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https://www.readbyqxmd.com/read/29763630/clinical-and-molecular-epidemiologic-characteristics-of-carbapenem-resistant-klebsiella-pneumoniae-infection-colonization-among-neonates-in-china
#1
Dandan Yin, Lei Zhang, Aimin Wang, Leiyan He, Yun Cao, Fupin Hu, Chuanqing Wang
BACKGROUND: The spread of carbapenem-resistant Klebsiella pneumoniae (CR-KPN) is a major concern, but data on CR-KPN infection/colonization in paediatric populations are limited. AIM: This study aimed to analyze epidemiologic and clinical characteristics, therapeutic options of CR-KPN infections in neonates in China. METHODS: A retrospective study was performed at the Children's Hospital of Fudan University, including 88 neonates with CR-KPN admitted between November 2015 and October 2016...
May 12, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29760136/aztreonam-avibactam-combination-restores-susceptibility-of-aztreonam-in-dual-carbapenemase-producing-enterobacteriaceae
#2
Ka Lip Chew, Michelle K L Tay, Bernadette Cheng, Raymond T P Lin, Sophie Octavia, Jeanette W P Teo
Newly approved Food and Drug Administration (FDA) β-lactam-β-lactamase inhibitor (βL-βLI) inhibitor combinations such as ceftazidime-avibactam and meropenem-vaborbactam are potent inhibitors of class A carbapenemase (typified by KPC [ Klebsiella pneumoniae carbapenemase]-like) (1, 2) but are ineffective against carbapenemase-producing Enterobacteriaceae (CPE) producing class B metallo-β-lactamases (MβLs) such as New Delhi metallo-β-lactamase (NDM) (1-4).….
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29749367/use-of-succinic-oxalic-acid-in-reducing-the-dosage-of-colistin-against-new-delhi-metallo-%C3%AE-lactamase-1-bacteria
#3
Ravichandiran Kumar, Brinda Chandar, Madasamy Parani
Background & objectives: New Delhi metallo-β-lactamase 1 (NDM-1) cleaves the beta-lactam ring, and confers bacterial resistance against most of the beta-lactam antibiotics, except tigecycline and colistin. Among these two antibiotics, colistin is considered toxic, and therefore, its clinical use and dosage need cautious approach. In the present study, six organic acids were screened individually and in combination of two acids for their effectiveness against NDM-1 Escherichia coli and a combination of colistin and oxalic or succinic acid was tested to find out the potential of combination therapy for reducing the dose of toxic colistin...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29749296/molecular-and-computational-approaches-to-understand-resistance-of-new-delhi-metallo-%C3%AE-lactamase-variants-ndm-1-ndm-4-ndm-5-ndm-6-ndm-7-producing-strains-against-carbapenems
#4
Abid Ali, Divya Gupta, Gaurava Srivastava, Ashok Sharma, Asad U Khan
The discovery of NDM-1 and its variants has caused the emergence of antibiotic resistance in the community and hospital setting, causing major concern for health care across the globe. New Delhi Metallo-β-lactamase is known to hydrolyze almost all β-lactam antibiotics. Studies have shown the hydrolytic activates of NDM-1 and some of its variants, however a comparative study of these NDM variants has not been explored in detail. Hence, we proposed to check their catalytic activity by performing a comparative study between NDM-1 and its variants...
May 11, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29744043/genome-based-analysis-of-carbapenemase-producing-klebsiella-pneumoniae-isolates-from-german-hospital-patients-2008-2014
#5
Laura Becker, Martin Kaase, Yvonne Pfeifer, Stephan Fuchs, Annicka Reuss, Anja von Laer, Muna Abu Sin, Miriam Korte-Berwanger, Sören Gatermann, Guido Werner
Background: By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014. Methods: We selected a representative subset of 107 carbapenemase-producing K. pneumoniae clinical isolates possessing the four most prevalent carbapenemase types in Germany (KPC-2, KPC-3, OXA-48, NDM-1). Isolates were processed via illumina NGS. Data were analysed using different SNP-based mapping and de-novo assembly approaches...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29728111/emergence-of-multidrug-resistant-providencia-rettgeri-isolates-co-producing-ndm-1-carbapenemase-and-per-1-extended-spectrum-%C3%AE-lactamase-causing-a-first-outbreak-in-korea
#6
Saeam Shin, Seok Hoon Jeong, Hyukmin Lee, Jun Sung Hong, Min-Jeong Park, Wonkeun Song
BACKGROUND: Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seoul, Korea. METHODS: A total of eight non-duplicate P. rettgeri isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit...
