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Ian A Harris, Adrian Traeger, Ralph Stanford, Christopher G Maher, Rachelle Buchbinder
Lumbar spine fusion is a common procedure associated with a high cost burden and risk of serious complications. We aimed to summarise systematic reviews on the effectiveness of lumbar spine fusion for most diagnoses. We found no high-quality systematic reviews and the risk of bias of the randomised controlled trials in the reviews was generally high. The available evidence does not support a benefit from spine fusion compared to non-operative alternatives for back pain associated with degeneration. The available evidence does not support a clinical benefit from spine fusion compared to non-operative treatment or stabilisation without fusion for thoracolumbar burst fractures...
December 2018: Internal Medicine Journal
Ronilda Lacson, Romeo Laroya, Aijia Wang, Neena Kapoor, Daniel I Glazer, Atul Shinagare, Ivan K Ip, Sameer Malhotra, Keith Hentel, Ramin Khorasani
Objective: Assess information integrity (concordance and completeness of documented exam indications from the electronic health record [EHR] imaging order requisition, compared to EHR provider notes), and assess potential impact of indication inaccuracies on exam planning and interpretation. Methods: This retrospective study, approved by the Institutional Review Board, was conducted at a tertiary academic medical center. There were 139 MRI lumbar spine (LS-MRI) and 176 CT abdomen/pelvis orders performed 4/1/2016-5/31/2016 randomly selected and reviewed by 4 radiologists for concordance and completeness of relevant exam indications in order requisitions compared to provider notes, and potential impact of indication inaccuracies on exam planning and interpretation...
December 5, 2018: Journal of the American Medical Informatics Association: JAMIA
Chen Li, Shuang Liu, Xin Sui, Jian Wang, Wei Song, Wenshuai Xu, Kai-Feng Xu, Xinlun Tian, Wen Zhang
OBJECTIVE: To characterize the high-resolution computed tomography (HRCT) pulmonary abnormalities in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. METHODS: Pulmonary HRCT images were reconstructed from whole-spine computed tomography (CT) images of 67 patients with SAPHO syndrome. HRCT images of 58 healthy controls were also obtained and reviewed. Patients with pneumonia and tuberculosis were excluded. Demographic and clinical data such as gender, age, onset age, disease duration, erythrocyte sedimentation rate (ESR), highly sensitive C-reactive protein (hs-CRP) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were collected from the SAPHO syndrome patients...
2018: PloS One
John R Humm, Narayan Yoganandan, Klaus G Driesslein, Frank A Pintar
OBJECTIVES: Analyses of recent automotive accident data indicate an increased risk of injury for small female occupants compared to males in similar accidents. Females have been shown to be more susceptible to spinal injuries than males. To protect this more vulnerable population, advanced anthropomorphic test devices (ATDs) and computer human body models are being developed and require biofidelity curves for validation. The aim of this study is to generate female-specific 3D kinematic corridors in near- and far-side oblique frontal impacts for the head, spine, and pelvis...
December 5, 2018: Traffic Injury Prevention
Wen Han, Xiao-Juan Bai, Lu-Lu Han, Xue-Feng Sun, Xiang-Mei Chen
OBJECTIVES: Changes in serum protein levels of fibroblast growth factor 23 (FGF23) and Klotho resulting from bone metabolism are still controversial. The purpose of this study was to observe the relationship between FGF23 and Klotho serum proteins and lumbar spine bone mineral density (LBMD) in northern Chinese postmenopausal women. METHODS: This was a community-based cross-sectional study carried out in Shenyang, a northern Chinese city. The study included 355 postmenopausal women with an average age of 62...
December 3, 2018: Menopause: the Journal of the North American Menopause Society
Asli Ayan, Aylin Akbulut, Guzin Deveci, Gokhan Koca
Primary diffuse leptomeningeal melanomatosis is a rare variant of malignant melanoma of the central nervous system, arising from melanocytes of leptomeninges. It may involve leptomeninges and may invade brain superficially. The diagnosis of the disease with conventional imaging techniques is quite difficult. This case demonstrates the F-FDG uptake of primary diffuse leptomeningeal melanomatosis matching with MRI contrast enhancement regions particularly in the lower thoracic and superior lumbar region.
