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New Delhi Metallo-beta-lactamase

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https://www.readbyqxmd.com/read/28416558/in-vitro-discordance-with-in-vivo-activity-humanized-exposures-of-ceftazidime-avibactam-aztreonam-and-tigecycline-alone-and-in-combination-against-new-delhi-metallo-%C3%AE-lactamase-producing-klebsiella-pneumoniae-in-a-murine-lung-infection-model
#1
M L Monogue, L M Abbo, R Rosa, J F Camargo, O Martinez, R A Bonomo, D P Nicolau
The management of infections with New Delhi Metallo-beta-lactamase-1 (NDM) producing bacteria remains clinically challenging given the multi-drug resistant (MDR) phenotype associated with these bacteria. Despite resistance in vitro, ceftazidime-avibactam previously demonstrated in vivo activity against NDM+ Enterobacteriaceae. Herein, we observed in vitro synergy with ceftazidime-avibactam and aztreonam against a MDR K. pneumoniae harboring NDM. In vivo, humanized doses of ceftazidime-avibactam monotherapy resulted in > 2 log10CFU bacterial reduction, therefore, no in vivo synergy was observed...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28357923/performance-of-carbanp-and-cim-tests-in-oxa-48-carbapenemase-producing-enterobacteriaceae
#2
Serap Süzük Yıldız, Banu Kaşkatepe, Havva Avcıküçük, Şükran Öztürk
This study applied two phenotypic tests, namely "Carbapenemase Nordmann-Poirel" (CarbaNP) test and "Carbapenem Inactivation Method" (CIM), against the isolates carrying the carbapenem resistance genes. The study included 83 carbapenem-resistant Enterobacteriaceae isolates producing oxacillinase-48 (OXA-48) and 30 carbapenem-sensitive Enterobacteriaceae isolates. Out of the total isolates studied, 77 isolates (92.77%) were identified as Klebsiella pneumoniae and six isolates (7.23%) were identified as Escherichia coli by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry...
March 1, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28345184/spatial-molecular-epidemiology-of-carbapenem-resistant-and-new-delhi-metallo-beta-lactamase-blandm-producing-escherichia-coli-strains-from-farmed-piglets-of-india
#3
B S Pruthvishree, O R Vinodh Kumar, D K Sinha, Y P S Malik, Z Dubal, P A Desingu, M Shivakumar, Narayanan Krishnaswamy, B R Singh
AIM: A cross-sectional study was conducted in ten government organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in Escherichia coli isolates. METHODS AND RESULTS: In this study, 673 fecal samples both from non- diarhhoeic (n=501) and diarrhoeic (n=172) piglets were processed for isolation of carbapenem resistant E. coli. Wherein, 112 confirmed E. coli isolates were further subjected for genotypic confirmation of carbapenem resistance and virulence factors...
March 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28242668/plasmid-mediated-novel-blandm-17-gene-encoding-a-carbapenemase-with-enhanced-activity-in-a-st48-escherichia-coli-strain
#4
Zhihai Liu, Yang Wang, Timothy R Walsh, Dejun Liu, Zhangqi Shen, Rongmin Zhang, Wenjuan Yin, Hong Yao, Jiyun Li, Jianzhong Shen
Carbapenem-resistant Enterobacteriaceae (CRE) have spread worldwide, leaving very few treatment options available. New Delhi metallo-beta-lactamase (NDM) is the main carbapenemase mediating CRE resistance, and is of increasing concern. NDM-positive Enterobacteriaceae of human origin are frequently identified; however, the emergence of NDM, particularly novel variants, in bacteria of food animal origin has never been reported. Here, we characterize a novel NDM variant (assigned NDM-17) identified in a β-lactam-resistant sequence type 48 (ST48) Escherichia coli strain that was isolated from a chicken in China...
