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anabolic-androgen steroids

Gulcin Elboga, Zeynel Abidin Sayiner
Hypogonadotropic hypogonadism is a rare congenital disorder characterised by the deficiency and the absence of puberty and infertility. It is caused by the deficient production, secretion or action of gonadotropin-releasing hormone, which is the master hormone regulating the reproductive axis. Gonadotropin-releasing hormone or gonadotropin injections and testosterone replacement therapy are required in the treatment of this disorder. Psychiatric symptoms and disorders may be seen with the use of anabolic androgenic steroids...
August 3, 2018: BMJ Case Reports
Siti Syairah Mohd Mutalip, Aishah Mohd Shah, Mashani Mohamad, Vasudevan Mani, Siti Nooraishah Hussin, Gurmeet Kaur Surindar Singh
Background Testosterone, nandrolone, and stanozolol are among the highly consumed anabolic androgenic steroids (AASs). Although the desired effects of AAS are being achieved by the abusers, unfortunately, this leads to numerous physical and physiological side effects. The present study was designed to investigate and determine whether early pubertal exposure to AAS treatment had detrimental effects on blood testosterone and estradiol concentrations, mating behavior, and pregnancy outcome during the pubertal period in male rats...
August 3, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Amany Mohamed Shalaby, Noha Gamal Bahey
Nandrolone decanoate is an anabolic-androgenic steroid that is frequently used at a very high dose to improve the physical performance. Recently, this drug has been abused by athletes to augment their muscle mass and improve their physical performance. However, this could have an impact on other body systems with the potential increase in its harmful effect. Therefore, the aim of this study was to evaluate the effect of administering a supraphysiological dose of nandrolone decanoate on the hepatic functions and structure of the adult rat and to test the potential reversibility after nandrolone withdrawal...
August 2018: Tissue & Cell
Joseph Matthew Armstrong, Ross A Avant, Cameron M Charchenko, Mary E Westerman, Matthew J Ziegelmann, Tanner S Miest, Landon W Trost
Background: To describe the impact of supra-physiologic anabolic-androgenic steroid (AAS) use, including agent, dosage, and duration of therapy, on sexual function. Methods: We reviewed data from an online survey of AAS users to evaluate their sexual function on and off AAS. The online survey consisted of questions addressing demographics, anabolic steroid use and patterns, ancillary medications, testosterone (T)-related symptoms while on and off of therapy, as well as sexual function which was assessed using the 5-item, International Index of Erectile Function (IIEF-5)...
June 2018: Translational Andrology and Urology
Ian A Jones, Ryan Togashi, George F Rick Hatch, Alexander E Weber, C Thomas Vangsness
One of the suspected deleterious effects of androgenic-anabolic steroids (AAS) is the increased risk for tendon rupture. However, investigations to date have produced inconsistent results and it is still unclear how AAS influence tendons. A systematic review of the literature was conducted to identify studies that have investigated the mechanical, structural or biologic effects that AAS have on tendons. In total, 18 highly heterogeneous studies were identified. Small animal studies made up the vast majority of published research, and contradictory results were reported frequently...
July 26, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Alberto Salomone, Enrico Gerace, Daniele Di Corcia, Eugenio Alladio, Marco Vincenti, Pascal Kintz
Clostebol is a synthetic anabolic androgenic steroid, with potential use as a performance-enhancing drug if taken for long periods in order to produce the desired effect. Recently, the use of medications containing clostebol acetate has led to the suspension of several athletes in various sports. Previous studies have shown that urine can result positive in case of single intake of a banned substance, including unintentional consumption of steroids. In this context, a hair test can contribute to exculpation of athletes by demonstrating alternative administration or contamination...
