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https://www.readbyqxmd.com/read/28717120/new-delhi-metallo-beta-lactamase-ndm-1-producing-klebsiella-pneumoniae-isolated-from-a-burned-patient
#1
Santiago Petersen-Morfin, Paola Bocanegra-Ibarias, Rayo Morfin-Otero, Elvira Garza-González, Hector Raul Perez-Gomez, Esteban González-Diaz, Sergio Esparza-Ahumada, Gerardo León-Garnica, Gabriel Amezcua-Salazar, Eduardo Rodriguez-Noriega
BACKGROUND Infections affecting burn patients are frequently caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacteriaceae species. Infections with these pathogens have become increasingly difficult to treat due to evolving antibiotic resistance mechanisms, including the production of carbapenemases. CASE REPORT The present case report describes the evolution of a burn patient with polymicrobial healthcare-associated burn infections, including a bloodstream infection due to an emergent multidrug-resistant New Delhi metallo-beta-lactamase (NDM-1)-producing Klebsiella pneumoniae...
July 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28706386/alarming-emergence-molecular-characterization-and-outcome-of-blandm-1-in-patients-infected-with-multidrug-resistant-gram-negative-bacilli-in-a-tertiary-care-hospital
#2
Huma Naim, Meher Rizvi, Mohd Azam, Richa Gupta, Neelam Taneja, Indu Shukla, Haris M Khan
INTRODUCTION: This study was conducted to assess the prevalence of metallo-beta-lactamases (MBLs) in general and blaNDM-1 in particular. It also aimed at evaluating clinical characteristics and outcome in patients infected with MBLs. MATERIALS AND METHODS: A total of 116 carbapenem-resistant Gram-negative bacilli (CRGNB) were evaluated in the study. These CRGNB were tested for MBL production both phenotypically for MBLs and genotypically for blaNDM-1 gene by polymerase chain reaction (PCR)...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28696242/metallo-%C3%AE-lactamases-dim-1-ndm-1-vim-2-and-a-16s-rrna-methyltransferase-rmtb4-rmtf2-producing-pseudomonas-aeruginosa-in-nepal
#3
Tatsuya Tada, Kayo Shimada, Kazuhito Satou, Takashi Hirano, Bharat M Pokhrel, Jeevan B Sherchand, Teruo Kirikae
A total of 11 multidrug-resistant Pseudomonas aeruginosa clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1, NDM-1 and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a substitution (K65E) compared with RmtF. To our knowledge, this is the first report describing carbapenemase- and 16S rRNA methyltransferase-co-producing P. aeruginosa clinical isolates in Nepal.
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28687066/genomic-characterization-of-a-large-plasmid-containing-a-bla-ndm-1-gene-carried-on-salmonella-enterica-serovar-indiana-c629-isolate-from-china
#4
Wei Wang, Zulqarnain Baloch, Zixin Peng, Yujie Hu, Jin Xu, Séamus Fanning, Fengqin Li
BACKGROUND: The bla NDM-1 gene in Salmonella species is mostly reported in clinical cases, but is rarely isolated from red and white meat in China. METHODS: A Salmonella Indiana (S. Indiana) isolate was cultured from a chicken carcass procured from a slaughterhouse in China. Antimicrobial susceptibility was tested against a panel of agents. Whole-genome sequencing of the isolate was carried out and data was analyzed. RESULTS: A large plasmid, denoted as plasmid pC629 (210,106 bp), containing a composite cassette, consisting of IS26-bla NDM-1-ble MBL -△trpF-tat-cutA-ISCR1-sul1-qacE△1-aadA2-dfrA12-intI1-IS26 was identified...
July 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28683827/expanding-landscapes-of-the-diversified-mcr-1-bearing-plasmid-reservoirs
#5
Qingjing Wang, Jian Sun, Jun Li, Youfa Ding, Xing-Ping Li, Jingxia Lin, Bachar Hassan, Youjun Feng
BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinical use. METHODS: The mcr-1-harboring plasmids were acquired from swine and human Escherichia coli isolated in China, from 2015 to 2016, and subjected to Illumina PacBio RSII and Hi-Seq2000 for full genome sequencing...
