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https://www.readbyqxmd.com/read/30093367/the-use-of-aspirin-to-reduce-the-risk-of-thrombotic-events-in-patients-with-end-stage-renal-disease-protocol-for-a-randomized-controlled-trial
#1
Tiago Lemos Cerqueira, Armando Fartolino Guerrero, Clara Krystal Pérez Fermin, Ricardo Wang, Evelin Elfriede Balbino, Janis L Breeze, Paola Gonzalez Mego, Daniele Argentina Silva, Walid Ezzeldin Omer, Nathalie Monique Vandevelde
BACKGROUND: End-stage renal disease (ESRD) is the last stage of chronic kidney disease, mainly caused by type 2 diabetes mellitus and characterized by an increased mortality risk related to cardiovascular disease. Low-dose aspirin (acetylsalicylic acid or ASA) seems to effectively prevent cardiovascular events in patients with ESRD. However, the number of interventional studies in this population remains limited and the mechanisms of aspirin-related bleeding remain poorly understood. Aspirin's efficacy and safety may be modified by the presence of type 2 diabetes mellitus or platelet hyperreactivity...
August 9, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30088358/medical-resource-consumption-and-quality-of-life-in-peripheral-arterial-disease-in-korea-pad-outcomes-pado-research
#2
Seung Woon Rha, Seung Hyuk Choi, Doo Il Kim, Dong Woon Jeon, Jae Hwan Lee, Kyung Soon Hong, Tae Joon Cha, Jang Hyun Cho, Sang Kon Lee, Yong Hwan Park, Woo Jung Park, Hyun Joo Kim, Young Joo Kim, Juneyoung Lee, Donghoon Choi
BACKGROUND AND OBJECTIVES: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. METHODS: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0...
June 18, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/30084749/validation-of-the-survival-benefits-of-metformin-in-middle-eastern-patients-with-type-ii-diabetes-mellitus-and-colorectal-cancer
#3
Amal Al Omari, Hadeel Abdelkhaleq, Maysa Al-Hussaini, Rim Turfa, Nour Awad, Manal M Hassan, Mahmoud A Alfaqih, Christopher R Garrett
Purpose Epidemiologic data from several populations suggest that metformin may decrease cancer risk and mortality in patients with colorectal cancer (CRC) and type II diabetes mellitus (DM). Although type II DM and CRC are major health problems in the Middle East, no investigations have been performed to test the effect metformin has on the outcome of patients with type II DM and CRC who are also treated with metformin. Materials and Methods We retrospectively reviewed the medical records of 1,902 patients diagnosed with CRC at King Hussein Cancer Center between January 2004 and December 2012, and identified 349 patients (18%) with type II DM; we censored the data of 28 patients because their antidiabetic medications were unknown...
July 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30081159/metformin-is-associated-with-improved-survival-and-decreased-cardiac-events-with-no-impact-on-patency-and-limb-salvage-after-revascularization-for-peripheral-arterial-disease
#4
Sikandar Z Khan, Mariel Rivero, Gregory S Cherr, Linda M Harris, Maciej L Dryjski, Nader D Nader, Hasan H Dosluoglu
OBJECTIVE: The incidence of cardiovascular and limb-specific adverse outcomes is higher in PAD patients with diabetes. Metformin is associated with improved cardiovascular morbidity and mortality. However, the effect of metformin on limb-specific outcomes is unclear. The objective of this study was to assess the effect of metformin on outcomes following intervention for PAD. METHODS: Patients who underwent revascularization for chronic limb ischemia (Rutherford 3-6) between 06/2001-12/2014 were retrospectively identified...
