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ceramide TGf-beta

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https://www.readbyqxmd.com/read/29876372/fibroblast-and-keratinocyte-gene-expression-following-exposure-to-the-extracts-of-holy-basil-plant-ocimum-tenuiflorum-malabar-nut-plant-justicia-adhatoda-and-emblic-myrobalan-plant-phyllanthus-emblica
#1
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R G S Wijesekara
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of holy basil plant ( Ocimum tenuiflorum ), sri lankan local name "maduruthala", 0.1% and 0.01% extracts of malabar nut plant ( Justicia adhatoda ), sri lankan local name "adayhoda" and 0.003% and 0.001% extracts of emblic myrobalan plant ( Phyllanthus emblica ), sri lankan local name "nelli", harvested in Sri Lanka. For fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (HAS1), hyaluronan synthase 2 (HAS2), hyaluronidase-1 (HYAL1), hyaluronidase-2 (HYAL2), versican, aggrecan, CD44, collagen, type I, alpha 1 (COL1A1), collagen, type III, alpha 1 (COL3A1), collagen, type VII, alpha 1 (COL7A1), matrix metalloproteinase 1 (MMP1), acid ceramidase, basic fibroblast growth factor (bFGF), fibroblast growth factor-7 (FGF7), vascular endothelial growth factor (VEGF), interleukin-1 alpha (IL-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (TGF-β), and aquaporin 3 (AQP3)...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29322079/fibroblast-and-keratinocyte-gene-expression-following-exposure-to-extracts-of-neem-plant-azadirachta-indica
#2
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R G S Wijesekara
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name "Kohomba" in Sri Lanka, harvested in Sri Lanka. For fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (HAS1), hyaluronan synthase 2 (HAS2), hyaluronidase-1 (HYAL1), hyaluronidase-2 (HYAL2), versican, aggrecan, CD44, collagen, type I, alpha 1 (COL1A1), collagen, type III, alpha 1 (COL3A1), collagen, type VII, alpha 1 (COL7A1), matrix metalloproteinase 1 (MMP1), acid ceramidase, basic fibroblast growth factor (bFGF), fibroblast growth factor-7 (FGF7), vascular endothelial growth factor (VEGF), interleukin-1 alpha (IL-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (TGF-β), and aquaporin 3 (AQP3)...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/26251179/metabolomics-analysis-reveals-the-association-between-lipid-abnormalities-and-oxidative-stress-inflammation-fibrosis-and-nrf2-dysfunction-in-aristolochic-acid-induced-nephropathy
#3
Ying-Yong Zhao, Hui-Ling Wang, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin, Nosratola D Vaziri
Alternative medicines are commonly used for the disease prevention and treatment worldwide. Aristolochic acid (AAI) nephropathy (AAN) is a common and rapidly progressive interstitial nephropathy caused by ingestion of Aristolochia herbal medications. Available data on pathophysiology and molecular mechanisms of AAN are limited and were explored here. SD rats were randomized to AAN and control groups. AAN group was treated with AAI by oral gavage for 12 weeks and observed for additional 12 weeks. Kidneys were processed for histological evaluation, Western blotting, and metabolomics analyses using UPLC-QTOF/HDMS...
August 7, 2015: Scientific Reports
https://www.readbyqxmd.com/read/24758915/ceramide-inhibits-connective-tissue-growth-factor-expression-by-human-retinal-pigment-epithelial-cells
#4
Shozo Sonoda, Chandrasekharam N Nagineni, Mizuki Kitamura, Christine Spee, Ram Kannan, David R Hinton
Connective tissue growth factor (CTGF) is known to be involved in retinal fibrotic disorders. We used human retinal pigment epithelial cells (HRPE), which play critical roles in retinal fibrosis, to examine the expression of CTGF and its regulation by ceramide and TGF-β. Real-time PCR analysis showed downregulation of CTGF mRNA by C2 ceramide and upregulation by TGF-β. C2 ceramide also inhibited constitutive and TGF-β-enhanced CTGF secretion by HRPE cells. Predominant secretion (>80% of total) of CTGF from the apical side was observed in highly polarized HRPE cells...
