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OCT retina

Hatice Kose Ozlece, Volkan Solmaz, Sadık Altan Özal, Yahya Çelik
PURPOSE: According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness. METHODS: In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the "International RLS Study Group" criteria and 31 healthy subjects...
October 19, 2018: Sleep & Breathing, Schlaf & Atmung
Jorge Orellana-Rios, Sho Yokoyama, Julia M Agee, Nayanika Challa, K Bailey Freund, Lawrence A Yannuzzi, R Theodore Smith
BACKGROUND AND OBJECTIVE: To use quantitative fundus autofluorescence (qAF) to analyze different stages of non-neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: In this cohort study, 38 pseudophakic patients and 36 age-matched controls participated. We performed near-infrared, spectral-domain optical coherence tomography and qAF imaging on 31 pseudophakic eyes and controls of participants older than 60 years with non-neovascular AMD phenotypes using the Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany)...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Xuejing Chen, Kendra A Klein, Chirag P Shah, Jeffery S Heier
BACKROUND AND OBJECTIVE: Patients with idiopathic epiretinal membranes (ERMs) and visual acuity of 20/40 or better are often monitored until vision or associated symptoms worsen to affect everyday living. This study looks at the rate of progression to surgery and the characteristics associated with progression. PATIENTS AND METHODS: This study was a retrospective, consecutive case series of patients with newly diagnosed idiopathic ERMs who were referred to the Retina Service at the Ophthalmic Consultants of Boston between January 2009 and May 2015 with 20/40 or better visual acuity...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Adam Wylęgała
PURPOSE OF REVIEW: The article reviews the recent findings on the use of optical coherence tomography angiography (OCTA) in neurology. RECENT FINDINGS: OCTA is a new addition to the powerful and complementary technology of the OCT. Due to its noninvasiveness, and reproducibility, it is possible to obtain high-resolution 3D images of the vessels of the human eye. As the vessels of the retina with the presence of endothelial cell's tight junctions resemble the brain vessels, it was hypothesized that the imaging of the retinal vessels might bring insight into brain vessels...
October 18, 2018: Current Neurology and Neuroscience Reports
Zahra Nafar, Rong Wen, Shuliang Jiao
We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image...
August 1, 2018: Biomedical Optics Express
Maddipatla Reddikumar, Joel Cervantes, Yukitoshi Otani, Barry Cense
As data acquisition for retinal imaging with optical coherence tomography (OCT) becomes faster, efficient collection of photons becomes more important to maintain image quality. One approach is to use a larger aperture at the eye's pupil to collect more photons that have been reflected from the retina. A 2.8-mm beam diameter system with only 7 reflecting surfaces was developed for low-loss retinal imaging. The larger beam size requires defocus and astigmatism correction, which was done in a closed loop adaptive optics method using a Shack-Hartmann wavefront sensor and a deformable mirror with 140 actuators and a +/-2...
October 16, 2018: Journal of Biophotonics
Yoshiaki Tanaka, Fumihiko Toyoda, Machiko Shimmura-Tomita, Nozomi Kinoshita, Hiroko Takano, Yoh Dobashi, Shigeki Yamada, Hiroto Obata, Akihiro Kakehashi
Purpose: The aim of this case series was to clarify the clinicopathological features of epiretinal membranes (ERMs) that developed in eyes after silicone oil (SO) tamponade to treat rhegmatog-enous retinal detachments (RRDs). Patients and methods: In the Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, patients with idiopathic ERMs (23 eyes) and ERMs in eyes filled with SO (SO ERMs) after vitreous surgery to treat RRDs (nine eyes) were enrolled from July 2012 to March 2014...
2018: Clinical Ophthalmology
Oscar M Carrasco-Zevallos, Christian Viehland, Brenton Keller, Ryan P McNabb, Anthony N Kuo, Joseph A Izatt
Ultrahigh speed optical coherence tomography (OCT) systems with >100 kHz A-scan rates can generate volumes rapidly with minimal motion artifacts and are well suited for 4D imaging (volumes through time) applications such as intra-operative imaging. In such systems, high OCT data acquisition efficiency (defined as the fraction of usable A-scans generated during the total acquisition time) is desired to maximize the volumetric frame rate and sampling pitch. However, current methods for beam scanning using non-resonant and resonant mirror scanners can result in severe scan distortion and transverse oversampling as well as require acquisition dead times, which limit the acquisition efficiency and performance of ultrahigh speed 4D OCT...
