keyword
https://read.qxmd.com/read/38535959/single-nucleotide-polymorphisms-associated-with-mercury-levels-and-neurological-symptoms-an-overview
#1
REVIEW
Jamila Alessandra Perini, Jessica Vilarinho Cardoso, Alana de Oliveira Knesse, Felipe Oliveira Pessoa-Silva, Ana Claudia Santiago de Vasconcellos, Daniel Escorsim Machado, Paulo Cesar Basta
Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations...
March 20, 2024: Toxics
https://read.qxmd.com/read/38534961/adult-neoneurogenesis-and-oligodendrogenesis-in-multiple-sclerosis-a-systematic-review-of-human-and-animal-studies
#2
JOURNAL ARTICLE
Andreas Liampas, Vasilis-Spyridon Tseriotis, Artemios Artemiadis, Panagiotis Zis, Chrysanthi Argyropoulou, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, Georgios Vavougyios
INTRODUCTION: The subventricular zone promotes remyelination through activation differentiation of oligodendroglial precursor cells (OPCs) and neural stem cells (NSCs) into mature oligodendrocytes and thus in the adult brain. In Multiple Sclerosis (MS) this regenerative capability in halted resulting in neurodegeneration. We aimed to systematically search and synthesize evidence on mechanisms and phenomena associated with SVZ dysfunction in MS. MATERIALS AND METHODS: Our systematic review was reported according to the PRISMA-ScR statement...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38533839/dysphagia-therapy-in-adults-with-a-tracheostomy-a-scoping-review-protocol
#3
JOURNAL ARTICLE
Waiza Kadri, Rhiannon Halfpenny, Breege Whiten, Siofra Mulkerrin, Christina Smith
BACKGROUND: Swallowing impairment (dysphagia) and tracheostomy coexist. Research in this area has often provided an overview of dysphagia management as a whole, but there is limited information pertaining to specific dysphagia therapy in the tracheostomy population. The aim of this scoping review is to provide a detailed exploration of the literature with regard to dysphagia therapeutic interventions in adults with a tracheostomy. The scoping review will describe current evidence and thus facilitate future discussions to guide clinical practice...
March 27, 2024: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/38533692/systematic-review-of-studies-on-exposure-to-arsenic-in-drinking-water-and-cognitive-and-neurobehavioral-effects
#4
REVIEW
Paolo Boffetta, Luisa Sambati, Michele Sassano
An association between exposure to arsenic (As) and neurologic and behavioral effects has been reported in some studies, but no systematic review is available of the evidence linking As in drinking water and neurobehavioral effects after consideration of study quality and potential confounding, with focus on low-level circumstances of exposure. We conducted a systematic review and reported it in compliance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, through a search of the databases PubMed, Web of Science, Scopus, and Embase...
March 27, 2024: Critical Reviews in Toxicology
https://read.qxmd.com/read/38533170/keto-clarity-a-comprehensive-systematic-review-exploring-the-efficacy-safety-and-mechanisms-of-ketogenic-diet-in-pediatric-epilepsy
#5
REVIEW
Youmna Faheem, Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Ann Kashmer Yu
Epilepsy, a widespread neurological disorder characterized by recurrent seizures, affects millions globally, with a significant impact on the pediatric population. Antiepileptic drugs (AEDs) constitute the primary treatment; however, drug-resistant epilepsy (DRE), especially in children, poses a therapeutic challenge. Alternative interventions, such as surgery, vagus nerve stimulation, and the ketogenic diet (KD), have been explored. This systematic review aims to investigate various types of KDs, their distinctions, their effectiveness, and their safety concerning the reduction of seizure frequency, achieving seizure freedom, and the occurrence of adverse events...
February 2024: Curēus
https://read.qxmd.com/read/38532189/encephalitis-like-episodes-with-cortical-edema-and-enhancement-in-patients-with-neuronal-intranuclear-inclusion-disease
#6
JOURNAL ARTICLE
Yu Shen, Kaiyan Jiang, Hanlin Liang, Ying Xiong, Ziwei Song, Bo Wang, Min Zhu, Yusen Qiu, Dandan Tan, Chengsi Wu, Jianwen Deng, Zhaoxia Wang, Daojun Hong
OBJECTIVES: Neuronal intranuclear inclusion disease (NIID) exhibited significant clinical heterogeneities. However, the clinical features, radiographic changes, and prognosis of patients with encephalitis-like NIID have yet to be systematically elucidated. METHODS: Clinical data including medical history, physical examination, and laboratory examinations were collected and analyzed. Skin and sural nerve biopsies were conducted on the patient. Repeat-primed PCR (RP-PCR) and fluorescence amplicon length PCR (AL-PCR) were used to detect the expansion of CGG repeat...
