Brunella Posteraro, Flavio De Maio, Yair Motro, Giulia Menchinelli, Desy De Lorenzis, Roberto B M Marano, Bessan Aljanazreh, Federica Maria Errico, Giuseppe Massaria, Teresa Spanu, Patrizia Posteraro, Jacob Moran-Gilad, Maurizio Sanguinetti
Bloodstream infection (BSI) caused by carbapenem-resistant Klebsiella pneumoniae (KP) poses significant challenges, particularly when the infecting isolate carries multiple antimicrobial resistance (AMR) genes/determinants. This study, employing short- and long-read whole-genome sequencing, characterizes six New Delhi metallo-β-lactamase (NDM) 1 and KP carbapenemase (KPC) 3 co-producing KP isolates, the largest cohort investigated in Europe to date. Five [sequence type (ST) 512] and one (ST11) isolates were recovered from patients who developed BSI from February to August 2022 or February 2023 at two different hospitals in Rome, Italy...
February 27, 2024: Microbiology Spectrum