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OCT retina

William Robert Kwapong, Hua Ye, Chenlei Peng, Xiran Zhuang, Jianhua Wang, Meixiao Shen, Fan Lu
Purpose: To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between the microvascular impairment and the neuronal damage. Methods: This is a prospective, observational study including 49 eyes from 38 PD patients in their early stages and 34 eyes from 28 healthy controls with comparable age range. Macula microvasculature was evaluated with the spectral-domain optical coherence tomography (SD-OCT) angiography and intraretinal layer thickness evaluated with the SD-OCT...
August 1, 2018: Investigative Ophthalmology & Visual Science
Kyoung Min Lee, Ho-Kyung Choung, Martha Kim, Sohee Oh, Seok Hwan Kim
Purpose: To investigate changes of β-zone parapapillary atrophy (PPA) during axial elongation. Methods: Change of β-zone PPA was evaluated by spectral-domain optical coherence tomography (SD-OCT) in myopic children for 2 years, prospectively. Using the infrared images acquired by a fixed scan circle in the glaucoma progression analysis (GPA) mode, the retinal pigment epithelial opening (RPEO) and the clinical disc margin (CDM) were manually delineated. The area and position of β-zone PPA was calculated as the differences from those of the RPEO and CDM, respectively...
August 1, 2018: Investigative Ophthalmology & Visual Science
Ilkay Kilic Muftuoglu, Tiezhu Lin, William R Freeman
PURPOSE: Automated segmentation of retinal layers by spectral-domain optical coherence tomography (SD-OCT) is usually erroneous in the presence of retinal diseases. The purpose of this study is to report the changes in ganglion cell complex (GCC) comprising retina nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) in neovascular age-related macular degeneration (AMD) patients by manually correcting the automated segmentation errors. METHODS: Thirty eyes of 30 patients with new-onset choroidal neovascularization secondary to neovascular AMD and 30 eyes of 30 healthy subjects were included...
August 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Fupeng Wang, Qinqin Zhang, Anthony J Deegan, Jun Chang, Ruikang K Wang
Background: There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA's imaging capabilities. Methods: Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns...
2018: Eye and Vision (London, England)
Dong-Hyun Lee, Ho Chul Yi, So Hyun Bae, Joon Hee Cho, Sang Wook Choi, Hakyoung Kim
OBJECTIVES: To determine the risk factors for retinal microvascular impairment on optical coherence tomography angiography (OCT-A) in type 2 diabetic patients without clinical diabetic retinopathy (DR). METHODS: This retrospective and cross-sectional study enrolled 74 diabetic patients without clinically evident DR for the study group and 34 healthy subjects for the control group. OCT-A parameters were measured to determine vascular density (VD) and the foveal avascular zone (FAZ) size in the superficial and deep capillary plexuses (SCP/DCP) of the retina...
2018: PloS One
Grace Tsai, Touka Banaee, Felipe F Conti, Rishi P Singh
Optical coherence angiography (OCTA) is a noninvasive technique that has been introduced in recent years to detect ophthalmological pathology. The growing usage of OCTA to detect retinal abnormalities can be attributed to its advantages over the reference-standard fluorescein angiography (FA), although both of these techniques can be used in association. OCTA's advantages include its dye independency, its ability to produce depth-resolved images of retinal and choroidal vessels that yield images of different vascular layers of the retina, and the better delineation of the foveal avascular zone...
July 2018: Journal of Ophthalmic & Vision Research
Mathieu F Bakhoum, K Bailey Freund, Rosa Dolz-Marco, Belinda Cs Leong, Caroline R Baumal, Jay S Duker, David Sarraf
PURPOSE: To analyze the spectrum of ischemia associated with paracentral acute middle maculopathy (PAMM) in eyes with acute retinal vascular occlusion and to describe an ischemic cascade. DESIGN: A retrospective observational case series. METHODS: Patients presenting with PAMM secondary to acute retinal vascular occlusion were identified. Analysis of multimodal imaging was performed at baseline and at follow up visits to elucidate the patterns and progression of ischemia within the retinal layers...
August 3, 2018: American Journal of Ophthalmology
Marta Zola, Aude Ambresin, Leonidas Zografos
PURPOSE: To report the case of a small pigmented tumor in the macular region investigated using optical coherence tomography angiography (OCT-A) in the context of a multimodal approach. METHODS: Case report RESULTS:: A 24-year-old man was referred for evaluation of an asymptomatic unilateral round comma-shaped pigmented tumor located in the macular region of his right eye. Spectral-domain OCT revealed an irregular hyperreflective mass within the retina, with a thickened hyaloid membrane and abrupt margins, and a complete posterior shadowing effect...