October 1, 2018: Biomedical Optics Express
Felipe Pereira, Luiz H Lima, Alexandre Gomes B de Azevedo, Claudio Zett, Michel E Farah, Rubens Belfort
BACKGROUND: Swept-source optical coherence tomography (SS-OCT) has a higher scanning rate and longer wavelength in comparison with spectral-domain OCT (SD-OCT), allowing an improved imaging of retinal vascular plexuses and choriocapillaris. The present two patients diagnosed with multiple evanescent white dot syndrome (MEWDS) underwent fundus autofluorescence (FAF), en-face SS-OCT, and SS-OCT angiography (OCTA) imaging, and its features were described and correlated. RESULTS: The clinical and imaging findings of both cases were consistent with the diagnosis of MEWDS...
October 13, 2018: Journal of Ophthalmic Inflammation and Infection
Mengshan He, Pan Long, Weiming Yan, Tao Chen, Lunfeng Guo, Zouming Zhang, Siwang Wang
AIMS: Acetaldehyde dehydrogenase 2 (ALDH2) was reported for its protective properties on myocardial damage, stroke and neurodegeneration disease, but the effects and mechanisms of ALDH2 in the modulation of diabetic retinopathy remain unclear. The present study evaluated the protection effects of ALDH2 on streptozocin (STZ)-induced aged diabetic rats retinas damage. MAIN METHODS: 24 aged male diabetic Sprague-Dawley (SD) rats induced by a single intraperitoneal injection of STZ were randomly divided into Alda1-treated group and dimethylsulfoxide (DMSO) group...
October 10, 2018: Life Sciences
Hsin-Yu Yang, Chang-Sue Yang
BACKGROUND: To demonstrate a full thickness macular hole (MH) development after vitrectomy (VT) for rhegmatogenous retinal detachment (RRD) and to investigate the possible disease mechanism with optical coherence tomography (OCT). CASE PRESENTATION: A 47-year-old female underwent 23G vitrectomy surgery to repair the macula-detached RRD successfully. However, intraretinal cysts initially developed two months after surgery. Cysts gradually increased in number and size, and cystoid macular edema was noted at the 5th month...
October 11, 2018: BMC Ophthalmology
Alexandros Rouvas, Nikolaos S Gouliopoulos, Marilita M Moschos, Panagiotis Theodossiadis
BACKGROUND: We report a rare case of a woman with optic disk melanocytoma (ODMC) in conjunction with polypoidal choroidal vasculopathy (PCV). We also present, for the first time in literature, the clinical and morphological outcomes of the applied treatment, consisting of a session of photodynamic therapy (PDT) and three monthly intravitreal aflibercept injections. CASE PRESENTATION: An 83-year-old Greek woman, complaining for visual decline at her left eye, referred to our department and was diagnosed with ODMC associated with PCV...
October 12, 2018: BMC Ophthalmology
Sruthi Arepalli, Sunil K Srivastava, Ming Hu, Peter M Kaiser, Neeley Dukles, Jamie L Reese, Justis P Ehlers
PURPOSE: Ellipsoid zone (EZ) and outer retinal integrity are strongly linked to visual prognosis, but quantitative normative data is lacking. This study evaluates the EZ, outer retina, and inner retina in eyes without macular disease across a wide age spectrum. METHODS: An IRB-approved study was performed for eyes without macular pathology undergoing Spectral Domain Optical Coherence Tomography (SD-OCT) scans on the Cirrus HD-OCT system (Carl Zeiss Meditec, Oberkochen, Germany)...
