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https://www.readbyqxmd.com/read/29679953/antinociception-by-the-anti-oxidized-phospholipid-antibody-e06
#1
Milad Mohammadi, Beatrice Oehler, Jan Kloka, Corinna Martin, Alexander Brack, Robert Blum, Heike L Rittner
BACKGROUND AND PURPOSE: Reactive oxygen species (ROS) and their downstream molecules such as oxidized phospholipids (OxPL) and 4-hydroxynonenal (4-HNE) activate transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) ion channels in vivo and in vitro shaping thermal and mechanical hypersensitivity in inflammatory pain. E06/T15 is a monoclonal autoantibody against oxidized phosphatidylcholine (OxPC) used in diagnostics in arteriosclerosis. Recently, we provided evidence that E06 also ameliorates inflammatory pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679944/epigallocatechin-3-gallate-attenuates-microcystin-lr-induced-apoptosis-in-human-umbilical-vein-endothelial-cells-through-activation-of-the-nrf2-ho-1-pathway
#2
Jun Shi, Min Zhang, Libin Zhang, Huipin Deng
Our previous study showed that the tea extract, epigallocatechin-3-gallate (EGCG), protects against microcystin-LR (MC-LR) -mediated apoptosis of human umbilical vein endothelial cells (HUVECs); however, the mechanism underlying MC-LR-induced HUVEC apoptosis remains incompletely understood. In this study, we investigated whether the nuclear factor erythroid-like 2 (NRF2)/heme oxygenase-1 (HO-1) pathway, which regulates antioxidant transcriptional regulation of oxidative stress and apoptosis, is involved in this process...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679934/nanopriming-with-zero-valent-iron-nzvi-enhances-germination-and-growth-in-aromatic-rice-cultivar-oryza-sativa-cv-gobindabhog-l
#3
Titir Guha, K V G Ravikumar, Amitava Mukherjee, Anita Mukherjee, Rita Kundu
Engineered nanoparticles are utilized in agriculture for various purposes. They can be used as fertilizer, carrier for macro/micro nutrients or priming agents. Various nanoparticles are reported to have toxicity at very high doses, but at optimum concentration, they can be beneficial for plant growth and development. In the present study, low concentrations of nZVI nanoparticles were evaluated for their growth enhancement potential as seed priming agent in an aromatic rice cultivar, Oryza sativa cv. Gobindabhog...
April 12, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29679930/mixed-culture-polyhydroxyalkanoate-pha-synthesis-from-nutrient-rich-wet-oxidation-liquors
#4
Suren Wijeyekoon, Carlo R Carere, Mark West, Shresta Nath, Daniel Gapes
Organic waste residues can be hydrothermally treated to produce organic acid rich liquors. These hydrothermal liquors are a potential feedstock for polyhydroxyalkanoate (PHA) production. We investigated the effect of dissolved oxygen concentration and substrate feeding regimes on PHA accumulation and yield using two hydrothermal liquors derived from a mixture of primary and secondary municipal wastewater treatment sludge and food waste. The enriched culture accumulated a maximum of 41% PHA of cell dry weight within 7 h; which is among the highest reported for N and P rich hydrothermal liquors...
April 12, 2018: Water Research
https://www.readbyqxmd.com/read/29679925/tocotrienol-rich-fraction-supplementation-reduces-hyperglycemia-induced-skeletal-muscle-damage-through-regulation-of-insulin-signaling-and-oxidative-stress-in-type-2-diabetic-mice
#5
Heaji Lee, Yunsook Lim
Chronic hyperglycemia induces impairment of muscle growth and development of diabetes mellitus (DM). Since skeletal muscle is the major site for disposal of ingested glucose, impaired glucose metabolism causes imbalance between protein synthesis and degradation which adversely affects physical mobility. In this study, we investigated the effect of tocotrienol-rich fraction (TRF) supplementation on skeletal muscle damage in diabetic mice. Diabetes was induced by a high-fat diet with streptozotocin (STZ) injection (100 mg/kg) in male C57BL/6J mice...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29679910/proteus-vulgaris-pt-electrode-system-for-urea-to-nitrogen-conversion-in-synthetic-urine
#6
Myreisa Morales-Cruz, Marjorie López-Nieves, Roberto Morales-Hernández, Gian C Rivera-Crespo, Gary A Toranzos, Ileana González-González, Carlos R Cabrera
One of the most challenging problems when trying to recycle urine for different purposes is the removal of urea. In this project we studied an ureolysis system using the bacterium Proteus vulgaris for the transformation of urea to ammonia and its subsequent oxidation to nitrogen at a Pt working electrode. Our system was tested under different pH, microbial reaction times, and urea and bacteria concentrations. Our results indicate that a pH8 is optimal for the combined Proteus vulgaris urease activity and the ammonia oxidation reaction at a Pt electrode...