July 24, 2018: Drug Testing and Analysis
José de Oliveira Vilar Neto, Carlos Alberto da Silva, Antônio Barroso Lima, Juan de Sá Roriz Caminha, Daniel Vieira Pinto, Felipe Rocha Alves, Jocasta Sousa Araújo, Elizabeth de Francesco Daher
The aim of this study was to evaluate the hypothalamic-pituitary-gonadal axis functionality on a bodybuilding competitioner before, during and after the use of anabolic-androgenic steroids. A young healthy man was followed up for 4 months. The subject reported his drug administration protocol through periodic interviews and performed laboratory tests to monitor the function of his hypothalamic-pituitary-gonadal axis. Time 1 (before the steroids use) shows all hormones levels (follicle-stimulating hormone = 4,2 mUI/ml, luteinising hormone = 3,7 mUI/ml and total testosterone = 5,7 ng/ml) within reference values...
July 23, 2018: Andrologia
Orlando Garner, Alfredo Iardino, Ana Ramirez, Maty Yakoby
Bodybuilders use anabolic-androgenic steroids to increase muscle mass, but abuse of these hormones has been related to cardiomyopathy in the past. A 60-year-old Caucasian male bodybuilder with medical history of male hypogonadism and on testosterone replacement therapy, allegedly preparing for a weightlifting competition and receiving stem cell infusions from his trainer, is transferred to the intensive care unit for worsening shortness of breath after failing treatment for community-acquired pneumonia. Chest X-ray on transfer was suggestive of pulmonary oedema, and transthoracic echocardiography showed an ejection fraction of 25%-30%...
July 23, 2018: BMJ Case Reports
Koji Sato, Motoyuki Iemitsu
Dehydroepiandrosterone (DHEA) is a precursor of sex steroid hormones and is converted to testosterone and estradiol. Normally, androgens and estrogens produced adrenal cortex, testis, and ovary; however, recent studies revealed androgens and estrogens are synthesized by peripheral tissues such as brain, skin, liver, kidney, bone, etc. We found skeletal muscles are also capable of synthesizing androgens and estrogens from DHEA. Circulating DHEA provides substrates required for conversion into potent androgens and estrogens in peripheral tissues...
2018: Vitamins and Hormones
Antonello D'Andrea, Juri Radmilovic, Stefano Caselli, Andreina Carbone, Raffaella Scarafile, Simona Sperlongano, Giampaolo Tocci, Tiziana Formisano, Francesca Martone, Biagio Liccardo, Michele D'Alto, Eduardo Bossone, Maurizio Galderisi, Paolo Golino
In the original publication of the article, the seventh author name "Giampaolo Tocci" has been misspelt. The correct name is given in this.
July 17, 2018: International Journal of Cardiovascular Imaging
Jon J Rasmussen, Morten Schou, Per L Madsen, Christian Selmer, Marie L Johansen, Peter S Ulriksen, Tina Dreyer, Thomas Kümler, Louis L Plesner, Jens Faber, Finn Gustafsson, Caroline Kistorp
No abstract text is available yet for this article.
June 27, 2018: American Heart Journal
Mary A Andrews, Charles D Magee, Travis M Combest, Rhonda J Allard, Kevin M Douglas
Many athletes use anabolic-androgenic steroids (AAS) for physical enhancement but the magnitude of these gains and associated adverse effects has not been rigorously quantified. MEDLINE, EMBASE, Cochrane, SPORTDiscus, and PsycINFO were searched to identify randomized placebo-controlled trials of AAS in healthy exercising adults that reported one of the following outcomes: muscular strength, body composition, cardiovascular endurance, or power. Two authors appraised abstracts to identify studies for full-text retrieval; these were reviewed in duplicate to identify included studies...
July 2018: Current Sports Medicine Reports
Timmy L S Choi, Karen Y Kwok, Wai Him Kwok, Yeuki Y K Tsoi, Jenny K Y Wong, Terence S M Wan
Anabolic and androgenic steroids (AAS) are banned substances in both human and equine sports. They are often administered intramuscularly to horses in esterified forms for the purpose of extending their time of action. The authors' laboratory has previously reported an UHPLC/HRMS method using quadrupole-Orbitrap mass spectrometer in full scan and parallel reaction monitoring (PRM) mode for the detection of 48 AAS and/or their esters in horse hair. However, two injections were required due to the long duty cycle time...
