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https://www.readbyqxmd.com/read/29679849/global-analysis-of-advanced-metastatic-breast-cancer-decade-report-2005-2015
#1
Fatima Cardoso, Danielle Spence, Shirley Mertz, Dian Corneliussen-James, Kimberly Sabelko, Julie Gralow, Maria-João Cardoso, Fedro Peccatori, Diego Paonessa, Ann Benares, Naomi Sakurai, Marc Beishon, Sarah-Jane Barker, Musa Mayer
Approximately 0.5 million people worldwide die from metastatic breast cancer (mBC) every year. This manuscript provides an overview on the status of mBC in several regions of the world, highlighting the gaps in care, resources, and support available for patients with mBC. Primary research was conducted in 2015 and 2016, comprising four global qualitative and quantitative surveys of approximately 15,000 individuals in 34 countries. Secondary research was conducted using literature reviews of peer-reviewed publications, patient survey reports, and media or online articles...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679815/dual-docking-robotic-surgical-staging-for-high-risk-endometrial-cancer
#2
Cécile Loaec, Anne-Sophie Bats, Charlotte Ngo, Caroline Cornou, Léa Rossi, Chérazade Bensaid, Claude Nos, Fabrice Lecuru
OBJECTIVE: The standard of care for patients with high intermediate and high risk endometrial cancer is surgical staging including total hysterectomy with bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Over the past decade, laparoscopic or robot-assisted minimally invasive surgery has showed many benefits in the management of endometrial cancer. Few studies have specifically assessed the use of minimally invasive surgery for staging of high risk endometrial cancer...
April 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29679763/leaving-the-nest-improving-food-allergy-management-on-college-campuses
#3
Ashley A Dyer, Amy O'Keefe, Madeleine K Kanaley, Lauren Kao, Ruchi S Gupta
BACKGROUND: The transition from adolescence to young adulthood marks a developmental period where responsibility for management of chronic conditions such as food allergy shifts from the caregiver to the young adult. Fatal food-induced anaphylaxis is most common among adolescents and young adults. However, colleges are currently not well-positioned to provide integrated support for students with food allergies. OBJECTIVE: The study objective was to explore the systems, structures, and policies that currently support students with food allergies at college, assess unmet needs, and develop pilot interventions through the use of patient-centered design processes...
April 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29679749/matching-adjusted-comparisons-demonstrate-better-clinical-outcomes-with-sc-peginterferon-beta-1a-every-two-weeks-than-with-sc-interferon-beta-1a-three-times-per-week
#4
Patricia K Coyle, Shulian Shang, Zhen Xiao, Qunming Dong, Carmen Castrillo-Viguera
BACKGROUND: Subcutaneous (SC) peginterferon beta-1a and SC interferon beta-1a (IFN beta-1a) have demonstrated efficacy in treating relapsing-remitting multiple sclerosis (RRMS) but have never been compared in direct head-to-head clinical trials, the gold-standard comparison. A well-balanced matching-adjusted comparison of weighted individual patient data on SC peginterferon beta-1a, and aggregate data from published phase 3 clinical trials of SC IFN beta-1a, was conducted to provide additional information on the comparative efficacy of these two agents...
February 18, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29679728/magnetic-resonance-imaging-of-the-lumbar-spine-determining-clinical-impact-and-potential-harm-from-overuse
#5
Nathan M Wnuk, Tarik K Alkasab, Daniel I Rosenthal
BACKGROUND: Lumbar spine MRI is frequently said to be "overused" in the evaluation of low-back pain, yet data concerning the extent of overuse and on potential harmful effects are lacking. PURPOSE: To determine the proportion of examinations with a detectable impact on patient care (actionable outcomes). STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: 5,365 outpatient lumbar spine MR examinations OUTCOME MEASURES: Actionable outcomes included: 1) findings leading to an intervention making use of anatomical information such as surgery; 2) new diagnoses of cancer, infection, or fracture; or 3) following known lumbar spine pathology...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679695/serial-nse-measurement-identifies-non-survivors-following-out-of-hospital-cardiac-arrest
#6
Kieran Gillick, Kieron Rooney
AIMS: Prognostication following out-of-hospital cardiac arrest (OHCA) remains challenging. A multimodal approach is favoured, including consideration of the biomarker neuron-specific enolase (NSE) (Sandroni et al., 2014). Our objective was to investigate the utility of serial NSE measurements and to determine an appropriate cut-off value for prediction of death before hospital discharge using data from our tertiary care centre. METHODS: Retrospective analysis of patients admitted to the critical care unit of a tertiary centre critical care unit in the UK following an out-of-hospital cardiac arrest...