August 2014: Cytokine
https://www.readbyqxmd.com/read/23313049/c6-ceramide-in-combination-with-transforming-growth-factor-%C3%AE-enhances-treg-cell-differentiation-and-stable-foxp3-expression-in-vitro-and-in-vivo
#5
Chin Siang Kue, Hui Xuan Lim, Mi Young Jung, Hye-Jin Hong, Daeho Cho, Tae Sung Kim
Ceramides, sphingosine-based lipid molecules, are generated mainly from the hydrolysis of sphingomyelin and play pivotal roles in biological processes including cell growth, differentiation, and inflammation. In this study, we investigated the effect of exogenous ceramides on the differentiation of regulatory T (Treg) cells and expression of FoxP3 gene in Treg cells. A cell-permeable C6-ceramide (C6) was capable of upregulating Treg cell differentiation when acting together with transforming growth factor-beta (TGF-β), and this induction was independent of T-cell receptor (TCR) and CD28 strength...
July 2013: Immunobiology
https://www.readbyqxmd.com/read/22882773/topical-application-of-phosphatidyl-inositol-3-5-bisphosphate-for-acute-lung-injury-in-neonatal-swine
#6
Stefanie Preuss, Friede D Omam, Julia Scheiermann, Sabrina Stadelmann, Supandi Winoto-Morbach, Philipp von Bismarck, Sabine Adam-Klages, Friederike Knerlich-Lukoschus, Dennis Lex, Daniela Wesch, Janka Held-Feindt, Stefan Uhlig, Stefan Schütze, Martin F Krause
Hypoxemic respiratory failure of the neonatal organism involves increased acid sphingomyelinase (aSMase) activity and production of ceramide, a second messenger of a pro-inflammatory pathway that promotes increased vascular permeability, surfactant alterations and alveolar epithelial apoptosis. We comparatively assessed the benefits of topical aSMase inhibition by either imipramine (Imi) or phosphatidylinositol-3,5-bisphosphate (PIP2) when administered into the airways together with surfactant (S) for fortification...
November 2012: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/22764777/beta-glucosidase-2-knockout-mice-with-increased-glucosylceramide-show-impaired-liver-regeneration
#7
Maria A Gonzalez-Carmona, Roger Sandhoff, Frank Tacke, Annabelle Vogt, Susanne Weber, Ali E Canbay, Gerhard Rogler, Tilman Sauerbruch, Frank Lammert, Yildiz Yildiz
BACKGROUND AND AIMS: Glycolipids have been shown to serve specialized functions in cell signalling, proliferation and differentiation processes, which are all important during liver regeneration. We previously generated beta-glucosidase 2 (GBA2) knockout mice that accumulate the glycolipid glucosylceramide in various tissues, including the liver. The present study addressed the role of GBA2-deficiency and subsequent glucosylceramide accumulation in liver regeneration. METHODS: Gba2 knockout and wild-type mice were subjected to two-third partial hepatectomy...
October 2012: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/22427838/invariant-natural-killer-t-cell-agonist-modulates-experimental-focal-and-segmental-glomerulosclerosis
#8
Rafael L Pereira, Vanessa O Reis, Patricia Semedo, Bruna N Buscariollo, Cassiano Donizetti-Oliveira, Marcos A Cenedeze, Maria Fernanda Soares, Alvaro Pacheco-Silva, Paul B Savage, Niels O S Câmara, Alexandre C Keller
A growing body of evidence demonstrates a correlation between Th2 cytokines and the development of focal and segmental glomerulosclerosis (FSGS). Therefore, we hypothesized that GSL-1, a monoglycosylceramide from Sphingomonas ssp. with pro-Th1 activity on invariant Natural Killer T (iNKT) lymphocytes, could counterbalance the Th2 profile and modulate glomerulosclerosis. Using an adriamycin(ADM)-based model of FSGS, we found that BALB/c mice presented albuminuria and glomerular degeneration in association with a Th2-like pro-fibrogenic profile; these mice also expressed a combination of inflammatory cytokines, such as IL-4, IL-1α, IL-1β, IL-17, TNF-α, and chemokines, such as RANTES and eotaxin...
