keyword
MENU ▼
Read by QxMD icon Read
search

NDM-1

keyword
https://www.readbyqxmd.com/read/27821458/co-production-of-mcr-1-and-ndm-1-by-colistin-resistant-escherichia-coli-isolated-from-a-healthy-individual
#1
Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong Shen, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian
mcr-1, the first transferable plasmid-mediated colistin resistance gene, was reported in Escherichia coli isolates from food animals, food and patients in China and now has been reported worldwide (1).….
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27809900/significance-of-nucleic-acid-testing-in-diagnosis-and-treatment-of-post-neurosurgical-meningitis-caused-by-multidrug-resistant-acinetobacter-baumannii-a-case-report
#2
Ngo Tat Trung, Trinh Van Son, Dao Thanh Quyen, Dang Thi Viet Anh, Vu Viet Sang, Nguyen Xuan Lam, Nguyen Dang Manh, Vuong Phuc Duong, Bui Tri Cuong, Quyen Dang Tuyen, Nguyen Xuan Chinh, Phan Quoc Hoan, Hoang Van Tong, Christian G Meyer, Le Huu Song
BACKGROUND: Neurosurgery may pose the risk of patients' developing nosocomial meningitis caused by infection with hospital pathogens. Rapid detection of the causative pathogens is essential for selecting the appropriate antibiotic treatment. However, the classical culture-based detection of bacterial infection is time-consuming and often fails to establish the correct diagnosis. Molecular techniques offer improved diagnostic means to guide the proper antibiotic therapy. CASE PRESENTATION: A 32-year-old Vietnamese man underwent neurosurgery and subsequently developed meningitis...
November 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27807154/detection-of-an-escherichia-coli-st167-strain-with-two-tandem-copies-of-blandm-1-encoded-in-the-chromosome
#3
Ping Shen, Maoli Yi, Ying Fu, Zhi Ruan, Xiaoxing Du, Yunsong Yu, Xinyou Xie
The emergence and spread of New Delhi metallo-β-lactamase-1 (NDM-1)-producing Enterobacteriaceae have disseminated rapidly throughout the world, posing an urgent threat to public health. Previous studies confirmed that the blaNDM-1 gene is typically encoded in plasmids, but rarely in chromosome. Here, we discovered a multi-drug resistant Escherichia coli strain Y5, originating from a urine sample and containing the blaNDM-1 gene, which were unable to transfer by either conjugation or electrotransformation...
November 2, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27796645/spread-and-exchange-of-bla-ndm-1-in-hospitalized-neonates-role-of-mobilizable-genetic-elements
#4
S Datta, S Mitra, P Chattopadhyay, T Som, S Mukherjee, S Basu
To investigate the mobilizable elements associated with bla NDM-1 in Enterobacteriaceae isolated from septicaemic neonates at a NICU in India, during December, 2008-2011. An attempt was also made to understand whether there was a pattern in the temporal acquisition of bla NDM-1 within the unit. Transferability of carbapenem resistance was tested by conjugation and transformation. Plasmid types and addiction systems were analysed. The genetic background of bla NDM-1 and association with class 1 integron were evaluated by PCR mapping...
October 28, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27795386/evaluation-of-the-carba-np-test-in-oregon-2013
#5
Karim E Morey, Robert Vega, P Maureen Cassidy, Genevieve L Buser, Jaipreet K Rayar, Jeffrey A Myers, Scott J Weissman, Zintars G Beldavs, Christopher D Pfeiffer
Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health threat. We evaluated the capacity of the Carba NP test to detect carbapenemase production in 206 isolates: 143 Enterobacteriaceae identified by Oregon's CRE surveillance in 2013 and 63 known carbapenemase-positive organisms. Overall, test sensitivity and specificity were 89% (59/66; 95% CI 81-97%) and 100% (140/140; 95% CI 98-100%), respectively. All KPC, NDM-1, VIM, and IMP-producers but no (0/7) OXA-48-like strains were Carba NP-positive prior to a post-hoc protocol modification...
