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https://www.readbyqxmd.com/read/28645127/-high-prevalence-of-antipsychotic-medication-use-in-dementia-patients-in-german-neuropsychiatric-practices
#1
Jens Bohlken, Anke Booker, Karel Kostev
Background The aim of the present study was to examine inpatients as well as patients living at home with respect to the frequency of antipsychotic medication use and to determine the factors leading to initial use of antipsychotics following dementia diagnosis. Methods This study included patients aged 60 years and over with an initial diagnosis of all-cause dementia (index date) by German psychiatrists in Disease Analyzer database (IMS Health). The main outcome measure was the proportion of patients who initially received an antipsychotic prescription after the index date...
June 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28644901/vascular-geometry-as-a-risk-factor-for-non-penetrating-traumatic-injuries-of-the-aortic-arch
#2
Andreas Schicho, Lukas Luerken, Christian Stroszczynski, Ramona Meier, Andreas G Schreyer, Lena-Marie Dendl, Stephan Schleder
PURPOSE: To assess biomechanical factors in aortic arch geometry contributing to the development of non-penetrating aortic arch injury (NAAI) in multiply injured patients with an Injury Severity Score (ISS) ≥ 16. MATERIAL AND METHODS: 230 consecutive multiply injured trauma patients with an ISS ≥ 16 admitted to our Level-I trauma center during a consecutive 24-month period were prospectively included of whom 13 presented with NAAI (5.7%). Standardized whole-body CT in a 2x128-detector-row scanner included a head-and-neck CTA...
2017: PloS One
https://www.readbyqxmd.com/read/28644249/incidental-hippocampal-hyperintensity-on-diffusion-weighted-mri-individual-susceptibility-to-transient-global-amnesia
#3
Moonyoung Jeong, Jaehyun Jin, Jeong Hee Kim, Yeonsil Moon, Jin Woo Choi, Hahn Young Kim
OBJECTIVES: Dot-like hippocampal hyperintensities (HHs) on diffusion-weighted MRI (DWI) have been reported as an interesting imaging finding of transient global amnesia (TGA) that is characterized by typical anterograde amnesia. However, we found that these dot-like HHs are occasionally seen in some patients without clinical symptoms of TGA. METHODS: We identified 8 patients who did not show clinical symptoms of TGA, despite the presence of hippocampal lesions on DWI (No-TGA group, n=8)...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28643948/investigating-the-separate-and-interactive-associations-of-trauma-and-depression-on-brain-structure-implications-for-cognition-and-aging
#4
Aimee J Karstens, Olusola Ajilore, Leah H Rubin, Shaolin Yang, Aifeng Zhang, Alex Leow, Anand Kumar, Melissa Lamar
OBJECTIVE: Trauma and depression are associated with brain structural alterations; their combined effects on these outcomes are unclear. We previously reported a negative effect of trauma, independent of depression, on verbal learning and memory; less is known about underlying structural associates. We investigated separate and interactive associations of trauma and depression on brain structure. METHODS: Adults aged 30-89 (N = 203) evaluated for depression (D+) and trauma history (T+) using structured clinical interviews were divided into 53 D+T+, 42 D+T-, 50 D-T+, and 58 D-T-...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28643678/prevalence-of-factors-related-to-vascular-calcifications-in-patients-with-chronic-kidney-disease-on-dialysis
#5
Guillermo Rosa-Diez, Griselda Bratti, Graciela Filannino, Adriana Peñalba, Fabián Otreras, Miriam Ledesma, Martín Ortemberg, Gustavo Laham, Mariana Vásquez-Durand, Soledad Crucelegui, Mariano Forrester, Carlos Musso, Marcelo Orias, Ricardo Heguilen, Carlos Díaz, Ricardo García-Mónaco, Oscar Velan, Hernán Trimarchi
The main aim of the study was to determine the prevalence of vascular calcifications in patients with chronic kidney disease on dialysis in our population assessed by X-ray. The secondary objectives were to determine the cardiovascular risk factors associated with the presence of vascular calcifications and to evaluate the complementary use of the echocardiogram in a cross-sectional, observational, multicentric study. We included patients with chronic kidney disease on dialysis, age =18 years with at least 3 months of renal replacement therapy in 8 dialysis centres in Argentina...
