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anabolic-androgen steroids

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https://www.readbyqxmd.com/read/30311477/possible-protective-role-of-whey-protein-on-the-rat-s-liver-tissues-treated-with-nandrolone-decanoate
#1
Ibtesam Saad Al-Dhuayan
BACKGROUND AND OBJECTIVE: Nandrolone and whey protein are used as supplementary food and athletic food. The aim of this study was to evaluate the possible histological and ultrastructural alterations in the liver of adult rats after treatment of the anabolic androgenic steroids (Nandrolone decanoate) and whey protein. MATERIALS AND METHODS: Twenty eight Wistar Albino male rats were used in the present study divided into 4 groups: Control group received 0.5 mL of saline solution by oral, Nandrolone group injected intramuscular (10 mg kg-1 b...
January 2018: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/30275027/primary-amenorrhoea-and-clitoromegaly-in-a-nulliparous-woman-successful-medical-and-surgical-management
#2
Aruna Nigam, Arifa Anwar Elahi, Neha Varun, Nidhi Gupta
Clitoromegaly is an important sign of virilisation and poses difficulty in sex determination, when present since birth. The diagnosis and treatment in an adult is a major challenge to the treating gynaecologist. The primary reason for its development is androgen excess due to congenital adrenal hyperplasia, polycystic ovarian syndrome, ovarian virilising tumours, neurofibromas, adrenal neoplasm and prolonged intake of anabolic steroids. A case of young nulliparous married woman who presented with primary amenorrhoea and clitoromegaly and was managed successfully has been reported...
September 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30270959/health-beliefs-as-a-key-determinant-of-intent-to-use-anabolic-androgenic-steroids-aas-among-high-school-football-players-implications-for-prevention
#3
Amanda E Halliburton, Matthew S Fritz
The use of anabolic-androgenic steroids (AAS) is problematic for youth because of negative effects such as reduced fertility, increased aggression and exposure to toxic chemicals. An effective programme for addressing this problem is Adolescents Training and Learning to Avoid Steroids (ATLAS). This secondary analysis expands prior research by identifying prominent mechanisms of change and highlighting key longitudinal processes that contributed to the success of ATLAS. The current sample consists of high-school football players ( N = 1...
2018: International Journal of Adolescence and Youth
https://www.readbyqxmd.com/read/30267392/anabolic-androgenic-steroid-abuse-the-effects-on-thrombosis-risk-coagulation-and-fibrinolysis
#4
Simon Chang, Anna-Marie B Münster, Jørgen Gram, Johannes J Sidelmann
Anabolic androgenic steroid (AAS) abuse surged during the 1980s and is seen in approximately 1 in 20 of all males today. A wide spectrum of AAS compounds and abuse regimens are applied and AAS abuse has been associated with an unfavorable cardiovascular profile. The aim of this review is to critique the collected data concerning effects of AAS abuse on thrombosis risk through presentation of condensed evidence from studies investigating AAS-induced changes in coagulation, fibrinolysis, and cardiovascular risk markers...
September 28, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/30264294/chronic-testosterone-increases-impulsivity-and-influences-the-transcriptional-activity-of-the-alpha-2a-adrenergic-receptor-signaling-pathway-in-rat-brain
#5
Juhee Agrawal, Birgit Ludwig, Bhaskar Roy, Yogesh Dwivedi
Testosterone is an anabolic androgenic steroid hormone involved in brain development, reproduction, and social behavior. Several studies have shown that testosterone can cause impulsivity in humans, which in turn, is linked with mood-related psychiatric disorders and higher risk of death by suicide. The mechanisms by which testosterone abuse influences impulsivity are unclear. The present study aims to understand how testosterone influences impulsivity in a rodent model both at behavioral and molecular levels...