October 17, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27794265/molecular-epidemiology-of-environmental-and-clinical-carbapenemase-producing-gram-negative-bacilli-from-hospitals-in-guelma-algeria-multiple-genetic-lineages-and-first-report-of-oxa-48-in-enterobacter-cloacae
#6
Widad Bouguenoun, Sofiane Bakour, Ahmed Aimen Bentorki, Charbel Al Bayssari, Tarek Merad, Jean-Marc Rolain
This study was designed to investigate environmental colonisation in Algerian hospitals by carbapenem-resistant Gram-negative bacilli (GNB), including molecular characterisation of their resistance, and to perform a comparative molecular analysis between clinical and environmental strains. GNB isolated from hospitalised patients and the hospital environment were identified using microbiological methods and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS). Antibiotic susceptibility testing was performed by disk diffusion and Etest methods...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27790412/first-report-of-complete-sequence-of-a-blandm-13-harboring-plasmid-from-an-escherichia-coli-st5138-clinical-isolate
#7
Jingnan Lv, Xiuqin Qi, Dan Zhang, Zhou Zheng, Yuehui Chen, Yinjuan Guo, Shanshan Wang, Liang Chen, Barry N Kreiswirth, Yi-Wei Tang, Zengqiang Chen, Longhua Hu, Liangxing Wang, Fangyou Yu
Since the first report of blaNDM-1, 16 blaNDM variants have been identified among Gram-negative bacteria worldwide. Recently, a novel blaNDM variant, blaNDM-13, was identified in the chromosome of an ST101 Escherichia coli isolate from Nepal. Here we first reported plasmid-mediated blaNDM-13 in a carbapenem-resistant E. coli ST5138 clinical isolate associated with hospital-acquired urinary tract infection from China. blaNDM-13 and blaSHV-12 coexisted on the a ~54 Kb self-transferable plasmid. Compared with NDM-1, NDM-13, NDM-3, and NDM-4 had two amino acid substitutions (D95N and M154L), one amino acid substitution (D95N) and one amino acid substitutions (M154L), respectively...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27754764/combination-of-tigecycline-and-levofloxacin-for-successful-treatment-of-nosocomial-pneumonia-caused-by-new-delhi-metallo-%C3%AE-lactamase-1-producing-raoultella-planticola
#8
Zhijie Pan, Rong Liu, Pei Zhang, Hua Zhou, Yiqi Fu, Jianying Zhou
Raoultella planticola is a gram-negative bacterium that rarely causes diseases in humans. Here, we present a case of hospital-acquired pneumonia caused by R. planticola that likely originated in the gastrointestinal tract. To the best of our knowledge, this is the second report describing the detection of the gene New Delhi Metallo-β-lactamase-1 (blaNDM-1) in multidrug-resistant R. planticola. Clinical samples were collected for bacterial culture and antimicrobial susceptibility testing from a patient during hospitalization...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27733128/nosocomial-outbreak-of-kpc-2-and-ndm-1-producing-klebsiella-pneumoniae-in-a-neonatal-ward-a-retrospective-study
#9
Jing Yu, Kun Tan, Zhihui Rong, Yue Wang, Zhongju Chen, Xuhui Zhu, Li Wu, Li Tan, Wei Xiong, Ziyong Sun, Ling Chen
BACKGROUND: The spread of resistance to carbapenems among Enterobacteriaceae has become a major public health problem in recent years. In this study, we describe an outbreak of Klebsiella pneumoniae in the neonatal ward. First, we aimed to study the drug resistance, genetic relatedness, and transmission mechanism of carbapenem-resistant K. pneumoniae; second, we implemented infection control measures to contain the outbreak. METHODS: We investigated 27 non-repetitive strains isolated from neonates and five strains cultured from around the neonatal ward...
October 12, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27714593/emergence-of-new-delhi-metallo-beta-lactamase-1-and-other-carbapenemase-producing-acinetobacter-calcoaceticus-baumannii-complex-among-patients-in-hospitals-in-ha-noi-viet-nam
#10
D N Tran, H H Tran, M Matsui, M Suzuki, S Suzuki, K Shibayama, T D Pham, T T Van Phuong, D A Dang, H S Trinh, C T Loan, L T V Nga, H R van Doorn, H F L Wertheim
Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems...
