keyword
https://read.qxmd.com/read/38516463/longitudinal-retinal-and-choroidal-image-analysis-in-a-set-of-monozygotic-twins
#21
Angela M Hemesath, Justin P Ma, Bryce W Polascik, Dilraj Grewal, Sharon Fekrat
We analyzed multimodal retinal and choroidal imaging, including optical coherence tomography (OCT) and OCT angiography (OCTA), to assess differences and characterize variations in the retinal and choroidal structure and microvasculature between healthy monozygotic twins without ocular or systemic pathology over a five-year period. Retinal imaging of both subjects revealed normal age-related changes. There was up to an 11% difference in OCT and OCTA variables within the subjects, both at baseline and at five years, and there was up to an 18% difference in OCT and OCTA parameters between the subjects for both time points...
February 2024: Curēus
https://read.qxmd.com/read/38516283/quantifying-fluid-and-function-in-suboptimal-responders-switched-from-an-anti-vascular-endothelial-growth-factor-vegf-to-faricimab
#22
JOURNAL ARTICLE
David Sutter, Abigail Anderson, Sheila Wheatley, Veeral Sheth
Background Anti-vascular endothelial growth factor (VEGF) injections have been successful in reducing vision loss from neovascular age-related macular degeneration, a leading cause of blindness. Due to the high treatment burden and suboptimal responses, switching to bi-specific faricimab treatment may lead to improved outcomes. Methods This retrospective chart review evaluated if suboptimal responders to anti-VEGF injections had better outcomes when switched to faricimab. Suboptimal responders were defined as patients with a history of >3 months of injections and the presence of fluid after ≥3 injections...
March 2024: Curēus
https://read.qxmd.com/read/38513980/oct-biomarkers-and-visual-acuity-in-the-treatment-of-diabetic-macular-edema
#23
JOURNAL ARTICLE
Hiroyuki Takahashi, Omar Abu-Qamar, Jessica M Girgis, Catherine Call, Benhur H Ghide, Anna Marmalidou, Yingna Liu, Nadia K Waheed
At baseline, visual acuity and the extent of vertical intraretinal fluid were predictive of better visual outcomes for 196 patients with diabetic macular edema who received tightly controlled treatment with 2mg intravitreal aflibercept injections.
March 19, 2024: Ophthalmology Retina
https://read.qxmd.com/read/38513243/ellipsoid-zone-recovery-in-macular-telangiectasia-type-2-mactel
#24
JOURNAL ARTICLE
Lukas Goerdt, Kristin Raming, José Luis Rodriguez Garcia, Kristina Pfau, Frank G Holz, Philipp Herrmann
PURPOSE: To describe imaging features of Macular Telangiectasia Type 2 (MacTel) eyes experiencing ellipsoid zone (EZ) recovery. METHODS: MacTel patients with EZ-recovery were identified from the Natural History and Observational Registry Study and underwent retinal imaging including optical coherence tomography (OCT) and fundus photography. Eyes were graded according to the classification system by Gass and Blodi, the EZ-loss area was measured and OCT parameters were assessed by two independent readers...
March 14, 2024: Retina
https://read.qxmd.com/read/38508519/central-bouquet-hemorrhages-in-pathologic-myopia-clinical-characteristics-and-prognostic-relevance
#25
JOURNAL ARTICLE
Andrea Ferri, Prithvi Ramtohul, Alessandro Russo, Ugo Introini, K Bailey Freund, Francesco Bandello, Maria Vittoria Cicinelli
PURPOSE: To compare the clinical implications of central bouquet hemorrhages (CBH) to primarily subretinal hemorrhages, both occurring in the setting of pathologic myopia with lacquer crack formation. DESIGN AND SETTING: Multi-center retrospective cohort study PARTICIPANTS: 25 eyes (11 primarily subretinal hemorrhages, 14 CBH) were monitored over a median of 35 months (interquartile range [IQR] 9.50-54). MAIN OUTCOMES MEASURES: Comprehensive ophthalmological examinations and optical coherence tomography (OCT) were reviewed...