September 7, 2018: Journal of Chromatography. A
Joshua Coutinho, Justin B Field, Anupam A Sule
Armour® Thyroid (Forest Pharmaceuticals, LLC; affiliate of Allergan, Dublin, Ireland) is a natural porcine derivative thyroid supplement that is frequently used without physician monitoring by health enthusiasts as a weight loss supplement. Although there are no publications associating Armour Thyroid and major coronary events, significant drug interactions may exist. A 32-year-old male with a history of hypothyroidism, cystic acne, and solitary congenital kidney presented to the emergency room after experiencing crushing substernal chest pain radiating to his left shoulder, accompanied by diaphoresis and shortness of breath...
April 24, 2018: Curēus
Daniel J Tobiansky, Kathryn G Wallin-Miller, Stan B Floresco, Ruth I Wood, Kiran K Soma
Multiple lines of evidence indicate that androgens, such as testosterone, modulate the mesocorticolimbic system and executive function. This review integrates neuroanatomical, molecular biological, neurochemical, and behavioral studies to highlight how endogenous and exogenous androgens alter behaviors, such as behavioral flexibility, decision making, and risk taking. First, we briefly review the neuroanatomy of the mesocorticolimbic system, which mediates executive function, with a focus on the ventral tegmental area (VTA), nucleus accumbens (NAc), medial prefrontal cortex (mPFC), and orbitofrontal cortex (OFC)...
2018: Frontiers in Endocrinology
Frederick J Flo, Obiajulu Kanu, Mohamed Teleb, Yuefeng Chen, Tariq Siddiqui
The abuse of anabolic androgenic steroids (AAS) has remained on the rise despite their well-known deleterious effects. We describe a case of AAS-induced multisystem failure following an extensive history of abuse in a 41-year-old bodybuilder. Furthermore, we review pertinent literature and discuss the different pathophysiologic mechanisms through which AAS affect the heart and other organs. This case points to the possibility of multiorgan involvement and severe cardiac effects of AAS abuse in young individuals who may not have any past medical history...
July 2018: Proceedings of the Baylor University Medical Center
Robert Carrasquillo, Kevin Chu, Ranjith Ramasamy
PURPOSE OF REVIEW: Hypogonadism and the treatment of low testosterone is increasingly a subject of medical inquiry and controversy. The few treatments that are FDA-approved such as testosterone topicals, injections, and pellets create significant demand from patients for treatments with more convenient means of administration, fewer adverse effects, and the ability to maintain male fertility. Off-label drugs are in abundant use for low testosterone, including selective estrogen receptor modulators, gonadotropins, and aromatase inhibitors...
June 9, 2018: Current Urology Reports
D L Smit, W de Ronde
BACKGROUND: Anabolic androgenic steroids (AAS) are used by approximately 20,000 amateur athletes in the Netherlands. AAS are harmful but data are lacking as to precisely how harmful they are. An outpatient clinic for past and current users of AAS was established in 2011 to acquire more knowledge about the health risks associated with AAS abuse. METHODS: All case files of the patients who visited the AAS clinic were reviewed retrospectively. RESULTS: 180 patients visited the AAS clinic between May 2011 and May 2016...
May 2018: Netherlands Journal of Medicine
Adverse Effects Of Anabolic Androgen Steroid Abuse In The Netherlands Tip Of The Iceberg
No abstract text is available yet for this article.
May 2018: Netherlands Journal of Medicine
Kathryn Wallin-Miller, Grace Li, Diana Kelishani, Ruth I Wood
Anabolic-androgenic steroid (AAS) abuse is implicated in maladaptive decision making such as increased risk taking and problem gambling. Endogenous testosterone correlates with economic risk taking in both the stock market (Coates & Herbert, 2008) and in the laboratory, as measured by the Iowa Gambling Task (Stanton, Liening, & Schultheiss, 2011). Additionally, AAS use has been associated with problem gambling behavior in adolescents (Proimos, DuRant, Pierce, & Goodman, 1998). Thus, AAS may impair economic decision making...
June 2018: Behavioral Neuroscience
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