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Alexander Ritz Mait, Jason Lee Forman, Bingbing Nie, John Paul Donlon, Adwait Mane, Ali Reza Forghani, Robert B Anderson, M Truitt Cooper, Richard W Kent
Background: Forced external rotation of the foot is a mechanism of ankle injuries. Clinical observations include combinations of ligament and osseous injuries, with unclear links between causation and injury patterns. By observing the propagation sequence of ankle injuries during controlled experiments, insight necessary to understand risk factors and potential mitigation measures may be gained. Hypothesis: Ankle flexion will alter the propagation sequence of ankle injuries during forced external rotation of the foot...
June 2018: Orthopaedic Journal of Sports Medicine
Harsh Durgia, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Rajan Palui, Kalyani Sridharan, Henith Raj
Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot (CF) presents with a red and swollen foot in contrast to the painless deformed one of chronic CF. Enhanced osteoclastogenesis plays a central role in the pathogenesis of acute CF. Many studies have shown elevated levels of bone turnover markers in patients with acute CF confirming it. These findings have led clinicians to use anti-resorptive agents [bisphosphonates (BP), calcitonin, and denosumab] along with immobilization and offloading in acute CF patients...
July 15, 2018: World Journal of Diabetes
Juan Wang, Di Li
In recent years, cloud computing and fog computing have appeared one after the other, as promising technologies for augmenting the computing capability of devices locally. By offloading computational tasks to fog servers or cloud servers, the time for task processing decreases greatly. Thus, to guarantee the Quality of Service (QoS) of smart manufacturing systems, fog servers are deployed at network edge to provide fog computing services. In this paper, we study the following problems in a mixed computing system: (1) which computing mode should be chosen for a task in local computing, fog computing or cloud computing? (2) In the fog computing mode, what is the execution sequence for the tasks cached in a task queue? Thus, to solve the problems above, we design a Software-Defined Network (SDN) framework in a smart factory based on an Industrial Internet of Things (IIoT) system...
August 1, 2018: Sensors
Bo Gu, Yapeng Chen, Haijun Liao, Zhenyu Zhou, Di Zhang
Mobile edge computing (MEC) is an emerging technology that leverages computing, storage, and network resources deployed at the proximity of users to offload their delay-sensitive tasks. Various existing facilities including mobile devices with idle resources, vehicles, and MEC servers deployed at base stations or road side units, could act as edges in the network. Since task offloading incurs extra transmission energy consumption and transmission latency, two key questions to be addressed in such an environment are (i) should the workload be offloaded to the edge or computed in terminals? (ii) Which edge, among the available ones, should the task be offloaded to? In this paper, we formulate the task assignment problem as a one-to-many matching game which is a powerful tool for studying the formation of a mutual beneficial relationship between two sets of agents...
July 25, 2018: Sensors
Michael B Strauss, Lientra Q Lu, Stuart S Miller
Introduction: In Part 1 of this three-part series, we provided an explanation as to why and at what sites decompression sickness (DCS) occurs, using the Gradient-Perfusion Model (GPM). In this part, we provide information to substantiate the concept and present clinical cases that were initially labeled as "unexplained DCS," but later disordering events were identified to explain the clinical presentations. Materials and Methods: Among 500 cases of DCS we have managed for over 50 years, a cohort of these patients was initially diagnosed as unexplained DCS...
May 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Sara Pizzi, Federica Rinaldi, Antonella Molinaro, Antonio Iera, Giuseppe Araniti
The forthcoming fifth generation (5G) networks are claimed to deliver the large amount of traffic generated by the huge number of heterogeneous devices that constitute the Internet of Things (IoT). This unprecedented volume of both human- and machine-generated traffic to be managed imposes 5G network operators to move the focus from throughput-optimized to energy-efficiency-optimized resource allocation solutions. Device-to-device (D2D) communications are recognized as an effective offloading technique that the 5G network can exploit to boost the capacity and energy efficiency of future 5G networks...
July 9, 2018: Sensors
Mengyu Li, Peter Vanberkel, Alix J E Carter
Ambulance offload delay (AOD) occurs when care of incoming ambulance patients cannot be transferred immediately from paramedics to staff in a hospital emergency department (ED). This is typically due to emergency department congestion. This problem has become a significant concern for many health care providers and has attracted the attention of many researchers and practitioners. This article reviews literature which addresses the ambulance offload delay problem. The review is organized by the following topics: improved understanding and assessment of the problem, analysis of the root causes and impacts of the problem, and development and evaluation of interventions...