February 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28239454/transcriptional-analysis-of-blandm-1-and-copy-number-alteration-under-carbapenem-stress
#5
Deepjyoti Paul, Amitabha Bhattacharjee, Dibyojyoti Bhattacharjee, Debadatta Dhar, Anand Prakash Maurya, Atanu Chakravarty
BACKGROUND: New Delhi metallo beta-lactamase is known to compromise carbapenem therapy and leading to treatment failure. However, their response to carbapenem stress is not clearly known. Here, we have investigated the transcriptional response of blaNDM-1 and plasmid copy number alteration under carbapenem exposure. METHODS: Three blaNDM-1 harboring plasmids representing three incompatibility types (IncFIC, IncA/C and IncK) were inoculated in LB broth with and without imipenem, meropenem and ertapenem...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28156193/characterization-of-ndm-7-carbapenemase-producing-escherichia-coli-isolates-in-the-arabian-peninsula
#6
Tibor Pál, Akela Ghazawi, Dania Darwish, Laura Villa, Alessandra Carattoli, Rayhan Hashmey, Zulfa Aldeesi, Wafaa Jamal, Vincent Rotimi, Amina Al-Jardani, Seif S Al-Abri, Ágnes Sonnevend
AIM: The purpose of this study was to characterize the New Delhi metallo-beta lactamase (NDM)-7-producing Enterobacteriaceae isolated in the Arabian Peninsula. METHODS: Enterobacteriaceae identified to carry blaNDM-7 in a collection of 157 NDM-producing isolates from Kuwait, Oman, Saudi Arabia, and the United Arab Emirates (UAE) were investigated for their antibiotic and disinfectant susceptibility, and resistance gene content. The virulence profile, phylogenetic and sequence types of the isolates were also determined...
February 3, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28150578/resistotyping-phenotyping-and-genotyping-of-new-delhi-metallo-%C3%AE-lactamase-ndm-among-gram-negative-bacilli-from-iranian-patients
#7
Dariush Shokri, Mohammad Rabbani Khorasgani, Seyed Masih Fatemi, Abbas Soleimani-Delfan
PURPOSE: The purpose of this study was investigation of New Delhi metallo-β-lactamase (NDM) production among gram negative bacilli. METHODOLOGY: Antibiogram-Resistotyping and detection of NDM in clinical isolates of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa and comparative evaluation of the diagnostic performance of three phenotypic methods for NDM detection considering PCR as gold standard were performed. Minimum Inhibitory Concentration (MIC) of antibiotics against NDM positive strains by E-test and clonal relationship analysis using Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR) in these strains were determined...
February 1, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28104504/diversity-of-new-delhi-metallo-beta-lactamase-producing-bacteria-in-china
#8
Xiaofeng Hu, Xuebing Xu, Xu Wang, Wencheng Xue, Haijian Zhou, Ling Zhang, Qiuxia Ma, Rongtao Zhao, Guozheng Li, Peng Li, Chuanfu Zhang, Yun Shi, Jian Wang, Leili Jia, Rongzhang Hao, Ligui Wang, Dayang Zou, Xuelin Liu, Shaofu Qiu, Hongbin Song, Yansong Sun
OBJECTIVES: The prevalence and dissemination of diverse NDM-producing bacteria in China was investigated. METHODS: We collected 1,162 isolates from 8 cities during December 2013∼May 2015 in China. The NDM-positive strains as well as the NDM genotypes in these sample were detected via Vitek 2 compact system (bioMérieux, France), 16S rRNA gene sequencing, PCR and an S1- pulsed-field gel electrophoresis assay and Southern blot hybridization. The horizontal-transfer capability of the blaNDM gene was assessed by filter mating by using a standard E...
February 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28087620/e152a-substitution-drastically-affects-ndm-5-activity
#9
Gaurav Kumar, Bagre Issa, Debasish Kar, Sarmistha Biswal, Anindya S Ghosh
New Delhi Metallo beta-lactamase (NDM) is of significant public health concern due to its enormous potential to hydrolyse all major beta-lactams including carbapenems. Amino acid substitutions outside the active site reportedly affect NDM beta-lactamase activities. Here, the effect of amino acid substitutions in the possible omega-like loop region of NDM-5 has been elucidated. Overall, three substitution mutations near active site of NDM-5 were done, namely, E152A, S191A and D223A and subsequently, the change in antimicrobial resistance was monitored upon expressing each mutant in a suitable host...