December 3, 2018: Clinical Nuclear Medicine
Arnold Y L Wong, Dino Samartzis, Prudence W H Cheung, Jason Pui Yin Cheung
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common spine deformity in adolescent patients. Although structural deformity may affect spinal biomechanics of patients with AIS, little is known regarding various period prevalence proportions of back pain and chronic back pain and factors associated with back pain in such patients. QUESTIONS/PURPOSES: (1) What are the period prevalence rates of back pain among teenagers with AIS? (2) Is back pain in patients with AIS associated with curve severity? METHODS: A total of 987 patients with AIS who were treated without surgery were recruited from a single center's scoliosis clinic...
November 13, 2018: Clinical Orthopaedics and related Research
Vivek Palepu, Melvin Helgeson, Michael Molyneaux-Francis, Srinidhi Nagaraja
Several approaches (anterior, posterior, lateral, and transforaminal) are used in lumbar fusion surgery. However, it is unclear whether one of these approaches has the greatest subsidence risk as published clinical rates of cage subsidence vary widely (7-70%). Specifically, there is limited data on how a patient's endplate morphometry and trabecular bone quality influences cage subsidence risk. Therefore, this study compared the subsidence between anterior (ALIF), lateral (LLIF), posterior (PLIF), and transforaminal (TLIF) lumbar interbody fusion cage designs to understand the impact of endplate and trabecular bone quality on subsidence...
December 5, 2018: Journal of Biomechanical Engineering
Matthew Mills, Nesrin Sarigul-Klijn
Mathematical models of the human spine can be used to investigate spinal biomechanics without the difficulties, limitations and ethical concerns associated with physical experimentation. Validation of such models is necessary to ensure the modeled system behavior accurately represents the physics of the actual system. The goal of this work was to validate a medical image-based nonlinear lumbosacral spine finite element model of a healthy 20-year-old female subject under physiological moments. Range of motion, facet joint forces, and intradiscal pressure were compared with experimental values and validated finite element models from the literature...
December 5, 2018: Journal of Biomechanical Engineering
Uruj Zehra, Jason Pui Yin Cheung, Cora Bow, William Lu, Dino Samartzis
The aim of the current study was to investigate the multi-dimensional characteristics of lumbar endplate defects in humans in relation to disc degeneration and other MRI phenotypes as well as their role with pain and disability. 108 subjects were recruited and underwent 3T MRI of the lumbar spine. Structural endplate defects were identified and their dimensions were measured in terms of maximum width and depth, and were then standardized to the actual width of the endplate and depth of the vertebral body, respectively...
December 4, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
S P Mohanty, M Pai Kanhangad, B Yogesh Kumar, A Singh
PURPOSE: The present study evaluated the clinical and radiological outcomes in patients with tuberculosis of the thoracic and thoracolumbar spine, treated by an operative technique in which anterior debridement with posterior instrumentation and global fusion was performed through a single-stage posterior approach. METHODS: Ninty-seven patients with spinal tuberculosis, between T1 and L1, in whom anterior debridement, bone grafting, with posterior instrumentation and fusion was performed through a single-stage posterior approach, with a minimum follow-up of 2 years, formed the basis of this study...
December 4, 2018: Musculoskeletal Surgery
Betül Ersoy, Deniz Özalp Kizilay, Seniha Kiremitci Yilmaz, Fatma Taneli, Gül Gümüşer
Peak bone mass is reached in late adolescence. Low peak bone mass is a well recognized risk factor for osteoporosis later in life. Our data do not support a link between vitamin D status, bone mineral density (BMD), and socioeconomic status (SES). However, there was a marked inadequacy of daily calcium intake and a high presence of osteopenia in females with low SES. PURPOSE: Our aims were to (1) examine the effects of different SES on BMD, vitamin D status, and daily calcium intake and (2) investigate any association between vitamin D status and BMD in female university students...
December 4, 2018: Archives of Osteoporosis
Christina R Vargas, Anubhav Kanwar, Khalid M Dousa, Marion J Skalweit, David Rowe, James Gatherwright
No abstract text is available yet for this article.
