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Termination of pregnancy

Rakesh Gupta, Ruby Nimesh, Girdhari Lal Singal, Parveen Bhalla, Shankar Prinja
The Government of India launched a nationwide programme to save and educate the girl child, Beti Bachao Beti Padhao (B3P), by stringent prohibition of sex-selective abortion, enforcement of Preconception and Prenatal Diagnostic Technique (PC-PNDT) and Medical Termination of Pregnancy (MTP) Acts, and social mobilization. We undertook this study to assess the effectiveness of intervention in Haryana state to improve sex ratio at birth (SRB). The monthly data on SRB (represented as girls per 1000 boys) were collected from civil registration system for the entire state of Haryana to evaluate the impact of B3P programme...
August 8, 2018: Health Policy and Planning
Manu Banadakoppa, Meena Balakrishnan, Chandra Yallampalli
PROBLEM: Antiangiogenic molecule soluble fms-like tyrosine kinase receptor 1 (sFLT1) released from trophoblast cells is associated with pregnancy-specific hypertensive disorder pre-eclampsia. Cause of elevated sFLT1 in pre-eclampsia patients is not well understood. Despite evidence of excess systemic and placental complement activation in pre-eclampsia patients, its role in pathophysiology is not clear. If the complement activation plays a role in upregulation and secretion of sFLT1 is not known...
August 12, 2018: American Journal of Reproductive Immunology: AJRI
Yuan Peng, Yuman Li, Haiyan Cao, Liu Hong, Yu Wang, Mingxing Xie
A pulmonary artery (PA) sling is a very rare congenital cardiovascular anomaly, and only a few studies have reported PA slings in fetuses. The relationship of the PA, aorta, ductus arteriosus, and trachea can be evaluated in the 3-vessel and 3-vessel and trachea views during fetal echocardiography. A PA sling can be detected by abnormal positioning of the left PA in relation to the trachea when sweeping from the 3-vessel view cranially to the 3-vessel and trachea view. Here we report 3 cases of fetal PA slings and their follow-ups...
August 12, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Mehmet Ozgur Akkurt, Iltac Akkurt, And Yavuz, Serenat Eris Yalcin, Bora Coskun, Mekin Sezik
AIM: To evaluate the effect of intracardiac potassium chloride feticide procedure (FP) on the induction-to-abortion (I-to-A) interval for various indications in the termination of pregnancy. METHOD: Medically indicated abortions between 17 and 28 weeks' gestation were retrospectively evaluated and allocated into 2 groups: Cases with (group 1, n = 58) or without an FP (group 2, n = 60). I-to-A intervals were compared across the groups, considering different baseline parameters and fetal abnormality categories...
August 10, 2018: Gynecologic and Obstetric Investigation
Shanshan Shi, Xiaomei Tang, Zijian Shi, Qingbing Zha, Ying Cheng, Zhanhui Zhang, Xiaomin Xiao, Yandong Yang, Yuanzong Song
OBJECTIVE: To detect mutations of SLC25A13 gene in 20 families affected with citrin deficiency and provide prenatal diagnosis for them. METHODS: The 20 probands and their parents were subjected to high-frequency mutation screening combined with Sanger sequencing. After confirming the genotype of each pedigree, genetic counseling and prenatal diagnosis were performed for their subsequent pregnancies. RESULTS: Biallelic pathogenic mutations of the SLC25A13 gene were identified in all probands...
August 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Olusola Oladeji, Bibilola Oladeji, Dick Chamla, Garba Safiyanu, Sule Mele, Helni Mshelia, John Agbor
Sexual violence is quite common in conflict situations and puts women at risk of unintended pregnancies. In the northeast region of Nigeria with the ongoing insurgency, a substantial number of women are kidnapped and subjected to forced marriages and repeated sexual assaults. This study set out to report on the disclosure and outcomes of sexual violence-related pregnancies (SVRPs) among women liberated from insurgents and relocated to one of largest Internally Displaced Persons (IDP) camps located in Borno State, northeast Nigeria...
August 10, 2018: Journal of Interpersonal Violence
Kazuya Mimura, Masayuki Endo, Keiko Matsuoka, Takuji Tomimatsu, Yuko Tazuke, Hiroomi Okuyama, Makoto Takeuchi, Tadashi Kimura
Congenital rachischisis and brachioesophagus with secondary intrathoracic stomach, which is described as "serpentine-like syndrome", is a very rare condition. We report the prenatal findings of serpentine-like syndrome in a fetus at 18 weeks of gestation. The stomach was entirely elevated into the thoracic area, but the liver retained its normal position. Our initial diagnosis was isolated left congenital diaphragmatic hernia (CDH). At 20 weeks of gestation, the pregnancy was terminated, and a male newborn weighing 338 g was vaginally delivered...
