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spontaneous recovery

Saleh Baeesa, Peter Jarzem, Mohammed Mansi, Rakan Bokhari, Mahdi Bassi
OBJECTIVE: Spontaneous spinal epidural hematomas (SSEH) are a rare and morbid entity whose prognosis is affected by delayed diagnosis and surgical intervention. Correlation with the time of intervention and neurological recovery is not clearly described in the literature. We present a retrospective study of SSEH, to determine the correlation between the timing of surgical intervention and changes in the spinal cord signal on MRI with the neurological outcome. METHODS: The records of 14 patients who underwent surgical decompression of SSEH over 10-year duration were reviewed...
October 15, 2018: World Neurosurgery
Lijuan Cheng, Daniela Cortese, Martin M Monti, Fuyan Wang, Francesco Riganello, Francesco Arcuri, Haibo Di, Caroline Schnakers
Objectives: Considering sensory stimulation programs (SSP) as a treatment for disorders of consciousness is still debated today. Previous studies investigating its efficacy were affected by various biases among which small sample size and spontaneous recovery. In this study, treatment-related changes were assessed using time-series design in patients with disorders of consciousness (i.e., vegetative state-VS and minimally conscious state-MCS). Methods: A withdrawal design (ABAB) was used. During B phases, patients underwent a SSP (3 days a week, including auditory, visual, tactile, olfactory, and gustatory stimulation)...
2018: Frontiers in Neurology
Paul C Kruger, Jack Hirsh, Vinai C Bhagirath, Ke Xu, Brian Dale, Tim A C de Vries, Jeffrey S Ginsberg, John W Eikelboom, Noel C Chan
BACKGROUND:  Ticagrelor is an anti-platelet agent that is indicated for prevention of thrombosis after acute coronary syndrome or intra-coronary artery stent implantation, but it increases the risk of bleeding. Platelet transfusion has the potential to treat or prevent bleeding in patients taking ticagrelor, but the optimal quantity of platelets and timing of administration have not been fully defined. METHODS AND RESULTS:  Ten healthy subjects took ticagrelor in combination with acetylsalicylic acid for 5 days, and had blood collected prior to treatment and at 2, 10, 24, 48, 72 and 96 hours after the last doses...
October 17, 2018: Thrombosis and Haemostasis
Rexiati Ruze, Zhibo Yan, Qunzheng Wu, Hanxiang Zhan, Guangyong Zhang
BACKGROUND: Seroma is the most common early minor complication of inguinal hernia repair. Seromas generally resolve spontaneously within a few weeks, but can sometimes cause other complications. The optimal ways to repair inguinal hernia and handle the hernial sac are still debatable. Large scale, prospective, randomized, controlled studies focusing on the correlation between transection of the hernial sac and seroma formation are scarce. METHODS: A total of 159 adult male patients with primary indirect inguinal hernia who underwent laparoscopic transabdominal preperitoneal repair were recruited...
October 16, 2018: Surgical Endoscopy
Pattara Rattanawong, Tanawan Riangwiwat, Pakawat Chongsathidkiet, Wasawat Vutthikraivit, Nath Limpruttidham, Narut Prasitlumkum, Napatt Kanjanahattakij, Chanavuth Kanitsoraphan
Background: Vasovagal syncope (VVS) is defined by transient loss of consciousness with spontaneous rapid recovery. Recently, a closed-loop stimulation pacing system (CLS) has shown superior effectiveness to conventional pacing in refractory VVS. However, systematic review and meta-analysis has not been performed. We assessed the impact of CLS implantation and reduction in recurrent VVS events by a systematic review and a meta-analysis. Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017...
October 2018: Journal of Arrhythmia
Durai Murugan Muniswami, George Tharion
Study Design: Olfactory ensheathing cells (OECs) from rat olfactory mucosa were cultured, characterized, and transplanted into a rat model of spinal cord injury (SCI). Purpose: To evaluate different doses of OECs in a rat model of SCI. Overview of Literature: SCI causes permanent functional deficit because the central nervous system lacks the ability to perform spontaneous repair. Cell therapy strategies are being explored globally. The clinical use of human embryonic stem cell is hampered by ethical controversies...