October 6, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27685673/emerging-new-delhi-metallo-%C3%AE-lactamase-1-type-producing-gram-negative-bacteria-isolated-from-cairo-university-pediatric-hospital-cairo-egypt
#11
Mona Wassef, Mona Abdelhaleim, Doaa Ghaith, Yasmin El-Mahdy
New Delhi metallo-β-lactamase (NDM) compromises the efficacy of almost all β-lactam antibiotics, including carbapenems. This study aimed to screen for the blaNDM-1-type gene and NDM-1-type carbapenemase production among Gram-negative bacteria in Cairo University Pediatric Hospital (Cairo, Egypt). Among 382 Gram-negative clinical isolates collected over the period October 2013 to May 2014, 100 clinical isolates showing reduced carbapenem (imipenem and meropenem) susceptibility were included in this study. Initial phenotypic screening for NDM enzyme production was performed by Etest for metallo-β-lactamases (EMBL)...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27681362/first-report-of-escherichia-coli-co-producing-ndm-1-and-oxa-232
#12
Anna Both, Jiabin Huang, Martin Kaase, Julia Hezel, Daniel Wertheimer, Ines Fenner, Thomas Günther, Adam Grundhoff, Henning Büttner, Martin Aepfelbacher, Holger Rohde, Moritz Hentschke
Recently Gram-negative bacteria co-producing multiple carbapenemases have emerged in different parts of the world. We report the first isolation of an Escherichia coli strain co-producing the carbapenemases NDM-1 and OXA-232.
September 16, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27671058/transposition-of-tn125-encoding-the-ndm-1-carbapenemase-in-acinetobacter-baumannii
#13
Séverine Bontron, Patrice Nordmann, Laurent Poirel
The blaNDM-1 gene encodes a carbapenemase that confers resistance to almost all β-lactams, including last-resort carbapenems. This is increasingly reported worldwide in nosocomial and community-acquired Gram-negative bacteria. Acinetobacter baumannii is an important opportunistic pathogen that is considered an intermediate reservoir for the blaNDM-1 gene. In this species, the blaNDM-1 gene is located within the Tn125 composite transposon. The mechanism driving the mobility of Tn125 has not yet been elucidated...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27668722/effect-of-single-dose-carbapenem-exposure-on-transcriptional-expression-of-blandm-1-and-mexa-in-pseudomonas-aeruginosa
#14
Debarati Choudhury, Deepjyoti Paul, Anindya Sundar Ghosh, Anupam Das Talukdar, Manabendra Dutta Choudhury, Anand Prakash Maurya, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
The therapeutic option of a carbapenem antibiotic is compromised in Pseudomonas aeruginosa owing both to acquired and intrinsic resistance mechanisms. In recent years, New Delhi metallo-β-lactamase has been the focus as a predominant carbapenem resistance determinant. However, it is unclear which of the mechanisms might be adopted by a P. aeruginosa strain possessing both blaNDM-1 and an overexpressed MexAB-OprM system during carbapenem therapy. This study investigated the interplay of both mechanisms in clinical isolates of P...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27667823/ndm-producing-enterobacteriaceae-in-a-chinese-hospital-2014-2015-identification-of-ndm-producing-citrobacterwerkmanii-and-acquisition-of-blandm-1-carrying-plasmid-in-vivo-in-a-clinical-escherichia-coli-isolate
#15
Jingna An, Ling Guo, Lin Zhou, Yanning Ma, Yanping Luo, Chuanmin Tao, Jiyong Yang
New Delhi metallo-β-lactamase (NDM)-producing Enterobacteriaceae (NPE) shows prevalence in China. Little is known about the mechanisms related to the spread of NPE. Recently, a total of 51 non-duplicated NPE isolates were collected from a tertiary-care hospital in China and analysed for genetic relatedness by PFGE, antimicrobial susceptibility by Etest and sequence type by multilocus sequence typing. S1-PFGE and Southern blot analysis or PCR amplification were used for plasmid profiling. Between 2014 and 2015, 22 Escherichia coli, 10 Klebsiella pneumoniae, 9 Enterobacter cloacae, 2 Enterobacter aerogenes, 3 Providencia rettgeri, 1 Klebsiella oxytoca, 1 Proteus mirabilis, 1 Citrobacter freundii, 1 Citrobacterwerkmanii and 1 Raoultella planticola were identified as NPE...