November 2018: Open Forum Infectious Diseases
Kellie S Gross, Kelsey M Moore, Robert L Meisel, Paul G Mermelstein
Gonadal hormones play a vital role in driving motivated behavior. They not only modulate responses to naturally rewarding stimuli, but also influence responses to drugs of abuse. A commonality between gonadal hormones and drugs of abuse is that they both impact the neurocircuitry of reward, including the regulation of structural plasticity in the nucleus accumbens (NAc). Previous hormonal studies have focused on the mechanisms and behavioral correlates of estradiol-induced dendritic spine changes in the female NAc...
2018: Frontiers in Neuroscience
Bing Yin, Xiaomeng Liu, Hongyan Gao, Tianda Fu, Jun Yao
Biological sensory organelles are often structurally optimized for high sensitivity. Tactile hairs or bristles are ubiquitous mechanosensory organelles in insects. The bristle features a tapering spine that not only serves as a lever arm to promote signal transduction, but also a clever design to protect it from mechanical breaking. A hierarchical distribution over the body further improves the signal detection from all directions. We mimic these features by using synthetic zinc oxide microparticles, each having spherically-distributed, high-aspect-ratio, and high-density nanostructured spines resembling biological bristles...
December 4, 2018: Nature Communications
Deanna L Benson, Bridget A Matikainen-Ankney, Ayan Hussein, George W Huntley
LRRK2 mutation is the most common inherited, autosomal dominant cause of Parkinson's disease (PD) and has also been observed in sporadic cases. Most mutations result in increased LRRK2 kinase activity. LRRK2 is highly expressed in brain regions that receive dense, convergent innervation by dopaminergic and glutamatergic axons, and its levels rise developmentally coincident with glutamatergic synapse formation. The onset and timing of expression suggests strongly that LRRK2 regulates the development, maturation and function of synapses...
December 4, 2018: Biochemical Society Transactions
Gabriel B Ayala, Kieu A Doan, Hie Ji Ko, Peter K Park, Edwin D Santiago, Shirly J Kuruvila, Amol J Ghia, Tina M Briere, Zhifei Wen
Spine stereotactic radiosurgery (SSRS) is a noninvasive treatment for metastatic spine lesions. MD Anderson Cancer Center reports a quality assurance (QA) failure rate approaching 15% for SSRS cases, which we hypothesized is due to difficulties in accurately calculating dose resulting from a large number of small-area segments. Clinical plans typically use 9 beams with an average of 10 segments per beam and minimum segment area of 2-3 cm2 . The purpose of this study was to identify a set of intensity-modulated radiation therapy (IMRT) planning parameters that attempts to optimize the balance among QA passing rate, plan quality, dose calculation accuracy, and delivery time for SSRS plans...
December 1, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Zhi-Jing Wen, Zheng-Chao Gao, Teng Lu, Yi-Bin Wang, Hui Liang, Xi-Jing He
OBJECTIVE: To systematically evaluate the efficacy of rapid prototyping drill navigation template-assisted pedicle screw fixation and traditional anatomic landmark-based fixation in the treatment of spinal disease by accessing and searching some relevant literatures home and abroad. METHODS: Randomized Controlled Trials (RCTs) and prospective case-control studies or retrospective case-control studies about rapid prototyping drill templates-assisted pedicle screw fixation and traditional anatomic landmark-based fixation for the treatment of spinal disease were searched electronically in PubMed, The Cochrane Library(Issue 5, 2017), Clinical Trial, Google Scholar, Web of Science, CNKI, Wanfang database and VIP database before June 2017...
November 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Wen Xue, Dong Wang, Yang Yang, Zeng-Ping Wang, Lin Liu, Yue-Wen Qian
No abstract text is available yet for this article.
November 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hong-Li Deng, Wen-Jie Gao, Jin-Wen Zhu, Xiao-Dong Wang, Jin-Song Zhou
OBJECTIVE: To investigate the early clinical effects of transforaminal endoscopic spine system (TESSYS) for the treatment of bilateral lumbar disc herniation in single segment. METHODS: The clinical data of 38 patients with single-segment bilateral lumbar disc herniation treated by TESSYS technique from February 2016 to February 2018 were retrospectively analyzed. There were 26 males and 12 females, aged from 30 to 55 years old with an average of(35.2±6.4) years, 6 cases of L₃,₄, 22 cases of L₄,₅, and 10 cases of L₅S₁1...
November 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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