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spontaneous recovery

Paul Walbron, Florence Müller, Laurence Mainard-Simard, Amandine Luc, Pierre Journeau
Quality of spontaneous amelioration of residual developmental dysplasia of the hip (DDH) is nowadays not possible to predict. Normal age-related values of the osseous acetabular index (OAI), cartilaginous acetabular index and labral acetabular index have been established on MRI. In this study, MRI of dysplastic hips has been evaluated, and further osseous acetabular maturation was followed-up over time on pelvic radiography to find a correlation between MRI findings and radiological evolution. This is a retrospective single-centre study...
December 13, 2018: Journal of Pediatric Orthopedics. Part B
Sarah Brookes, Sherry Voytik-Harbin, Hongji Zhang, Lujuan Zhang, Stacey Halum
OBJECTIVE: Tissue engineering of the larynx requires a complex, multiple tissue layer design. Additionally, spontaneous reinnervation of the larynx after recurrent laryngeal nerve (RLN) injury is often disorganized, resulting in subpar function. This study investigates use of tissue-engineered cartilage and motor endplate-expressing (MEE) tissue-engineered skeletal muscle implants for laryngeal reconstruction and the promotion of organized reinnervation after RLN injury. METHODS: F344 rat primary muscle progenitor cells (MPCs) were isolated...
December 12, 2018: Laryngoscope
Miguel Goulão, Biswarup Ghosh, Mark W Urban, Malya Sahu, Christina Mercogliano, Brittany A Charsar, Sreeya Komaravolu, Cole G Block, George M Smith, Megan C Wright, Angelo C Lepore
Stem/progenitor cell transplantation delivery of astrocytes is a potentially powerful strategy for spinal cord injury (SCI). Axon extension into SCI lesions that occur spontaneously or in response to experimental manipulations is often observed along endogenous astrocyte "bridges," suggesting that augmenting this response via astrocyte lineage transplantation can enhance axon regrowth. Given the importance of respiratory dysfunction post-SCI, we transplanted glial-restricted precursors (GRPs)-a class of lineage-restricted astrocyte progenitors-into the C2 hemisection model and evaluated effects on diaphragm function and the growth response of descending rostral ventral respiratory group (rVRG) axons that innervate phrenic motor neurons (PhMNs)...
December 11, 2018: Glia
Joakim Holger Waage Brinch, Carl Martin Söderström, Mona Ring Gätke, Matias Vested Madsen
BACKGROUND: Mivacurium is a short-acting non-depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase. The neuromuscular block (NMB) can be antagonized with cholinesterase inhibitors (CHEI), but the short duration of action of mivacurium questions the need. This systematic review evaluated if the use of CHEIs (neostigmine, pyridostigmine or edrophonium) facilitates reversal of mivacurium-induced NMB. METHOD: Randomized controlled trials and crossover-studies comparing spontaneous recovery with CHEI reversal in patients with mivacurium-induced NMB, assessed with quantitative neuromuscular monitoring, were included...
December 11, 2018: Acta Anaesthesiologica Scandinavica
Duilio M Potenza, Radoslav Janicek, Miguel Fernandez-Tenorio, Emmanuel Camors, Roberto Ramos-Mondragón, Héctor H Valdivia, Ernst Niggli
During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent "hyperphosphorylation" of the RyR2 channel has been proposed as a major impairment that contributes to progression of heart failure. However, the sites of PKA phosphorylation and their phosphorylation status in cardiac diseases are not well defined...
December 12, 2018: Journal of General Physiology
M Guida, D Maffucci, G Iannuzzi, M Giordano, G Luciano, L Di Benedetto, R Cantarella, A Rescigno, L Giugliano
Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Ovarian reserve appears to be affected by UAE in pre-menopausal women. However, younger ovaries (according to biological ovarian age) exhibit a greater capacity for recovery after ovarian damage...
2018: International Journal of Women's Health
Wei Song, Guiyun Song, Can Zhao, Xiaoguang Li, Xiaojiao Pei, Wen Zhao, Yudan Gao, Jia-Sheng Rao, Hongmei Duan, Zhaoyang Yang
The purpose of this study was to assess the pathological variation in white matter tracts in the adult severe thoracic contusion spinal cord injury (SCI) rat models combined with in vivo magnetic resonance imaging (MRI), as well as the effect of spared white matter (WM) quantity on hindlimb motor function recovery. 7.0T MRI was conducted for all experimental animals before SCI and 1, 3, 7, and 14 days after SCI. The variation in the white matter tract in different regions of the spinal cord after SCI was examined by luxol fast blue (LFB) staining, NF200 immunochemistry, and diffusion tensor imaging (DTI) parameters, including fraction anisotropy, mean diffusivity, axial diffusion, and radial diffusivity...
