Olga Araújo, Ricardo P Casaroli-Marano, José Hernández-Rodríguez, Marc Figueras-Roca, Vanesa Budi, Montse Morató, Halbert Hernández-Negrín, José Ríos, Alfredo Adan, Gerard Espinosa, Laura Pelegrín, Ricard Cervera
OBJECTIVE: To compare multimodal structural and functional diagnostic methods in patients with systemic lupus erythematosus (SLE) treated with hydroxychloroquine, to identify the best complementary approach for detecting subclinical retinal toxicity. METHODS: A cross-sectional, unicentric study was conducted on patients with SLE treated with hydroxychloroquine. Each patient underwent a comprehensive ophthalmic evaluation, comprising structural tests (spectral-domain optical coherence tomography (SD-OCT), en face OCT, en face OCT angiography (OCTA), fundus autofluorescence (FAF)) and functional tests (automated perimetry for visual field (VF) testing, multifocal electroretinography (mfERG))...
March 18, 2024: BMJ Open Ophthalmology