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Termination of pregnancy

Yun-Zhi Shi, Song Jin, Han Qin, Heng-Bo Jiang, Guo-Hua Song, Shu-Cun Qin
Dehydration is one of the intrauterine abnormalities that could lead to fetal growth retardation and to increase the risk of a variety of adult diseases later in life. This study were to determine the impact of hydrogen-rich water (HRW) supplementation on placental angiotensin II type 1 receptor and placental oxidative stress induced by water restriction. Pregnant Wistar rat were randomly assigned to one of the three groups ( n =12 per group). In control group, pure water and food were supplied ad libitum. Water restriction group and HRW group were respectively given pure water and HRW with free access to food, excepting only one hour was available for drinking from day 7 to day 17 of pregnancy...
July 2018: Medical Gas Research
Yinfeng Wang, Changchang Hu, Ningpin Pan, Chaolu Chen, Ruijin Wu
Objective This study was performed to assess whether prophylactic uterine artery embolization (UAE) is beneficial for second-trimester abortion with complete placenta previa (CPP). Methods Patients with CPP who underwent second-trimester pregnancy termination by labor induction with or without UAE from January 2010 to January 2018 were retrospectively reviewed. In total, 25 patients were eligible for analysis. The primary outcomes were the abortion success rate and bleeding volume, and the secondary outcomes were the induction-to-abortion time, length of hospital stay, and complications...
October 14, 2018: Journal of International Medical Research
Pranvera Zejnullahu Raçi, Lea Hošnjak, Mario Poljak, Snježana Židovec Lepej, Adriana Vince
OBJECTIVES: Kosovo's current health care system does not support organized nationwide cervical cancer screening and human papillomavirus (HPV) vaccination programs. To date, no reliable data are available on cervical cancer incidence and mortality in Kosovo, or on high-risk HPV (HR-HPV) prevalence and HPV type distribution. Our aim is to determinate the pre-vaccination prevalence and distribution of HR-HPVs and to assesses the associations between sociodemographic characteristics and increased risk of HPV infection in women from Kosovo...
2018: Ginekologia Polska
Craig C Morton, Amy Metcalfe, Kamran Yusuf, Barbara Sibbald, R Douglas Wilson
BACKGROUND & OBJECTIVES: Prenatal screening and diagnostic imaging advances have led to an increased detection of CNS anomalies, including ventriculomegaly/congenital hydrocephalus (HCP), Dandy-Walker malformation (DWM), and myelomeningocele (MMC). Data on pregnancy outcomes and the impact of prenatal diagnosis on neonatal outcomes is limited. Our study aimed to provide data on obstetric and neonatal outcomes following prenatal diagnosis of one of three CNS anomalies. METHODS: A retrospective search of two databases in Alberta, Canada and NICU chart review of cases between 2001 and 2011was completed...
October 10, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
L Tomasoni, G Messina, F Genco, L Scudeller, M Prestia, V Spinoni, C Bonfanti, F Prefumo, F Castelli, V Meroni
OBJECTIVES: Congenital toxoplasmosis (CT) affects 1-10 fetuses/10,000 live newborns in western countries. Without knowing pre-conception serostatus, it is hard to date the infection when anti-Toxoplasma IgG and IgM antibodies are positive at first screening. While a high IgG avidity index (AI) in the first trimester excludes CT, the same cannot be said of intermediate and low AI. The aim of this study was to estimate the risk of CT when intermediate or low AI is detected in the first trimester of pregnancy...
October 10, 2018: Clinical Microbiology and Infection
Philipp Velicky, Gudrun Meinhardt, Kerstin Plessl, Sigrid Vondra, Tamara Weiss, Peter Haslinger, Thomas Lendl, Karin Aumayr, Mario Mairhofer, Xiaowei Zhu, Birgit Schütz, Roberta L Hannibal, Robert Lindau, Beatrix Weil, Jan Ernerudh, Jürgen Neesen, Gerda Egger, Mario Mikula, Clemens Röhrl, Alexander E Urban, Julie Baker, Martin Knöfler, Jürgen Pollheimer
Genome amplification and cellular senescence are commonly associated with pathological processes. While physiological roles for polyploidization and senescence have been described in mouse development, controversy exists over their significance in humans. Here, we describe tetraploidization and senescence as phenomena of normal human placenta development. During pregnancy, placental extravillous trophoblasts (EVTs) invade the pregnant endometrium, termed decidua, to establish an adapted microenvironment required for the developing embryo...