2012: PloS One
https://www.readbyqxmd.com/read/21480330/lithocholic-acid-disrupts-phospholipid-and-sphingolipid-homeostasis-leading-to-cholestasis-in-mice
#9
Tsutomu Matsubara, Naoki Tanaka, Andrew D Patterson, Joo-Youn Cho, Kristopher W Krausz, Frank J Gonzalez
UNLABELLED: Lithocholic acid (LCA) is an endogenous compound associated with hepatic toxicity during cholestasis. LCA exposure in mice resulted in decreased serum lysophosphatidylcholine (LPC) and sphingomyelin levels due to elevated lysophosphatidylcholine acyltransferase (LPCAT) and sphingomyelin phosphodiesterase (SMPD) expression. Global metabolome analysis indicated significant decreases in serum palmitoyl-, stearoyl-, oleoyl-, and linoleoyl-LPC levels after LCA exposure. LCA treatment also resulted in decreased serum sphingomyelin levels and increased hepatic ceramide levels, and induction of LPCAT and SMPD messenger RNAs (mRNAs)...
April 2011: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/19936233/il-6-deficiency-attenuates-murine-diet-induced-non-alcoholic-steatohepatitis
#10
Emmanuel Mas, Marie Danjoux, Virginie Garcia, Stéphane Carpentier, Bruno Ségui, Thierry Levade
BACKGROUND: The role of inflammation in the pathogenesis of non-alcoholic steatohepatitis (NASH), a common cause of liver disease, is still poorly understood. This study aimed at assessing the involvement of a major inflammatory cytokine, IL-6, in NASH. MATERIALS AND METHODS: Steatohepatitis was induced by feeding wild-type or IL-6(-/-) mice for 5 weeks with a methionine and choline-deficient (MCD) diet. RESULTS: Whereas MCD diet-induced weight loss and decreases in serum glucose, cholesterol and triglyceride levels were similar in both genotypes, serum alanine aminotransferase was less elevated in IL-6(-/-) mice than in wild-type animals...
2009: PloS One
https://www.readbyqxmd.com/read/19276645/differential-effects-of-ceramide-on-cell-viability-and-extracellular-matrix-remodeling-in-keratinocytes-and-fibroblasts
#11
N Philips, M Tuason, T Chang, Y Lin, M Tahir, S G Rodriguez
Ceramides are used in skin care and treatment of dermatological diseases. Cell viability and extracellular matrix (ECM) remodeling are important parameters in skin health. Skin photoaging, from exposure to ultraviolet radiation, is associated with epidermal hyperplasia and dermal ECM atrophy caused by alterations in expression of matrixmetalloproteinases (MMPs), elastin and transforming growth factor-beta (TGF-beta). The purpose of this study was to determine the effects of c2-ceramide (ceramide) on the cell viability and expression of TGF-beta, MMP-1 and elastin in cultured keratinocytes and fibroblasts...
2009: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/19140218/natural-killer-t-cells-regulate-the-homing-of-chemokine-cxc-receptor-3-positive-regulatory-t-cells-to-the-liver-in-mice
#12
Tania Santodomingo-Garzon, Jinglan Han, Tai Le, Yang Yang, Mark G Swain
UNLABELLED: Natural killer T (NKT) cells and regulatory T cells (Tregs) are both found within the liver and are known to exhibit immune regulatory functions. Hepatic NKT cells are activated early during inflammatory responses and release cytokines, including interferon gamma (IFN-gamma), which we speculated could regulate Treg recruitment to the liver. To examine this, we treated C57BL/6 mice with a specific NKT cell activating ligand alpha galactosyl-C18-ceramide (alphaGal-C18-Cer) and examined the hepatic recruitment of Tregs...
