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Vein pathology

Xin-Wen Ke, Xing Zeng, Xian Wei, Yuan-Qing Shen, Jia-Hua Gan, Ji-Hua Tian, Zhi-Quan Hu
This study was designed to explore the safety and feasibility of robotic-assisted laparoscopic nephrectomy with vein thrombectomy (RAL-NVT) for the treatment of renal cell carcinoma (RCC) with venous tumor thrombus (VTT). Clinical data of 6 patients treated with RAL-NVT between July 2016 and November 2017 in our hospital were retrospectively collected and analyzed. There were 5 males and 1 female with their age ranging from 48 years to 68 years. Five renal tumors were right-sided and one left-sided. Three cases fell in level 0 VTT, one in level I and two in level II...
October 2018: Current medical science
Feng Guo, Tianyou Li, Wei Liu, Gang Wang, Rui Ma, Rongde Wu
BACKGROUND: Wilms tumor is the most common renal tumor of childhood. Duplication of the inferior vena cava is an uncommon anomaly. In the present study, we present a case of Wilms tumor with the inferior vena cava duplication, which has not been reported previously. CASE PRESENTATION: A 14-month-old female presented with an enlarging abdominal mass. Computed tomography imaging demonstrated a large mass in the right kidney, duplication of the inferior vena cava below the renal veins and compression of the right inferior vena cava caused by the enormous mass...
October 19, 2018: BMC Urology
Radosław Pietura, Tomasz Smyk, Łukasz Tułecki, Andrzej Kleinrok, Michał Toborek, Andrzej Kutarski
No abstract text is available yet for this article.
2018: Kardiologia Polska
Nathan C Denham, Charles M Pearman, Jessica L Caldwell, George W P Madders, David A Eisner, Andrew W Trafford, Katharine M Dibb
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship exists between the two-AF exacerbates heart failure causing a significant increase in heart failure symptoms, admissions to hospital and cardiovascular death, while pathological remodeling of the atria as a result of heart failure increases the risk of AF. A comprehensive understanding of the pathophysiology of AF is essential if we are to break this vicious circle. In this review, the latest evidence will be presented showing a fundamental role for calcium in both the induction and maintenance of AF...
2018: Frontiers in Physiology
D M Rogers, L M Shah, R H Wiggins
BACKGROUND AND PURPOSE: Demyelination is a recently recognized cause of FLAIR hyperintensities associated with developmental venous anomalies. Our purpose was to quantify the prevalence of white matter signal abnormalities associated with developmental venous anomalies in patients with multiple sclerosis compared with controls. MATERIALS AND METHODS: A retrospective, blinded, multireader study compared the prevalence of FLAIR hyperintense signal abnormalities adjacent to developmental venous anomalies in patients with MS compared with controls (patients with developmental venous anomalies without MS)...
October 18, 2018: AJNR. American Journal of Neuroradiology
Nazife Dinc, Sae-Yeon Won, Nina Brawanski, Johanna Quick-Weller, Eva Herrmann, Volker Seifert, Gerhard Marquardt
To evaluate potential bleeding sources and predictive variables for basal ganglia hemorrhage. Fifty-seven patients with basal ganglia hemorrhage admitted to our neurosurgical ICU between 2005 and 2016 were retrospectively reviewed. Univariate and multivariate logistic analyses were used to assess predictive variables for identifying the bleeding source and outcome. ROC curves were plotted for a cutoff value for age and hematoma volume in patients with a vascular pathology and patients without a vascular pathology...
October 17, 2018: Neurosurgical Review
B Delahunt, J R Srigley, M J Judge, M B Amin, A Billis, P Camparo, A J Evans, S Fleming, D Griffiths, A Lopez-Beltran, G Martignoni, H Moch, J N Nacey, M Zhou
AIMS: The International Collaboration on Cancer Reporting (ICCR) has provided detailed datasets based upon the published reporting protocols of the Royal College of Pathologists, The Royal College of Pathologists of Australasia and the College of American Pathologists. METHODS AND RESULTS: The dataset for carcinomas of renal tubular origin treated by nephrectomy was developed to provide a minimum structured reporting template suitable for international use and incorporated recommendations from the 2012 Vancouver Consensus Conference of the International Society of Urological Pathology and the fourth edition of the World Health Organization Bluebook on tumours of the urinary and male genital systems published in 2016...
