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https://www.readbyqxmd.com/read/30514262/the-asamet-trial-a-randomized-phase-ii-double-blind-placebo-controlled-multicenter-2-%C3%A3-2-factorial-biomarker-study-of-tertiary-prevention-with-low-dose-aspirin-and-metformin-in-stage-i-iii-colorectal-cancer-patients
#1
Marilena Petrera, Laura Paleari, Matteo Clavarezza, Matteo Puntoni, Silvia Caviglia, Irene Maria Briata, Massimo Oppezzi, Eva Mihajlovic Mislej, Borut Stabuc, Michael Gnant, Thomas Bachleitner-Hofmann, Wilfried Roth, Dominique Scherer, Walter-E Haefeli, Cornelia M Ulrich, Andrea DeCensi
BACKGROUND: Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal cancer (CRC) incidence and mortality, including inhibition of distant metastases. Metformin has also been associated with decreased colon adenoma recurrence in clinical trials and lower CRC incidence and mortality in epidemiological studies in diabetics. While both drugs have been tested as single agents, their combination has not been tested in cancer prevention trials...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30505747/dual-antiplatelet-therapy-versus-aspirin-monotherapy-in-diabetics-with-stable-ischemic-heart-disease-undergoing-coronary-artery-bypass-grafting
#2
Makoto Mori, Kayoko Shioda, Syed Usman Bin Mahmood, Abeel A Mangi, James J Yun, Arnar Geirsson
Background: Dual antiplatelet therapy (DAPT) in patients presenting with acute coronary syndrome (ACS) undergoing CABG is recommended to prevent recurrent ischemic events. The benefit of DAPT post-CABG in patients with stable ischemic heart disease (SIHD) is unknown. The aim of this study was to evaluate the utilization rate of DAPT and associated outcomes in patients with SIHD undergoing CABG via a secondary analysis of Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial data...
September 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/30498684/diabetes-and-antiplatelet-therapy-from-bench-to-bedside
#3
REVIEW
Jose R Rivas Rios, Francesco Franchi, Fabiana Rollini, Dominick J Angiolillo
Diabetes mellitus (DM) is a metabolic disorder associated with accelerated atherogenesis and an increased risk of atherothrombotic complications. Multiple mechanisms contribute to the pro-thrombotic status which characterizes DM patients underscoring the importance of antiplatelet therapies used for secondary prevention in these patients. For many years, dual antiplatelet therapy (DAPT) with aspirin and the P2Y12 inhibitor clopidogrel has represented the mainstay of treatment following an acute coronary syndrome (ACS) or in patients undergoing percutaneous coronary interventions (PCI)...
October 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/30488889/aspirin-for-primary-prevention-of-cardiovascular-disease-events-in-diabetes-the-balancing-act
#4
M M Thabah, R Sharma
No abstract text is available yet for this article.
December 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/30487058/one-quarter-of-total-myocardial-infarctions-are-silent-manifestation-in-patients-with-type-2-diabetes-mellitus
#5
Hirofumi Soejima, Hisao Ogawa, Takeshi Morimoto, Sadanori Okada, Mio Sakuma, Masafumi Nakayama, Izuru Masuda, Naofumi Doi, Shiro Uemura, Hideaki Jinnouchi, Seigo Sugiyama, Masako Waki, Yoshihiko Saito
BACKGROUND: Silent events with newly developed Q waves in electrocardiogram (ECG) [silent myocardial infarction (MI)] in diabetic patients is reported to be independently associated with an increased risk of fatal MI. However, the incidence rate of silent MI in diabetic patients has yet to be clarified. We sought to determine the incidence rate of first symptomatic MI and silent MI in diabetic patients. METHODS: We conducted a prospective cohort study on patients enrolled in the Japanese primary prevention of atherosclerosis with aspirin for diabetes (JPAD) trial which was started in 2002...