April 2009: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/19037882/thyroid-transcription-factor-1-ttf-1-nkx2-1-titf1-gene-regulation-in-the-lung
#13
REVIEW
Vijay Boggaram
TTF-1 [thyroid transcription factor-1; also known as Nkx2.1, T/EBP (thyroid-specific-enhancer-binding protein) or TITF1] is a homeodomain-containing transcription factor essential for the morphogenesis and differentiation of the thyroid, lung and ventral forebrain. TTF-1 controls the expression of select genes in the thyroid, lung and the central nervous system. In the lung, TTF-1 controls the expression of surfactant proteins that are essential for lung stability and lung host defence. Human TTF-1 is encoded by a single gene located on chromosome 14 and is organized into two/three exons and one/two introns...
January 2009: Clinical Science (1979-)
https://www.readbyqxmd.com/read/19010461/murine-nkt-cells-produce-th17-cytokine-interleukin-22
#14
Megumi Goto, Masao Murakawa, Kumiko Kadoshima-Yamaoka, Yoshitaka Tanaka, Kazuhiro Nagahira, Yoshiaki Fukuda, Takashi Nishimura
Natural killer T (NKT) cells are known to produce Th17 cytokine IL-17 in addition to Th1/2 cytokines. In this study, the ability of NKT cells to produce IL-22, another Th17 cytokine, was examined in mice. When murine spleen cells were stimulated with alpha-galactosyl ceramide, a ligand for NKT cells, not only Th1/2 cytokines (IFN-gamma, IL-4) but Th17 cytokines (IL-17, IL-22) were produced. NKT cells isolated from splenocytes released IL-17 and IL-22 following CD3, CD3/IL-2 or CD3/CD28 stimulation, in which CD3/CD28 costimulation was most effective...
2009: Cellular Immunology
https://www.readbyqxmd.com/read/17522181/critical-role-for-sphingosine-kinase-1-in-regulating-survival-of-neuroblastoma-cells-exposed-to-amyloid-beta-peptide
#15
Anne Gomez-Brouchet, Dimitri Pchejetski, Leyre Brizuela, Virginie Garcia, Marie-Françoise Altié, Marie-Lise Maddelein, Marie-Bernadette Delisle, Olivier Cuvillier
We examined the role of sphingosine kinase-1 (SphK1), a critical regulator of the ceramide/sphingosine 1-phosphate (S1P) biostat, in the regulation of death and survival of SH-SY5Y neuroblastoma cells in response to amyloid beta (Abeta) peptide (25-35). Upon incubation with Abeta, SH-SY5Y cells displayed a marked down-regulation of SphK1 activity coupled with an increase in the ceramide/S1P ratio followed by cell death. This mechanism was redox-sensitive; N-acetylcysteine totally abrogated the down-regulation of SphK1 activity and strongly inhibited Abeta-induced cell death...
August 2007: Molecular Pharmacology
https://www.readbyqxmd.com/read/15630137/nkt-cells-promote-antibody-induced-joint-inflammation-by-suppressing-transforming-growth-factor-beta1-production
#16
COMPARATIVE STUDY
Hye Young Kim, Hyun Jung Kim, Hye Sook Min, Sanghee Kim, Weon Seo Park, Seong Hoe Park, Doo Hyun Chung
Although NKT cells has been known to exert protective roles in the development of autoimmune diseases, the functional roles of NKT cells in the downstream events of antibody-induced joint inflammation remain unknown. Thus, we explored the functional roles of NKT cells in antibody-induced arthritis using the K/BxN serum transfer model. NKT cell-deficient mice were resistant to the development of arthritis, and wild-type mice administrated with alpha-galactosyl ceramide, a potent NKT cell activator, aggravated arthritis...