November 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27659734/st147-ndm-1-producing-klebsiella-pneumoniae-spread-in-two-tunisian-hospitals
#16
Aziza Messaoudi, Marisa Haenni, Wejdene Mansour, Estelle Saras, Anis Bel Haj Khalifa, Cherifa Chaouch, Walid Naija, Noureddine Boujâafar, Olfa Bouallègue, Jean-Yves Madec
No abstract text is available yet for this article.
September 22, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27649032/carbapenem-resistance-in-clonally-distinct-clinical-strains-of-vibrio-fluvialis-isolated-from-diarrheal-samples
#17
Goutam Chowdhury, Gururaja Perumal Pazhani, Anirban Sarkar, Krishnan Rajendran, Asish K Mukhopadhyay, Mihir K Bhattacharya, Amit Ghosh, Thandavarayan Ramamurthy
Carbapenems have been used for many years to treat severe nosocomial Enterobacteriaceae infections. The spread of resistance to these drugs among other bacterial families is an emerging problem worldwide, mostly caused by New Delhi metallo-β-lactamase (NDM-1). We screened for the prevalence of NDM-1-expressing enteric pathogens from hospitalized patients with acute diarrhea in Kolkata, India, and identified 27 Vibrio fluvialis-harboring blaNDM-1 (NDM-VF) strains. These isolates were also resistant to all the tested antimicrobial drugs except doxycycline...
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27633338/total-synthesis-of-aspergillomarasmine%C3%A2-a-and-related-compounds-a-sulfamidate-approach-enables-exploration-of-structure-activity-relationships
#18
Silvia A Albu, Kalinka Koteva, Andrew M King, Salma Al-Karmi, Gerard D Wright, Alfredo Capretta
The fungal secondary metabolite aspergillomarasmine A (AMA) has recently been identified as an inhibitor of metallo-β-lactamases NDM-1 and VIM-2. Described herein is an efficient and practical route to AMA and its related compounds by a sulfamidate approach. In addition, a series of derivatives has been prepared and tested for biological activity in an effort to explore preliminary structure activity relationships. While it was determined that natural LLL isomer of AMA remains the most effective inactivator of NDM-1 enzyme activity both in vitro and in cells, the structure is highly tolerant of the changes in the stereochemistry at positions 3, 6, and 9...
October 10, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27624807/an-irish-outbreak-of-new-delhi-metallo-%C3%AE-lactamase-ndm-1-carbapenemase-producing-enterobacteriaceae-increasing-but-unrecognized-prevalence
#19
C O'Connor, M Cormican, T W Boo, E McGrath, B Slevin, A O'Gorman, M Commane, S Mahony, E O'Donovan, J Powell, R Monahan, C Finnegan, M G Kiernan, J C Coffey, L Power, N H O'Connell, C P Dunne
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) may cause healthcare-associated infections with high mortality rates. New Delhi metallo-β-lactamase-1 (NDM-1) is among the most recently discovered carbapenemases. AIM: To report the first outbreak of NDM-1 CPE in Ireland, including microbiological and epidemiological characteristics, and assessing the impact of infection prevention and control measures. METHODS: This was a retrospective microbiological and epidemiological review...
December 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27623409/bisthiazolidines-a-substrate-mimicking-scaffold-as-an-inhibitor-of-the-ndm-1-carbapenemase
#20
Mariano M González, Magda Kosmopoulou, Maria F Mojica, Valerie Castillo, Philip Hinchliffe, Ilaria Pettinati, Jürgen Brem, Christopher J Schofield, Graciela Mahler, Robert A Bonomo, Leticia I Llarrull, James Spencer, Alejandro J Vila
Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major public health threat. Zn(II)-dependent or metallo-β-lactamases (MBLs) produced by these bacteria inactivate most β-lactam antibiotics, including the carbapenems, which are "last line therapies" for life-threatening Gram-negative infections. NDM-1 is a carbapenemase belonging to the MBL family that is rapidly spreading worldwide. Regrettably, inhibitors of MBLs are not yet developed. Here we present the bisthiazolidine (BTZ) scaffold as a structure with some features of β-lactam substrates, which can be modified with metal-binding groups to target the MBL active site...
November 13, 2015: ACS Infectious Diseases
keyword
keyword
16404
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"