February 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28081065/notes-from-the-field-pan-resistant-new-delhi-metallo-beta-lactamase-producing-klebsiella-pneumoniae-washoe-county-nevada-2016
#10
Lei Chen, Randall Todd, Julia Kiehlbauch, Maroya Walters, Alexander Kallen
No abstract text is available yet for this article.
January 13, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27934850/erratum-endemic-indian-clones-of-klebsiella-pneumoniae-harbouring-new-delhi-metallo-beta-lactamase-1-on-a-hybrid-plasmid-replicon-type-a-case-of-changing-new-delhi-metallo-beta-lactamase-plasmid-landscapes-in-india
#11
(no author information available yet)
[This corrects the article DOI: 10.4103/0255-0857.188314.].
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27714593/emergence-of-new-delhi-metallo-beta-lactamase-1-and-other-carbapenemase-producing-acinetobacter-calcoaceticus-baumannii-complex-among-patients-in-hospitals-in-ha-noi-viet-nam
#12
D N Tran, H H Tran, M Matsui, M Suzuki, S Suzuki, K Shibayama, T D Pham, T T Van Phuong, D A Dang, H S Trinh, C T Loan, L T V Nga, H R van Doorn, H F L Wertheim
Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems...
February 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27600040/molecular-epidemiology-and-genome-dynamics-of-new-delhi-metallo-%C3%AE-lactamase-producing-extraintestinal-pathogenic-escherichia-coli-strains-from-india
#13
Amit Ranjan, Sabiha Shaik, Agnismita Mondal, Nishant Nandanwar, Arif Hussain, Torsten Semmler, Narender Kumar, Sumeet K Tiwari, Savita Jadhav, Lothar H Wieler, Niyaz Ahmed
The global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinical Escherichia coli isolates recovered from extraintestinal infections in two hospitals in Pune, India. We screened a large sample size of 510 E. coli isolates for MBL production wherein we profiled their molecular determinants, antimicrobial resistance phenotypes, functional virulence properties, genomic features, and transmission dynamics...
November 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27565452/detection-of-new-delhi-metallo-beta-lactamase-encoded-by-blandm-1-in-enterobacter-aerogenes-in-china
#14
Yong Shen, Wei-Qiang Xiao, Jiao-Mei Gong, Jun Pan, Qing-Xia Xu
BACKGROUND: The increase in blaNDM-1 in Enterobacteriaceae has become a major concern worldwide. In previous study, we investigated clonal dissemination and mechanisms of resistance to carbapenem in China. METHODS: We carried out retrospective surveillance for blaNDM-1 among carbapenem-resistant enterobacter strains, which were isolated from patients at our hospital by bacterial strains selection, antimicrobial susceptibility testing, species identification, and molecular detection of resistance gene...
August 27, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27534373/the-role-of-doxycycline-in-the-therapy-of-multidrug-resistant-e-coli-an-in-vitro-study
#15
Chih-Cheng Lai, Chi-Chung Chen, Hui-Ling Huang, Yin-Ching Chuang, Hung-Jen Tang
This study assessed the in vitro antibacterial activity of combinations of amikacin and doxycycline or tigecycline against multidrug-resistant E. coli isolates. Twenty-four different pulsotypes, including 10 extended-spectrum β-lactamase (ESBL)-, 10 carbapenem-resistant, 2 New Delhi Metallo-beta-lactamase (NDM)- and 2 Klebsiella pneumoniae carbapenemase (KPC)-E. coli isolates were collected. All 24 isolates were susceptible to amikacin and tigecycline. Only 30% of ESBL and 50% of carbapenem-resistant E. coli were susceptible to doxycycline...