March 18, 2024: Ophthalmology Retina
https://read.qxmd.com/read/38506800/impact-of-acute-ocular-hypertension-on-retinal-ganglion-cell-loss-in-mice
#26
JOURNAL ARTICLE
Meng Xuan, Wei Wang, Gabriella Bulloch, Jian Zhang, Jason Ha, Qilin Wang, Juanjuan Wang, Xingyan Lin, Mingguang He
PURPOSE: To assess the correlation between intraocular pressure (IOP) levels and retinal ganglion cell (RGC) loss across different fixed-duration episodes of acute ocular hypertension (AOH). METHODS: AOH was induced in Thy1-YFP-H transgenic mice by inserting a needle connected to a saline solution container into the anterior chamber. Thirty-one groups were tested, each comprising three to five mice exposed to IOP levels ranging from 50 to 110 mm Hg in 5/10 mm Hg increments for 60/90/120 minutes and a sham control group...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38504966/choroid-and-retinal-effects-of-epilepsy-and-epilepsy-subgroups
#27
JOURNAL ARTICLE
Isil Merve Torun, Taha Baysal, Mirac Aysen Unsal, Murat Sonmez
OBJECTIVES: The objective were to evaluate structural alterations in the retina and choroid tissue of epilepsy patients and subtypes using enhanced depth imaging optic coherence tomography (EDI-OCT). METHODS: 46 epilepsy patients and 50 sex- and age-matched control patients were analyzed in the study. Patients' epilepsy types were recorded. The central macular thickness (CMT), retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and choroidal thickness (CT) were investigated through the Spectralis-OCT device (SD-OCT)...
2024: Beyoglu eye journal
https://read.qxmd.com/read/38504520/rescue-of-cone-and-rod-photoreceptor-function-in-a-cdhr1-model-of-age-related-retinal-degeneration
#28
JOURNAL ARTICLE
Imran H Yusuf, Thomas Burgoyne, Ahmed Salman, Michelle E McClements, Robert E MacLaren, Peter Charbel Issa
Age-related macular degeneration is the most common cause of untreatable blindness in the developed world. Recently, CDHR1 has been identified as the cause of a subset of age-related macular degeneration that has the appearance the 'dry' form, or geographic atrophy. Biallelic variants in CDHR1 - a specialised protocadherin highly expressed in cone and rod photoreceptors - result in blindness from shortened photoreceptor outer segments and progressive photoreceptor cell death. Here we demonstrate long-term morphological, ultrastructural, functional and behavioural rescue following CDHR1 gene therapy in a relevant murine model, sustained to 23-months post-injection...
March 18, 2024: Molecular Therapy
https://read.qxmd.com/read/38502890/prednisolone-eye-drops-as-a-potential-treatment-in-non-neovascular-pachychoroid-related-diseases
#29
JOURNAL ARTICLE
Femke M van den Tillaart, Irene M Temmerman, Franca Hartgers, Suzanne Yzer
PURPOSE: To investigate the functional and structural outcomes after treatment with prednisolone eye drops in the following pachychoroid related diseases: chronic central serous chorioretinopathy (cCSC), pachychoroid pigment epitheliopathy (PPE) and peripapillary pachychoroid syndrome (PPS). METHODS: In this retrospective study, 54 eyes of 48 patients with pachychoroid related disease were treated with prednisolone acetate 1% eye drops for 3 times a day. Change in macular volume and retinal central subfield thickness on optical coherence tomography was measured...
March 18, 2024: Retina
https://read.qxmd.com/read/38499344/new-proposal-for-a-multimodal-imaging-approach-for-the-subclinical-detection-of-hydroxychloroquine-induced-retinal-toxicity-in-patients-with-systemic-lupus-erythematosus
#30
JOURNAL ARTICLE
Olga Araújo, Ricardo P Casaroli-Marano, José Hernández-Rodríguez, Marc Figueras-Roca, Vanesa Budi, Montse Morató, Halbert Hernández-Negrín, José Ríos, Alfredo Adan, Gerard Espinosa, Laura Pelegrín, Ricard Cervera
OBJECTIVE: To compare multimodal structural and functional diagnostic methods in patients with systemic lupus erythematosus (SLE) treated with hydroxychloroquine, to identify the best complementary approach for detecting subclinical retinal toxicity. METHODS: A cross-sectional, unicentric study was conducted on patients with SLE treated with hydroxychloroquine. Each patient underwent a comprehensive ophthalmic evaluation, comprising structural tests (spectral-domain optical coherence tomography (SD-OCT), en face OCT, en face OCT angiography (OCTA), fundus autofluorescence (FAF)) and functional tests (automated perimetry for visual field (VF) testing, multifocal electroretinography (mfERG))...
