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spontaneous recovery

Haodong Zhou, Guy Trudel, Hans K Uhthoff, Odette Laneuville
INTRODUCTION: Knee injuries are common in sports, and post-injury immobilization is often required to protect healing tissues and alleviate pain, but both the injury and the immobilization can lead to a knee contracture. Knee flexion contractures limit performance. Previous research has identified posterior knee capsule fibrosis as a contributor to immobility-induced knee flexion contractures. This study aims to measure posterior knee capsule length at various durations of remobilization after knee immobilization and to correlate with the recovery of knee range of motion...
August 15, 2018: Medicine and Science in Sports and Exercise
Min Fu, Dongdong Li
Effects of general anesthesia combined with epidural anesthesia on the postoperative cognitive functions in pregnant women with dystocia were investigated. Postoperative cognitive functions of 84 dystocia pregnant women treated with cesarean section were retrospectively analyzed. Patients who received general anesthesia were included in group A (n=42), and those who received general anesthesia combined with epidural anesthesia were included in group B (n=42). Mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS) at different time-points after anesthesia in the two groups of patients were observed and compared...
August 2018: Experimental and Therapeutic Medicine
Napplika Kongpolprom, Jiraphat Cholkraisuwat
Background: Currently, there are limited data of prognostic clues for neurological recovery in comatose survivors undergoing therapeutic hypothermia (TH). We aimed to evaluate clinical signs and findings that could predict neurological outcomes, and determine the optimal time for the prognostication. Materials and Methods: We retrospectively reviewed database of postarrest survivors treated with TH in our hospital from 2006 to 2014. Cerebral performance category (CPC), neurological signs and findings in electroencephalography (EEG) and brain computed tomography (CT) were evaluated...
July 2018: Indian Journal of Critical Care Medicine
Cornel Balta, Alina Ciceu, Hildegard Herman, Marcel Rosu, Oana Maria Boldura, Anca Hermenean
Liver fibrosis represents an overaccumulation of extracellular matrix (ECM). This study was designed to investigate the effect of chrysin on established ECM overproduction in carbon tetrachloride (CCl4 ) mouse liver fibrosis. Experimental fibrosis was induced by intraperitoneal injection of 2 mL/kg CCl4 twice a week, for 7 weeks. Mice were orally treated with 3 doses of chrysin (5,7-dihydroxyflavone). For the assessment of the spontaneous reversion of fibrosis, CCl4 -treated mice were investigated after 2 weeks of recovery time...
July 2018: Dose-response: a Publication of International Hormesis Society
Dana J Caldwell, Kaelyn E Petras, Brandi L Mattison, Raegan J Wells, Victoria L Heffelman
OBJECTIVE: To describe the clinical presentation of a dog with spontaneous hemoperitoneum associated with anaphylactic shock from Hymenoptera envenomation. CASE SUMMARY: An 8-year-old female neutered Beagle presented as an emergency for acute onset of collapse, hematemesis, and hematochezia. The dog was tachycardic, tachypneic, and hypotensive. Initial assessment revealed a hemoperitoneum with documentation of a nonclotting sanguineous peritoneal effusion with PCV 81% and total protein concentration 65 g/L (6...
August 13, 2018: Journal of Veterinary Emergency and Critical Care
Jens Fichtner, Christian T Ulrich, Christian Fung, Debora Cipriani, Jan Gralla, Eike Immo Piechowiak, Felix Schlachetzki, Werner J Z'Graggen, Andreas Raabe, Jürgen Beck
Objective Spontaneous intracranial hypotension is caused by spinal cerebrospinal fluid leakage. Patients with orthostatic headaches and cerebrospinal fluid leakage show a decrease in optic nerve sheath diameter upon movement from supine to upright position. We hypothesized that the decrease in optic nerve sheath diameter upon gravitational challenge would cease after closure of the leak. Methods We included 29 patients with spontaneous intracranial hypotension and refractory symptoms admitted from 2013 to 2016...
August 12, 2018: Cephalalgia: An International Journal of Headache
Edward J Ciaccio, Nicholas S Peters, Hasan Garan
BACKGROUND: Atrial fibrillation (AF) is the most common heart arrhythmia, and permanent AF is an intractable medical problem. If cessation of permanent AF were possible, via extensive substrate ablation or multisite stimulation, it could significantly improve the public health. METHOD: A cellular automaton composed of 576 × 576 computerized grid nodes, described in detail previously, was used to test hypotheses concerning the cessation of fibrillatory electrical activity...