July 6, 2017: Microbiome
https://www.readbyqxmd.com/read/28676118/dissemination-of-carbapenem-resistant-klebsiella-pneumoniae-clinical-isolates-with-various-combinations-of-carbapenemases-kpc-2-ndm-1-ndm-4-and-oxa-48-and-16s-rrna-methylases-rmtb-and-rmtc-in-vietnam
#6
Tatsuya Tada, Mitsuhiro Tsuchiya, Kayo Shimada, Tran Thi Thanh Nga, Le Thi Anh Thu, Truong Thien Phu, Norio Ohmagari, Teruo Kirikae
METHODS: Twenty-seven clinical isolates of carbapenem-resistant Klebsiella pneumoniae with MICs ≥4 mg/L for imipenem or meropenem were obtained from inpatients in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence typing and the presence of drug resistant genes were determined and a maximum-likelihood phylogenetic tree was constructed by SNP alignment of whole genome sequencing data. RESULTS: All the isolates harbored one of genes encoding carbapenemases, including KPC-2, NDM-1, NDM-4 and OXA-48...
July 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28674063/first-report-of-klebsiella-oxytoca-strain-simultaneously-producing-ndm-1-imp-4-and-kpc-2-carbapenemases
#7
Juan Wang, Min Yuan, Hai Chen, Xia Chen, Yuanchun Jia, Xiong Zhu, Li Bai, Xue Bai, Séamus Fanning, Jinxing Lu, Juan Li
The nucleotide sequences of 5 plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that blaNDM-1 was carried on an IncX3 plasmid. The blaIMP-4 and blaKPC-2 were located on an IncN and an IncP-6 plasmid, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harbouring plasmids among different enterobacterial species. It reports for the first time coproducing NDM-1, KPC-2 and IMP-4 carbapenemases on a K. oxytoca isolate...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28671537/the-distribution-of-carbapenem-and-colistin-resistance-in-gram-negative-bacteria-from-the-tamil-nadu-region-in-india
#8
Prasanth Manohar, Thamaraiselvan Shanthini, Ramankannan Ayyanar, Bulent Bozdogan, Aruni Wilson, Ashok J Tamhankar, Ramesh Nachimuthu, Bruno S Lopes
PURPOSE: The occurrence of carbapenem- and colistin-resistance among Gram-negative bacteria is increasing worldwide. The aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in Tamil Nadu, India. METHODOLOGY: The clinical isolates (n=89) used in this study were collected from two diagnostic centres in Tamil Nadu, India. The bacterial isolates were screened for meropenem- and colistin-resistance. Further, resistance genes blaNDM-1, blaOXA-48-like, blaIMP, blaVIM, blaKPC, mcr-1 and mcr-2 and integrons were studied...
July 3, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28668692/wastewater-is-a-reservoir-for-clinically-relevant-carbapenemase-and-16s-rrna-methylase-producing-enterobacteriaceae
#9
Katrin Zurfluh, Claudia Bagutti, Peter Brodmann, Monica Alt, Jürg Schulze, Séamus Fanning, Roger Stephan, Magdalena Nüesch-Inderbinen
The aim of the study was to evaluate wastewater for carbapenemase producing Enterobacteriaceae (CPE) and 16S rRNA methylase producing Gram negative bacteria (MPB), and to assess their occurrence following wastewater treatment. Wastewater samples were collected between June 2015 and March 2016 in the sewage network of the city of Basel from sites located before and after influx of wastewater from the hospital into the sewage network. Samples were also obtained from the influent and from the effluent of the receiving wastewater treatment plant...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28664213/real-time-activity-monitoring-of-new-delhi-metallo-%C3%AE-lactamase-1-in-living-bacterial-cells-by-uv-vis-spectroscopy
#10
Ke-Wu Yang, Yajun Zhou, Ying Ge, Yuejuan Zhang
We report an UV-Vis method for monitoring the hydrolysis of the β-lactam antibiotics inside living bacterial cells. Cell-based studies demonstrated that the hydrolysis of cefazolin was inhibited by three known NDM-1 inhibitors. This approach can be applied to the monitoring of reactions in a complex biological system, for instance in medical testing.