April 4, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29679909/mechanisms-of-the-active-components-from-korean-pine-nut-preventing-and-treating-d-galactose-induced-aging-rats
#7
Jianmei Zhang, Weiwei Lin, Ruijun Wu, Yanmeng Liu, Kai Zhu, Jinyu Ren, Sufang Zhang, Xiaomei Ling
Age-related neuronal injury and oxidative damage are the predominant factors for neurodegenerative diseases like Alzheimer's disease (AD). The aim of this study was to explore whether chronic administration of d-galactose (d-gal) can cause neuronal injury and oxidative damage, and to investigate the neuroprotective and antioxidative effects of the active components (UPNO-1) from Korean pine nut (Pinus koraiensis). Two dosing regimens were designed, one for the evaluation of preventive effects in which the rats were simultaneously administrated d-gal and UPNO-1/fishoil for 12 weeks, the other for the evaluation of therapeutic effects in which the rats were given d-gal for 8 weeks before treated with UPNO-1/selegiline for 8 weeks...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679894/nicotinamide-riboside-attenuates-alcohol-induced-liver-injuries-via-activation-of-sirt1-pgc-1%C3%AE-mitochondrial-biosynthesis-pathway
#8
Sufan Wang, Ting Wan, Mingtong Ye, Yun Qiu, Lei Pei, Rui Jiang, Nengzhi Pang, Yuanling Huang, Baoxia Liang, Wenhua Ling, Xiaojun Lin, Zhenfeng Zhang, Lili Yang
BACKGROUND: Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD+ ) precursor which is present in foods such as milk and beer. It was reported that NR can prevent obesity, increase longevity, and promote liver regeneration. However, whether NR can prevent ethanol-induced liver injuries is not known. This study aimed to explore the effect of NR on ethanol induced liver injuries and the underlying mechanisms. METHODS: We fed C57BL/6 J mice with Lieber-DeCarli ethanol liquid diet with or without 400 mg/kg·bw NR for 16 days...
April 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679889/interpretation-of-60-co-radiation-effects-in-metal-oxide-semiconductors-in-terms-of-the-mobility-and-interface-trap-density-with-a-drain-current-gate-voltage-model
#9
Liu Changshi, Zhang Jianxin
The voltage-dependent current is a crucial parameter for determining the electrical properties of microelectronic devices. In this study, we aimed to extend a generic dc model to successfully explain the drain current (Id ) for metal-oxide semiconductors (MOSs) and thin-film transistors (TFTs) based on the gate voltage (Vg ), where the threshold voltage (Vth ) could also be obtained from this model in a nature manner. This dc model meets the requirements for compact modeling, including modeling computer circuit simulators...
April 4, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29679882/the-effect-of-resveratrol-on-glycation-and-oxidation-products-in-plasma-and-liver-of-chronic-methylglyoxal-treated-rats
#10
Zülbiye Yılmaz, Esra Betül Kalaz, A Fatih Aydın, Vakur Olgaç, Semra Doğru-Abbasoğlu, Müjdat Uysal, Necla Koçak-Toker
BACKGROUND: Methylglyoxal (MG) is a highly reactive dicarbonyl compound. It is produced by processes like glycolysis, glucose autooxidation, lipid peroxidation, and protein glycation. It is a major precursor of advanced glycation end products (AGE). It also exacerbates oxidative stress in the organism. Although there are some in vitro studies investigating the effect of resveratrol (RES) as an antioxidant and antiglycating agent on MG-induced toxicity, in vivo effect of RES is unknown...