March 18, 2024: BMJ Open Ophthalmology
https://read.qxmd.com/read/38499321/acute-spontaneous-vortex-vein-occlusion-clinical-features-multimodal-imaging-and-natural-course
#31
JOURNAL ARTICLE
Kang Xue, Fengxi Meng, Hui Ren, Han Yue, Lin Jonathan He, Ruiqi Ma, Xintong Lin, Jiang Qian, Jie Guo
AIMS: To describe the clinical features, multimodal imaging, treatments and natural course of acute spontaneous vortex vein occlusion. METHODS: Clinical data were collected on nine patients with acute vortex vein occlusion. The symptoms and signs, multimodal imaging, treatments and follow-up results were summarised. RESULTS: Six patients (66.7%) were men and three (33.3%) were women. The mean age was 47.8±15.4 years. Patients were initially misdiagnosed as having choroidal tumour (66...
March 18, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38496013/structural-changes-in-the-retina-as-a-potential-biomarker-in-parkinson-s-disease-an-approach-from-optical-coherence-tomography
#32
JOURNAL ARTICLE
Santiago Poveda, Ximena Arellano, Oscar Bernal-Pacheco, Alejandro Valencia López
INTRODUCTION: Parkinson's disease (PD) presents challenges in early diagnosis and follow-up due to the lack of characteristic findings. Recent studies suggest retinal changes in PD are possibly indicative of neurodegeneration. We explored these changes using optical coherence tomography (OCT) to assess retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness. METHODS: Thirty PD and non-PD patients were matched according to demographic characteristics and OCT and clinical evaluations to rule out other neurodegenerative and visual diseases...
2024: Front Neuroimaging
https://read.qxmd.com/read/38495698/self-attention-cnn-for-retinal-layer-segmentation-in-oct
#33
JOURNAL ARTICLE
Guogang Cao, Yan Wu, Zeyu Peng, Zhilin Zhou, Cuixia Dai
The structure of the retinal layers provides valuable diagnostic information for many ophthalmic diseases. Optical coherence tomography (OCT) obtains cross-sectional images of the retina, which reveals information about the retinal layers. The U-net based approaches are prominent in retinal layering methods, which are usually beneficial to local characteristics but not good at obtaining long-distance dependence for contextual information. Furthermore, the morphology of retinal layers with the disease is more complex, which brings more significant challenges to the task of retinal layer segmentation...
March 1, 2024: Biomedical Optics Express
https://read.qxmd.com/read/38495595/metastatic-papillary-renal-cell-carcinoma-to-the-retina-and-vitreous
#34
Aaron M Fairbanks, Diva R Salomao, Andrew J Barkmeier
PURPOSE: To describe the presentation, evaluation, and management of vitreoretinal metastasis from papillary renal cell carcinoma. OBSERVATIONS: A 53-year-old woman presented with a six-week history of dark floaters in the right eye. Vitreous veils and white pre-retinal plaques were identified in the posterior pole and extended to a temporal peripheral lesion suggestive of retinal infiltration. Optical coherence tomography revealed clumps of pre-retinal hyper-reflective material in the macula and a large hyper-reflective plaque-like lesion involving the internal limiting membrane in the temporal periphery...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38494278/paraneoplastic-vision-loss
#35
REVIEW
Deena Tajfirouz, John J Chen
Paraneoplastic vision loss, which represents a small percentage of paraneoplastic neurologic syndromes, can be a blinding disease. Presenting visual symptoms are variable, making diagnosis challenging. History of the presenting illness, ocular examination, and utilization of various modalities, such as automated perimetry, ocular coherence tomography, and electroretinogram allow for localization of vision loss to the optic nerves or retina, guiding in diagnosis and management. Paraneoplastic vision loss is often painless, bilateral, and subacute, and accompanies other neurologic symptoms but can be the first presenting symptom...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38489765/deep-learning-for-automatic-prediction-of-early-activation-of-treatment-na%C3%A3-ve-non-exudative-mnvs-in-amd
#36
JOURNAL ARTICLE
Emanuele Crincoli, Fiammetta Catania, Riccardo Sacconi, Nicolò Ribarich, Silvia Ferrara, Mariacristina Parravano, Eliana Costanzo, Giuseppe Querques
BACKGROUND: Around 30% of non-exudative macular neovascularizations(NE-MNVs) exudate within 2 years from diagnosis in patients with age-related macular degeneration(AMD).The aim of the study is to develop a deep learning classifier based on optical coherence tomography(OCT) and OCT angiography(OCTA) to identify NE-MNVs at risk of exudation. METHODS: AMD patients showing OCTA and fluorescein angiography (FA) documented NE-MNV with a 2-years minimum imaging follow-up were retrospectively selected...