June 30, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28660132/new-delhi-metallo-%C3%AE-lactamase-1-ndm-1-escherichia-coli-isolated-from-household-vacuum-cleaner-oregon-2013
#11
Genevieve L Buser, P Maureen Cassidy, Christopher D Pfeiffer, John M Townes, Karim E Morey, Jaipreet Rayar, Kirthi K Kutumbaka, Sukkyun Han, Cesar Nadala, Mansour Samadpour, Scott J Weissman, Robert Vega, Zintars G Beldavs
The first Oregon case of New Delhi metallo-β-lactamase-1 (NDM-1)-producing Escherichia coli was reported during November 2013. Epidemiologic investigation revealed only local outpatient medical care and no travel outside Oregon for both the patient and his household contact. Environmental sampling discovered a matching isolate from the patient's household vacuum cleaner, suggesting environmental persistence.
2017: IDCases
https://www.readbyqxmd.com/read/28652234/meropenem-vaborbactam-tested-against-contemporary-gram-negative-isolates-collected-worldwide-during-2014-including-carbapenem-resistant-kpc-producing-multidrug-resistant-and-extensively-drug-resistant-enterobacteriaceae
#12
Mariana Castanheira, Michael D Huband, Rodrigo E Mendes, Robert K Flamm
We evaluated the activity of meropenem-vaborbactam against contemporary non-fastidious gram-negative clinical isolates, including resistant phenotypes and carbapenemase genotypes of Enterobacteriaceae Meropenem-vaborbactam (inhibitor at 8 μg/ml) and comparators were susceptibility tested using reference broth microdilution methods against 14,304 gram-negative clinical isolates collected worldwide during 2014. Carbapenemase encoding genes were screened by PCR/sequencing. Meropenem-vaborbactam (MIC50/90, ≤0...
June 26, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28650688/multidrug-resistant-enterobacteriaceae-in-lebanese-hospital-wastewater-implication-in-the-one-health-concept
#13
Ziad Daoud, Jina Farah, Elie Salem Sokhn, Khalil El Kfoury, Elias Dahdouh, Khalil Masri, Claude Afif, Roula M Abdel-Massih, Ghassan M Matar
Extended-spectrum beta-lactamases (ESBL) and carbapenemase-producing organisms pose severe problems for hospitalized patients. In the absence of efficient sanitation and sewage disposal, the risks for transmission of hospital organisms into the community are high. Our objectives were to study the occurrence and mechanisms of resistance of multidrug-resistant gram-negative bacilli in two Lebanese hospital sewage treatment plants. Wastewater samples were collected, filtered, and cultivated on MacConckey+cefotaxime agars...
June 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28643488/multidrug-resistance-mechanisms-of-carbapenem-resistant-klebsiella-pneumoniae-strains-isolated-in-chongqing-china
#14
Jinrong Yan, Shuli Pu, Xiaojiong Jia, Xiuyu Xu, Shuangshuang Yang, Jing Shi, Shan Sun, Liping Zhang
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR mechanisms of CRKP and identified their clonal characteristics. METHODS: PCR and sequencing were utilized to identify antibiotic resistance determinants. Integron gene cassette arrays were determined by restriction fragment length polymorphism (RFLP) analysis...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28639165/molecular-characterization-of-intestinal-carriage-of-carbapenem-resistant-enterobacteriaceae-among-inpatients-at-two-iranian-university-hospitals-first-report-of-co-production-of-bla-ndm-7-and-bla-oxa-48
#15
H Solgi, F Badmasti, Z Aminzadeh, C G Giske, M Pourahmad, F Vaziri, S A Havaei, F Shahcheraghi
Gastrointestinal colonization of carbapenem-resistant Enterobacteriaceae (CRE) could serve as a reservoir for the transmission of these pathogens in the clinical setting. The aim of this study was to investigate the intestinal carriage of CRE and to analyze risk factors for CRE carriage. Rectal swabs were collected from 95 patients at two Iranian university hospitals. CRE screening was performed using selective media (CHROMagar and MacConkey agar). Polymerase chain reaction (PCR) was used to detect carbapenemase-encoding genes...