August 2, 2018: Computers in Biology and Medicine
Moussa A Chalah, Samar S Ayache
Background: Major depressive disorder (MDD) stands among the most frequent psychiatric disorders. Cognitive behavioral therapy (CBT) has been shown to be effective for treating depression, yet its neural mechanisms of action are not well elucidated. The objective of this work is to assess the available neuroimaging studies exploring CBT's effects in adult patients with MDD. Methods: Computerized databases were consulted till April 2018 and a research was conducted according to PRISMA guidelines in order to identify original research articles published at any time in English and French languages on this topic...
August 9, 2018: Brain Sciences
Munehiro Iiya, Masato Shimizu, Kohei Takahashi, Hiroyuki Fujii, Makoto Suzuki, Noriyoshi Yamawake, Mitsuhiro Nishizaki
PURPOSE: To predict neurological outcome following out-of-hospital cardiac arrest (OHCA) using a combination of hemoglobin (Hb) and low-flow duration (LFD). MATERIALS AND METHODS: We retrospectively examined 131 patients (75 ± 13 years, 64 men) with return of spontaneous circulation (ROSC) following non-traumatic OHCA. The LFD was the duration from the start of cardiopulmonary resuscitation to ROSC. To obtain the Hb/LFD value, we divided the Hb level by the LFD...
August 6, 2018: Journal of Critical Care
Andrew R Swartz, Wilfred Chen
E2 nanocages functionalized with Z-domain-elastin-like polypeptide affinity ligands (Z-ELP40) using Sortase A (SrtA) ligation have been shown to be a promising scaffold for purifying monoclonal antibodies (mAbs) based on affinity precipitation. However, the reversible nature of SrtA reaction has been attributed to the low ligation efficiency (< 25%) and has significantly limited the practical utility of the technology. Here, we reported an improved conjugation platform using the SpyTag/SpyCatcher pair to enable the spontaneous isopeptide bond formation between SpyTag-E2 and Z-ELP-SpyCatcher fusion proteins of two different ELP chain-lengths...
August 10, 2018: Bioconjugate Chemistry
Laura D Lewis, Giovanni Piantoni, Robert A Peterfreund, Emad N Eskandar, Priscilla Grace Harrell, Oluwaseun Akeju, Linda S Aglio, Sydney S Cash, Emery N Brown, Eran A Mukamel, Patrick L Purdon
During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input. How the brain reaches this state spontaneously is not known. General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness. We used intracranial electrocorticography and scalp EEG in humans to track neural dynamics during emergence from propofol general anesthesia. We identify a distinct transient brain state that occurs immediately prior to recovery of behavioral responsiveness...
August 10, 2018: ELife
Vasileios Karamouzos, Christos Prokakis, Fotini Kosmopoulou, Evangelos Karanikolas, Christina Kalogeropoulou, Diamanto Aretha, Nikolaos Panagiotopoulos, Efstratios Koletsis, Dimitrios Velissaris
We report a case of a young female with known history of pulmonary Langerhans cell histiocytosis who was initially presented in the emergency department of a university hospital with respiratory distress. Clinical assessment and diagnostic workup revealed left hemithorax subcutaneous emphysema, bilateral pneumothorax, and atelectasis in both lower lung lobes. The patient was treated with bilateral staged thoracoscopic bullectomy and mechanical abrasion of the parietal pleura combined with chemical pleurodesis with talc...
January 2018: Journal of Investigative Medicine High Impact Case Reports
Imran S Sheikh, Kathleen M Keefe, Noelle A Sterling, Ian P Junker, Chidubem I Eneanya, Yingpeng Liu, Xiao-Qing Tang, George M Smith
Retrograde tracing is a key facet of neuroanatomical studies involving long distance projection neurons. Previous groups have utilized a variety of tools ranging from classical chemical tracers to newer methods employing viruses for gene delivery. Here, we highlight the usage of a lentivirus that permits highly efficient retrograde transport (HiRet) from synaptic terminals within the cervical and lumbar enlargements of the spinal cord. By injecting HiRet, we can clearly identify supraspinal and propriospinal circuits innervating motor neuron pools relating to forelimb and hindlimb function...
2018: Frontiers in Neural Circuits
Emily S Barrett, Wendy Vitek, Omar Mbowe, Sally W Thurston, Richard S Legro, Ruben Alvero, Valerie Baker, G Wright Bates, Peter Casson, Christos Coutifaris, Esther Eisenberg, Karl Hansen, Stephen Krawetz, Randal Robinson, Mitchell Rosen, Rebecca Usadi, Heping Zhang, Nanette Santoro, Michael Diamond
STUDY QUESTION: Among infertile women undergoing ovarian stimulation, is allostatic load (AL), a measure of chronic physiological stress, associated with subsequent fertility and pregnancy outcomes? SUMMARY ANSWER: AL at baseline was not associated with conception, spontaneous abortion or live birth, however, it was significantly associated with increased odds of pre-eclampsia and preterm birth among women who had a live birth in the study. WHAT IS KNOWN ALREADY: Several studies have linked AL during pregnancy to adverse outcomes including preterm birth and pre-eclampsia, hypothesizing that it may contribute to well-documented disparities in pregnancy and birth outcomes...