January 3, 2005: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/15485866/sphingosine-kinase-1-sphk1-is-induced-by-transforming-growth-factor-beta-and-mediates-timp-1-up-regulation
#17
Masayoshi Yamanaka, Daniel Shegogue, Heuping Pei, Shizhong Bu, Alicja Bielawska, Jacek Bielawski, Benjamin Pettus, Yusuf A Hannun, Lina Obeid, Maria Trojanowska
Transforming growth factor-beta (TGF-beta) signaling plays a pivotal role in extracellular matrix deposition by stimulating collagen production and other extracellular matrix proteins and by inhibiting matrix degradation. The present study was undertaken to define the role of sphingosine kinase (SphK) in TGF-beta signaling. TGF-beta markedly up-regulated SphK1 mRNA and protein amounts and caused a prolonged increase in SphK activity in dermal fibroblasts. Concomitantly, TGF-beta reduced sphingosine-1-phosphate phosphatase activity...
December 24, 2004: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/15459768/involvement-of-growth-differentiation-factor-15-macrophage-inhibitory-cytokine-1-gdf-15-mic-1-in-oxldl-induced-apoptosis-of-human-macrophages-in-vitro-and-in-arteriosclerotic-lesions
#18
Daniel Schlittenhardt, Andreas Schober, Jens Strelau, Gabriel A Bonaterra, Walther Schmiedt, Klaus Unsicker, Jürgen Metz, Ralf Kinscherf
Growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) is a new member of the transforming growth factor beta (TGF-beta) superfamily, which has most recently been found in activated macrophages (MPhi). We have now investigated GDF-15/MIC-1 in human MPhi after exposure to oxidized low-density lipoproteins (oxLDL) related mediators in vitro and in arteriosclerotic carotid arteries. Using RT-PCR and Western blotting a pronounced induction of GDF-15/MIC-1 expression by oxLDL, C6-ceramide, tumor necrosis factor (TNFalpha) and hydrogen peroxide (H2O2) was found in cultured human MPhi...
November 2004: Cell and Tissue Research
https://www.readbyqxmd.com/read/12832851/prostaglandin-f2alpha-induced-functional-regression-of-the-corpus-luteum-and-apoptosis-in-rodents
#19
Zhiyan Wang, Kazuhiro Tamura, Mikihiro Yoshie, Hiroshi Tamura, Kazuhiko Imakawa, Hiroshi Kogo
We investigated the relationship between prostaglandin (PG) F(2)(alpha)-induced functional luteal regression and apoptosis in the rodent ovary. Administration of PGF(2)(alpha) significantly decreased the serum levels of progesterone within 12 h after treatment in pseudopregnant mice. Apparent signals were detected in luteal tissues at 24 to 72 h by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick endo labeling (TUNEL) assay. PGF(2)(alpha) significantly increased the levels of the cleavage nuclear poly (ADP-ribose) polymerase fragment and transforming growth factor-beta (TGF-beta) mRNA within 48 h...
May 2003: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/12728250/tgf-beta1-suppresses-apoptosis-via-differential-regulation-of-map-kinases-and-ceramide-production
#20
H-H Chen, S Zhao, J-G Song
Serum deprivation induces apoptosis in NIH3T3 cells, which is associated with increased intracellular ceramide generation and with the activation of p38 mitogen-activated protein (MAP) kinase. Treatment of cells with transforming growth factor-beta1 (TGF-beta1) activated the extracellular signal regulated kinases 1 and 2 (ERK1/ERK2), inhibited the serum deprivation-induced p38 activation and the increase in intracellular ceramide formation, leading to the stimulation of cell proliferation and the suppression of apoptosis...
May 2003: Cell Death and Differentiation
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