Michael J Yew, Sarah E Heywood, Joe Ng, Olivia M West, Martin Pal, Andrew Kueh, Graeme I Lancaster, Stephen Myers, Christine Yang, Yingying Liu, Saskia Reibe, Natalie A Mellett, Peter J Meikle, Mark A Febbraio, David W Greening, Brian G Drew, Darren C Henstridge
AIM: Acyl-coenzyme A dehydrogenase family member 10 (ACAD10) is a mitochondrial protein purported to be involved in the fatty acid oxidation pathway. Metformin is the most prescribed therapy for type 2 diabetes; however, its precise mechanisms of action(s) are still being uncovered. Upregulation of ACAD10 is a requirement for metformin's ability to inhibit growth in cancer cells and extend lifespan in Caenorhabditis elegans. However, it is unknown whether ACAD10 plays a role in metformin's metabolic actions...
February 13, 2024: Diabetes, Obesity & Metabolism