August 1, 2018: Retinal Cases & Brief Reports
Hongxi Wu, Jia Li, Xinbang Mao, Guodong Li, Lin Xie, Zhipeng You
AIM OF STUDY: To evaluate the feasibility of transplantation of embryonic stem cell (ESC)-derived retinal cells in the treatment of retinal degeneration. MATERIALS AND METHODS: Rat ESCs were isolated and induced into retinal progenitor cells (RPCs) in vitro, which were subsequently induced into retinal pigment epithelium cells (RPEs) and photoreceptors (PRCs). All cells were identified by Western blot detection of their specific markers. RPEs and PRCs were, respectively, injected into the retina of Royal College of Surgeons (RCSs) rats...
August 3, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Sean T Garrity, Andrea Govetto, Jean Pierre Hubschman
PURPOSE: To report a case of branch retinal artery wall rupture and subsequent branch retinal artery occlusion occurring during a routine pars plana vitrectomy with epiretinal membrane and internal limiting membrane peeling. METHODS: Case report. Multimodal imaging including fluorescein angiography, spectral domain optical coherence tomography (OCT), en face OCT, and OCT angiography were performed. RESULTS: An 86-year-old woman presented with a symptomatic epiretinal membrane in the right eye...
July 30, 2018: Retinal Cases & Brief Reports
Dehui Xiang, Haihong Tian, Xiaoling Yang, Fei Shi, Weifang Zhu, Haoyu Chen, Xinjian Chena
Age-related macular degeneration is one of the main causes of blindness. However, the internal structures of retinas are complex and difficult to be recognized due to the occurrence of neovascularization. Traditional surface detection methods may fail in the layer segmentation. In this paper, a supervised method is reported for simultaneously segmenting layers and neovascularization. Three spatial features, seven gray level based features and fourteen layer-like features are extracted for the neural network classifier...
July 26, 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
M Ourak, J Smits, L Esteveny, G Borghesan, A Gijbels, L Schoevaerdts, Y Douven, J Scholtes, E Lankenau, T Eixmann, H Schulz-Hildebrandt, G Hüttmann, M Kozlovszky, G Kronreif, K Willekens, P Stalmans, K Faridpooya, M Cereda, A Giani, G Staurenghi, D Reynaerts, E B Vander Poorten
PURPOSE: Retinal vein cannulation is an experimental procedure during which a clot-dissolving drug is injected into an obstructed retinal vein. However, due to the fragility and minute size of retinal veins, such procedure is considered too risky to perform manually. With the aid of surgical robots, key limiting factors such as: unwanted eye rotations, hand tremor and instrument immobilization can be tackled. However, local instrument anatomy distance and force estimation remain unresolved issues...
July 28, 2018: International Journal of Computer Assisted Radiology and Surgery
Edmund Arthur, Joel A Papay, Bryan P Haggerty, Christopher A Clark, Ann E Elsner
PURPOSE: To detect and localise subtle changes in retinas of diabetic patients who clinically have no diabetic retinopathy (DR) or non-proliferative DR (NPDR) as compared to age- and sex- matched controls. Spectral Domain Optical Coherence Tomography (SD-OCT) and software to examine all retinal layers, including deeper layers, were used to quantify foveal avascular zone size and inner and outer retinal layer thicknesses, as well as to detect axial location of prominent lesions. METHODS: Diabetic subjects, 19 total with 16 having no DR and three having non-proliferative retinopathy, were matched with 19 controls with respect to age and sex...
July 26, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
Peter Maloca, Pascal W Hasler, Daniel Barthelmes, Patrik Arnold, Mooser Matthias, Hendrik P N Scholl, Heinrich Gerding, Justus Garweg, Tjebo Heeren, Konstantinos Balaskas, J Emanuel Ramos de Carvalho, Catherine Egan, Adnan Tufail, Sandrine A Zweifel
Purpose: To study a novel and fast optical coherence tomography (OCT) device for home-based monitoring in age-related macular degeneration (AMD) in a small sample yielding sparse OCT (spOCT) data and to compare the device to a commercially available reference device. Methods: In this prospective study, both eyes of 31 participants with AMD were included. The subjects underwent scanning with an OCT prototype and a spectral-domain OCT to compare the accuracy of the central retinal thickness (CRT) measurements...