2018: BioMed Research International
J Laulan
High radial palsy is primarily associated with humeral shaft fractures, whether primary due to the initial trauma, or secondary to their treatment. The majority will spontaneously recover, therefore early surgical exploration is mainly indicated for open fractures or if ultrasonography shows severe nerve damage. Initial signs of nerve recovery may appear between 2 weeks and 6 months. Otherwise, the decision to explore the nerve is based on the patient's age, clinical examination and electroneuromyography, as well as ultrasonography findings...
December 5, 2018: Hand Surgery and Rehabilitation
Jun Hyung Kim, Sung Ho Lee, Seung-Jung Park, Kyoung Min Park, Young Keun On, June Soo Kim
BACKGROUND: Atrial fibrillation (AF) often progresses to more sustained forms and raises the risk of ischemic stroke or sinus node dysfunction (SND). However, there has been no data on the clinical outcomes of AF developed during head-up tilt testing (HUT). OBJECTIVE: The purpose of this study was to evaluate the clinical significance of AF detected during HUT performed for syncope evaluation. METHODS: We analyzed incidence, short-and long-term prognosis, and predictors for adverse outcomes of AF detected during HUTs which were performed in 6780 consecutive patients without AF history...
December 4, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Bradley Porter, Martin J Bishop, Simon Claridge, Nicholas Child, Stefan Van Duijvenboden, Julian Bostock, Benjamin J Sieniewicz, Justin Gould, Baldeep Sidhu, Ben Hanson, Zhong Chen, Christopher A Rinaldi, Peter Taggart, Jaswinder S Gill
BACKGROUND: Enhanced beat-to-beat variability of repolarization (BVR) is strongly linked to arrhythmogenesis and is largely due to variation in ventricular action potential duration (APD). Previous studies in humans have relied on QT interval measurements; however, a direct relationship between beat-to-beat variability of APD and arrhythmogenesis in humans has yet to be demonstrated. OBJECTIVES: This study aimed to explore the beat-to-beat repolarization dynamics within a heart failure population at the level of ventricular APD...
December 4, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Di Wu, Rui Guo, Huiling Guo, Yushu Li, Haixia Guan, Zhongyan Shan
BACKGROUND: Resistance to thyroid hormone beta (RTHβ) results in symptoms of both increased and decreased thyroid hormone action. The effect of thyroid hormone changes in different types of autoimmune thyroid disease (AITD) in RTHβ is dynamic. CASE PRESENTATION: A 25-year-old Asian female had a RTHβ Y321C mutation with Hashimoto's thyroiditis and type 2 diabetes mellitus. She was followed-up through gestation and two years postpartum, revealing development of postpartum thyroiditis (PPT) with characteristic wide fluctuations in serum thyrotropin levels, and of spontaneous recovery from an episode of transient hypothyroidism...
December 3, 2018: BMC Pregnancy and Childbirth
Sudhir Karthikeyan, Matthew Strider Jeffers, Anthony Carter, Dale Corbett
BACKGROUND: Stroke is a leading cause of neurological disability, often resulting in long-term motor impairments due to damage to cortical or subcortical motor areas. Despite the high prevalence of subcortical strokes in the clinical population, preclinical research has primarily focused on investigating and treating cortical strokes. Moreover, while both humans and animals show spontaneous recovery following stroke, little is known about how injury location affects this process. OBJECTIVE: To capture the heterogeneity of human stroke and examine how stroke location affects spontaneous motor recovery following damage to cortical, subcortical, or a combination of both areas...
December 10, 2018: Neurorehabilitation and Neural Repair
Denise A Duricki, Svetlana Drndarski, Michel Bernanos, Tobias Wood, Karen Bosch, Qin Chen, H David Shine, Camilla Simmons, Steven C R Williams, Stephen B McMahon, David J Begley, Diana Cash, Lawrence D F Moon
OBJECTIVES: Neurotrophin-3 (NT3) plays a key role in the development and function of locomotor circuits including descending serotonergic and corticospinal tract (CST) axons and afferents from muscle and skin. We have previously shown that gene therapy delivery of human NT3 into affected forelimb muscles improves sensorimotor recovery after stroke in adult and elderly rats. Here, to move towards the clinic, we tested the hypothesis that intramuscular infusion of NT3 protein could improve sensorimotor recovery after stroke...