March 14, 2024: Retina
https://read.qxmd.com/read/38488431/roboctnet-robotics-and-deep-learning-for-referable-posterior-segment-pathology-detection-in-an-emergency-department-population
#37
JOURNAL ARTICLE
Ailin Song, Jay B Lusk, Kyung-Min Roh, S Tammy Hsu, Nita G Valikodath, Eleonora M Lad, Kelly W Muir, Matthew M Engelhard, Alexander T Limkakeng, Joseph A Izatt, Ryan P McNabb, Anthony N Kuo
PURPOSE: To evaluate the diagnostic performance of a robotically aligned optical coherence tomography (RAOCT) system coupled with a deep learning model in detecting referable posterior segment pathology in OCT images of emergency department patients. METHODS: A deep learning model, RobOCTNet, was trained and internally tested to classify OCT images as referable versus non-referable for ophthalmology consultation. For external testing, emergency department patients with signs or symptoms warranting evaluation of the posterior segment were imaged with RAOCT...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38488413/acetazolamide-challenge-changes-outer-retina-bioenergy-linked-and-anatomical-oct-biomarkers-depending-on-mouse-strain
#38
JOURNAL ARTICLE
Bruce A Berkowitz, Anuhya Paruchuri, Josh Stanek, Robert H Podolsky, Karen Lins Childers, Robin Roberts
PURPOSE: The purpose of this study was to test the hypothesis that optical coherence tomography (OCT) bioenergy-linked and anatomical biomarkers are responsive to an acetazolamide (ACZ) provocation. METHODS: C57BL/6J mice (B6J, a strain with relatively inefficient mitochondria) and 129S6/ev mice (S6, a strain with relatively efficient mitochondria) were given a single IP injection of ACZ (carbonic anhydrase inhibitor) or vehicle. In each mouse, the Mitochondrial Configuration within Photoreceptors based on the profile shape Aspect Ratio (MCP/AR) index was determined from the hyper-reflective band immediately posterior to the external limiting membrane (ELM)...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38484106/longitudinal-adaptive-optics-scanning-laser-ophthalmoscopy-reveals-regional-variation-in-cone-and-rod-photoreceptor-loss-in-stargardt-disease
#39
JOURNAL ARTICLE
Hongxin Song, Hui Hang, Kaiwen Li, Ethan A Rossi, Jie Zhang
PURPOSE: To investigate the temporal sequence of changes in the photoreceptor cell mosaic in patients with Stargardt disease type 1 (STGD1), using adaptive optics scanning laser ophthalmoscopy (AOSLO). METHODS: Two brothers with genetically confirmed STGD1 underwent comprehensive eye exams, spectral-domain optical coherence tomography (SD-OCT), fundus auto fluorescence (FAF) and AOSLO imaging 3 times over the course of 28 months. Confocal images of the cones and rods were obtained from the central fovea to 10 degrees inferiorly...
March 13, 2024: Retina
https://read.qxmd.com/read/38483364/clinical-grade-human-embryonic-stem-cell-derived-mesenchymal-stromal-cells-ameliorate-diabetic-retinopathy-in-db-db-mice
#40
JOURNAL ARTICLE
Liyuan Rong, Wumei Wei, Yifan Fang, Yanchen Liu, Tingting Gao, Liu Wang, Jie Hao, Xianliang Gu, Jun Wu, Wei Wu
BACKGROUND AIMS: Mesenchymal stromal cells (MSCs) hold great promise in the treatment of diabetic retinopathy (DR), as evidenced by increasing preclinical and clinical studies. However, the absence of standardized and industrialized clinical-grade donor cells hampers the continued development and large-scale clinical application of MSCs-based therapies for DR. Previously, we have identified a unique population of MSCs generated from a clinical-grade human embryonic stem cell (hESC) line under Good Manufacturing Practice conditions that could be a potential source to address the issues...
March 4, 2024: Cytotherapy
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