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https://www.readbyqxmd.com/read/29747346/-phenotype-and-mechanism-of-inducible-ppp2r1a-knockout-mouse-model
#1
J L Fan, F P Wang, S Wang, X L Liu, X N Wu, W Chen, L P Chen, W X Li
Objective: Investigate the effects of inducible ppp2r1a knockout on main physiological function in adult mice and study the mechanism. Methods: Ppp2r1a(flox/flox) mice and CAGG-CreER mice were hybridized to obtain 20 CAGG-CreER ppp2r1a(flox/flox) and 20 mice in homozygous group. Two groups of mice were divided into 4 groups respectively, finally we got 8 groups with 5 mice in each group. Tamoxifen was injected intraperitoneally to acquire inducible ppp2r1a knockout mice. The knockout efficiency of PP2A Aα in vital organs was measured by Western blot...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29709303/assessment-of-longitudinal-systolic-function-using-tissue-motion-annular-displacement-in-healthy-dogs
#2
Marcela Wolf, Stephany B Lucina, Bruna C Brüler, Giovana L R Tuleski, Vinícius B C Silva, Marlos G Sousa
INTRODUCTION: Left ventricular systolic function is one of the main parameters studied in echocardiography. Longitudinal systolic function, however, is less commonly evaluated in routine examinations but may provide early information on systolic dysfunction. The movement of the mitral annulus toward the apex has already been determined as a method for evaluation of longitudinal systolic function in dogs, but the study of this movement by speckle tracking with the tissue motion annular displacement (TMAD) technique has not yet been evaluated...
April 27, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29698247/higher-heart-weight-in-new-zealand-m%C3%A4-ori-and-pacific-islanders
#3
Winston Philcox, Jack Garland, Faseeh Zaidi, Paul Morrow, Kilak Kesha, Simon Stables, Christopher X Wong, Amy Spark, Rexson Tse
Heart weight is dependent on sex, age, height, and weight. Although previous autopsy studies showed no differences in heart weight between different ethnic groups, none have examined the New Zealand population of Māori and Pacific Islanders (Polynesians). The presented study compared heart weights between 101 European and 85 Polynesian suicide hanging deaths from New Zealand. Univariate linear regression coefficients for age, male sex, height, body weight, body mass index, and Polynesian ethnicity were positive and significant (P < 0...
April 26, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29663586/adiposity-body-composition-and-ventricular-arterial-stiffness-in-the-elderly-the-atherosclerosis-risk-in-communities-study
#4
Miguel M Fernandes-Silva, Amil M Shah, Brian Claggett, Susan Cheng, Hirofumi Tanaka, Odilson M Silvestre, Wilson Nadruz, Barry A Borlaug, Scott D Solomon
AIM: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. METHODS AND RESULTS: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage...
April 16, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29526564/normative-data-for-left-and-right-ventricular-systolic-strain-in-healthy-caucasian-italian-children-by-two-dimensional-speckle-tracking-echocardiography
#5
Massimiliano Cantinotti, Marco Scalese, Raffaele Giordano, Eliana Franchi, Nadia Assanta, Marco Marotta, Cecilia Viacava, Sabrina Molinaro, Giorgio Iervasi, Giuseppe Santoro, Martin Koestenberger
BACKGROUND: There is an increasing interest in echocardiographic strain (ε) measurements for the assessment of ventricular myocardial function in children; however, pediatric nomograms remain limited. Our aim was to establish pediatric nomograms for the left ventricular (LV) and the right ventricular (RV) ε measured by two-dimensional speckle-tracking echocardiography (2D-STE) in a large cohort of healthy children prospectively enrolled. METHODS: Echocardiographic measurements included STE LV longitudinal and circumferential and RV longitudinal global end-systolic ε...
March 8, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29457247/development-of-a-multiroute-physiologically-based-pharmacokinetic-model-for-orbifloxacin-in-rabbits
#6
F Yang, F Yang, W Shi, H Si, T Kong, G Wang, J Zhang
To predict the orbifloxacin concentrations in rabbits after multiple routes of administration, a flow-limited multiroute physiologically based pharmacokinetic (PBPK) model was developed. Three routes of administration (IV, IM, and PO) were incorporated into this model. Physiological parameters including tissue weights and blood flows through different tissues were obtained from the literature. The tissue/plasma partition coefficients (PX s) for noneliminating tissues were calculated according to the area method, while the PX s for kidney and the rest of the body compartment, together with other parameters for absorption and elimination, were optimized based on the published concentrations...