December 7, 2018: Annals of Neurology
Marita Pietrucha-Dutczak, Marialaura Amadio, Stefano Govoni, Joanna Lewin-Kowalik, Adrian Smedowski
Retinal neurons are not able to undergo spontaneous regeneration in response to damage. A variety of stressors, i.e., UV radiation, high temperature, ischemia, allergens, and others, induce reactive oxygen species production, resulting in consecutive alteration of stress-response gene expression and finally can lead to cell apoptosis. Neurons have developed their own endogenous cellular protective systems. Some of them are preventing cell death and others are allowing functional recovery after injury. The high efficiency of these mechanisms is crucial for cell survival...
2018: Frontiers in Neuroscience
Elena Kondratskaya, Oleksandr Ievglevskyi, Mark Züchner, Athina Samara, Joel C Glover, Jean-Luc Boulland
The spinal locomotor central pattern generator (CPG) in neonatal mice exhibits diverse output patterns, ranging from sub-rhythmic to multi-rhythmic to fictive locomotion, depending on its general level of excitation and neuromodulatory status (Sharples and Whelan, 2017). We have recently reported that the locomotor CPG in neonatal mice rapidly recovers the ability to produce neurochemically induced fictive locomotion following an upper lumbar spinal cord compression injury (Züchner et al., 2018). Here we address the question of recovery of multi-rhythmic activity and the serotonin-sensitivity of the CPG...
December 3, 2018: Brain Research
Javiera P Oyarzún, Estela Càmara, Sid Kouider, Lluis Fuentemilla, Ruth de Diego-Balaguer
INTRODUCTION: It has long been posited that threat learning operates and forms under an affective and a cognitive learning system that is supported by different brain circuits. A primary drawback in exposure-based therapies is the high rate of relapse that occurs when higher order areas fail to inhibit responses driven by the defensive circuit. It has been shown that implicit exposure of fearful stimuli leads to a long-lasting reduction in avoidance behavior in patients with phobia. Despite the potential benefits of this approach in the treatment of phobias and posttraumatic stress disorder, implicit extinction is still underinvestigated...
December 4, 2018: Brain and Behavior
Christoph Sossou, Chaitanya Pal, Jose R Bustillo
This is a case of a 38-year-old female with latent TB complicated by disseminated peritoneal TB with associated spontaneous abortion, who was initially thought to have an ovarian neoplasm, prompting extensive workup. Laparoscopy with biopsy later confirmed the patient's condition; she was initiated on the appropriate therapy and had a full recovery.
2018: Case Reports in Infectious Diseases
Chang-Hee Kim, Jung Eun Shin, Myung Hoon Yoo, Hong Ju Park
Objectives: Direction-changing positional nystagmus (PN) was considered to indicate the presence of benign paroxysmal positional vertigo involving lateral semicircular canal in most cases. We investigated the incidence of PN on the supine head-roll test and compared the characteristics of nystagmus in patients with vestibular neuritis (VN) and Meniere disease (MD). Methods: A retrospective review of patients, who were diagnosed with unilateral VN or unilateral definite MD between September 2005 and November 2011, was conducted...
December 5, 2018: Clinical and Experimental Otorhinolaryngology
Yuhong Xie, Xiaojie Wang, Zhifen Chen, Pan Chi, Guoxian Guan, Huiming Lin, Xingrong Lu, Ying Huang, Zhengqiong Wang, Mingxing Wang, Jie Chen, Xiuying Li, Min Wang, Xuezhen Zheng, Ximei Zheng, Ran Li, Qianqian Lin
OBJECTIVE: To investigate the efficacy and safety of the bladder training in male patients before urinary catheter removal after mid-low rectal cancer surgery. METHODS: This was a prospective, open, randomized controlled study. INCLUSION CRITERIA: male patients; pathologically diagnosed as mid-low rectal adenocarcinoma; distance from tumor lower edge to anal margin ≤10 cm; standard radical surgery for rectal cancer, including intestinal resection and regional lymph node dissection...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Zhenwei Pan, Tomohiko Ai, Po-Cheng Chang, Ying Liu, Jijia Liu, Mitsunori Maruyama, Mohamed Homsi, Michael C Fishbein, Michael Rubart, Shien-Fong Lin, Deyong Xiao, Hanying Chen, Peng-Sheng Chen, Weinian Shou, Bai-Yan Li
Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC -FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 mice. Spontaneous AF was documented by telemetry in vivo and Langendorff-perfused hearts of αMyHC-FKBP12 and littermate control mice in vitro. Atrial conduction velocity was evaluated by optical mapping. Patch-clamp technique was applied to determine the potentially altered electrophysiology in atrial myocytes...
November 30, 2018: American Journal of Physiology. Heart and Circulatory Physiology
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