August 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27524536/dissemination-and-spread-of-new-delhi-metallo-beta-lactamase-1-superbugs-in-hospital-settings
#16
Erum Khan, Seema Irfan, Binish Arif Sultan, Amna Nasir, Rumina Hasan
OBJECTIVE: To find out frequency of isolation of carbapenem-resistant enterobacteriaceae and the predominantly responsible metallo-beta-lactamasegene in a hospital setting. METHODS: The descriptive, cross-sectional study was conducted from May 2009 to June 2012 at the Aga Khan University Hospital, Karachi, and comprised non-duplicate clinical carbapenem-resistant enterobacteriaceae isolates obtained from different collection units across Pakistan. Kirby-Bauer disk diffusion screening of carbapenem-resistant enterobacteriaceae was confirmed by minimum inhibitory concentration using E-test...
August 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27514962/multidrug-resistance-mediated-by-co-carriage-of-extended-spectrum-beta-lactamases-ampc-and-new-delhi-metallo-beta-lactamase-1-genes-among-carbapenem-resistant-enterobacteriaceae-at-five-indian-medical-centres
#17
A Manoharan, G S Barla, R Peter, M Sugumar, D Mathai
In this study, we evaluated the coexistence of extended-spectrum beta-lactamases (ESBL), AmpC and New Delhi metallo-beta-lactamase-1 (NDM-1) genes among carbapenem-resistant Enterobacteriaceae (CRE) recovered prospectively from patients at multiple sites. The study included 285 CRE strains from 2782 Gram-negative Bacilli collected from multiple centres during 2007-2010, of which 87 were characterised. Standard and reference laboratory methods were used for resistance determination. Detection of blaNDM-1 , blaAmpC , blaTEM , blaSHV and blaCTX-M was done by polymerase chain reaction...
July 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27514958/reduced-susceptibility-to-chlorhexidine-disinfectant-among-new-delhi-metallo-beta-lactamase-1-positive-enterobacteriaceae-and-other-multidrug-resistant-organisms-report-from-a-tertiary-care-hospital-in-karachi-pakistan
#18
P B Mal, J Farooqi, S Irfan, M A Hughes, E Khan
We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms...
July 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27514948/endemic-indian-clones-of-klebsiella-pneumoniae-harbouring-new-delhi-metallo-beta-lactamase-1-on-a-hybrid-plasmid-replicon-type-a-case-of-changing-new-delhi-metallo-beta-lactamase-plasmid-landscapes-in-india
#19
G K Subramanian, P G Soundari, V Ramanathan, P Krishnan
PURPOSE: blaNDM genes are MBL genes that confer resistance to carbapenems. Globally, they are associated with diverse clones and plasmids. In this study, we characterised three isolates of Klebsiella pneumoniae-harbouring blaNDM1 from patients undergoing chronic haemodialysis and renal transplantation. MATERIALS AND METHODS: 3 blaNDM1 -producing K. pneumoniae were isolated from end-stage renal disease patients undergoing haemodialysis and renal transplantation from a nephrology unit...
July 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27496450/successful-treatment-of-urinary-tract-infection-in-kidney-transplant-recipients-caused-by-multiresistant-klebsiella-pneumoniae-producing-new-delhi-metallo-beta-lactamase-ndm-1-with-strains-genotyping
#20
P Wilkowski, M Ciszek, K Dobrzaniecka, J Sańko-Resmer, A Łabuś, K Grygiel, T Grochowiecki, G Młynarczyk, L Pączek
BACKGROUND: Klebsiella pneumoniae New Delhi metallo-beta-lactamase-1 (NDM-1) strains have recently become a new threat in kidney transplant recipients due to the strains' resistance to almost all antibiotics, including carbapenems. METHODS: We present a case series of 3 patients with urinary tract infections (UTIs) caused by multiresistant K pneumoniae NDM-1 strains who were treated with the same protocol. Genotyping sequencing with pulsed-field gel electrophoresis was performed in all cases...
June 2016: Transplantation Proceedings
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