October 16, 2018: Asian Spine Journal
Pei-Wen Wang, Tung-Ho Wu, Tai-Long Pan, Mu-Hong Chen, Shigeru Goto, Chao-Long Chen
Acute rejection (AR) and spontaneous tolerance may occur after allograft orthotopic liver transplants (OLT) performed in certain combinations of donor and recipient rat strains, yet the underlying molecular cascades involved in these conditions remain poorly understood. Comprehensive analysis with proteomic tools revealed that ceruloplasmin was highly expressed during the tolerant period on day 63 post-OLT (POD 63) compared to the rejected samples on POD 14. Meanwhile, cytokine expression profiles implied that the inflammation was significantly stimulated in the AR subjects...
2018: Frontiers in Immunology
Charlotte Cordonnier, Andrew Demchuk, Wendy Ziai, Craig S Anderson
Acute spontaneous intracerebral haemorrhage is a life-threatening illness of global importance, with a poor prognosis and few proven treatments. As a heterogeneous disease, certain clinical and imaging features help identify the cause, prognosis, and how to manage the disease. Survival and recovery from intracerebral haemorrhage are related to the site, mass effect, and intracranial pressure from the underlying haematoma, and by subsequent cerebral oedema from perihaematomal neurotoxicity or inflammation and complications from prolonged neurological dysfunction...
October 6, 2018: Lancet
Arturo Bevilacqua, Jessica Dragotto, Alessandro Giuliani, Mariano Bizzarri
Mice exposed to continuous light undergo functional and histological changes that mimic those of human Polycystic Ovary Syndrome (PCOS). We herein induced the syndrome by exposing 30-day-old females to 10 weeks of permanent light. Ovarian morphology and histology, as well as reproductive parameters (time of observed pregnancy/delivery) were investigated. Ovaries of PCOS-modeled mice showed lack of tertiary follicles and corpora lutea, altered ovarian architecture, and increased thickness of the theca layer...
October 14, 2018: Journal of Cellular Physiology
Anita Shea, Alex Hatch, Luisa De Risio, Elsa Beltran
BACKGROUND: Abnormal sleep behavior has been reported in 5 dogs during recovery from tetanus. HYPOTHESIS: REM sleep behavior disorder (RBD) is a more common consequence of tetanus than previously reported in veterinary literature and easily confused for epileptic seizures. ANIMALS: Sixty-one client-owned dogs diagnosed with tetanus at 2 UK referral centers. METHODS: A retrospective review of medical records was combined with a questionnaire sent to owners of surviving dogs, to identify cases that developed clinically probable RBD and determine its clinical progression and effect on quality of life of affected dogs and their owners...
October 12, 2018: Journal of Veterinary Internal Medicine
Chiu-Jung Lin, Hsiu-Fen Lin
PURPOSE: Hemiballism caused by hypoglycemia is rare. We presented a case who suffered from episodic hemiballism induced by hypoglycemia with spontaneously recovery after sleep. The possible mechanism of these self-limited episodes was also discussed. CASE REPORT: An 82-year-old female diabetic patient took oral anti-diabetic drugs (OADs) regularly. The doctor changed OADs doses and her appetite became poor before admission. She suffered from episodic left side involuntary movements with consciousness disturbance, and recovered spontaneously after a six-to-eight hour sleep in every attack at home...
March 15, 2018: Acta Neurologica Taiwanica
Debbie R Pan, Nancy Jiang
OBJECTIVE: Vocal fold motion impairment (VFMI) is a potential consequence of intubation. Studies describing the natural course of this complication are largely case reports. This study aims to evaluate outcomes for a cohort of patients who endured varying degrees of vocal fold immobility or hypomobility post-intubation. STUDY DESIGN: Retrospective chart review. METHODS: Upon excluding known causes of VFMI, such as surgeries and tumors involving the head and neck, VFMI cases (ICD-9 diagnosis code 478...
October 8, 2018: Journal of Voice: Official Journal of the Voice Foundation
Marie-Christine J P Franken, Simone P C Koenraads, Carike E M Holtmaat, Marc P van der Schroeff
PURPOSE: The first purpose was to define the recovery rate in children who stutter in a clinical sample, adding self-report to validate recovery status. The second purpose was to explore whether children who were judged to be recovered showed subjective experiences that might be interpreted as coping behaviors used to control speech fluency. METHODS: In this longitudinal study, preschool-age children whose parents consulted a speech-language pathologist about stuttering were followed for 9 years...