October 12, 2018: PLoS Genetics
Jennifer A Hutcheon, Susan Moskosky, Cande V Ananth, Olga Basso, Peter A Briss, Cynthia D Ferré, Brittni N Frederiksen, Sam Harper, Sonia Hernández-Díaz, Ashley H Hirai, Russell S Kirby, Mark A Klebanoff, Laura Lindberg, Sunni L Mumford, Heidi D Nelson, Robert W Platt, Lauren M Rossen, Alison M Stuebe, Marie E Thoma, Catherine J Vladutiu, Katherine A Ahrens
BACKGROUND: Meta-analyses of observational studies have shown that women with a shorter interpregnancy interval (the time from delivery to start of a subsequent pregnancy) are more likely to experience adverse pregnancy outcomes, such as preterm delivery or small for gestational age birth, than women who space their births further apart. However, the studies used to inform these estimates have methodological shortcomings. METHODS: In this commentary, we summarise the discussions of an expert workgroup describing good practices for the design, analysis, and interpretation of observational studies of interpregnancy interval and adverse perinatal health outcomes...
October 12, 2018: Paediatric and Perinatal Epidemiology
Amy Reed-Sandoval
In response to the Eighth Amendment to the Constitution of Ireland, which states that the fetus and the mother have equal rights to life and that nearly all abortions are therefore illegal, many Irish feminists sported luggage tags that read "HEALTHCARE NOT AIRFARE." The expression-which recently became a popular twitter hashtag for pro-choice citizens of Ireland leading up to the historic referendum to repeal that abortion ban-refers to the fact that pregnant women from Ireland have long been forced to travel to other European countries in order to legally terminate their pregnancies...
September 2018: Hastings Center Report
Agneta Wikman, Elisabeth Jalkesten, Gunilla Ajne, Petter Höglund, Anette Mörtberg, Eleonor Tiblad
BACKGROUND: The optimal strategy to monitor RhD-immunized pregnancies is not evident. Whether a quantitative analysis of anti-D antibodies adds valuable information to anti-D titre is unclear. The aim of this study was to evaluate the relevance of anti-D quantification in routine monitoring of RhD-immunized pregnancies. MATERIALS AND METHODS: In a retrospective study, 64 consecutive pregnancies in 61 immunized women with anti-D titre ≥128 at any time during pregnancy were included...
October 11, 2018: Vox Sanguinis
Katherine A Johansen Taber, Kyle A Beauchamp, Gabriel A Lazarin, Dale Muzzey, Aishwarya Arjunan, James D Goldberg
PURPOSE: Expanded carrier screening (ECS) informs couples of their risk of having offspring affected by certain genetic conditions. Limited data exists assessing the actions and reproductive outcomes of at-risk couples (ARCs). We describe the impact of ECS on planned and actual pregnancy management in the largest sample of ARCs studied to date. METHODS: Couples who elected ECS and were found to be at high risk of having a pregnancy affected by at least one of 176 genetic conditions were invited to complete a survey about their actions and pregnancy management...
October 11, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Olga Grechukhina, Uma Deshmukh, Linda Fan, Katherine Kohari, Sonya Abdel-Razeq, Mert Ozan Bahtiyar, Anna K Sfakianaki
OBJECTIVE: To describe the treatment and subsequent pregnancy outcomes in patients with cesarean scar pregnancies at a single institution over 5 years. METHODS: This is a case series of all cesarean scar pregnancies diagnosed from May 2013 to March 2018 at Yale-New Haven Hospital. Data were collected on each patient using electronic medical record review and included patient demographics; medical, surgical, and obstetric history; pregnancy characteristics; treatment modalities used; response to therapy; complications; and subsequent pregnancy outcomes...
October 5, 2018: Obstetrics and Gynecology
Jason C Carson, Lori Hoffner, Laura Conlin, W Tony Parks, Rosemary A Fisher, Nancy Spinner, Svetlana A Yatsenko, Jeffrey Bonadio, Urvashi Surti
Triploidy is the presence of an extra haploid set of chromosomes and can exist in complete or mosaic form. The extra haploid set of chromosomes in triploid cells can be of maternal or paternal origin. Diploid/triploid mixoploidy is a unique form of triploid mosaicism that requires the aberrant segregation of entire parental genomes into distinct blastomere lineages (heterogoneic cell division) at the earliest zygotic divisions. Here we report on eight cases of diploid/triploid mixoploidy from our institution and conduct a comprehensive review of the literature...
October 10, 2018: American Journal of Medical Genetics. Part A
Atakan Tanacan, Canan Unal, Halise Meltem Yucesoy, Sinem Ayse Duru, Mehmet Sinan Beksac
PURPOSE: To evaluate the clinical characteristics, obstetric/neonatal outcomes, and pregnancy complications of pregnant women with Takayasu arteritis (TA). METHODS: We retrospectively evaluated the data of 22 pregnancies of 11 patients with TA between January 1 2000, and December 31 2017. Patient characteristics, severity of disease, obstetric outcomes, pregnancy complications, mode of delivery, and neonatal outcomes were evaluated. RESULTS: Based on the angiographic classification, four, two, one, three, and one patient were classified into groups I, IIa, III, IV, and V, respectively...