September 27, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30247933/anabolic-androgenic-steroids-procurement-and-administration-practices-of-doping-athletes
#6
Julius Fink, Brad Jon Schoenfeld, Anthony C Hackney, Masahito Matsumoto, Takahiro Maekawa, Koichi Nakazato, Shigeo Horie
Performance enhancing substances are becoming increasingly popular amongst bodybuilders and people who want to enhance their physiques. However, due to the rise of the Internet and laws prohibiting sales of these substances without prescription, the route of procurement and administration practices have become more and more dangerous. Prior to the mid-1970's, anabolic steroids were not regulated and easily available from physicians and pharmacies in several countries. In 1990, the United States enacted the Anabolic Steroid Control Act, leading to the proliferation of black markets and underground laboratories...
September 24, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/30239802/the-health-threat-posed-by-the-hidden-epidemic-of-anabolic-steroid-use-and-body-image-disorders-among-young-men
#7
Anna L Goldman, Harrison G Pope, Shalender Bhasin
Context: The prevalence of body image disorders and anabolic-androgenic steroid (AAS) use is increasing, despite the evidence of their serious adverse health effects and despite the passage of laws regulating their sales. Here we review the evolution of the dual emerging epidemics of body image disorders and AAS use, adverse health effects of AAS, and the need for an integrated health policy and regulatory response to stem these epidemics. Evidence Acquisition: We searched for studies published in English language prior to June 2018...
September 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30237683/sports-pharmacology-a-medical-pharmacologist-s-perspective
#8
REVIEW
Harshad O Malve
Abuse of substances or methods to enhance the performance is becoming very common in the sports, which often destroys the spirit of competition. The regulatory bodies for sports have reported rates ranging from 5% to 31% for the use of performance-enhancing substances among athletes. Athletes can have serious injuries and morbidities, leading to poor health with the use of such substances. Commonly abused agents in sports include anabolic-androgenic steroids and its analogs, blood, erythropoietin, growth hormone and its derivatives, nutritional supplements, creatine, amphetamines, beta-hydroxy-beta-methylbutyrate (HMB), stimulants, and analgesics...
July 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/30232035/correlation-between-chronological-and-physiological-age-of-males-from-their-multivariate-urinary-endogenous-steroid-profile-and-prostatic-carcinoma-induced-deviation
#9
Eleonora Amante, Eugenio Alladio, Alberto Salomone, Marco Vincenti, Federico Marini, Giorgio Alleva, Stefano De Luca, Francesco Porpiglia
The biosynthesis of endogenous androgenic anabolic steroids (EAAS) in males varies with age. Knowledge of the general urinary EAAS profile's dependence from aging - not reported up to now - may represents a prerequisite for its exploitation in the screening and diagnostic support for several pathologies. Extended urinary EAAS profiles were obtained from healthy and pathological individuals, using a GC-MS method which was fully validated by a stepwise, analyst-independent scheme. Seventeen EAAS and five of their concentration ratios were determined and investigated using multivariate statistical methods...
September 16, 2018: Steroids
https://www.readbyqxmd.com/read/30216576/comparison-of-gas-chromatography-quadrupole-time-of-flight-and-quadrupole-orbitrap-mass-spectrometry-in-anti-doping-analysis-i-detection-of-anabolic-androgenic-steroids
#10
Wadha Abushareeda, Marc Tienstra, Arjen Lommen, Marco Blokland, Saskia Sterk, Suhail Kraiem, Peter Horvatovich, Michel Nielen, Muhammad Al-Maadheed, Costas Georgakopoulos
RATIONALE: The Worla Anti-doping Agency (WADA) encourages drug-testing laboratories to develop screening methods that can detect as many doping substances as possible in urine. The use of full-scan high-resolution acquisition (FS/HR) with GC/MS for the detection of known and unknown trimethylsilyl (TMS) derivatives of anabolic-androgenic steroids (AAS) provides anti-doping testing bodies with a new analytical tool. METHODS: The AAS were extracted from urine samples by generic liquid-liquid extraction, after enzymatic hydrolysis, and TMS derivatization...