January 2019: Journal of Cardiology
https://www.readbyqxmd.com/read/30476583/liver-fat-is-associated-with-markers-of-inflammation-and-oxidative-stress-in-analysis-of-data-from-the-framingham-heart-study
#6
Zachary P Fricker, Alison Pedley, Joseph M Massaro, Ramachandran S Vasan, Udo Hoffmann, Emelia J Benjamin, Michelle T Long
BACKGROUND & AIMS: Non-alcoholic fatty liver disease is an inflammatory condition that results in progressive liver disease. It is unknown if individuals with hepatic steatosis, but not known to have liver disease, have higher serum concentrations of markers of systemic inflammation and oxidative stress METHODS: We collected data from 2482 participants from the Framingham Heart Study (mean age, 51±11 years; 51% women) who underwent computed tomography and measurement of 14 serum markers of systemic inflammation...
November 23, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30456985/myeloperoxidase-activity-and-acute-coronary-syndrome-survival-long-term-evaluation-in-the-erico-study
#7
Alessandra Vl Quidim, Tatiana C Bruno, Paola Caroline Lacerda Leocádio, Penélope Lacrísio Dos Reis Menta, Jacqueline Isaura Alvarez-Leite, Itamar S Santos, Paulo A Lotufo, Isabela M Benseñor, Alessandra C Goulart
AIM: We aimed to analyze the influence of myeloperoxidase (MPO) activity on mortality in the Acute Coronary Syndrome Registry Strategy (ERICO) study. METHODS: MPO activity levels were evaluated in 342 patients. We performed survival analyses using Kaplan-Meier curves and Cox regression with respective hazard ratios, 95% CI, according to MPO tertiles distribution up to 7 years of follow-up. RESULTS: Higher MPO activity levels were seen in men, smokers, diabetics and those who were taking aspirin...
November 20, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/30447210/predictive-performance-of-the-competing-risk-model-in-screening-for-preeclampsia
#8
David Wright, Min Yi Tan, Neil O'Gorman, Liona C Poon, Argyro Syngelaki, Alan Wright, Kypros H Nicolaides
BACKGROUND: The established method of screening for preeclampsia (PE) is to identify risk factors from maternal demographic characteristics and medical history; in the presence of such factors the patient is classified as high-risk and in their absence as low-risk. However, the performance of such approach is poor. We developed a competing risks model which allows combination of maternal factors (age, weight, height, race, parity, personal and family history of PE, chronic hypertension, diabetes mellitus, systemic lupus erythematosus or antiphospholipid syndrome, method of conception and interpregnancy interval), with biomarkers to estimate the individual patient-specific risks of PE requiring delivery before any specified gestation...
November 14, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30446735/platelet-microparticles-contribute-to-aortic-vascular-endothelial-injury-in-diabetes-via-the-mtorc1-pathway
#9
Gui-Hua Wang, Kun-Ling Ma, Yang Zhang, Ze-Bo Hu, Liang Liu, Jian Lu, Pei-Pei Chen, Chen-Chen Lu, Xiong-Zhong Ruan, Bi-Cheng Liu
Platelet microparticles (PMPs) are closely associated with diabetic macrovascular complications. The present study aimed to investigate the effects of PMPs in diabetes on aortic vascular endothelial injury and to explore the underlying mechanisms. Peritoneal injection of streptozotocin was used to generate a diabetic rat model in vivo, and human umbilical vein endothelial cells (HUVECs) treated with PMPs were used in vitro. PMP levels in the circulation and aorta tissues were time-dependently increased in streptozotocin-induced diabetic rats at weeks 4, 8, and 12 (P < 0...
November 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/30425764/comparison-of-comorbid-conditions-between-cancer-survivors-and-age-matched-patients-without-cancer
#10
Satyajeet Roy, Shirisha Vallepu, Cristian Barrios, Krystal Hunter
Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer. Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Results: Mean age of the cancer survivors was 72...