October 16, 2018: Histopathology
Sonia L Hernandez, Mildred Nelson, Georgia R Sampedro, Naina Bagrodia, Ann M Defnet, Bianca Lec, Jared Emolo, Rebecca Kirschner, Lydia Wu, Henry Biermann, Stephanie Shen, Juliane Bubeck Wardenburg, Jessica J Kandel
Staphylococcus aureus infection is one of the leading causes of morbidity in hospitalized patients in the United States, an effect compounded by increasing antibiotic resistance. The secreted agent hemolysin alpha toxin (Hla) requires the receptor A Disintegrin And Metalloproteinase domain-containing protein 10 (ADAM10) to mediate its toxic effects. We hypothesized that these effects are in part regulated by Notch signaling, for which ADAM10 activation is essential. Notch proteins function in developmental and pathological angiogenesis via the modulation of key pathways in endothelial and perivascular cells...
October 15, 2018: Angiogenesis
Michele Malaguarnera, Saverio Latteri, Gaetano Bertino, Roberto Madeddu, Vito Emanuele Catania, Giuseppe Currò, Antonio Maria Borzì, Filippo Drago, Giulia Malaguarnera
Purpose: Portal vein thrombosis (PVT) is one of the severe complications of hepatocellular carcinoma (HCC). PVT deteriorates the liver, and its dysfunction increases the risk of bleeding, influencing the prognosis of patients with liver cirrhosis and HCC. The aim of our study was to investigate whether D-dimer testing could be a sensitive marker for the diagnosis and prognosis of HCC patients with PVT. Patients and methods: Between June 2010 and December 2015, 118 HCC patients were admitted to Cannizzaro Hospital, Catania, and 50 controls were recruited from their relatives for health examinations...
2018: Clinical and Experimental Gastroenterology
Qian Zhang, Li-Xin Zhang, Jing An, Liang Yan, Cui-Cui Liu, Jing-Jing Zhao, Hao Yang
Flavonoids from Huangqin (dried roots of Scutellaria baicalensis Georgi) have anti-inflammatory effects, and are considered useful for treatment of spinal cord injury. To verify this hypothesis, the T9-10 spinal cord segments of rats were damaged using Allen's method to establish a rat spinal cord injury model. Before model establishment, Huangqin flavonoid extraction (12.5 g/kg) was administered intragastrically for 1 week until 28 days after model establishment. Methylprednisolone (30 mg/kg) was injected into the tail vein at 30 minutes after model establishment as a positive control...
December 2018: Neural Regeneration Research
Zheng Zhang, Jin-Long Yang, Lin-Lei Zhang, Zhen-Zhen Chen, Jia-Ou Chen, Yun-Gang Cao, Man Qu, Xin-Da Lin, Xun-Ming Ji, Zhao Han
We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin (2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI (3 mg/kg) through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion...
December 2018: Neural Regeneration Research
I S Mukhamadeev, A A Oborin
Described herein is a variant of surgical reconstruction performed in a male patient with a retroaortic position of the left renal vein by means of creating a vein-allograft-vein configuration. Unfortunately, to date, there are no generally accepted recommendations on proper treatment of patients presenting with similar pathology. A situation wherein it is impossible to create an intervenous anastomosis (because of a significantly altered portion of the vein and prestenotic dilataion) dictates the necessity of searching for new variants of surgical management...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
S G Gavrilov, D A Son, I S Lebedev, K Iu Savinkova, M D Temirbolatov
The work was based on the results of examination and treatment of 43 female patients presenting with varicose transformation of pelvic, perineal, and lower-limb veins. The inclusion criteria were as follows: the presence of visually determined varicose transformation of the veins of the external genital organs, perineum, posterior surface of the thighs, as well as valvular insufficiency of the mentioned veins by the findings of ultrasonographic angioscanning (USAS). The following exclusion criteria were applied: the presence of pregnancy, symptoms of pelvic venous plethora (PVP), and varicothrombophlebitis...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
O A Tsarev, A Iu Anisimov, F G Prokin, Iu V Mashchenko, A V Lobanov
The authors examined the effect of the presence of undifferentiated connective tissue dysplasia (UCTD) on the clinical course of lower-limb varicose veins (LLVV) and acute varicothrombophlebitis (AVTP) in patients after the Troyanov-Trendelenburg operation. We carried out a prospective comparative study of the remote results during three years after the Troyanov-Trendelenburg operation in a total of 132 patients suffering from AVTP. The Study Group included 67 patients found to have more than four phenotypic traits of UCTD, thus suggesting the presence of UCTD...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