September 24, 2018: Journal of Fluency Disorders
Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of the disease (epileptogenesis). There are no treatments for preventing seizures or improving disease prognosis, including neurological comorbidities. The search of pathogenic mechanisms of epileptogenesis highlighted that neuroinflammatory cytokines [i.e. interleukin-1β (IL-1β), tumour necrosis factor-α (Tnf-α)] are induced in human and experimental epilepsies, and contribute to seizure generation in animal models...
October 10, 2018: Brain: a Journal of Neurology
Yu-Hua Lin, Chun-Hou Liao, Bing-Jun Jiang, Tzu-Hung Chen
Vascular complications are serious problems after kidney transplantation. An aneurysm or rupture in a graft artery is a rare but potentially devastating complication, which may lead to renal function impairment, graft loss, or even death. In this paper, we present two rare vascular complications in the early postoperative course after renal transplantation from the same deceased donor. In the first case, a 49-year-old woman who had spontaneous graft arterial rupture 13 days after kidney transplantation presented with sudden distension in the right lower abdomen...
October 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Le Shi, Jiahui Deng, Sijing Chen, Jianyu Que, Yekun Sun, Zhong Wang, Xiaojie Guo, Ying Han, Yuxin Zhou, Xiujun Zhang, Wen Xie, Xiao Lin, Jie Shi, Lin Lu
Fear is prone to return following extinction that is the basis of exposure therapy for fear-related disorders. Manipulations that enhance the extinction process can be beneficial for treatment. Animal studies have shown that fasting or caloric restriction can enhance extinction and inhibit the return of fear. The present study examined the effects of fasting on fear acquisition, extinction, and the return of fear in humans. One hundred and twenty-five male participants were randomized into a fasting group and food group and exposed to a Pavlovian fear conditioning paradigm...
October 9, 2018: Translational Psychiatry
Andrew R Brown, Marina Martinez
After an incomplete spinal cord injury (SCI) spontaneous motor recovery can occur in mammals, but the underlying neural substrates remain poorly understood. The motor cortex is crucial for skilled motor learning and the voluntary control of movement and is known to reorganize after cortical injury to promote recovery. Motor cortex plasticity has also been shown to parallel the recovery of forelimb function after cervical SCI, but whether cortical plasticity participates in hindlimb recovery after SCI remains unresolved...
October 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Hyejin Joo, Jinhyun Bae, Jun-Seon Lee, Yumi Bang, Beom-Joon Lee, Jae-Woo Park, Kyungjin Lee, Jae-Heung Cho, Youngmin Bu
Epimedii Herba (EH) has been used in traditional Asian medicine to treat hemiplegia following stroke. Icariin, its major active component, is used as a quality-control marker and for its various pharmacological effects. We hypothesized that icariin would show protective effects following traumatic brain injury (TBI). The TBI mouse model was induced using a controlled cortical impact method. Body weight, brain damage, motor function, and cognitive function were evaluated. Synaptogenesis markers were analyzed to investigate potential mechanisms of action...
October 9, 2018: Planta Medica
Selina Traxler, Ann-Christin Bischoff, Radost Saß, Phillip Trefz, Peter Gierschner, Beate Brock, Theresa Schwaiger, Claudia Karte, Ulrike Blohm, Charlotte Schröder, Wolfram Miekisch, Jochen K Schubert
Influenza is one of the most common causes of virus diseases worldwide. Virus detection requires determination of Influenza RNA in the upper respiratory tract. Efficient screening is not possible in this way. Analysis of volatile organic compounds (VOCs) in breath holds promise for non-invasive and fast monitoring of disease progression. Breath VOC profiles of 14 (3 controls and 11 infected animals) swine were repeatedly analyzed during a complete infection cycle of Influenza A under high safety conditions...
October 5, 2018: Scientific Reports
Satomi Kasashima, Kawashima Atsuhiro, Satoru Ozaki, Kita Toshiyuki, Araya Tomoyuki, Ohta Yasuhiko, Mitsutaka Suzuki
OBJECTIVE: IgG4-related disease is a recently described systemic immune-mediated fibro-inflammatory disease that frequently occurs in tumorous form. Herein, we elucidated the clinicopathological and cytological characteristics of IgG4-related pleural lesions (IgG4-PL). PATIENTS AND METHODS: Among 22 patients with fibro-inflammatory pleural lesions of idiopathic etiology, 8 cases were diagnosed as IgG4-PL and the remaining 14 as non-IgG4-PL according to comprehensive diagnostic criteria for IgG4-related disease...
October 5, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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