May 5, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29727717/coexistence-of-ndm-1-producing-escherichia-coli-and-citrobacter-freundii-in-the-same-patient
#7
Bo Zhu, Chaoqun Ying, Hao Xu, Jingjing Ying
OBJECTIVES: Although blaNDM-1 has now been widely detected in various Enterobacteriaceae clinical isolates, multiple blaNDM-1 colonizations within the same patient remain rare. The aim of the study was to describe a patient with respiratory tract colonization of NDM-1-producing Escherichia coli and Citrobacter freundii during a hospitalization in China. METHODS: Two carbapenem-resistant isolates were analysed. Susceptibility testing, metallo-β-lactamase production, conjugation, plasmid analysis, and molecular typing were performed...
May 1, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29726673/vancomycin-analogue-restores-meropenem-activity-against-ndm-1-gram-negative-pathogens
#8
Venkateswarlu Yarlagadda, Paramita Sarkar, Sandip Samaddar, Goutham Belagula Manjunath, Susweta Das Mitra, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
New Delhi Metallo-β-lactamase-1 (NDM-1) is the major contributor to the emergence of carbapenem-resistance in Gram-negative pathogens (GNPs) and has caused many clinically available β-lactam antibiotics to become obsolete. A clinically approved inhibitor of metallo-β-lactamase (MBL) that could restore the activity of carbapenems against resistant GNPs has not yet been found, making NDM-1 a serious threat to human health. Here, we have rationally developed an inhibitor for the NDM-1 enzyme, which has the ability to penetrate the outer membrane of GNPs and inactivate the enzyme by depleting the metal ion (Zn2+) from the active site...
May 4, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29724185/clonal-diversity-and-genetic-profiling-of-antibiotic-resistance-among-multidrug-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-a-tertiary-care-hospital-in-saudi-arabia
#9
Taher Uz Zaman, Maha Alrodayyan, Maha Albladi, Mohammed Aldrees, Mohammed Ismail Siddique, Sameera Aljohani, Hanan H Balkhy
BACKGROUND: The nexus between resistance determinants, plasmid type, and clonality appears to play a crucial role in the dissemination and survival of carbapenem-resistant Klebsiella pneumoniae (CRKP). The incidence of infections involving CRKP in Saudi Arabia is increasing and there is a need for detailed molecular profiling of this pathogen for CRKP surveillance and control. METHODS: The resistance determinants of 71 non-redundant CRKP isolates were investigated by polymerase chain reaction (PCR) and sequencing...
May 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29723841/klebsiella-pneumoniae-as-a-key-trafficker-of-drug-resistance-genes-from-environmental-to-clinically-important-bacteria
#10
REVIEW
Kelly L Wyres, Kathryn E Holt
Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae's contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists...