August 1, 2018: Human Reproduction
David Church, Luís Cardoso, Richard G Kay, Claire L Williams, Bernard Freudenthal, Catriona Clarke, Julie Harris, Myuri Moorthy, Efthmia Karra, Fiona M Gribble, Frank Reimann, Keith Burling, Alistair J K Williams, Alia Munir, T Hugh Jones, Dagmar Führer, Lars C Moeller, Mark Cohen, Bernard Khoo, David Halsall, Robert Semple
Context: Insulin autoimmune syndrome (IAS), spontaneous hyperinsulinemic hypoglycemia due to insulin-binding autoantibodies, may be difficult to distinguish from tumoral or other forms of hyperinsulinemic hypoglycemia including surreptitious insulin administration. No standardized treatment regimen exists. Objectives: To evaluate an analytic approach to IAS and responses to different treatments. Design and Setting: Observational study in the UK Severe Insulin Resistance Service...
July 31, 2018: Journal of Clinical Endocrinology and Metabolism
Na Yao, Xuntong Zhang, Zhen Yang, Weiben Yang, Ziqi Tian, Limin Zhang
Graphene oxide (GO) is a competitive candidate used for adsorption of emerging organic contaminants (EOCs) from water. To overcome GO's spontaneous aggregation tendency in adsorption and to ease contaminant desorption from the adsorbent for adsorbent regeneration, a modified GO (P-GO), with temperature-switchable hydrophilicity/hydrophobicity, obtained by grafting temperature-responsive poly(N-n-propylacrylamide) was proposed. Two model EOCs, norfloxacin (NOR) and bisphenol A (BPA), with distinct hydrophilicity/hydrophobicity were employed...
August 7, 2018: ACS Applied Materials & Interfaces
Shunsuke Funazaki, Hodaka Yamada, Kazuo Hara, San-E Ishikawa
Lymphocytic hypophysitis (LyH) has been known to be associated with pregnancy. We herein report the case of a 33-year-old woman who underwent vaginal delivery without massive bleeding at 40 weeks of gestation. Because of the presence of headache and terrible fatigue after childbirth, she visited our hospital. Severe hyponatremia (Na, 118 mEq/L) and visual field abnormality was noted upon examination. MRI revealed pituitary enlargement with a swollen pituitary stalk, albeit at low signal intensity. Basal pituitary hormone levels were all reduced and remained low after exogenous administration of hypothalamic-releasing hormones...
2018: Endocrinology, Diabetes & Metabolism Case Reports
Jessica L Slabaugh, Lucia Brunello, Mohammad T Elnakish, Nima Milani-Nejad, Sandor Gyorke, Paul M L Janssen
In myocardial tissue, Ca2+ release from the sarcoplasmic reticulum (SR) that occurs via the ryanodine receptor (RyR2) channel complex. Ca2+ release through RyR2 can be either stimulated by an action potential (AP) or spontaneous. The latter is often associated with triggered afterdepolarizations, which in turn may lead to sustained arrhythmias. It is believed that some synchronization mechanism exists for afterdepolarizations and APs in neighboring myocytes, possibly a similarly timed recovery of RyR2 from refractoriness, which enables RyR2s to reach the threshold for spontaneous Ca2+ release simultaneously...
2018: Frontiers in Physiology
Greg J Duncan, Sohrab B Manesh, Brett J Hilton, Peggy Assinck, Jie Liu, Aaron Moulson, Jason R Plemel, Wolfram Tetzlaff
Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter...
August 3, 2018: Nature Communications
Gabor Erdoes, Wulf Dietrich, Monika Pia Stucki, Tobias Michael Merz, Anne Angelillo-Scherrer, Michael Nagler, Thierry Carrel, Balthasar Eberle
Low plasma fibrinogen level is common after cardiopulmonary bypass (CPB). Current substitution practice with fibrinogen concentrate generally follows a single measurement and cut-off values from the literature, whereas early postoperative endogenous fibrinogen kinetics is incompletely described and widely disregarded. The aim of this study was to determine the short-term recovery pattern of plasma fibrinogen after CPB weaning. Our hypothesis was that in the absence of surgical bleeding, CPB-induced hypofibrinogenemia would resolve spontaneously and predictably within a few hours...
2018: PloS One
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