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https://www.readbyqxmd.com/read/30511784/aberrant-visual-pathway-development-in-albinism-from-retina-to-cortex
#1
Sarim Ather, Frank Anthony Proudlock, Thomas Welton, Paul S Morgan, Viral Sheth, Irene Gottlob, Rob A Dineen
Albinism refers to a group of genetic abnormalities in melanogenesis that are associated neuronal misrouting through the optic chiasm. We perform quantitative assessment of visual pathway structure and function in 23 persons with albinism (PWA) and 20 matched controls using optical coherence tomography (OCT), volumetric magnetic resonance imaging (MRI), diffusion tensor imaging and visual evoked potentials (VEP). PWA had a higher streamline decussation index (percentage of total tractography streamlines decussating at the chiasm) compared with controls (Z = -2...
December 4, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/30510856/effects-of-age-race-and-ethnicity-on-the-optic-nerve-and-peripapillary-region-using-spectral-domain-oct-3d-volume-scans
#2
Linda Yi-Chieh Poon, Hussein Antar, Edem Tsikata, Rong Guo, Georgia Papadogeorgou, Madeline Freeman, Ziad Khoueir, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian John Que, Johannes F de Boer, Teresa C Chen
Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV)...
November 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/30506013/spectral-domain-oct-findings-of-retinal-vascular-avascular-junction-in-infants-with-retinopathy-of-prematurity
#3
Xi Chen, Shwetha Mangalesh, Alexandria Dandridge, Du Tran-Viet, David K Wallace, Sharon F Freedman, Cynthia A Toth
PURPOSE: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic en face viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascular junction, a critical location for pathogenesis of ROP, to date this has not been possible in vivo . Here we present bedside, non-sedated in vivo cross-sectional imaging and analysis of retinal microstructures at the vascular-avascular junction in infants with ROP using handheld spectral-domain optical coherence tomography (SDOCT)...
September 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/30505992/macular-pigment-density-changes-in-central-serous-chorioretinopathy
#4
Ruxandra Tudosescu, Cristina Mihaela Alexandrescu, Sinziana Luminita Istrate, Alexandra Vrapciu, Radu Constantin Ciuluvica, Liliana Mary Voinea
Aim: To present a series of 2 cases of central serous chorioretinopathy and the changes in the macular pigment optical density during the evolution of the disease. Material and methods: A 32-year-old patient presented himself for blurred vision on his LE. The SD OCT imaging revealed serous macular detachment of the neurosensory retina on the LE. The MPOD results were 0.72 on RE and 0.91 on LE. After treatment and resorption of the subretinal fluid, the MPOD values were 0.72 on the RE and 0.82 on the LE. The second patient was a 36-year-old male with metamorphopsia on LE and serous macular detachment on this eye...
July 2018: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/30499539/-effect-of-corneal-refractive-surgery-on-optical-coherence-tomography-measurements
#5
A A Shpak, S V Kostenev, I A Mushkova, M V Korobkova
The effect of significant changes in corneal power after refractive surgery on the parameters of optical coherence tomography (OCT) has not been sufficiently studied. PURPOSE: To study effects of corneal refractive surgery on optical coherence tomography (OCT) measurements in patients with moderate and high myopia. MATERIAL AND METHODS: OCT was performed in 62 patients (62 eyes) with myopia over 4 D before and one month after LASIK. The changes in 14 parameters of the thickness of the retina, ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were analyzed...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/30499516/-morphogenesis-of-choroidal-melanomas-in-oct-imaging
#6
A S Stoyukhina, I V Musatkina
When planning conservation therapy for choroidal melanoma (CM), evaluation of its size and stage is done using various methods of visualization, among which is optical coherence tomography (OCT). A recently introduced modification of OCT - Enhanced Depth Imaging (EDI) allows observation of deep choroid and sclera. PURPOSE: To specify clinicomorphologic correlations between OCT signs related to CM and its pathomorphological state as described in literature. MATERIAL AND METHODS: The study included 33 patients with predominantly small CM who were examined with EDI-OCT...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/30489610/vertical-hyperreflective-lesions-on-optical-coherence-tomography-in-vitreoretinal-lymphoma
#7
Gábor Gy Deák, Debra A Goldstein, Mei Zhou, Amani A Fawzi, Lee M Jampol
Importance: Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear. Objective: To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma. Design, Setting, and Participants: This case series study was a retrospective medical record review of patients who received a diagnosis of vitreoretinal lymphoma at the Department of Ophthalmology at Northwestern University between July 2014 and January 2016...