April 30, 2018: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29722581/antibacterial-activity-of-3-methylbenzo-d-thiazol-methylquinolinium-derivatives-and-study-of-their-action-mechanism
#11
Ning Sun, Ruo-Lan Du, Yuan-Yuan Zheng, Qi Guo, Sen-Yuan Cai, Zhi-Hua Liu, Zhi-Yuan Fang, Wen-Chang Yuan, Ting Liu, Xiao-Mei Li, Yu-Jing Lu, Kwok-Yin Wong
The increasing incidence of multidrug resistant bacterial infection renders an urgent need for the development of new antibiotics. To develop small molecules disturbing FtsZ activity has been recognized as promising approach to search for antibacterial of high potency systematically. Herein, a series of novel quinolinium derivatives were synthesized and their antibacterial activities were investigated. The compounds show strong antibacterial activities against different bacteria strains including MRSA, VRE and NDM-1 Escherichia coli...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29708847/preliminary-study-on-the-antibacterial-activity-of-essential-oils-alone-and-in-combination-with-gentamicin-against-extended-spectrum-%C3%AE-lactamase-producing-and-new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates
#12
Paweł Kwiatkowski, Agata Pruss, Bartłomiej Grygorcewicz, Bartosz Wojciuk, Barbara Dołęgowska, Stefania Giedrys-Kalemba, Ewa Kochan, Monika Sienkiewicz
AIM: The aim of the study was to investigate possible synergistic effects between several selected, commercially available essential oils and gentamicin against extended-spectrum β-lactamase (ESBL)-producing and New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae isolates. MATERIALS AND METHODS: ESBLs production was confirmed by double-disk synergy test. Isolates positive for blaNDM-1 gene were found among the tested strains. K. pneumoniae ATCC® BAA-1705™ strain was used as a control...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29698126/whole-genome-sequencing-of-ndm-1-producing-st11-klebsiella-pneumoniae-isolated-in-a-private-laboratory-in-greece
#13
Georgios Meletis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Fani Tsingerlioti, Christina Botziori, Georgios Tzimagiorgis, Lemonia Skoura
The emergence and spread of NDM-1-encoding Klebsiella pneumoniae is causing worldwide concern, whereas a second epicenter of their dissemination after the Indian subcontinent is thought to be located in the Balkans. In this study, the complete genome sequencing of an NDM-1-producing ST11 K. pneumoniae isolated in a private laboratory in Greece is presented. The genome sequencing was performed on Illumina MiniSeq. Multilocus Sequence Typing was determined using a BLAST-based approach whereas antimicrobial resistance genes and plasmid replicons were identified by ResFinder and PlasmidFinder respectively...
April 26, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29692579/molecular-characterization-and-antimicrobial-susceptibility-profile-of-new-delhi-metallo-beta-lactamase-1-producing-escherichia-coli-among-hospitalized-patients
#14
Anjali Agarwal, Jyoti Srivastava, Ujjwal Maheshwari, Mohd Iftikhar
BACKGROUND: Carbapenemase-producing microorganisms are becoming a major concern among hospital-acquired infections. There is also increased multidrug resistance seen among these isolates. AIMS: We have conducted this study to determine the prevalence of New Delhi metallo-beta-lactamase-1 (NDM-1) gene-producing Escherichia coli among hospitalized patients in a tertiary care hospital in Northern India. SETTINGS AND DESIGN: The study was conducted in the Department of Microbiology with the tertiary care hospital settings...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29692474/molecular-detection-of-bla-ndm-1-new-delhi-metallobetalactamase-1-in-nosocomial-enterobacteriaceae-isolates-by-nested-multiplex-polymerase-chain-reaction
#15
Parnika Chandola, R M Gupta, Mahima Lall, Sourav Sen, S P S Shergill, Vibha Dutta
Background: Carbapenems are considered "drugs of last resort" in many life-threatening infections. Advent of carbapenemases like KPC, OXA-48, VIM, IMP, and NDM have greatly affected the efficacy of these drugs, posing serious threat to global health and infection control. NDM bears special significance to the India subcontinent, labeled as place of origin and reservoir. NDM tends to escape detection by routine phenotypic methods, requiring molecular confirmation. This study utilizes nested, multiplex polymerase chain reaction (PCR) for reliable detection of bla NDM-1 in nosocomial Enterobacteriaceae isolates...
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29687124/a-protein-structure-guided-covalent-scaffold-selectively-targets-the-b1-and-b2-subclass-metallo-%C3%AE-lactamases
#16
Cheng Chen, Yang Xiang, Ke-Wu Yang, Yuejuan Zhang, Wen-Ming Wang, Jian-Peng Su, Ying Ge, Ya Liu
We report the discovery of ebselen-based dual covalent inhibitors of metallo-β-lactamases. Fluorescence and MALDI-TOF analysis suggested that the scaffold could bind to NDM-1 by forming a S-Se bond with Cys221 and an amide bond with Lys224 of NDM-1, thereby exhibiting selective inhibition and labeling against B1 and B2 subclass enzymes in vitro and in vivo.