December 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30418226/correlation-of-cardiovascular-risk-factors-and-biomarkers-with-platelet-reactivity-in-coronary-artery-disease
#11
Elena Bobescu, Alexandru Covaciu, Horatiu Rus, Mariana Radoi, Mihaela Badea, Silvia N Moga, Valentina Benza, Luigi G Marceanu
BACKGROUND: Low response to aspirin, aspirin resistance, and high platelet reactivity on aspirin treatment are similar names for lack of response to block arachidonic acid-induced aggregation with aspirin therapy and have an important role in the evolution of coronary artery disease (CAD) with thromboembolic events. STUDY QUESTION: Was to evaluate the correlation between cardiovascular risk factors, biomarkers, and low response to aspirin in patients (pts) with CAD...
October 29, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/30402961/cardiovascular-disease-management-in-people-with-diabetes-outside-north-america-and-western-europe-in-2006-and-2015
#12
M Tabesh, D J Magliano, S K Tanamas, F Surmont, S Bahendeka, C-E Chiang, J F Elgart, J J Gagliardino, S Kalra, S Krishnamoorthy, A Luk, H Maegawa, A A Motala, F Pirie, A Ramachandran, K Tayeb, O Vikulova, J Wong, J E Shaw
AIM: Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015. METHODS: Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39 684 people...
November 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30400937/low-dose-aspirin-in-the-prevention-of-pre-eclampsia-in-china-appec-study-protocol-for-a-multicentre-randomized-controlled-trial
#13
Li Lin, Yuchun Zhu, Boya Li, Huixia Yang
BACKGROUND: Low-dose aspirin (LDA) has been proposed as a safe and inexpensive prophylactic agent. Studies in European/Western populations have shown promising results indicating that LDA can reduce the occurrence of pre-eclampsia (PE) in women with identifiable risk factors. However, few controlled trials, particularly large randomized controlled trials, have been performed in Asian populations. The aim of this project is to evaluate the effect of LDA for PE prevention on high-risk pregnant women in China, where PE is highly prevalent and the LDA supply status is commonly suboptimal...
November 6, 2018: Trials
https://www.readbyqxmd.com/read/30391673/berberine-mitigates-high-glucose-potentiated-platelet-aggregation-and-apoptosis-by-modulating-aldose-reductase-and-nadph-oxidase-activity
#14
Manoj Paul, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S Girish
Diabetes mellitus (DM) is a serious metabolic disorder affecting millions of people worldwide. The high rate of mortality and morbidity during DM is attributed to the increased atherothrombotic events due to platelet activation and apoptosis leading to macro and micro vascular occlusions. The platelet hyper-reactivity and apoptosis during DM is accounted for the accumulated reactive oxygen species (ROS) due to increased aldose reductase (AR) and NADPH oxidase (NOX) activities. Considering aspirin insensitivity in DM patients, new therapies targeting the underlying mechanism is urgently warranted...
November 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30376415/prescription-rate-of-anti-atherosclerotic-drugs-in-german-nursing-homes-and-its-impact-on-outcome
#15
Noemi Galas, Ingrid Becker, Tomasz Ficon, Maik Sakrauski, Rita Reichert, Wael Ahmad, Spyridon Mylonas, Jan Brunkwall, Payman Majd
BACKGROUND: Peripheral arterial disease (PAD) is one of the major manifestations of general atherosclerosis and strongly associated with increased cardiovascular morbidity and mortality. Because only few epidemiologic studies are available concerning the prevalence of PAD in inhabitants ≥ 80 years of age, we screened inhabitants of nursing care homes in Germany for PAD and cardiovascular diseases and to assess the one year mortality. PATIENTS AND METHODS: We conducted a prospective cohort study, screening inhabitants of 42 nursing homes for PAD...