July 7, 2018: Health Care Management Science
Gareth G Jones, Martin Jaere, Susannah Clarke, Justin Cobb
High tibial osteotomy (HTO) is a relatively conservative surgical option in the management of medial knee pain. Thus far, the outcomes have been variable, and apparently worse than the arthroplasty alternatives when judged using conventional metrics, owing in large part to uncertainty around the extent of the correction planned and achieved.This review paper introduces the concept of detailed 3D planning of the procedure, and describes the 3D printing technology that enables the plan to be performed.The different ways that the osteotomy can be undertaken, and the varying guide designs that enable accurate registration are discussed and described...
May 2018: EFORT Open Reviews
Elizabeth Gianino, Craig Miller, Jordon Gilmore
Given their severity and non-healing nature, diabetic chronic wounds are a significant concern to the 30.3 million Americans diagnosed with diabetes mellitus (2015). Peripheral arterial diseases, neuropathy, and infection contribute to the development of these wounds, which lead to an increased incidence of lower extremity amputations. Early recognition, debridement, offloading, and controlling infection are imperative for timely treatment. However, wound characterization and treatment are highly subjective and based largely on the experience of the treating clinician...
June 26, 2018: Bioengineering
Xiao Ma, Chuang Lin, Han Zhang, Jianwei Liu
Mobile edge computing is proposed as a promising computing paradigm to relieve the excessive burden of data centers and mobile networks, which is induced by the rapid growth of Internet of Things (IoT). This work introduces the cloud-assisted multi-cloudlet framework to provision scalable services in cloudlet-based mobile edge computing. Due to the constrained computation resources of cloudlets and limited communication resources of wireless access points (APs), IoT sensors with identical computation offloading decisions interact with each other...
June 15, 2018: Sensors
Shelain Patel, Parag Garg, M Ali Fazal, Muhammad S Shahid, Derek H Park, Pinak S Ray
BACKGROUND: The reverse camber shoe is commonly used after hallux valgus corrective surgery to offload the forefoot but is associated with back pain and poor compliance. Recent designs of postoperative shoes may obviate the need for a reverse camber. The purpose of this study was to compare the effects of a reverse camber shoe and a noncambered shoe with transitional rigidity after hallux valgus correction. METHODS: A cohort of 80 feet was prospectively studied undergoing surgery at a single NHS trust...
June 1, 2018: Foot & Ankle Specialist
Matthew Strohl, Lorant Gonczi, Zsuzsanna Kurt, Talat Bessissow, Peter L Lakatos
Inflammatory bowel disease (IBD) is a lifelong, progressive disease that has disabling impacts on patient's lives. Given the complex nature of the diagnosis of IBD and its management there is consequently a large economic burden seen across all health care systems. Quality indicators (QI) have been created to assess the different façades of disease management including structure, process and outcome components. Their development serves to provide a means to target and measure quality of care (QoC). Multiple different QI sets have been published in IBD, but all serve the same purpose of trying to achieve a standard of care that can be attained on a national and international level, since there is still a major variation in clinical practice...
June 14, 2018: World Journal of Gastroenterology: WJG
Ken Zafren, Anne Brants, Katie Tabner, Andrew Nyberg, Matiram Pun, Buddha Basnyat, Monika Brodmann Maeder
The Nepal Earthquake of 2015 killed over 8000 people and injured over 20,000 in Nepal. Moments after the earthquake, an avalanche of falling ice came down from above Everest Base Camp (EBC). The air blast created by the avalanche flattened the middle part of EBC, killing 15 people and injuring at least 70. The casualties were initially triaged and treated at EBC and then evacuated by air to Kathmandu for definitive care. There were intermediate stops at the villages of Pheriche and Lukla during which the casualties were offloaded, retriaged, treated, and loaded again for further transport...