November 29, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/30476946/comparison-of-optical-coherence-tomography-with-fundus-photographs-fluorescein-angiography-and-histopathologic-analysis-in-assessing-coats-disease
#8
Sally S Ong, Thomas J Cummings, Lejla Vajzovic, Prithvi Mruthyunjaya, Cynthia A Toth
Importance: Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. Objective: To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic findings in Coats disease. Design, Setting, and Participants: This retrospective cohort study was conducted in a single tertiary institution (Duke Eye Center) and identified 28 children with Coats disease through a review of medical records from December 2002 to January 2018...
November 21, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/30476517/follow-up-at-5-years-of-non-fibrotic-scars-in-the-comparison-of-age-related-macular-degeneration-treatments-trials-catt
#9
Ebenezer Daniel, Gui-Shuang Ying, Benjamin J Kim, Cynthia A Toth, Frederick Ferris, Daniel F Martin, Juan E Grunwald, Glenn J Jaffe, Joshua L Dunaief, Wei Pan, Maureen G Maguire
OBJECTIVE: To describe changes in visual acuity (VA) and macular morphology at 5 years in eyes with non-fibrotic scars (NFS) identified at 1 year in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective cohort study within a randomized clinical trial. PARTICIPANTS: Participants in CATT. METHODS: Participants assigned to ranibizumab or bevacizumab and to 1 of 3 dosing regimens were released from the clinical trial protocol after 2 years and recalled at 5 years...
November 23, 2018: Ophthalmology
https://www.readbyqxmd.com/read/30475789/optical-coherence-tomography-angiography-features-of-subretinal-fibrosis-after-myopic-neovascularization
#10
Paolo Milani, Marco Pellegrini, Amedeo Massaccesi, Fabrizio Scotti, Stefania Moschini, Marco Setaccioli, Roberta Secondi, Fulvio Bergamini
PURPOSE: To describe the optical coherence tomography (OCT) angiography features of subretinal fibrosis in eyes with myopic choroidal neovascularization after natural evolution or secondary to intravitreal anti-vascular endothelial growth factor therapy. METHODS: Retrospective observational case series. All eyes underwent a multimodal imaging examination including fluorescein angiography, spectral domain OCT, OCT angiography, and en face OCT. RESULTS: Twenty-five eyes of 25 patients with mean age of 56...
November 16, 2018: Retina
https://www.readbyqxmd.com/read/30470956/correlation-between-macular-structure-and-function-in-patients-with-age-related-macular-degeneration-treated-with-intravitreal-ranibizumab-12-month-results
#11
Tomoharu Nishimura, Shigeki Machida
PURPOSE: To determine the significance of the correlation between optical coherence tomographic (OCT) findings and focal macular electroretinograms (fmERG) at 12 months after beginning intravitreal injections of ranibizumab (IVR) in eyes with age-related macular degeneration (AMD). STUDY DESIGN: Prospective, clinical study. METHOD: We studied 28 eyes of 28 patients with AMD treated with IVR at monthly intervals for the initial three months...
November 23, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/30469023/sequential-phases-of-rgc-axonal-and-somatic-injury-in-eae-mice-examined-using-dti-and-oct
#12
Christopher Nishioka, Hsiao-Fang Liang, Barsam Barsamian, Shu-Wei Sun
BACKGROUND: Clinical imaging modalities including optical coherence tomography (OCT) and diffusion tensor imaging (DTI) are vital in Multiple Sclerosis (MS), but their relationships during the different phases of Retinal ganglion cell (RGC) degeneration are not clear. We hypothesize that initial injury in optic nerve causes axonal degeneration leading to RGC loss in retina, which can be characterized by a combination of DTI and OCT. Our objective was to examine the correlation between noninvasive and histological data to chronicle the degeneration profile of RGCs in the retina and optic nerve in a mouse model of MS...
November 13, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30467423/macular-microvasculature-features-before-and-after-vitrectomy-in-idiopathic-macular-epiretinal-membrane-an-oct-angiography-analysis
#13
Hui Chen, Wei Chi, Xiaojuan Cai, Yang Deng, Xintong Jiang, Yantao Wei, Shaochong Zhang
PURPOSE: To evaluate pre-operative and post-operative morphologic characteristics in idiopathic macular epiretinal membrane (ERM) by optical coherence tomography angiography (OCTA). METHODS: Thirty-three subjects with unilateral idiopathic ERM were enrolled and the contralateral eyes served as controls. Vascular parameters including superficial capillary plexus (SCP), deep capillary plexus (DCP), outer capillary plexus (OCP), and choroidal capillary plexus (CCP) were evaluated by OCTA...
November 22, 2018: Eye
https://www.readbyqxmd.com/read/30466418/a-rodent-model-of-anterior-ischemic-optic-neuropathy-aion-based-on-laser-photoactivation-of-verteporfin
#14
Jing-Yu Min, Yanan Lv, Lei Mao, Yuan-Yuan Gong, Qing Gu, Fang Wei
BACKGROUND: A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further investigated. METHODS: Photodynamic treatment was conducted on the optic nerve head (ONH) following administration of the photosensitizer. The fellow eye was considered as sham control. Fundus Fluorescein angiography (FFA), spectral domain optical coherence tomography (SD-OCT) and Flash-visual evoked potential (F-VEP) recordings were conducted at different time points...