December 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29679875/impurity-profiling-of-varenicline-tartrate-by-lc-qtof-mass-spectrometric-techniques-during-drug-development
#11
Yuting Lu, Xiyang Sun, Fan Song, Lei Wang, Min Song, Taijun Hang
An LC-QTOF-MS method was developed for the separation and characterization of related substances in varenicline tartrate. The separation was established on an InertSustain C18 column (4.6 mm × 150 mm, 5 μm) by liner gradient elution using 0.05% trifluoroacetic acid as mobile phase A and acetonitrile as mobile phase B. The degradation studies were conducted under the ICH prescribed stress conditions. Varenicline tartrate was found to be unstable to alkaline, oxidative, thermal and photolytic stresses, while relatively stable under acid stress condition...
April 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29679867/n-acetylcysteine-protects-against-microcystin-lr-induced-endoplasmic-reticulum-stress-and-germ-cell-apoptosis-in-zebrafish-testes
#12
Sujuan Zhao, Ying Liu, Fang Wang, Dexiang Xu, Ping Xie
Previous studies have shown that microcystin-LR (MCLR) is a reproductive toxicant that induces germ cell apoptosis in the testes, but the underlying mechanisms have not been well understood. In this study, we investigated that MCLR induces germ cell apoptosis is through activation of endoplasmic reticulum (ER) stress and N-acetylcysteine (NAC), an antioxidant could protect against germ cell apoptosis by inhibiting the ER stress. Healthy male zebrafish were intraperitoneally injected with NAC (500 nM), beginning at 2 h before different doses of MCLR (0, 50, 100, 200 μg/kg)...
April 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679858/anti-inflammatory-effect-of-apo-9-fucoxanthinone-via-inhibition-of-mapks-and-nf-kb-signaling-pathway-in-lps-stimulated-raw-264-7-macrophages-and-zebrafish-model
#13
Eun-A Kim, Seo-Young Kim, Bo-Ram Ye, Junseong Kim, Seok-Chun Ko, Won Woo Lee, Kil-Nam Kim, Il-Whan Choi, Won-Kyo Jung, Soo-Jin Heo
In this study, we confirmed the anti-inflammatory effect of Apo-9-fucoxanthinone (AF) in in vitro RAW 264.7 cells and in vivo zebrafish model. In lipopolysaccharide (LPS)-stimulated zebrafish, AF significantly decreased the production of reactive oxygen species (ROS), nitric oxide (NO) and cell death. In addition, the mRNA expression of inducible nitric oxide synthase (iNOS), suppressed cyclooxygenase-2 (COX-2) and an inflammatory cytokines; IL-1β, TNF-α were shown reduction. And AF significantly inhibited NO production and expression of iNOS in LPS-stimulated RAW 264...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679855/rutin-and-rutin-conjugated-gold-nanoparticles-ameliorate-collagen-induced-arthritis-in-rats-through-inhibition-of-nf-%C3%AE%C2%BAb-and-inos-activation
#14
Anum Gul, Bimal Kunwar, Maryam Mazhar, Shaheen Faizi, Dania Ahmed, Muhammad Raza Shah, Shabana U Simjee
Numerous studies have suggested that nuclear factor-κB (NF-κB) and inducible nitric oxide synthase (iNOS) are important mediators of inflammatory response in human and animal models of arthritis. Besides, oxidative stress markers, nitric oxide (NO) and peroxide (PO) are also major contributors in the pathogenesis of rheumatoid arthritis (RA). Over expression of these inflammatory mediators leads to the extracellular matrix degradation, and excessive cartilage and bone resorption, ultimately leading to the irreversible damage to joints...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679835/adsorption-mechanism-of-emerging-and-conventional-phenolic-compounds-on-graphene-oxide-nanoflakes-in-water
#15
Hepsiba Niruba Catherine, Ming-Han Ou, Basavaraju Manu, Yang-Hsin Shih
Emerging contaminants (ECs) such as bisphenol A (BPA), 4-nonylphenol (4-NP) and tetrabromobisphenol A (TBBPA) have gained immense attention worldwide due to their potential threat to humans and environment. Graphene oxide (GO) nanomaterial is considered as an important sorbent due to its exceptional range of environmental application owing to its unique properties. GO was also considered as one of ECs because of its potential hazard. The adsorption of organic contaminants such as phenolic ECs on GO affects the stability of GO nanoflakes in water and the fate of organic contaminants, which would cause further environmental risk...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679833/the-contribution-of-cattle-urine-and-dung-to-nitrous-oxide-emissions-quantification-of-country-specific-emission-factors-and-implications-for-national-inventories