September 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/30153114/appearance-image-and-performance-enhancing-drug-users-a-forensic-approach
#11
Monia Lusetti, Manuela Licata, Enrico Silingardi, Alessandro Bonsignore, Cristian Palmiere
Image- and performance-enhancing drugs include a wide range of substances used to promote physical changes to enhance appearance. Anabolic androgen steroids are the most widely used image- and performance-enhancing drugs along with a wide variety of additional substances. The aim of this study was to identify the pathological changes pertaining to the cardiovascular system possibly involved in the death and characterize the substances associated with steroid use and their possible role in the death. A series of deaths involving image- and performance-enhancing drug users were selected...
August 27, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/30151111/left-ventricular-assist-device-for-ventricular-recovery-of-anabolic-steroid-induced-cardiomyopathy
#12
Jessica G Y Luc, Holger Buchholz, Daniel H Kim, Roderick G G MacArthur
Herein we report a case of a 26-year-old gentleman with severe cardiomyopathy likely secondary to anabolic-androgenic steroid (AAS) abuse who received a HeartMate II (Abbott Laboratories, Abbott Park, IL) left ventricular assist device (LVAD) for rapidly deteriorating heart failure with hemodynamic compromise. Following 18 months on LVAD support, excellent recovery of ventricular function was achieved to allow for LVAD discontinuation. Given that active substance abuse is a contraindication to heart transplantation, few options remain for patients with AAS induced heart failure...
August 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30119263/reversible-effects-of-anabolic-steroid-abuse-on-cyto-architectures-of-the-heart-kidneys-and-testis-in-adult-male-mice
#13
Aida Kahal, Rachida Allem
The importance of the present study comes from the lack of sufficient information about the reversibility of the histopathological alterations which may result from anabolic androgenic drugs abuse after some times of stop treatment, as it is one of the prior studies which explored the negative effects of Deca-Durabolin abuse in particular on the hearts, kidneys and testis structures. For this aim, study was performed on 40 male adult mices. Animals were divided into five groups of 8 animals each as follows: treated by Deca-Durabolin (nandrolone decanoate) at 30 g/kg of BW, weekly during one month (GI); two months (GII); three months (GIII); three months followed by six weeks of treatment discontinuation (GIV) and Control (C)...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30118779/development-of-an-extraction-method-for-anabolic-androgenic-steroids-in-dietary-supplements-and-analysis-by-gas-chromatography-mass-spectrometry-application-for-doping-control
#14
Hajer Dahmani, Kaouthar Louati, Adel Hajri, Senda Bahri, Fathi Safta
Several studies have highlighted that nutritional supplements may contain undeclared anabolic steroids that are banned by the International Olympic Committee/World Anti-Doping Agency. Any kind of abuse with these drugs is extremely dangerous because of their side effects. Thus, the control of food additives in order to protect the best consumer health and to limit fraudulent practices in the field of sports is essential. This paper describes a simple and effective qualitative gas chromatography-mass spectrometry (GC-MS) method to detect anabolic androgenic steroids (AAS): androsterone, nandrolene, dehydroepiandrosterone, 5ɑ-androstane-3β, 17β-diol, dihydrotestosterone, testosterone, methenolone acetate, methandienone, boldenone and fluoxymesterone, in food supplements...