2017: Medicina
https://www.readbyqxmd.com/read/28643575/combined-rex-bypass-shunt-with-pericardial-devascularization-alleviated-prehepatic-portal-hypertension-caused-by-cavernomatous-transformation-of-portal-vein
#6
Ruo-Yi Wang, Jun-Feng Wang, Qian Liu, Nan Ma, Wei-Xiu Chen, Jin-Liang Li
OBJECTIVE: To evaluate the effects of combined Rex-bypass shunt and pericardial devascularization on prehepatic portal hypertension secondary to cavernomatous transformation of portal vein (CTPV). METHODS: Forty-two patients aged from 3 years to 49 years (divided into 3 groups), 26 cases male and 16 female, with prehepatic vascular hepertention were treated with Rex-bypass shunt combined with pericardial devascularization. In each patient, preoperative assessment included ultrasound and computed tomographic angiography of the portal vein and blood analysis...
June 23, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28643315/-technical-advantages-of-nano-carbon-development-combined-with-artery-approach-in-lymph-node-sorting-of-rectal-cancer
#7
Yuzhou Zhao, Guangsen Han, Jian Li, Yanhui Gu, Pengfei Ma, Chenyu Liu, Mingke Huo, Junli Zhang, Yanghui Cao, Shijia Zhang
OBJECTIVE: To explore the technical advantages of nano carbon development combined with artery approach in lymph node sorting of rectal cancer. METHODS: From December 2015 to June 2016, 70 patients with of rectal cancer in General Surgery Department of Henan Cancer Hospital were randomly divided into nano carbon development combined with artery approach group(artery approach group) and conventional group. Specimen of artery approach group was placed on the sorting table...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28643127/preoperative-evaluation-of-left-common-iliac-vein-in-oblique-lateral-interbody-fusion-at-l5-s1
#8
Nam-Su Chung, Chang-Hoon Jeon, Han-Dong Lee, Heon-Ju Kweon
PURPOSE: Oblique lateral interbody fusion (OLIF) L5-S1 is essentially to perform an anterior lumbar interbody fusion (ALIF) in the lateral position. Because the surgical procedures are performed "obliquely" over the left common iliac vein (LCIV), ensuring that the vein is protected which is particularly important. We aimed to evaluate the configuration of LCIV and its risk of mobilization during anterior approach at L5-S1 segment. METHODS: This study involved 65 consecutive patients who underwent anterior lumbar fusion (ALIF, n = 39; OLIF, n = 26) at the L5-S1 segment...
June 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28643039/primary-intraventricular-meningiomas-in-children-experience-of-two-cases-with-review-of-literature
#9
Kapil D Muley, Salman T Shaikh, Chandrashekhar E Deopujari, Uday B Andar
Meningiomas are rare in the pediatric age group, more so in the intraventricular location. They arise in the lateral ventricles from the arachnoid cells contained within the choroid plexus, in the third ventricle from the velum interpositum and in the fourth ventricle from the choroids. These tumors are usually large and have an aggressive behaviour. Surgical management of intra-ventricular meningiomas is challenging because of their deep location, large size at presentation and increased vascularity. The authors report two such cases who presented with symptoms of raised intra cranial pressure and on evaluation were found to have associated hydrocephalus...
June 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28642699/cerebral-blood-flow-and-amyloid-%C3%AE-interact-to-affect-memory-performance-in-cognitively-normal-older-adults
#10
Katherine J Bangen, Alexandra L Clark, Emily C Edmonds, Nicole D Evangelista, Madeleine L Werhane, Kelsey R Thomas, Lyzette E Locano, My Tran, Zvinka Z Zlatar, Daniel A Nation, Mark W Bondi, Lisa Delano-Wood
Cerebral blood flow (CBF) alterations and amyloid-β (Aβ) accumulation have been independently linked to cognitive deficits in older adults at risk for dementia. Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. Therefore, we examined potential statistical interactions between CBF and Aβ status in regions typically affected in Alzheimer's disease (AD) within a sample of older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Sixty-two cognitively normal participants (mean age = 72 years) underwent neuroimaging and memory testing...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28642238/ager-deletion-enhances-ischemic-muscle-inflammation-neoangiogenesis-and-blood-flow-recovery-in-diabetic-mice
#11
Raquel Lopez Diez, Xiaoping Shen, Gurdip Daffu, Md Khursheed, Jiyuan Hu, Fei Song, Rosa Rosario, Yunlu Xu, Qing Li, Xiangmei Xi, Yu Shan Zou, Huilin Li, Ann Marie Schmidt, Shi Fang Yan
OBJECTIVE: Diabetic subjects are at higher risk of ischemic peripheral vascular disease. We tested the hypothesis that advanced glycation end products (AGEs) and their receptor (RAGE) block neoangiogenesis and blood flow recovery after hindlimb ischemia induced by femoral artery ligation through modulation of immune/inflammatory mechanisms. APPROACH AND RESULTS: Wild-type mice rendered diabetic with streptozotocin and subjected to unilateral femoral artery ligation displayed increased accumulation and expression of AGEs and RAGE in ischemic muscle...