August 3, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30075542/association-of-early-loss-of-primary-functional-patency-of-arteriovenous-access-with-mortality-in-incident-hemodialysis-patients-a-nationwide-population-based-observational-study
#5
Chung-Kuan Wu, Chia-Hsun Lin, Chih-Cheng Hsu, Der-Cherng Tarng, Chew-Teng Kor, Yi-Chun Chen, Chia-Lin Wu, Chia-Chu Chang
The long-term survival and life quality of hemodialysis (HD) patients depend on adequacy of dialysis via a well-functioning vascular access. Loss of primary functional patency (PFP) of an arteriovenous access (AVA) eventually happens in HD patients. The association between time to loss of PFP of AVAs and mortality in HD patients remains unclear. The retrospective nationwide population-based cohort study compared the hazards of mortality with time to loss of PFP. We enrolled 1618 adult incident HD patients who received HD via AVAs for at least 90 days between January 1, 2001 and December 31, 2013...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30074112/ticagrelor-and-the-prevention-of-microvascular-complications-in-diabetes-patients-with-lower-extremity-arterial-disease-rationale-and-design-of-the-hema-kinesis-trial
#6
Robert S Rosenson, Qinzhong Chen, Sherwin D Najera, Martin L Lee, Daniel J Cho
BACKGROUND: Lower extremity arterial disease (LEAD) occurs more common in patients with diabetes than without diabetes. Microvascular complications of diabetes contribute to higher rates of adverse limb events in patients with LEAD. Blood flow in the macrocirculation and microcirculation is reduced with increasing low-shear and high-shear blood viscosity. We hypothesize that the adenosine enhancing properties of ticagrelor will reduce low-shear blood viscosity and improve microcirculatory flow in the dorsum of the feet of patients with type 2 diabetes...
August 3, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/30064844/the-impact-of-foot-infection-on-infrainguinal-bypass-outcomes-in-patients-with-chronic-limb-threatening-ischemia
#7
Jessica M Mayor, Wilmer Valentin, Sherene Sharath, Neal R Barshes, Jayer Chung, Panos Kougias, Joseph L Mills
BACKGROUND: Despite advances in endovascular therapy, infrainguinal bypass continues to play a major role in achieving limb salvage. In this study, we sought to compare outcomes of infrainguinal bypass in patients with limb-threatening ischemia who presented with or without foot infection. METHODS: We conducted a retrospective cohort study of patients who underwent infrainguinal bypass for chronic limb-threatening ischemia at a single institution. End points of interest included long-term mortality, 45-day readmission, postoperative length of stay (LOS), major amputation, and time to wound healing...
July 28, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30062075/management-of-atrial-fibrillation-in-patients-on-ibrutinib-a-cleveland-clinic-experience
#8
Sidra Khalid, Samin Yasar, Aariez Khalid, Timothy Pp Spiro, Abdo Haddad, Hamed Daw
Background Ibrutinib is a Bruton's tyrosine kinase inhibitor, which is United States Food and Drug Administration (FDA)-approved for chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenström's macroglobulinemia. Ibrutinib is associated with atrial fibrillation and bleeding events. Our aim is to determine the management of prior atrial fibrillation when starting ibrutinib, as well as ibrutinib-induced atrial fibrillation. Our focus is on which rate and rhythm control strategies to use and decisions regarding the use of antiplatelet and anticoagulation agents...
May 29, 2018: Curēus
https://www.readbyqxmd.com/read/30046729/effects-of-daily-aspirin-on-cancer-incidence-and-mortality-in-the-elderly-japanese
#9
Kenji Yokoyama, Naoki Ishizuka, Naomi Uemura, Yuji Mizokami, Hideyuki Hiraishi, Mitsuru Murata, Shinichiro Uchiyama, Tamio Teramoto, Kazuyuki Shimada, Tsutomu Yamazaki, Shinichi Oikawa, Masahiro Sugawara, Katsuyuki Ando, Yasuo Ikeda
<AbstractText Label="Background" NlmCategory="UNASSIGNED">Long-term follow-up of studies to investigate preventive effects of aspirin on arterial thrombosis indicate that aspirin reduces the incidence and mortality of some cancers in Western populations. Objectives: To explore the effects of aspirin on cancer incidence and mortality in the elderly Japanese. Patients/Methods: Patients aged 60 to 85 years, presenting with hypertension, dyslipidemia, or diabetes mellitus (n = 14 601, 7297 in the aspirin group and 7304 in the no-aspirin group) participated the Japanese Primary Prevention Project (JPPP), a multicenter, open-label, randomized, parallel-group trial...