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29679694/the-introduction-of-a-rapid-response-system-in-acute-hospitals-a-pragmatic-stepped-wedge-cluster-randomised-controlled-trial
#7
Filip Haegdorens, Peter Van Bogaert, Ella Roelant, Koen De Meester, Marie Misselyn, Kristien Wouters, Koenraad G Monsieurs
AIM: Deterioration of hospitalised patients is often missed, misinterpreted, and mismanaged. Rapid Response Systems (RRSs) have been proposed to solve this problem. This study aimed to investigate the effect of an RRS on the incidence of unexpected death, cardiac arrest with cardiopulmonary resuscitation (CPR), and unplanned intensive care unit (ICU) admission. METHODS: We conducted a stepped wedge cluster randomised controlled trial including 14 Belgian acute care hospitals with two medical and two surgical wards each...
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29679596/observational-studies-of-inhaled-corticosteroid-effectiveness-in-copd-lessons-learned
#8
Samy Suissa, Pierre Ernst
BACKGROUND: Randomized controlled trials at times investigate findings suggested by observational studies. For example, the TORCH trial, which did not show a mortality reduction with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), was motivated by some observational studies that suggested considerable reductions in mortality with these drugs. Reasons for these discrepancies are unclear. METHODS: We searched the literature to identify all observational studies, including cohort and case-control studies, investigating the effectiveness of ICS on major outcomes in COPD patients, including death and hospitalization for COPD...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679591/the-intrauterine-device-as-emergency-contraception-how-much-do-young-women-know
#9
Suzan R Goodman, Alison M El Ayadi, Corinne H Rocca, Julia E Kohn, Courtney E Benedict, Jessica R Dieseldorff, Cynthia C Harper
BACKGROUND: Unprotected intercourse is common, especially among teens and young women. Access to intrauterine device (IUD) as emergency contraception (EC) can help interested patients more effectively prevent unintended pregnancy and can also offer ongoing contraception. This study evaluated young women's awareness of IUD as EC and interest in case of need. STUDY DESIGN: We conducted a secondary analysis of data from young women, ages 18-25years, not desiring pregnancy within 12months, and receiving contraceptive counseling within a cluster-randomized trial in 40U...
April 18, 2018: Contraception
https://www.readbyqxmd.com/read/29679531/the-association-of-early-postoperative-lactate-levels-with-morbidity-after-elective-major-abdominal-surgery
#10
Jelena Veličković, Ivan Palibrk, Biljana Miličić, Dejan Veličković, Bojan Jovanović, Goran Rakić, Milorad Petrović, Vesna Bumbaširević
Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POC), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L0], 4 hours (L4), 12 hours (L12), and 24 hours (L24) after the operation. Demographic and perioperative clinical data were collected...
April 21, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29679504/intraoral-frostbite-and-leidenfrost-effect
#11
Divya Vinayachandran, Saravanakarthikeyan
Intraoral frostbite as such, is an unusual occurrence. Careful literature review revealed rare cases of intraoral frostbite, attributed to intentional inhalational abuse of fluorinated hydrocarbons, dry ice, liquid nitrogen etc,.1,2 Hypothermal injuries of the gastric mucosa caused by ingestion of liquid nitrogen have been reported but none of these patients suffered from any direct injury affecting the oral mucosa.3 Here, we report the first case of intraoral frostbite causing injury to the oral mucosal tissues due to the direct contact of liquid nitrogen, highlighting the mechanism of the injury...
April 21, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29679480/association-between-online-information-seeking-and-adherence-to-guidelines-for-breast-and-prostate-cancer-screening
#12
Hankyul Kim, Christopher Filson, Peter Joski, Silke von Esenwein, Joseph Lipscomb
INTRODUCTION: From 2012 through 2014, the US Preventive Services Task Force (USPSTF) recommended biennial mammography for women aged 50 to 75 and recommended against the prostate specific antigen (PSA) test for men of any age, emphasizing informed decision making for patients. Because of time constraints and other patient health priorities, health care providers often do not discuss benefits and risks associated with cancer screening. We analyzed the association between seeking information online about breast and prostate cancer and undergoing mammography and PSA screening...
April 19, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29679479/health-care-disparities-between-men-and-women-with-type-2-diabetes
#13
Marady Sabiaga Mesa
INTRODUCTION: Regular medical checkups indicate a patient's level of adherence to health care treatment, and the frequency of cancelled appointments or no-shows can indicate adherence. This study investigated the use of health care services by men and women and its impact on the control of their type 2 diabetes. METHODS: This study observed 100 patients with type 2 diabetes aged 45 years or older who lived in Ventura County, California, during January 1, 2015, to January 31, 2016...
April 19, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29679443/a-20-year-review-the-use-of-exception-from-informed-consent-and-waiver-of-informed-consent-in-emergency-research
#14
Lauren Klein, Johanna Moore, Michelle Biros
BACKGROUND: Due to the acuity and time sensitive needs of their clinical condition, patients presenting with certain emergent pathologies may lack capacity to provide meaningful prospective informed consent to participate in clinical research. For these reasons, these populations have often been excluded from research investigations. To mitigate this, regulations allowing Exception from Informed Consent (EFIC) (21 CFR 50.24) or Waiver of Informed Consent (WIC) (45 CFR 46.101) were developed in 1996...