June 22, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28642220/low-pulse-pressure-after-acute-ischemic-stroke-is-associated-with-unfavorable-outcomes-the-taiwan-stroke-registry
#12
Sung-Chun Tang, Jiu-Haw Yin, Chung-Hsiang Liu, Ming-Hui Sun, Jiunn-Tay Lee, Yu Sun, Chih-Shan Hsu, Mu-Chien Sun, Ching-Huang Lin, Chih-Hung Chen, Li-Ming Lien, Chih-Hsin Muo, Jiann-Shing Jeng, Chung Y Hsu
BACKGROUND: Pulse pressure (PP) is related to cardiac function, arterial stiffness, fluid status, and vascular events. This study aimed to explore the prognostic role of PP upon admission in patients with acute ischemic stroke (AIS) based on a nation-wide stroke registry. METHODS AND RESULTS: We evaluated the association between PP upon admission and outcomes 3 months after a stroke in patients who had an AIS registered in the Taiwan Stroke Registry, including 56 academic and community hospitals between 2006 and 2013...
June 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28642014/acute-hemodynamic-effects-of-intravenous-adenosine-in-patients-with-associated-pulmonary-arterial-hypertension-comparison-with-intravenous-epoprostenol
#13
Rosario Rossi, Francesca Coppi, Fabio Sgura, Daniel Monopoli, Giuseppe Boriani
Exogenous intravenous (IV) adenosine and epoprostenol are effective vasodilator agents, causing a substantial reduction in pulmonary vascular resistance in patients affected by idiopathic pulmonary arteriolar hypertension (PAH). Their action, in patients with PAH associated with other pathological conditions, is not well defined. In the present paper the authors retrospectively analyzed the acute hemodynamic effects of intravenous adenosine and epoprostenol in 30 consecutive patients (mean age: 58 ± 15 years; 21 females, and 9 males) affected by PAH associated with other pathological conditions, as determined by changes from baseline in systemic and pulmonary hemodynamic parameters...
June 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28641891/inter-arm-systolic-blood-pressure-differences-relations-with-future-vascular-events-and-mortality-in-patients-with-and-without-manifest-vascular-disease
#14
Guido Kranenburg, Wilko Spiering, Pim A de Jong, L Jaap Kappelle, Gert Jan de Borst, Maarten J Cramer, Frank L J Visseren, Victor Aboyans, Jan Westerink
BACKGROUND: Inter-arm systolic blood pressure difference (SBPD) is an easily obtained patient characteristic which relates to vascular disease. We aimed to identify determinants of large inter-arm SBPD and to investigate the relation between inter-arm SBPD and vascular events in patients with and without manifest vascular disease. METHODS: In a cohort of 7344 patients with manifest vascular disease or vascular risk factors alone enrolled in the Second Manifestations of ARTerial disease (SMART) study, single bilateral non-simultaneous blood pressure measurements were performed...
June 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28641790/ideal-cardiovascular-health-mortality-and%C3%A2-vascular-events-in-elderly-subjects-the%C3%A2-three-city%C3%A2-study
#15
Bamba Gaye, Marianne Canonico, Marie-Cécile Perier, Cecilia Samieri, Claudine Berr, Jean-François Dartigues, Christophe Tzourio, Alexis Elbaz, Jean-Philippe Empana
BACKGROUND: The benefit of ideal cardiovascular health (CVH) on health-related outcomes in middle-aged patients is firmly established. In the growing elderly population, the high prevalence of comorbidities and medications for chronic diseases may offset such benefit. OBJECTIVES: This study analyzed the association of ideal CVH with mortality, incident coronary heart disease, and stroke events in elderly individuals from the community. METHODS: Between 1999 and 2001, 9,294 men and women, noninstitutionalized and aged 65 years and over were examined, and thereafter followed up for the occurrence of vascular events and mortality within the Three-City Study...