April 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30034875/arachidonic-acid-in-health-and-disease-with-focus-on-hypertension-and-diabetes-mellitus-a-review
#10
REVIEW
Undurti N Das
Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting. Studies showed that AA and its metabolites especially, lipoxin A4 (LXA4) and epoxyeicosatrienoic acids (EETs), potent anti-inflammatory metabolites, have a crucial role in the pathobiology of hypertension and diabetes mellitus...
May 2018: Journal of Advanced Research
https://www.readbyqxmd.com/read/30033753/combined-use-of-polypill-components-in-patients-with-type-2-diabetes-mellitus
#11
Vivi E Janssen, Frank L Visseren, Anthonius de Boer, Diederick E Grobbee, Jan Westerink, Yolanda van der Graaf, Melvin Lafeber
Objectives A polypill containing aspirin, a statin and blood pressure (BP)-lowering agents has been proposed for the prevention of cardiovascular disease. To increase adherence and reduce the gaps between indicated and used therapy, a polypill might be of interest for patients with type 2 diabetes (T2DM). Our aim was to assess the prevalence of the combined use of polypill components in patients with T2DM over time. Methods The combined use of polypill components was assessed between 1996 and 2015 in patients with T2DM in the prospective SMART cohort ( n = 1828)...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/30025445/correlation-of-androgen-deprivation-therapy-with-cognitive-dysfunction-in-patients-with-prostate-cancer-a-nationwide-population-based-study-using-the-national-health-insurance-service-database
#12
Bum Sik Tae, Byung Jo Jeon, Seung Hun Shin, Hoon Choi, Jae Hyun Bae, Jae Young Park
Purpose: The purpose of this study was to evaluate the association of androgen deprivation therapy (ADT) with cognitive dysfunction. Material and Methods: Using the National Health Insurance Service database of the entire Korean adult prostate cancer population (n=236,391), data on ADT and cognitive dysfunction between 2008 and 2015 were analyzed. We excluded patients previously diagnosed with cognitive dysfunction, dementia, or a cerebral event history. We tested the effect of ADT on the risk of cognitive dysfunction using propensity score-matched Cox proportional hazards regression models and Kaplan-Meier survival analysis...
July 18, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30023382/low-dose-aspirin-for-primary-cardiovascular-prevention-in-diabetic-patients-the-issue-to-believe-it-or-not
#13
EDITORIAL
Priscilla Lamendola, Angelo Villano, Augusto Fusco, Massimo Leggio
No abstract text is available yet for this article.
June 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30023381/aspirin-and-diabetes-mellitus-in-primary-prevention-the-endless-conundrum
#14
EDITORIAL
Rubén Casado-Arroyo
No abstract text is available yet for this article.
June 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30017552/effects-of-aspirin-on-risks-of-vascular-events-and-cancer-according-to-bodyweight-and-dose-analysis-of-individual-patient-data-from-randomised-trials
#15
Peter M Rothwell, Nancy R Cook, J Michael Gaziano, Jacqueline F Price, Jill F F Belch, Maria Carla Roncaglioni, Takeshi Morimoto, Ziyah Mehta
BACKGROUND: A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes. METHODS: Using individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm bands) on the effects of low doses (≤100 mg) and higher doses (300-325 mg or ≥500 mg) of aspirin in randomised trials of aspirin in primary prevention of cardiovascular events...