March 26, 2024: Neurological Sciences
https://read.qxmd.com/read/38531575/survival-and-neurological-function-in-patients-treated-with-extracorporeal-membrane-oxygenation-and-therapeutic-hypothermia-a-protocol-for-updating-a-systematic-review
#7
JOURNAL ARTICLE
Pengfei Cheng, Haizhen Wang, Luyao Guo, Meiling Wang, He Xu, Peipei Gu, Jinjing Wu, Minfei Yang
INTRODUCTION: The widespread application of extracorporeal membrane oxygenation (ECMO) has enhanced clinical outcomes for patients experiencing cardiac arrest. However, its effectiveness is still limited and falls short of the desired level. Therapeutic hypothermia, which maintains body temperatures between 32°C and 36°C in cardiac arrest patients treated with ECMO, has been proposed as a potential means of neuroprotection and increased survival rates. Nevertheless, it remains controversial, and its impact on patient complications has yet to be fully understood...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531246/early-adolescent-development-in-the-face-of-violence-a-systematic-review-running
#8
REVIEW
Emma Jagasia, India Bloom, Katie E Nelson, Jacquelyn Campbell
BACKGROUND: Exposure to violence has severe and lasting effects on development. Despite the body of research examining childhood exposures to violence and victimization, developmental outcomes during early adolescence are poorly understood. OBJECTIVE: To synthesize existing research on the effects of violence exposure on early adolescent development (youth 9-14 years old) and highlight areas for future research. METHOD: We conducted a systematic search of PubMed, CINAHL, Web of Science, Scopus, and EMBASE for articles published between 2012 and 2023...
March 25, 2024: Child Abuse & Neglect
https://read.qxmd.com/read/38531194/safety-of-local-anesthesia-in-endovascular-treatment-of-aneurysms-a-systematic-review-and-meta-analysis
#9
REVIEW
Sávio Batista, Marcio Yuri Ferreira, Jordana Borges, Leonardo de Barros Oliveira, Eric Slawka, Raphael Bertani, Raphael Muszkat Besborodco, Jhon E Bocanegra-Becerra, Dan Zimelewicz Oberman, José Alberto Almeida Filho
BACKGROUND: Endovascular treatment of intracranial aneurysms (EVTIAs) is increasingly popular due to its minimally invasive nature and high success rate. While general anesthesia (GA) has been the historical preference for EVTIAs, there's growing interest in local anesthesia (LA). However, concerns persist about LA safety for EVTIAs. Therefore, we conducted a systematic review and meta-analysis to assess LA safety for EVTIAs. METHODS: Following PRISMA guidelines, we searched PubMed, Embase, and Web of Science databases...
March 25, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38531021/neurodevelopmental-and-functional-outcomes-following-in-utero-exposure-to-antiseizure-medication-a-systematic-review
#10
JOURNAL ARTICLE
Eliza Honybun, Emily Cockle, Charles B Malpas, Terence J O'Brien, Frank J Vajda, Piero Perucca, Genevieve Rayner
BACKGROUND AND OBJECTIVES: To undertake a systematic review of the available literature to examine the relationship between prenatal antiseizure medication (ASM) exposure and adverse postnatal neurodevelopmental outcomes, focusing on social, emotional, behavioral, and adaptive domains of human function, and the frequency of neurodevelopmental and psychiatric disorders in ASM-exposed offspring. METHODS: Electronic searches of MEDLINE, PsychINFO, and EMBASE were conducted and limited to studies published between 1990 and 2023 in English...
April 23, 2024: Neurology
https://read.qxmd.com/read/38531010/covert-cerebrovascular-changes-in-people-with-heart-disease-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Zien Zhou, Shoujiang You, Yuki Sakamoto, Ying Xu, Song Ding, Wenyi Xu, Wenjie Li, Jie Yu, Yanan Wang, Katie Harris, Candice Delcourt, Mathew J Reeves, Richard I Lindley, Mark W Parsons, Mark Woodward, Craig Anderson, Xin Du, Jun Pu, Joanna M Wardlaw, Cheryl Carcel
BACKGROUND AND OBJECTIVES: To determine the prevalence of silent brain infarction (SBI) and cerebral small vessel disease (CSVD) in adults with atrial fibrillation (AF), coronary artery disease, heart failure or cardiomyopathy, heart valve disease, and patent foramen ovale (PFO), with comparisons between those with and without recent stroke and an exploration of associations between heart disease and SBI/CSVD. METHODS: Medline, Embase, and Cochrane Library were systematically searched for hospital-based or community-based studies reporting SBI/CSVD in people with heart disease...