April 21, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29679441/feasibility-safety-and-outcome-of-recanalisation-treatment-in-childhood-stroke
#15
Sandra Bigi, Andrea Dulcey, Jan Gralla, Corrado Bernasconi, Amber Melliger, Alexandre N Datta, Marcel Arnold, Johannes Kaesmacher, Joel Fluss, Annette Hackenberg, Oliver Maier, Johannes Weber, Claudia Poloni, Urs Fischer, Maja Steinlin
Objective Intravenous thrombolysis and endovascular therapy (IVT/EVT) are evidence-based treatments for adults with arterial ischemic stroke (AIS). However, randomized controlled trials in pediatric patients are lacking. This study aimed to describe feasibility, safety, and outcome of IVT/EVT in children with AIS. Methods Retrospective study (01/2000-12/2015) of a multicenter, population-based consecutive cohort of patients aged 1 month - 16 years diagnosed with AIS presenting with a pedNIHSS ≥4. Clinical and radiological data of patients receiving IVT/EVT were compared to those receiving standard care (SC) using linear regression to adjust for potential confounders...
April 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29679408/prehospital-emergency-care-nurses-strategies-while-caring-for-patients-with-limited-swedish-english-proficiency
#16
A Alm Pfrunder, A Falk, V Vicente, V Lindström
AIMS AND OBJECTIVES: To explore the strategies of nurses working in the ambulance service while caring for patients with limited Swedish-English proficiency. BACKGROUND: Communication difficulties due to lack of mutual language is a challenge in health care systems around the world. Little is known about nurses' strategies while caring for patients with whom they do not share a mutual language in an unstructured, unplanned prehospital emergency environment, the ambulance service...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679403/nature-and-scope-of-certified-nurse-midwifery-practice-in-one-large-state-in-the-united-states
#17
Marie Hastings-Tolsma, Sarah Wilcox Foster, Mary C Brucker, Priscilla Nodine, Rebecca Burpo, Barbara Camune, Jackie Griggs, Tiffany J Callahan
AIMS AND OBJECTIVES: To describe the nature and scope of nurse-midwifery practice in Texas and to determine legislative priorities and practice barriers. BACKGROUND: Across the globe, midwives are the largest group of maternity care providers despite little known about midwifery practice. With a looming shortage of midwives, there is a pressing need to understand midwives' work environment and scope of practice. DESIGN: Mixed methods research utilizing prospective descriptive survey and interview...
April 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679397/development-of-tools-to-measure-dignity-for-older-people-in-acute-hospitals
#18
Marcelle Tauber-Gilmore, Christine Norton, Sue Procter, Trevor Murrells, Gulen Addis, Lesley Baillie, Pauline Velasco, Preet Athwal, Saeema Kayani, Zainab Zahran
BACKGROUND: Dignity is a concept that applies to all patients. Older patients can be particularly vulnerable to experiencing a loss of dignity in hospital. Previous tools developed to measure dignity have been aimed at palliative and end of life care. No tools for measuring dignity in acute hospital care have been reported. OBJECTIVES: To develop tools for measuring patient dignity in acute hospitals. SETTING: A large UK acute hospital. We purposively selected 17 wards where at least 50% of patients are 65 or over...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679387/the-pharmacokinetics-and-pharmacodynamics-of-carfentanil-after-recreational-exposure-a-case-report
#19
Uvaraj Uddayasankar, Colin Lee, Curtis Oleschuk, Gregg Eschun, Robert E Ariano
Carfentanil and related fentanyl analogues have been linked to a number of overdose deaths from drug users in several cities across North America. Diagnosis of carfentanil exposure requires a very high index of clinical suspicion, especially because available laboratory narcotic screens do not detect this agent. We describe a 34-year-old male admitted with depressed level of consciousness and in respiratory failure after recreational exposure to a white powder later inferred to contain carfentanil. Urine and whole blood samples were obtained for conventional preliminary drug screen immunoassays for unknown exposures; in addition to utilizing high pressure liquid chromatography tandem mass spectrometry assay for quantification of carfentanil and its metabolite...
April 20, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29679383/shortened-courses-of-antibiotics-for-bacterial-infections-a-systematic-review-of-randomized-controlled-trials
#20
Alexandra M Hanretty, Jason C Gallagher
BACKGROUND: Commonly prescribed durations of therapy for many, if not most, bacterial infections are not evidence-based. Misunderstandings by clinicians and patients alike influence perspectives on antibiotic use, including duration of therapy and its role in antibiotic resistance. OBJECTIVE: To demonstrate that shorter durations of antibiotic therapy are as efficacious as longer durations for many infections. DATA SOURCES: A systematic review of English language articles using PubMed were identified for inclusion...
April 20, 2018: Pharmacotherapy
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