April 24, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29673980/photoactivated-2-3-distyrylindoles-kill-multi-drug-resistant-bacteria
#17
Leslie Edwards, Danielle Turner, Cody Champion, Megha Khandelwal, Kailee Zingler, Cassidy Stone, Ruwini D Rajapaksha, Jing Yang, Mahinda I Ranasinghe, Alexander Kornienko, Liliya V Frolova, Snezna Rogelj
Compounds based on the 2,3-distyrylindole scaffold were found to exhibit bactericidal properties upon irradiation with white light. At the concentration of 1 μM, the lead compound 1 completely (ca. 109  CFU/mL) eradicated such Gram-positive organisms as S. aureus (MRSA, MSSA), E. faecalis (VRE), S. pyogenes and S. mutans when irradiated with white light for 2 min. At the concentration of 5 μM and in the presence of polymyxin E at non-bactericidal 1.25 μg/mL concentration, 1 also showed a 7-log to 9-log reductions in bacterial counts of such Gram-negative organisms as multi-drug resistant (MDR) A...
April 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29673319/carbapenemase-producing-enterobacteriaceae-in-mexico-report-of-seven-non-clonal-cases-in-a-pediatric-hospital
#18
Alejandra Aquino-Andrade, Jocelin Merida-Vieyra, Eduardo Arias de la Garza, Patricia Arzate-Barbosa, Agustín De Colsa Ranero
BACKGROUND: Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epidemiological, and molecular characteristics of seven consecutive cases in a third-level pediatric hospital in Mexico City over a four-month period during 2016. RESULTS: The Enterobacteriaceae identified were three Escherichia coli strains (producing OXA-232, NDM-1 and KPC-2), two Klebsiella pneumoniae strains (producing KPC-2 and NDM-1), one Klebsiella oxytoca strain producing OXA-48 and one Enterobacter cloacae strain producing NDM-1...
April 19, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29670701/rhodanine-as-a-potent-scaffold-for-the-development-of-broad-spectrum-metallo-%C3%AE-lactamase-inhibitors
#19
Yang Xiang, Cheng Chen, Wen-Ming Wang, Li-Wei Xu, Ke-Wu Yang, Peter Oelschlaeger, Yuan He
A series of rhodanines was constructed, their Z-configuration was confirmed by small molecule X-ray crystal structures, and their activity against metallo-β-lactamases (MβLs) was measured. The obtained 26 molecules and a thioenolate specifically inhibited the MβL L1 with an IC50 range of 0.02-1.7 μM, and compounds 2h - m exhibited broad-spectrum inhibition of the MβLs NDM-1, VIM-2, ImiS, and L1 with IC50 values <16 μM. All inhibitors increased the antimicrobial effect of cefazolin against E. coli cells expressing L1, resulting in a 2-8-fold reduction in MIC...
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29670607/carbapenem-resistant-e-cloacae-in-southwest-china-molecular-analysis-of-resistance-and-risk-factors-for-infections-caused-by-ndm-1-producers
#20
Xiaojiong Jia, Wei Dai, Weijia Ma, Jinrong Yan, Jianchun He, Shuang Li, Congya Li, Shuangshuang Yang, Xiuyu Xu, Shan Sun, Jing Shi, Liping Zhang
Carbapenem-resistant Enterobacteriaceae (CRE) has been considered a serious global threat, but carbapenem resistance remains relatively uncommon in E. cloacae , especially in China. The aim of this study was to characterize carbapenem-resistant E. cloacae (CR-ECL) isolates from 2012 to 2016 in Southwest China. Our study revealed that 20 (15.2%) of the 132 CR-ECL isolates obtained from patients were identified as NDM-1, with most isolates carrying the IncFIIA plasmids. Notably, we initially observed that the E...
2018: Frontiers in Microbiology
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