April 23, 2024: Neurology
https://read.qxmd.com/read/38530807/variables-included-in-cerebral-palsy-registries-globally-a-scoping-review
#12
REVIEW
Thembi J Katangwe, Mariana Kruger, Takondwa Chimowa, Innocent Maposa, Ronald Van Toorn, Regan Solomons, Kirsten A Donald
AIM: To identify cerebral palsy (CP) variables collected in CP registries from high-income countries (HICs) and low- and middle-income countries (LMICs) to assist with the development of a regional CP registry relevant to the African region. METHOD: A systematic search of online databases to identify peer-reviewed publications and grey literature about CP risk-factor variables, using Ovid MEDLINE, Embase Ovid, CINAHL, and Google Scholar. RESULTS: A total of 197 studies published from global CP registries between 1990 and 2023 were identified...
March 26, 2024: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38529956/moderate-traumatic-brain-injury-in-adult-population-the-latin-american-brain-injury-consortium-consensus-for-definition-and-categorization
#13
JOURNAL ARTICLE
Daniel Agustin Godoy, Andres M Rubiano, Sergio Aguilera, Manuel Jibaja, Walter Videtta, Maximiliano Rovegno, Jorge Paranhos, Eduardo Paranhos, Robson Luis Oliveira de Amorim, Ruy Castro Monteiro da Silva Filho, Wellingson Paiva, Jorge Flecha, Rodrigo Moreira Faleiro, David Almanza, Eliana Rodriguez, Jorge Carrizosa, Gregory W J Hawryluk, Alejandro A Rabinstein
Moderate traumatic brain injury (TBI) is a diagnosis that describes diverse patients with heterogeneity of primary injuries. Defined by a Glasgow Coma Scale between 9 and 12, this category includes patients who may neurologically worsen and require increasing intensive care resources and/or emergency neurosurgery. Despite the unique characteristics of these patients, there have not been specific guidelines published before this effort to support decision-making in these patients. A Delphi consensus group from the Latin American Brain Injury Consortium was established to generate recommendations related to the definition and categorization of moderate TBI...
March 26, 2024: Neurosurgery
https://read.qxmd.com/read/38529614/the-epidemiology-of-eye-illness-in-para-athletes-in-the-winter-and-summer-settings-a-systematic-review
#14
JOURNAL ARTICLE
Lovemore Kunorozva, Phoebe Runciman, Ali Ganai, Wayne E Derman
The aim of this systematic review was to evaluate eye illnesses in Para athletes in the Winter and Summer settings. A search was conducted using PubMed-Medline, EbscoHost, and Web of Science for full-text original research articles published anytime until November 2022. Studies that reported quantitative data on eye illness in highly active individuals and Para athletes, at any level of performance (elite/non-elite/recreational), aged 15-75 years were included. Of the eight studies included, two reported eye pathologies in athletes with visual impairment (VI) only, and six studies reported specific factors associated with eye illnesses in various impairments...
March 25, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38529035/disease-modifying-therapy-in-progressive-multiple-sclerosis-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#15
Xin Wu, Shixin Wang, Tao Xue, Xin Tan, Jiaxuan Li, Zhouqing Chen, Zhong Wang
BACKGROUND: Currently, disease-modifying therapies (DMTs) for progressive multiple sclerosis (PMS) are widely used in clinical practice. At the same time, there are a variety of drug options for DMTs, but the effect of the drugs that can better relieve symptoms and improve the prognosis are still inconclusive. OBJECTIVES: This systematic review aimed to evaluate the efficacy and safety of DMTs for PMS and to identify the best among these drugs. METHODS: MEDLINE, EMBASE, the Cochrane Library, and clinicaltrials...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38528450/the-effect-of-early-mobilisation-%C3%A2-14%C3%A2-days-on-pathophysiological-and-functional-outcomes-in-animals-with-induced-spinal-cord-injury-a-systematic-review-with-meta-analysis
#16
JOURNAL ARTICLE
Natalie Gray, Junaid Shaikh, Alison Cowley, Vicky Goosey-Tolfrey, Pip Logan, Nasir Quraishi, Vicky Booth
INTRODUCTION: The optimum time to mobilise (standing, walking) following spinal cord injury (SCI) is unknown but may have implications for patient outcomes. There are no high-quality experimental studies that examine this issue, with a paucity of guidance for clinicians. Pre-clinical studies lead research in this field and can contribute to knowledge and support future clinical practice. OBJECTIVE: to evaluate the effect of early compared to no mobilisation on pathophysiological and functional outcomes in animals with induced SCI...