June 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28636666/molecular-and-microbiological-report-of-a-hospital-outbreak-of-ndm-1-carrying-enterobacteriaceae-in-mexico
#16
Paola Bocanegra-Ibarias, Elvira Garza-González, Rayo Morfín-Otero, Humberto Barrios, Licet Villarreal-Treviño, Eduardo Rodríguez-Noriega, Ulises Garza-Ramos, Santiago Petersen-Morfin, Jesus Silva-Sanchez
OBJECTIVES: To characterize the microbiological, molecular and epidemiological data of an outbreak of carbapenem-resistant Enterobacteriaceae (CRE) in a tertiary-care hospital in Mexico. METHODS: From September 2014 to July 2015, all CRE clinical isolates recovered during an outbreak in the Hospital Civil "Fray Antonio Alcalde" in Jalisco, Mexico were screened for antimicrobial susceptibility, carbapenemase production, carbapenemase-encoding genes, and plasmid profiles...
2017: PloS One
https://www.readbyqxmd.com/read/28634354/primary-osteomyelitis-caused-by-an-ndm-1-producing-k-pneumoniae-strain-of-the-highly-virulent-sequence-type-23
#17
Fabrice Compain, Alexis Vandenberghe, Marie Gominet, Nathalie Genel, David Lebeaux, Astrid Ramahefasolo, Isabelle Podglajen, Dominique Decré
No abstract text is available yet for this article.
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28627648/characterization-of-a-blandm%C3%A2-1%C3%A2-harboring-plasmid-from-a-salmonella%C3%A2-enterica-clinical-isolate-in-china
#18
Jinwei Huang, Shanshan Deng, Jianmin Ren, Jianfei Tu, Meiping Ye, Minggui Wang
The plasmid-mediated transmission of antibiotic resistance genes has been reported to be involved in the development of antibiotic resistance in bacteria, and poses a serious threat for the success of bacterial infection treatment and human health worldwide. The present study used a 454 GS‑FLX pyrosequencing system to determine the ~140 kb nucleotide sequence of plasmid pHS36‑NDM, which was identified in a Salmonella Stanley isolate from the stool sample of an 11‑month‑old girl at Lishui Central Hospital, China, and which contains a New Delhi metallo‑β‑lactamase‑1 (NDM‑1) carbapenem resistance gene (blaNDM‑1)...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28610832/comparison-of-antimicrobial-activity-between-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-multidrug-resistant-isolates-of-escherichia-coli-klebsiella-pneumoniae-and-pseudomonas-aeruginosa
#19
Adnan Alatoom, Hashim Elsayed, Karen Lawlor, Laila AbdelWareth, Rania El-Lababidi, Lysettee Cardona, Mohammad Mooty, Maria-Fernanda Bonilla, Ahmad Nusair, Imran Mirza
OBJECTIVE: This study compared the activity of ceftolozane-tazobactam and ceftazidime-avibactam against 120 bacterial strains, including extended-spectrum beta-lactamase (ESBL) producers, carbapenem-resistant Enterobacteriaceae (CRE), and Pseudomonas aeruginosa, isolated from patients admitted to Cleveland Clinic Abu Dhabi, United Arab Emirates. METHODS: In vitro susceptibility was tested using the Etest strip minimum inhibitory concentration (MIC) method, and PCR was used to characterize the carbapenemase enzymes produced by CRE strains...
June 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28602387/surveillance-of-carbapenemase-producing-enterobacteriaceae%C3%A2-in-the-indian-ocean-region-between-january-2010%C3%A2-and-december-2015
#20
A M Holman, J Allyn, G Miltgen, N Lugagne, N Traversier, S Picot, A Lignereux, C Oudin, O Belmonte, N Allou
BACKGROUND: The aim of this study was to trace the emergence of carbapenemase-producing Enterobacteriaceae (CPE) on Reunion Island, a French overseas territory well suited for the surveillance of CPE emergence in patients from the entire Indian Ocean Region. METHODS: This retrospective multicenter study was conducted on Reunion Island between 2010 and 2015. RESULTS: A total of 43 CPEs were isolated during the course of the study, in 36 patients (50% in the last year alone)...
June 8, 2017: Médecine et Maladies Infectieuses
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