk factors...
August 24, 2018: Lancet
https://www.readbyqxmd.com/read/30153096/hydroxycarbamide-plus-aspirin-versus-aspirin-alone-in-patients-with-essential-thrombocythemia-age-40-to-59-years-without-high-risk-features
#19
Anna L Godfrey, Peter J Campbell, Cathy MacLean, Georgina Buck, Julia Cook, Julie Temple, Bridget S Wilkins, Keith Wheatley, Jyoti Nangalia, Jacob Grinfeld, Mary Frances McMullin, Cecily Forsyth, Jean-Jacques Kiladjian, Anthony R Green, Claire N Harrison
Purpose Cytoreductive therapy is beneficial in patients with essential thrombocythemia (ET) at high risk of thrombosis. However, its value in those lacking high-risk features remains unknown. This open-label, randomized trial compared hydroxycarbamide plus aspirin with aspirin alone in patients with ET age 40 to 59 years and without high-risk factors or extreme thrombocytosis. Patients and Methods Patients were age 40 to 59 years and lacked a history of ischemia, thrombosis, embolism, hemorrhage, extreme thrombocytosis (platelet count ≥ 1,500 × 109 /L), hypertension, or diabetes requiring therapy...
August 28, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/30146931/effects-of-aspirin-for-primary-prevention-in-persons-with-diabetes-mellitus
#20
(no author information available yet)
Background Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. Methods We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive aspirin at a dose of 100 mg daily or matching placebo. The primary efficacy outcome was the first serious vascular event (i...
August 26, 2018: New England Journal of Medicine
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