July 2018: Translational Vision Science & Technology
Lei Ye, Shuang-Shuang Zhou, Wen-Long Yang, Jing Bao, Nan Jiang, You-Lan Min, Qing Yuan, Gang Tan, Mei Shen, Yi Shao
OBJECTIVE: It is uncertain whether there is an increased retinal vessel density in patients with thyroid-associated ophthalmology (TAO), or if ocular hemodynamic changes are associated with their vision. Many techniques have been applied to analyze ocular hemodynamic changes in TAO patients; however, they suffer from limitations. Optical coherence tomography angiography (OCTA) is more sensitive to hemodynamic changes. We performed OCTA to determine whether there is an increased retinal vessel density in TAO patients, and investigate associations with their vision...
July 2018: Endocrine Practice
Jian-Wei Wang, Chuan-Hong Jie, Yong-Jian Tao, Ning Meng, Yuan-Chun Hu, Zheng-Zheng Wu, Wen-Jing Cai, Xi-Mei Gong
AIM: To respectively evaluate macular morphological features and functional parameters by using spectral-domain optical coherence tomography (SD-OCT) and macular integrity assessment (MAIA) in patients with diabetic macular edema (DME). METHODS: This prospective, non-controlled, open study included 61 eyes of 38 consecutive patients with DME. All patients underwent best-corrected visual acuity (BCVA) measurement, MAIA microperimetry, and SD-OCT. DME morphology, including central retinal thickness (CRT) and central retinal volume (CRV); integrity of the external limiting membrane (ELM) and photoreceptor inner segment/outer segment (IS/OS) junction; and the deposition of hard macular exudates were assessed within a 1000-µm central subfield area...
2018: International Journal of Ophthalmology
Eiko Ohsugi, Yoshinori Mitamura, Kayo Shinomiya, Masanori Niki, Hiroki Sano, Toshihiko Nagasawa, Yukiko Shimizu, Daisuke Nagasato, Hitoshi Tabuchi
AIM: To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness. METHODS: This study included 64 eyes of 34 healthy Japanese children with a mean age (±SD) of 4.4 (±0.4)y (range, 3.6-5.8y) at baseline. Swept-source optical coherence tomography (SS-OCT) was used to record images of the retina and choroid at the baseline and after a mean follow-up period of about 1...
2018: International Journal of Ophthalmology
Vincent Gualino, Ramin Tadayoni, Salomon Yves Cohen, Ali Erginay, Franck Fajnkuchen, Belkacem Haouchine, Valérie Krivosic, Gabriel Quentel, Eric Vicaut, Alain Gaudric
PURPOSE: To determine the sensitivity and specificity of different retinal imaging combinations for the diagnosis of choroidal neovascularization (CNV) in age-related macular degeneration. METHODS: Patients aged 50 years or older referred for suspicious recent-onset CNV related to age-related macular degeneration were prospectively included for 6 months. Data recorded included color fundus photographs (CFPs), spectral domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA) images...
July 24, 2018: Retina
M Y Vishal, Naresh Babu, Piyush Kohli, Anand Rajendran, Kim Ramasamy
Purpose: The aim is to study the changes in ocular coherence tomography (OCT) parameters of large (≥400 μ) full-thickness macular holes (FTMHs) after a failed surgery and evaluate the outcome of fluid-gas exchange (FGE) in the treatment of persistent macular hole and role of OCT in predicting outcome after the secondary intervention. Methods: Changes occurring in the OCT parameters of FTMH after a failed vitrectomy were evaluated. FGE was done in an operating room with three pars plana sclerostomy ports...
August 2018: Indian Journal of Ophthalmology
Amy S Babiuch, Mehnaz Khan, Ming Hu, Peter K Kaiser, Sunil K Srivastava, Rishi P Singh, Allison Watts, Jamie L Reese, Justis P Ehlers
Purpose: To compare review strategies for optical coherence tomography angiography (OCT-A) for multiple disease features found in common diseases of the choroid and retina. Design: Prospective, observational study. Participants: Patients with macular disease undergoing routine spectral-domain optical coherence tomography (SDOCT). Methods: Eyes were imaged with the Avanti RTVue XR HD (Optovue, Fremont, CA), and the split-spectrum amplitude decorrelation angiography (SSADA) algorithm software was utilized for OCT-A performance...
June 2018: Ophthalmology Retina
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