July 12, 2018: Lancet
https://www.readbyqxmd.com/read/30011059/aspirin-in-primary-prevention-for-patients-with-diabetes-still-a-matter-of-debate
#16
REVIEW
Aldo Bonaventura, Luca Liberale, Fabrizio Montecucco
BACKGROUND: Patients with diabetes are at high cardiovascular (CV) risk due to an exaggerated platelet activation and aggregation. In the first 2000s low-dose aspirin was first recommended for primary prevention, but then re-discussed. METHODS: This short narrative review, based on the material searched for and obtained via PubMed up to February 2018, aims at clarifying this controversial topic. RESULTS: The JPAD2 study has been designed to evaluate the occurrence of any CV event in a cohort of patients with diabetes and concluded that low-dose aspirin did not influence the risk for CV events while increasing the risk for gastrointestinal (GI) bleeding...
July 16, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30002948/are-patients-with-high-risk-polycythemia-vera-receiving-cytoreductive-medications-a-retrospective-analysis-of-real-world-data
#17
Dilan Paranagama, Philomena Colucci, Kristin A Evans, Machaon Bonafede, Shreekant Parasuraman
Background: Patients with polycythemia vera (PV) have a higher mortality risk compared with the general population, primarily driven by cardiovascular disease, thrombotic events (TEs), and hematologic transformations. The goal of risk-adapted therapy in PV is prevention of TEs. Current treatment recommendations indicate that high-risk patients (aged ≥ 60 years and/or with history of TEs) should be managed with cytoreductive medications, phlebotomy, and low-dose aspirin. This noninterventional study was conducted to describe real-world cytoreductive medication treatment in adult patients with PV, stratified by risk, in the United States...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29998344/screening-for-peripheral-artery-disease-and-cardiovascular-disease-risk-assessment-with-the-ankle-brachial-index-us-preventive-services-task-force-recommendation-statement
#18
Susan J Curry, Alex H Krist, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Martha Kubik, C Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng, John B Wong
Importance: Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the lower limbs. It can impair walking and, in severe cases, can lead to tissue loss, infection, and amputation. In addition to morbidity directly caused by PAD, patients with PAD are at increased risk for cardiovascular disease (CVD) events, because atherosclerosis is a systemic disease that also causes coronary and cerebrovascular events. Objective: To update the 2013 US Preventive Services Task Force (USPSTF) recommendation on screening for PAD and CVD risk with the ankle-brachial index (ABI)...
July 10, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29998343/screening-for-peripheral-artery-disease-using-the-ankle-brachial-index-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#19
REVIEW
Janelle M Guirguis-Blake, Corinne V Evans, Nadia Redmond, Jennifer S Lin
Importance: Peripheral artery disease (PAD) is associated with a high risk for cardiovascular events and poor ambulatory function, even in the absence of symptoms. Screening for PAD with the ankle-brachial index (ABI) may identify patients in need of treatment to improve health outcomes. Objective: To systematically review evidence for the US Preventive Services Task Force on PAD screening with the ABI, the diagnostic accuracy of the test, and the benefits and harms of treatment of screen-detected PAD...
July 10, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29985735/comparison-of-nine-platelet-function-tests-used-to-determine-responses-to-different-aspirin-dosages-in-people-with-type-2-diabetes
#20
Paul Harrison, M Angelyn Bethel, Irene Kennedy, Robert Dinsdale, Ruth Coleman, Rury R Holman
The antiplatelet efficacy of aspirin (ASA) is reduced in type 2 diabetes (T2D). As the best ex vivo method of measuring ASA efficacy remains uncertain, we compared nine platelet function tests to assess responsiveness to three ASA dosing regimens in 24 T2D patients randomized in a three-treatment crossover design to ASA 100 mg/day, 200 mg/day, or 100 mg twice daily for 2-week treatment periods. Platelet function tests compared were as follows: light transmission aggregometry (LTA)-0.5 mg/mL of arachidonic acid (AA) and 10 µM adenosine diphosphate (ADP); multiplate whole blood aggregometry (WBA)-0...
July 9, 2018: Platelets
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