#16
D R Chadwick, L M Cardenas, M S Dhanoa, N Donovan, T Misselbrook, J R Williams, R E Thorman, K L McGeough, C J Watson, M Bell, S G Anthony, R M Rees
Urine patches and dung pats from grazing livestock create hotspots for production and emission of the greenhouse gas, nitrous oxide (N2 O), and represent a large proportion of total N2 O emissions in many national agricultural greenhouse gas inventories. As such, there is much interest in developing country specific N2 O emission factors (EFs) for excretal nitrogen (EF3, pasture, range and paddock) deposited during gazing. The aims of this study were to generate separate N2 O emissions data for cattle derived urine and dung, to provide an evidence base for the generation of a country specific EF for the UK from this nitrogen source...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679831/nitrogen-fate-in-a-subtropical-mangrove-swamp-potential-association-with-seawater-groundwater-exchange
#17
Kai Xiao, Jiapeng Wu, Hailong Li, Yiguo Hong, Alicia M Wilson, Jiu Jimmy Jiao, Meghan Shananan
Coastal mangrove swamps play an important role in nutrient cycling at the land-ocean boundary. However, little is known about the role of periodic seawater-groundwater exchange in the nitrogen cycling processes. Seawater-groundwater exchange rates and inorganic nitrogen concentrations were investigated along a shore-perpendicular intertidal transect in Daya Bay, China. The intertidal transect comprises three hydrologic subzones (tidal creek, mangrove and bare mudflat zones), each with different physicochemical characteristics...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679819/submarine-groundwater-discharge-and-chemical-behavior-of-tracers-in-laizhou-bay-china
#18
Yan Zhang, Hailong Li, Xuejing Wang, Chaoyue Wang, Kai Xiao, Wenjing Qu
Naturally occurring radon (222 Rn) and radium isotopes are widely used to trace water mixing and submarine groundwater discharge (SGD) in the coastal zones. However, their activities in groundwater are variable both spatially and temporally. Here, time series sampling of 222 Rn and radium was conducted to investigate their behavior in intertidal groundwater of Laizhou Bay, China. The result shows that groundwater redox conditions have an important impact on the behavior of tracers. The activities of tracers will decrease under oxidizing conditions and increase under reducing conditions...
April 18, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29679812/protective-role-of-nimbolide-against-chemotherapeutic-drug-hydroxyurea-induced-genetic-and-oxidative-damage-in-an-animal-model
#19
Md Fahim Ahmad, Mohd Owais Ansari, Sana Jameel, Ab Latif Wani, Nuzhat Parveen, Hifzur R Siddique, G G H A Shadab
Nimbolide is known to be an antioxidant found in neem plant. Hydroxyurea is a medication frequently used in sickle-cell disease, different cancers and HIV infection. The present study aimed to evaluate the adverse effect of HU and possible amelioration by nimbolide in Wistar rats. To test our hypothesis, we performed genotoxicity tests, biochemical assays, and histopathological studies. We observed that HU caused higher levels of genotoxicity in the treated animals. The observed genetic and oxidative damage might be due to the presence of reactive species as HU increased the level of the malondialdehyde-a biomarker of oxidative damage...
April 12, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29679799/refolding-kinetics-of-cytochrome-c-studied-with-microsecond-timescale-continuous-flow-uv-vis-spectroscopy-and-rapid-freeze-quench-epr
#20
Batoul Srour, Marc J F Strampraad, Wilfred R Hagen, Peter-Leon Hagedoorn
The study of the structure, function, folding and conformational transitions of cytochrome c is of great interest because this protein plays an important role in biological electron transport and apoptosis. The different native and non-native conformations have been studied extensively under equilibrium conditions at different pH values, however, kinetic studies are rare because they require technically challenging rapid mixing and spectroscopic monitoring techniques. Here we present the refolding kinetics of acid denatured cytochrome c using the pH jump technique from pH 2 to pH 4...
April 11, 2018: Journal of Inorganic Biochemistry
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