E Iu Iupatov, I M Ignat'ev, E E Fomina
The problem of chronic venous insufficiency in women during pregnancy is of current concern. A total of 115 pregnant women in the first, second and third trimesters of gestation were examined in a stage-wise manner. During the first stage we conducted a comprehensive clinical study with the obligatory consultation by the obstetrician-gynaecologist. At the second stage, all women were subjected to ultrasonographic examination of the venous system of both lower extremities and the small pelvis. Studying the diameters of the deep veins of the right and left lower limbs, as well as the paired veins of the small pelvis demonstrated no statistically significant differences, which made it possible to evaluate these parameters as a whole...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Jing Han, Yang Tang, Mingjian Lu, Haiqing Hua
Background: Methionine aminopeptidase 2 (MetAP2) cleaves the initiator methionine from nascent peptides during translation. In both preclinical and clinical studies, the pharmacological inhibition of MetAP2 in obese subjects results in the suppression of food intake and body weight loss. However, the mechanism of action of body weight loss caused by MetAP2 inhibition remains to be elucidated, and the sites of action by pharmacological MetAP2 inhibition remain unknown. Methods: In the present study, a comprehensive analysis of the MetAP2 expression pattern in mice was performed...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Rogger P Carmen-Orozco, Danitza G Dávila-Villacorta, Yudith Cauna, Edson G Bernal-Teran, Leandra Bitterfeld, Graham L Sutherland, Nancy Chile, Rensson H Céliz, María C Ferrufino-Schmidt, Cesar M Gavídia, Charles R Sterling, Héctor H García, Robert H Gilman, Manuela Renee Verástegui
Neurocysticercosis (NCC) is a helminth infection affecting the central nervous system caused by the larval stage (cysticercus) of Taenia solium. Since vascular alteration and blood-brain barrier (BBB) disruption contribute to NCC pathology, it is postulated that angiogenesis could contribute to the pathology of this disease. This study used a rat model for NCC and evaluated the expression of two angiogenic factors called vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF2). Also, two markers for BBB disruption, the endothelial barrier antigen and immunoglobulin G, were evaluated using immunohistochemical and immunofluorescence techniques...
October 13, 2018: Journal of Neuroscience Research
Ying-Xin Qi, Yue Han, Zong-Lai Jiang
Vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) are constantly exposed to hemodynamic forces in vivo, including flow shear stress and cyclic stretch caused by the blood flow. Numerous researches revealed that during various cardiovascular diseases such as atherosclerosis, hypertension, and vein graft, abnormal (pathological) mechanical forces play crucial roles in the dysfunction of ECs and VSMCs, which is the fundamental process during both vascular homeostasis and remodeling. Hemodynamic forces trigger several membrane molecules and structures, such as integrin, ion channel, primary cilia, etc...
2018: Advances in Experimental Medicine and Biology
Songping Cui, Hui Li, Bo Tian, Chunfeng Song, Bin Hu
BACKGROUND: The Previous study has indicated that the incidence of venous thromboembolism (VTE) after lung cancer surgery is not uncommon. The aim of this study is to analyze the risk factors of postoperative VTE in lung cancer patients and provide a clinical basis for further prevention and treatment of VTE. METHODS: This study was a single-center study. From July 2016 to December 2017, all patients with lung cancer who underwent surgery in our department were enrolled into this study...
October 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Chunyu Yuan, Congsong Sun, Yexiang Sun, Qincheng Wang, Biao Wang, Chunhua Wang, Yizhong Tang, Delin Hu, Xingzhao Li, Junhui Song
OBJECTIVE: To explore the mechanism of hypertonic salt solution (HS) alleviates lung injury of rats at the early stage of severe scald. METHODS: Thirty-two female Sprague-Dawley (SD) rats were randomly assigned to sham group, lactated Ringer solution (LR) group, HS200 group (200 mmol/L HS group, 1 L 200 mmol/L HS contained 955 mL LR and 45 mL 10% NaCl) and HS400 group (400 mmol/L HS group, 1 L 400 mmol/L HS contained 846 mL LR and 154 mL 10% NaCl), with 8 rats in each group...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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