March 25, 2024: BMC Neuroscience
https://read.qxmd.com/read/38527637/physical-activity-and-prevention-of-mental-health-complications-an-umbrella-review
#17
REVIEW
Masoud Rahmati, San Lee, Dong Keon Yon, Seung Won Lee, Raphael Udeh, Mark McEvoy, Hans Oh, Laurie Butler, Helen Keyes, Yvonne Barnett, Ai Koyanagi, Jae Il Shin, Lee Smith
The potential of physical activity in preventing mental health issues has garnered interest among health professionals. We conducted a systematic umbrella review of evidence supporting the relationship between physical activity and the prevention of mental health complications. Our findings revealed a significant association between higher physical activity levels and reduced risk of depression (OR = 0.77, 95% CI 0.72 - 0.82). This association was consistent across various age groups, sex, and geographical regions...
March 23, 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38526931/interventions-to-optimize-spinal-cord-perfusion-in-patients-with-acute-traumatic-spinal-cord-injury-an-updated-systematic-review
#18
JOURNAL ARTICLE
Nathan Evaniew, Benjamin Davies, Farzin Farahbakhsh, Michael G Fehlings, Mario Ganau, Daniel Graves, James D Guest, Radha Korupolu, Allan R Martin, Stephen L McKenna, Lindsay A Tetreault, Aditya Vedantam, Erika D Brodt, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Systematic review update. OBJECTIVES: Interventions that aim to optimize spinal cord perfusion are thought to play an important role in minimizing secondary ischemic damage and improving outcomes in patients with acute traumatic spinal cord injuries (SCIs). However, exactly how to optimize spinal cord perfusion and enhance neurologic recovery remains controversial. We performed an update of a recent systematic review (Evaniew et al, J. Neurotrauma 2020) to evaluate the effects of Mean Arterial Pressure (MAP) support or Spinal Cord Perfusion Pressure (SCPP) support on neurological recovery and rates of adverse events among patients with acute traumatic SCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526929/timing-of-decompressive-surgery-in-patients-with-acute-spinal-cord-injury-systematic-review-update
#19
JOURNAL ARTICLE
Michael G Fehlings, Laureen D Hachem, Lindsay A Tetreault, Andrea C Skelly, Joseph R Dettori, Erika D Brodt, Shay Stabler-Morris, Britt J Redick, Nathan Evaniew, Allan R Martin, Benjamin Davies, Farzin Farahbakhsh, James D Guest, Daniel Graves, Radha Korupolu, Stephen L McKenna, Brian K Kwon
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: Surgical decompression is a cornerstone in the management of patients with traumatic spinal cord injury (SCI); however, the influence of the timing of surgery on neurological recovery after acute SCI remains controversial. This systematic review aims to summarize current evidence on the effectiveness, safety, and cost-effectiveness of early (≤24 hours) or late (>24 hours) surgery in patients with acute traumatic SCI for all levels of the spine...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526927/definition-frequency-and-risk-factors-for-intra-operative-spinal-cord-injury-a-knowledge-synthesis
#20
JOURNAL ARTICLE
Michael G Fehlings, Ayesha Quddusi, Andrea C Skelly, Erika D Brodt, Ali Moghaddamjou, Anahita Malvea, Nader Hejrati, Nisaharan Srikandarajah, Mohammed Ali Alvi, Shay Stabler-Morris, Joseph R Dettori, Lindsay A Tetreault, Nathan Evaniew, Brian K Kwon
STUDY DESIGN: Mixed-methods approach. OBJECTIVES: Intra-operative spinal cord injury (ISCI) is a devastating complication of spinal surgery. Presently, a uniform definition for ISCI does not exist. Consequently, the reported frequency of ISCI and important risk factors vary in the existing literature. To address these gaps in knowledge, a mixed-methods knowledge synthesis was undertaken. METHODS: A scoping review was conducted to review the definitions used for ISCI and to ascertain the frequency of ISCI...
March 2024: Global Spine Journal
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