October 30, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/30369326/central-obesity-and-visceral-adipose-tissue-are-not-associated-with-incident-atherosclerotic-cardiovascular-disease-events-in-older-men
#16
John T Schousboe, Allyson M Kats, Lisa Langsetmo, Tien N Vo, Brent C Taylor, Ann V Schwartz, Peggy M Cawthon, Cora E Lewis, Elizabeth Barrett-Connor, Andrew R Hoffman, Eric S Orwoll, Kristine E Ensrud
Background Visceral adipose tissue ( VAT ) and other measures of central obesity predict incident atherosclerotic cardiovascular disease ( ASCVD ) events in middle-aged individuals, but these associations are less certain in older individuals age 70 years and older. Our objective was to estimate the associations of VAT and the android-gynoid fat mass ratio, another measure of central obesity, with incident ASCVD events among a large cohort of older men. Methods and Results Two thousand eight hundred ninety-nine men (mean [ SD ] age 76...
August 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30366771/risk-factors-for-upper-gastrointestinal-bleeding-among-aspirin-users-an-old-issue-with-new-findings-from-a-population-based-cohort-study
#17
Pei-Jui Luo, Xi-Hsuan Lin, Chung-Chi Lin, Jiing-Chyuan Luo, Hsiao-Yun Hu, Po-Hsiang Ting, Ming-Chih Hou
BACKGROUND/PURPOSE: We aimed to identify the risk factors of first-time occurrence of non-variceal upper gastrointestinal bleeding (UGIB) among aspirin users after adjusting for confounding factors like age, gender, underlying co-morbidities, and medications. METHODS: Using the National Health Insurance Research Database of Taiwan and matching age, gender, underlying co-morbidities and enrollment time by propensity score, 11105 aspirin users and 11105 controls were identified for comparison from a cohort dataset of 1,000,000 randomly sampled subjects...
October 23, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30360849/medical-and-lifestyle-management-of-peripheral-arterial-disease
#18
REVIEW
Saman L Parvar, Robert Fitridge, Joseph Dawson, Stephen J Nicholls
OBJECTIVE: Peripheral arterial disease (PAD) is a global health issue associated with impaired functional capacity and elevated risk of major adverse cardiovascular events (MACEs). With changing risk factor profiles and an aging population, the burden of disease is expected to increase. This review considers evidence for the noninvasive management of PAD and makes clinical recommendations accordingly. METHODS: A comprehensive literature review was performed to examine the evidence for smoking cessation, exercise therapy, antiplatelet therapy, anticoagulant therapy, antihypertensive therapy, lipid-lowering therapy, and glycemic control in diabetes for patients with PAD...
November 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30359352/are-the-benefits-of-aspirin-likely-to-exceed-the-risk-of-major-bleeds-among-people-in-whom-aspirin-is-recommended-for-the-primary-prevention-of-cardiovascular-disease
#19
Vanessa Selak, Rod Jackson, Katrina Poppe, Andrew Kerr, Sue Wells
AIM: The 2018 New Zealand Consensus Statement on cardiovascular disease (CVD) risk assessment and management recommends the use of aspirin in people aged less than 70 years with a five-year CVD risk >15% but without prior CVD. We determined whether the estimated number of CVD events avoided by taking aspirin is likely to exceed the number of additional major bleeds caused by aspirin in this patient population. METHOD: Major bleeding rates were obtained from the PREDICT primary care study, a large New Zealand cohort of people eligible for CVD risk assessment, after excluding those with no other indications for (eg, established CVD) or contraindications/cautions (eg, prior major bleed) to aspirin use...
October 26, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/30352719/use-of-preventive-health-services-among-cancer-survivors-in-the-u-s
#20
Soham Gupta, Alexander P Cole, Maya Marchese, Ye Wang, Jacqueline M Speed, Sean A Fletcher, Junaid Nabi, Sebastian Berg, Stuart R Lipsitz, Toni K Choueiri, Steven L Chang, Adam S Kibel, Annemarie Uhlig, Quoc-Dien Trinh
INTRODUCTION: With improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medical complications and secondary malignancies. METHODS: The 2013 National Health Interview Survey was utilized to assess the association between personal history of cancer and receipt of U...
October 20, 2018: American Journal of Preventive Medicine
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