June 8, 2018: Wilderness & Environmental Medicine
Manon Westra, Jaap J van Netten, Hendrik A Manning, Jeff G van Baal, Sicco A Bus
BACKGROUND: Non-removable knee-high devices, such as a total contact cast (TCC), are recommended for offloading diabetic plantar forefoot ulcers. However, it is insufficiently known how each of the different design characteristics of these devices contribute to offloading the diabetic foot. RESEARCH QUESTION: What is the offloading effect of the different design characteristics that make up a non-removable knee-high cast for people with diabetes and active or previous plantar forefoot ulcers? METHODS: Sixteen persons with diabetes, peripheral neuropathy and a healed or active plantar forefoot ulcer had their plantar pressures measured during walking in a non-removable knee-high device (TCC), in that device made removable (BTCC), in that device made below-ankle (cast shoe), in that cast shoe worn with a different walking sole and in a newly made cast shoe without a custom-moulded foot-device interface...
July 2018: Gait & Posture
Haibo Mei, Kezhi Wang, Kun Yang
In this paper, we work on a Cache and Multi-layer MEC enabled C-RAN (CMM-CRAN) to handle various user tasks with minimized latency and energy cost. We intend to solve two particular problems of CMM-CRAN. First, because CMM-CRAN has to maximally cache the most frequently requested data from Service Provide Server (SPS) to Remote Radio Head (RRH) and later offered to proximity mobile users, the cache content placement from SPSs to RRHs becomes a many-to-many matching problem with peer effects. Second, because of multi-layer MEC, a user task has to be dynamically controlled to be offloaded to the best fit cloud, i...
June 5, 2018: Sensors
Takefumi Kuranaga, Kenichi Matsuda, Ayae Sano, Masakazu Kobayashi, Akihiro Ninomiya, Kentaro Takada, Shigeki Matsunaga, Toshiyuki Wakimoto
The cathepsin B inhibitor surugamide B (2), along with structurally related derivatives (A and C-E), has previously been isolated from the marine actinomycete Streptomyces sp. JAMM992. The biosynthetic genes are unexpectedly part of a cluster of four non-ribosomal peptide synthetase (NRPS) genes, two of which are responsible for the biosynthesis of the additional linear decapeptide surugamide F. However, the thioesterase domain required for the later stage of the biosynthesis of the cyclic peptides surugamides A-E is not present in any module architecture of the surugamide NRPSs...
May 29, 2018: Angewandte Chemie
Vladimir Stojanović, Rajeev J Ram, Milos Popović, Sen Lin, Sajjad Moazeni, Mark Wade, Chen Sun, Luca Alloatti, Amir Atabaki, Fabio Pavanello, Nandish Mehta, Pavan Bhargava
Integrating photonics with advanced electronics leverages transistor performance, process fidelity and package integration, to enable a new class of systems-on-a-chip for a variety of applications ranging from computing and communications to sensing and imaging. Monolithic silicon photonics is a promising solution to meet the energy efficiency, sensitivity, and cost requirements of these applications. In this review paper, we take a comprehensive view of the performance of the silicon-photonic technologies developed to date for photonic interconnect applications...
May 14, 2018: Optics Express
Ernst Joachim Houtgast, Vlad-Mihai Sima, Koen Bertels, Zaid Al-Ars
We present our work on hardware accelerated genomics pipelines, using either FPGAs or GPUs to accelerate execution of BWA-MEM, a widely-used algorithm for genomic short read mapping. The mapping stage can take up to 40% of overall processing time for genomics pipelines. Our implementation offloads the Seed Extension function, one of the main BWA-MEM computational functions, onto an accelerator. Sequencers typically output reads with a length of 150 base pairs. However, read length is expected to increase in the near future...
August 2018: Computational Biology and Chemistry
Lindsay Schakenbach Regele
The business records of textile entrepreneur and inventor Erastus Bigelow offer extraordinary detail about how financing innovation worked on the ground in the antebellum United States. For the first decades of the nineteenth century, increasing numbers of Americans sought patent protection, even as patents often brought little monetary benefit or status to their holders. Historians have tended to look to the court system to account for why this was the case, even though only a small percentage of patent holders ever litigated...
2018: Technology and Culture
Amanda L Killeen, Jodi L Walters
INTRODUCTION: Diabetic foot ulcers (DFUs) are associated with increased morbidity, mortality, and resource utilization. Remote temperature monitoring (RTM) is an evidence-based and recommended component of standard preventative foot care for high-risk populations that can detect the inflammation preceding and accompanying DFUs. OBJECTIVE: This case series illustrates the use of a RTM foot mat for the early detection and prevention of DFUs in patients with a history of DFUs...
April 2018: Wounds: a Compendium of Clinical Research and Practice
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