2018: PloS One
Taimur Hassan, M Usman Akram, Mahmood Akhtar, Shoab Ahmad Khan, Ubaidullah Yasin
Maculopathy is the group of diseases that affects central vision of a person and they are often associated with diabetes. Many researchers reported automated diagnosis of maculopathy from optical coherence tomography (OCT) images. However, to the best of our knowledge there is no literature that presents a complete 3D suite for the extraction as well as diagnosis of macula. Therefore, this paper presents a multilayered convolutional neural networks (CNN) structure tensor Delaunay triangulation and morphing based fully autonomous system that extracts up to nine retinal and choroidal layers along with the macular fluids...
October 4, 2018: Journal of Medical Systems
Hisashi Matsubara, Eriko Uchiyama, Katsuya Suzuki, Yoshito Matsuda, Mineo Kondo
Focal choroidal excavation (FCE) is described as an excavated lesion of the choroid that can be detected by optical coherence tomography (OCT). While the exact pathogenesis of FCE remains unclear, it has been proposed in some cases that there is an association with the inflammation in the outer retina. We present a case of FCE development that was detected by spectral domain OCT (SD-OCT) and found to be associated with multiple evanescent white dot syndrome (MEWDS). A 40-year-old Japanese woman was diagnosed with MEWDS based on multiple white dots observed from the posterior pole to the midperiphery, along with yellow granularity in the fovea...
May 2018: Case Reports in Ophthalmology
Muhammad Usman
Diabetic macular ischemia (DMI) is a troublesome complication of diabetes mellitus. The pathogenesis, progression, consequences, and treatment options for this disease are still poorly understood. However, it is believed that this complication is associated with several risk factors like poor glycemic control and high blood pressure. Two factors have been identified in the pathogenesis of the disease that play pivotal roles in disease development and progression. One of these factors includes extensive damage to the microvasculature of the retina...
July 30, 2018: Curēus
Alison D Treister, Peter L Nesper, Alaa E Fayed, Manjot K Gill, Rukhsana G Mirza, Amani A Fawzi
Purpose: To determine the prevalence of subclinical choroidal neovascularization (CNV) in fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA) and to quantify choriocapillaris nonperfusion adjacent to CNV. Methods: We retrospectively reviewed all patients with AMD who underwent OCTA and identified eyes with unilateral exudative AMD. We determined the presence of subclinical CNV on custom en face macular slabs of the outer retina and choriocapillaris and confirmed on cross-sectional scans...
September 2018: Translational Vision Science & Technology
Mingui Kong, Da Ye Choi, Gyule Han, Yun-Mi Song, Sung Yong Park, Joohon Sung, Sungsoon Hwang, Don-Il Ham
Purpose: We investigate the measurable range of subfoveal choroidal thickness (SFCT) with conventional spectral domain optical coherence tomography (SD-OCT) in normal healthy eyes. Methods: All subjects underwent an SD-OCT horizontal line scan centered at the fovea with standard and enhanced depth imaging (EDI) techniques. Two independent observers manually measured SFCT on standard and EDI-OCT images, if two choroidal borders were identified. The rate of successful measurement with standard OCT was evaluated...
September 2018: Translational Vision Science & Technology
Mohammad Ali Shariati, Varun Kumar, Tao Yang, Chandrani Chakraborty, Ben Anthony Barres, Frank Michael Longo, Yaping Joyce Liao
PURPOSE: Brain-derived neurotrophic factor (BDNF) and activation of its high affinity receptor tropomyosin kinase (Trk) B promote retinal ganglion cells (RGCs) survival following injury. In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years. METHODS: We assessed drug effects on immunopanned, cultured RGCs and calculated RGC survival and assessed TrkB receptor activation by mitogen-activated protein (MAP) kinase translocation...
October 1, 2018: Current Eye Research
Zhipeng Zhu, Chao He, Yingli Zhang, Xiangji Yue, Dechun Ba
PURPOSE: The purpose of this study was to quantitatively investigate the haemodynamics and oxygen transmission of the retina. METHODS: Considering the effect of Fåhraeus-Lindqvist effect on the apparent viscosity of blood and the actual haematocrit in blood vessels, this study used the currently known retinal parameters (e.g. blood flow obtained by Doppler Fourier domain optical coherence tomography, FD-OCT for short) to construct a retinal blood circulation model consisting of an asymmetric vascular network system...
October 1, 2018: European Journal of Ophthalmology
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