November 22, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/30460133/automated-identification-of-cone-photoreceptors-in-adaptive-optics-optical-coherence-tomography-images-using-transfer-learning
#15
Morgan Heisler, Myeong Jin Ju, Mahadev Bhalla, Nathan Schuck, Arman Athwal, Eduardo V Navajas, Mirza Faisal Beg, Marinko V Sarunic
Automated measurements of the human cone mosaic requires the identification of individual cone photoreceptors. The current gold standard, manual labeling, is a tedious process and can not be done in a clinically useful timeframe. As such, we present an automated algorithm for identifying cone photoreceptors in adaptive optics optical coherence tomography (AO-OCT) images. Our approach fine-tunes a pre-trained convolutional neural network originally trained on AO scanning laser ophthalmoscope (AO-SLO) images, to work on previously unseen data from a different imaging modality...
November 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30458564/-optical-coherence-tomography-in-disorders-of-the-central-nervous-system
#16
Athina Papadopoulou, Frederike Cosima Oertel, Hanna Zimmermann, Oliver Zeitz, Alexander U Brandt, Friedemann Paul
Retinal changes and visual symptoms are present in several inflammatory, degenerative and tumorous disorders of the central nervous system (CNS). Optical coherence tomography (OCT) is a method that can be used in clinical practice to detect and quantify the structural correlates of these visual symptoms in neurological disorders. OCT is a non-invasive imaging technique, based on interferometry, which can create high-resolution images of the retina and measure the thickness and volume of the different retinal layers...
November 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/30457660/single-retinal-layer-changes-after-subthreshold-micropulse-yellow-laser-in-diabetic-macular-edema
#17
Stela Vujosevic, Luisa Frizziero, Ferdinando Martini, Silvia Bini, Enrica Convento, Fabiano Cavarzeran, Edoardo Midena
A pilot prospective, interventional study has been conducted on 10 patients with diabetic macular edema (DME) treated with subthreshold micropulse laser (SMPL) to evaluate changes of individual retinal layers and to correlate with functional changes. All patients underwent complete ophthalmologic evaluation including spectral-domain optical coherence tomography (OCT) and microperimetry at baseline, 3 months, 6 months, 9 months, and 12 months. Compared with baseline, a significant decrease was found in inner nuclear layer (INL) and outer retinal layer (ORL) thickness in the central 1 mm (P < ...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30457656/comparison-of-zeiss-cirrus-and-optovue-rtvue-oct-angiography-systems-a-quantitative-and-qualitative-approach-examining-the-three-capillary-networks-in-diabetic-retinopathy
#18
Christopher S Chung, Peter L Nesper, Justin J Park, Amani A Fawzi
BACKGROUND AND OBJECTIVES: Construct a method for visualizing the middle capillary plexus (MCP) using Zeiss optical coherence tomography angiography (OCTA) and compare to established segmentation methods using the Optovue system. PATIENTS AND METHODS: Twenty eyes with diabetic retinopathy were imaged. Visualization of the MCP, image artifacts, preservation of pathological changes, foveal avascular zone (FAZ) area, and vessel length density (VLD) were compared between devices...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30457654/visualizing-structure-and-vascular-interactions-macular-nonperfusion-in-three-capillary-plexuses
#19
Justin J Park, Christopher S Chung, Amani A Fawzi
BACKGROUND AND OBJECTIVE: To assess the relationship between retinal vascular and structural changes in the superficial, middle, and deep capillary plexuses (SCP, MCP, DCP) using optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Patients with diabetic retinopathy were imaged using the Cirrus HD-OCT with AngioPlex. Using manual segmentation of the retinal layers, the authors compared OCTA to en face OCT images to examine corresponding patterns in each of the three capillary plexuses...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30457647/anatomic-localization-of-type-1-and-type-2-macular-neovascularization-using-swept-source-oct-angiography
#20
Elie H Motulsky, Fang Zheng, Yingying Shi, Giovanni Gregori, Philip J Rosenfeld
BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography angiography (SS-OCTA) and different boundary-specific segmentation strategies were used to distinguish type 1 macular neovascularization (MNV) from type 2 MNV in eyes with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Eyes with exudative AMD were enrolled in a prospective study. Segmentation strategies included a slab from the outer retina (OR) to the choriocapillaris (CC) for the entire MNV, a slab from the retinal pigment epithelium (RPE) to the CC for the type 1 MNV, and a slab from the OR to the RPE for the type 2 MNV...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
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