August 9, 2018: Journal of Medical Ultrasonics
Jennifer Scott, Monica A Onyango, Gillian Burkhardt, Colleen Mullen, Shada Rouhani, Sadia Haider, Katherine Albutt, Ashley Greiner, Michael VanRooyen, Susan Bartels
BACKGROUND: Sexual violence is prevalent in conflict-affected settings and may result in sexual violence-related pregnancies (SVRPs). There are limited data on how women with SVRPs make decisions about pregnancy continuation or termination, especially in contexts with limited or restricted access to comprehensive reproductive health services. METHODS: A qualitative study was conducted in Bukavu, Democratic Republic of the Congo (DRC) as part of a larger mixed methods study in 2012...
August 8, 2018: BMC Pregnancy and Childbirth
Trinadha Rao Sornapudi, Rakhee Nayak, Prashanth Kumar Guthikonda, Anil Kumar Pasupulati, Srinivas Kethavath, Vanita Uppada, Sukalpa Mondal, Sailu Yellaboina, Sreenivasulu Kurukuti
The development of mammary gland as a lactogenic tissue is a highly coordinated multistep process. The epithelial cells of lactiferous tubules undergo profound changes during the developmental window of puberty, pregnancy, and lactation. Several hormones including estrogen, progesterone, glucocorticoids and prolactin act in concert, and orchestrate the development of mammary gland. Understanding the gene regulatory networks that coordinate proliferation and differentiation of HC11 Mammary Epithelial stem-like Cells (MEC) under the influence of lactogenic hormones is critical for elucidating the mechanism of lactogenesis in detail...
August 6, 2018: Scientific Reports
Per Damkier, Louise Skov Christensen, Anne Broe
AIMS: To analyze prescribing patterns during pregnancy for antipsychotics (AP), antidepressants (AD) and mood-stabilizing antiepileptics (AEDs) in Denmark from 2000-2016. METHODS: Data were obtained from the Danish Medical Birth Register, the Register for Legally Induced Abortions, the Danish National Patient Register and the Register of Medicinal Product Statistics. Data were linked through a unique personal identifier (CPR) by Statistics Denmark. RESULTS: The use of antipsychotics (AP) increased 2...
August 5, 2018: British Journal of Clinical Pharmacology
Chaitra Venkataswamy, Umamaheswari Gurusamy, S Vidhya Lakshmi
OBJECTIVES: The objective of this study is to analyze the second-trimester fetal autopsies and to reemphasize the role of autopsy by comparing autopsy findings with prenatal ultrasound observations. MATERIALS AND METHODS: Retrospective analysis of second-trimester fetal autopsies over a period of 7.5 years (January 2009-June 2016). A standard protocol of autopsy procedure was followed, which included external examination with photography, X-ray, internal examination, and histopathological examination...
July 2018: Journal of Laboratory Physicians
Pawel Szulc, Kim Naylor, Marie-Eva Pickering, Nicholas Hoyle, Richard Eastell, Elizabeth Leary
The International osteoporosis foundation and the International federation of clinical chemistry (IFCC) Bone marker standards working group have identified N-terminal propeptide of type I procollagen (PINP) and C-terminal telopeptide of type I collagen (CTX-I) in blood to be the reference markers of bone turnover for the fracture risk prediction and monitoring of osteoporosis treatment. Although used in clinical research for many years, bone turnover markers (BTM) have not been widely adopted in clinical practice primarily due to their poor within-subject and between-lab reproducibility...
August 1, 2018: Annales de Biologie Clinique
Donghua Xie, Junqun Fang, Zhiyu Liu, Hua Wang, Tubao Yang, Zhenqiu Sun, Aihua Wang, Lili Xiong
Congenital heart defects (CHDs) are the most common birth defects (BDs) and account for nearly one-third of all BDs. The aim of this article was to investigate the epidemiology and major subtypes of CHDs in Hunan Province, China in the last 5 years.CHD surveillance data from 2012 to 2016 were collected from 52 registered hospitals in Hunan. The prevalence rates of CHDs, incidence rates of CHDs combined with other BDs, and rates of termination of pregnancy (TOP) for CHDs among different regions, infant sexes, and maternal ages were calculated for both early fetuses (<28 weeks of gestation) and perinatal infants (PIs) (between 28 weeks of gestation and 7 days after birth)...