October 2018: Steroids
https://www.readbyqxmd.com/read/30116498/grape-seed-proanthocyanidin-ameliorates-cardiac-toxicity-induced-by-boldenone-undecylenate-through-inhibition-of-nadph-oxidase-and-reduction-in-the-expression-of-nox2-and-nox4
#15
Ehab Tousson, Rehab Mohmed Elgharabawy, Thanaa Ahmed Elmasry
The effect of anabolic androgenic steroids on the cardiovascular system is poorly understood. Increased production of free radicals is coupled to the pathophysiology of many alterations within the circulatory system. The only function of the enzyme family NADPH oxidases (NOXs) is the generation of reactive oxygen species (ROS). Therefore, this study investigated the beneficial role of grape seed proanthocyanidin extract (GSPE) in ameliorating cardiac toxicity induced by the anabolic steroid Boldenone in male rats through NOX inhibition and reduction in the expression of NOX2 and NOX4...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30076163/rare-cause-of-manic-period-trigger-in-bipolar-mood-disorder-testosterone-replacement
#16
Gulcin Elboga, Zeynel Abidin Sayiner
Hypogonadotropic hypogonadism is a rare congenital disorder characterised by the deficiency and the absence of puberty and infertility. It is caused by the deficient production, secretion or action of gonadotropin-releasing hormone, which is the master hormone regulating the reproductive axis. Gonadotropin-releasing hormone or gonadotropin injections and testosterone replacement therapy are required in the treatment of this disorder. Psychiatric symptoms and disorders may be seen with the use of anabolic androgenic steroids...
August 3, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30074896/pubertal-anabolic-androgenic-steroid-exposure-in-male-rats-affects-levels-of-gonadal-steroids-mating-frequency-and-pregnancy-outcome
#17
Siti Syairah Mohd Mutalip, Aishah Mohd Shah, Mashani Mohamad, Vasudevan Mani, Siti Nooraishah Hussin, Gurmeet Kaur Surindar Singh
Background Testosterone, nandrolone, and stanozolol are among the highly consumed anabolic androgenic steroids (AASs). Although the desired effects of AAS are being achieved by the abusers, unfortunately, this leads to numerous physical and physiological side effects. The present study was designed to investigate and determine whether early pubertal exposure to AAS treatment had detrimental effects on blood testosterone and estradiol concentrations, mating behavior, and pregnancy outcome during the pubertal period in male rats...
August 3, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30060826/reversal-of-the-hepatic-damage-induced-by-the-supraphysiological-dose-of-nandrolone-decanoate-after-its-withdrawal-in-the-adult-male-rat
#18
Amany Mohamed Shalaby, Noha Gamal Bahey
Nandrolone decanoate is an anabolic-androgenic steroid that is frequently used at a very high dose to improve the physical performance. Recently, this drug has been abused by athletes to augment their muscle mass and improve their physical performance. However, this could have an impact on other body systems with the potential increase in its harmful effect. Therefore, the aim of this study was to evaluate the effect of administering a supraphysiological dose of nandrolone decanoate on the hepatic functions and structure of the adult rat and to test the potential reversibility after nandrolone withdrawal...
August 2018: Tissue & Cell
https://www.readbyqxmd.com/read/30050806/impact-of-anabolic-androgenic-steroids-on-sexual-function
#19
Joseph Matthew Armstrong, Ross A Avant, Cameron M Charchenko, Mary E Westerman, Matthew J Ziegelmann, Tanner S Miest, Landon W Trost
Background: To describe the impact of supra-physiologic anabolic-androgenic steroid (AAS) use, including agent, dosage, and duration of therapy, on sexual function. Methods: We reviewed data from an online survey of AAS users to evaluate their sexual function on and off AAS. The online survey consisted of questions addressing demographics, anabolic steroid use and patterns, ancillary medications, testosterone (T)-related symptoms while on and off of therapy, as well as sexual function which was assessed using the 5-item, International Index of Erectile Function (IIEF-5)...
June 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/30047601/anabolic-steroids-and-tendons-a-review-of-their-mechanical-structural-and-biologic-effects
#20
REVIEW
Ian A Jones, Ryan Togashi, George F Rick Hatch, Alexander E Weber, C Thomas Vangsness
One of the suspected deleterious effects of androgenic-anabolic steroids (AAS) is the increased risk for tendon rupture. However, investigations to date have produced inconsistent results and it is still unclear how AAS influence tendons. A systematic review of the literature was conducted to identify studies that have investigated the mechanical, structural, or biologic effects that AAS have on tendons. In total, 18 highly heterogeneous studies were identified. Small animal studies made up the vast majority of published research, and contradictory results were reported frequently...
July 26, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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