June 27, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28641315/sequential-vs-concurrent-epirubicin-and-docetaxel-as-adjuvant-chemotherapy-for-high-risk-node-negative-early-breast-cancer-an-interim-analysis-of-a-randomised-phase-iii-study-from-the-hellenic-oncology-research-group
#16
Dimitrios Mavroudis, Emmanouil Saloustros, Ioannis Boukovinas, Pavlos Papakotoulas, Stylianos Kakolyris, Nikolaos Ziras, Charalampos Christophylakis, Nikolaos Kentepozidis, Georgios Fountzilas, Georgios Rigas, Ioannis Varthalitis, Konstantinos Kalbakis, Sofia Agelaki, Dora Hatzidaki, Vasilios Georgoulias
BACKGROUND: Sequential anthracyclines and taxanes are standard adjuvant chemotherapy for patients with high-risk axillary node-positive breast cancer. We compared a sequential to a concurrent regimen in high-risk node-negative early breast cancer. METHODS: Patients were eligible if they had tumours >2 cm or T1c with two of the following characteristics: no oestrogen receptor (ER) and progesterone receptor (PR) expression, histological grade III, Ki67 >40% and vascular, lymphovascular or perineural invasion...
June 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28640987/independent-effects-of-apolipoprotein-e-and-cerebrovascular-burden-on-later-life-depression-the-wisconsin-longitudinal-study
#17
Rosanna G Scott, Daniel L Paulson
OBJECTIVE: Studies evaluating the effect of apolipoprotein E (APOE) on vascular depression are sparse, employ heterogeneous methods, and yield inconsistent results. One possibility is that APOE is a moderator of another predictor such as cerebrovascular burden. This longitudinal study examines the relationships between APOE, cerebrovascular burden, and depressive symptomatology in a large cohort sample from midlife to later life. METHODS: Data include 3,203 participants across 18 years (1993-2011) from the Wisconsin Longitudinal Study (baseline mean age = 53 years)...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28640364/a-phase-2-study-of-the-efficacy-and-biomarker-on-the-combination-of-transarterial-chemoembolization-and-axitinib-in-the-treatment-of-inoperable-hepatocellular-carcinoma
#18
Stephen L Chan, Winnie Yeo, Frankie Mo, Anthony W H Chan, Jane Koh, Leung Li, Edwin P Hui, Charing C N Chong, Paul B S Lai, Tony S K Mok, Simon C H Yu
BACKGROUND: A surge of vascular endothelial growth factor (VEGF) after transarterial chemoembolization (TACE) may contribute to tumor progression. Axitinib is a potent antiangiogenic agent with main activity against VEGF receptors 1 to 3. To the authors' knowledge, its role in combination with TACE for the treatment of patients with inoperable hepatocellular carcinoma (HCC) is unclear. METHODS: A phase 2 clinical trial (ClinicalTrials.gov identifier NCT01352728) was conducted to evaluate the combination treatment...
June 22, 2017: Cancer
https://www.readbyqxmd.com/read/28640089/functional-outcomes-of-gartland-iii-supracondylar-humerus-fractures-with-early-neurovascular-complications-in-children-a-retrospective-observational-study
#19
Sung Il Wang, Tae Young Kwon, Hong Pil Hwang, Jung Ryul Kim
This was a retrospective observational study. The aim of this study was to evaluate functional outcomes in children treated for Gartland III supracondylar humerus (SCH) fracture with neurovascular (NV) injuries using validated outcome measures. A secondary goal was to determine whether clinical parameters such as age at injury, sex, weight, fracture site, and/or direction of displacement could predict NV injury at the time of fracture or long-term functional outcomes in these patients.One hundred fifty-four patients of Gartland III SCH fractures between March 2004 and May 2013 were studied retrospectively...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639927/carotid-artery-plaque-vulnerability-assessment-using-noninvasive-ultrasound-elastography-validation-with-mri
#20
Marie-Hélène Roy Cardinal, Maarten H G Heusinkveld, Zhao Qin, Richard G P Lopata, Cyrille Naim, Gilles Soulez, Guy Cloutier
OBJECTIVE: Vulnerable and nonvulnerable carotid artery plaques have different tissue morphology and composition that may affect plaque biomechanics. The objective of this study is to evaluate plaque vulnerability with the use of ultrasound noninvasive vascular elastography (NIVE). MATERIALS AND METHODS: Thirty-one patients (mean [± SD] age, 69 ± 7 years) with stenosis of the internal carotid artery of 50% or greater were enrolled in this cross-sectional study...
July 2017: AJR. American Journal of Roentgenology
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