August 2018: Medicine (Baltimore)
Brandy Lamb, Erin Johnson, Leslie Francis, Melinda Fagan, Naomi Riches, Isabella Canada, Alena Wilson, Amber Mathiesen, Maya Sabatello, Shawn Gurtcheff, Erica Johnstone, Erin Rothwell
PURPOSE: Embryo testing to improve pregnancy outcomes among individuals who are seeking assisted reproduction technologies is increasing. The purpose of this study was to assess decisional factors through in-depth interviews for why women would accept or decline preimplantation genetic testing for aneuploidy (PGT-A) with in vitro fertilization (IVF). METHODS: Semi-structured telephone interviews were conducted with 37 women who were offered PGT-A with IVF during the summer 2017...
August 3, 2018: Journal of Assisted Reproduction and Genetics
Tadele Girum, Abebaw Wasie
Introduction: Along with increasing availability and utilization of contraception, It is also important to confirm that the effects of contraception use on resumption of fertility after discontinuation However currently evidences on resumption of fertility after contraception use are inconclusive and practically fertility after termination of contraception remains a big concern for women who are using contraception. This fear poses a negative impact on utilization and continuation of contraception...
2018: Contraception and Reproductive Medicine
S Kariv, F Azibani, J Baard, A Osman, P Soma-Pillay, J Anthony, K Sliwa
OBJECTIVE: To document maternal and foetal morbidity and mortality in anticoagulated, pregnant patients with mechanical heart valves until 42 days postpartum. METHODS: In a tertiary single-centre, prospective cohort, 178 consecutive patients at the cardiac-obstetric clinic were screened for warfarin use between 1 July 2010 and 31 December 2015. Of 33 pregnancies identified, 29 were included. Patients received intravenous unfractionated heparin from six to 12 weeks' gestation and peripartum, and warfarin from 12 to 36 weeks...
June 13, 2018: Cardiovascular Journal of Africa
Takeshi Umazume, Takahiro Yamada, Satoshi Yamada, Satoshi Ishikawa, Itsuko Furuta, Hiroyuki Iwano, Daisuke Murai, Taichi Hayashi, Kazunori Okada, Mamoru Morikawa, Takashi Yamada, Kota Ono, Hiroyuki Tsutsui, Hisanori Minakami
Objective: This longitudinal study was performed to determine changes in echocardiography parameters in association with various biomarker levels in pregnancy/postpartum. Methods: Fifty-one healthy pregnant women underwent echocardiography with simultaneous determination of blood levels of five biomarkers at each of the first, second and third trimesters of pregnancy, immediately postpartum within 1 week after childbirth and approximately 1 month postpartum...
2018: Open Heart
Tereza Cindrova-Davies, Norah M E Fogarty, Carolyn J P Jones, John Kingdom, Graham J Burton
INTRODUCTION: Premature ageing has been implicated in placental dysfunction. Senescence can be activated by oxidative stress, a key intermediary in the pathophysiology of pre-eclampsia. We examined senescence markers across normal gestation, and in pathological and post-mature pregnancies. Inducers of oxidative stress were used to mimic senescence changes in term explants. METHODS: Placental samples were collected with ethical approval and informed consent: first and second trimester samples from surgical terminations; term and pre-term controls, and early-onset pre-eclampsia samples from caesarean deliveries...
August 2018: Placenta
Malvern Chiweshe, Catriona Macleod
Political discussions on abortion in Africa take place in the context of most countries having restrictive abortion legislation and high levels of unsafe abortion. In this paper two major political positions regarding abortion in Africa: a de-colonisation approach based on a homogenized view of "culture", and a liberal approach based on "choice" and rights are outlined. Using the Questions and Answers sessions of a United Nations event on maternal health in Africa as an exemplar of these positions, the paper argues that neither approach is emancipatory in the African context...
June 2018: African Journal of Reproductive Health
Nina D Paauw, A Titia Lely
Preeclampsia is a pregnancy-specific disorder complicating 2%-8% of pregnancies worldwide and characterized by de novo development of hypertension and proteinuria. Current understanding of the pathophysiology of preeclampsia is limited. A main feature is disrupted spiral artery remodeling in the placenta, which restricts the blood flow to the placenta, which in turn leads to decreased uteroplacental perfusion. Impaired blood flow through the placenta might result in fetal growth restriction and secretion of several factors by the placenta-mainly pro-inflammatory cytokines and anti-angiogenic factors-which spread into the maternal circulation, leading to endothelial dysfunction, which subsequently results in disrupted maternal hemodynamics...
2018: Advances in Experimental Medicine and Biology
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