October 9, 2018: Archives of Gynecology and Obstetrics
Lucy E Higgins, Alexander E P Heazell, Melissa K Whitworth
BACKGROUND: The UK Medical Certificate of Stillbirth (MCS) records information relevant to the cause of stillbirth of infants ≥24 weeks' gestation. A cross-sectional audit demonstrated widespread inaccuracies in MCS completion in 2009 in North West England. A repeat study was conducted to assess whether practice had improved following introduction of a regional care pathway. METHODS: 266 MCS issued in 14 North West England obstetric units during 2015 were studied retrospectively...
September 2018: Paediatric and Perinatal Epidemiology
Elizabeth Quinlan-Jones, Jenny Lord, Denise Williams, Sue Hamilton, Tamas Marton, Ruth Y Eberhardt, Gabriele Rinck, Elena Prigmore, Rebecca Keelagher, Dominic J McMullan, Eamonn R Maher, Matthew E Hurles, Mark D Kilby
PURPOSE: To determine the diagnostic yield of combined exome sequencing (ES) and autopsy in fetuses/neonates with prenatally identified structural anomalies resulting in termination of pregnancy, intrauterine, neonatal, or early infant death. METHODS: ES was undertaken in 27 proband/parent trios following full autopsy. Candidate pathogenic variants were classified by a multidisciplinary clinical review panel using American College of Medical Genetics and Genomics (ACMG) guidelines...
October 8, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Z L Bao, J Zhang
Objective: To summarize and analyze the methods of termination of pregnancy in the first and second trimester of pregnancy with severe cardiovascular disease. Methods: A retrospective analysis of 27 cases of termination of pregnancy in the first and second trimester of pregnancy in Beijing Anzhen Hospital from January 1, 2016 to December 30, 2017. All of these pregnant women were pregnancy complicated with severe cardiovascular disease in grade Ⅴ pregnancy risk. Results: (1) The age of 27 pregnant women was 22-40 years, gestational age was 6-27 weeks; cardiac function grade before induced labor was: 5 cases of grade Ⅱ, 15 cases of grade Ⅲ, 7 cases of grade Ⅳ...
September 25, 2018: Zhonghua Fu Chan Ke za Zhi
(no author information available yet)
No abstract text is available yet for this article.
September 25, 2018: Zhonghua Fu Chan Ke za Zhi
Tianhua Huang, Shelley Dougan, Mark Walker, Christine M Armour, Nan Okun
BACKGROUND: In 2014, Ontario augmented its publicly funded multiple-marker screening program for prenatal aneuploidy by incorporating cell-free fetal DNA (cffDNA) analysis for high-risk pregnancies. We assessed trends in the use of multiple-marker screening, cffDNA screening and prenatal diagnostic testing before and after implementation of public funding. METHODS: We conducted a descriptive study based on data from the Better Outcomes Registry & Network (BORN) Ontario...
October 2018: CMAJ Open
Patrizia Rovere-Querini, Valentina Canti, Roberta Erra, Esperia Bianchi, Giorgio Slaviero, Armando D'Angelo, Susanna Rosa, Massimo Candiani, Maria Teresa Castiglioni
RATIONALE: Hypercoagulability and pregnancy morbidity are hallmarks of the antiphospholipid syndrome (APS). Catastrophic antiphospholipid syndrome (CAPS) is a potentially life-threatening omplication of APS, with widespread acute thrombotic microangiopathy (TMA) that can be precipitated by pregnancy and delivery and result in multiorgan damage. Unrestrained activation of the complement cascade is involved, favoring endothelial activation, tissue factor expression by leukocytes, and platelet aggregation...
October 2018: Medicine (Baltimore)
Sharin Baldwin, Mary Malone, Jane Sandall, Debra Bick
OBJECTIVE: The aim of this systematic review was to identify and synthesize the best available evidence on first time fathers' experiences and needs in relation to their mental health and wellbeing during their transition to fatherhood. INTRODUCTION: Men's mental health and wellbeing during their transition to fatherhood is an important public health issue that is currently under-researched from a qualitative perspective and poorly understood. INCLUSION CRITERIA: Resident first time fathers (biological and non-biological) of healthy babies born with no identified terminal or long-term conditions were included...
October 4, 2018: JBI Database of Systematic Reviews and Implementation Reports
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