February 18, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29309514/follicle-stimulating-hormone-levels-and-subclinical-atherosclerosis-in-older-postmenopausal-women
#7
Elizabeth R Bertone-Johnson, Jyrki K Virtanen, Tarja Nurmi, Leo Niskanen, Jaakko Mursu, Sari Voutilainen, Kimmo Ronkainen, Jussi Kauhanen, Tomi-Pekka Tuomainen
Recent studies of perimenopausal women suggest that follicle-stimulating hormone (FSH) levels may be associated with atherosclerosis, independent of estradiol. Whether FSH is related to atherosclerosis in older postmenopausal women, who have completed the menopausal transition, remains unknown. We assessed the relationship of serum FSH and estradiol levels with carotid artery intima-media thickness (IMT) among 587 postmenopausal participants in the Kuopio Ischemic Heart Disease Risk Factor Study (Kuopio, Finland)...
January 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29302896/comparison-of-the-accuracy-of-noninvasive-hemoglobin-monitoring-for-preoperative-evaluation-between-adult-and-pediatric-patients-a-retrospective-study
#8
Yong-Hee Park, Seho Lim, Hyun Kang, Hwa-Yong Shin, Chong Wha Baek, Young Cheol Woo
We measured noninvasive hemoglobin (SpHb) levels during the pre-anesthesia visit in patients planning elective surgery. Differences between SpHb and laboratory-measured hemoglobin (Hblab ) were compared between adult and pediatric patients. In the pre-anesthesia visiting office, we routinely monitor noninvasive Hb levels with oxygen saturation and heart rate using Masimo Radical-7® Pulse CO-Oximetry (Masimo Corp., Irvine, CA, USA). We attached the R1 20 (body weight, 10-50 kg) or R1 25 (body weight > 30 kg) probe on the index finger...
January 4, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29137941/acute-and-sub-acute-oral-toxicity-studies-of-the-aqueous-extract-from-radix-radix-with-cortex-and-cortex-of-psammosilene-tunicoides-in-mice-and-rats
#9
Yi-Chen, Min-Xuan Wu, Jie-Liu, Xiao-Jie Ma, Jin-Li Shi, Sheng-Nan Wang, Zhi-Quan Zheng, Jian-You Guo
ETHNOPHARMACOLOGICAL RELEVANCE: Psammosilene tunicoides is one of the important ingredients of a famous Chinese traditional medicine formulation "Yunnan Baiyao". Also, this plant is commonly used as an anodyne and hemostatic agent in southwest China. Currently, little toxicological information is available on its safety following prolonged use. AIM OF THE STUDY: In this study, we sought to evaluate the toxicity of the three different parts of Psammosilene tunicoides: Psammosilenes Radix (PR), Psammosilenes Radix with Cortex (PRC) and Psammosilenes Cortex (PC) by acute and sub-acute toxicity studies...
March 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29045282/prediction-model-for-wait-times-in-cardiac-transplantation
#10
David L Joyce, Brian D Lahr, Lyle D Joyce, Sudhir S Kushwaha, Richard C Daly
Wait times have increased for patients approved for heart transplants. We reviewed United Network for Organ Sharing (UNOS) data for 14,242 patients listed for isolated heart transplant (2009-2013) to develop a risk score model for timing left ventricular assist device (LVAD) implantation in bridge-to-transplant patients. We used a multivariable Cox proportional hazards regression model with subsequent bootstrap resampling for internal validation to develop a scoring system that combined risk factors, weighted by the corresponding regression coefficients, to define an individual's risk score...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28922944/revised-inverse-problem-algorithm-based-prediction-of-coronary-artery-stenosis-readings-from-the-clinical-data-of-patients-with-coronary-heart-diseases
#11
Lung-Fa Pan, Shao-Wen Chiu, Min-Feng Xiao, Chia-Hui Chen, Lung-Kwang Pan
AIM: Coronary artery stenosis readings were predicted in this study on the basis of clinical data for patients with coronary heart diseases using the inverse problem algorithm. METHOD: Five factors, including age, BSA (body surface area), MAP (mean artery pressure), sugar AC (ante cibum), and LDL-C (low-density Lipoprotein-Cholesterol) were incorporated into a nonlinear first-order regression fit analysis to develop a prediction equation with sixteen terms derived via a revised inverse problem algorithm implemented through the STATISTICA default regression fit...
September 18, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/28872781/a-method-for-assessment-of-the-dynamic-response-of-the-arterial-baroreflex
#12
M T Lund, M Salomonsson, T E N Jonassen, N-H Holstein-Rathlou
AIM: The baroreflex is a key mechanism in cardiovascular regulation, and alterations in baroreceptor function are seen in many diseases, including heart failure, obesity and hypertension. We propose a new method for analysing baroreceptor function from continuous blood pressure (BP) and heart rate (HR) in both health and disease. METHODS: Forty-eight-hour data series of BP and HR were collected with telemetry. Sprague Dawley rats on standard chow (n = 11) served as controls, while rats on a high-fat, high-fructose (HFHC) diet (n = 6) constituted the obese-hypertensive model...
February 2018: Acta Physiologica
https://www.readbyqxmd.com/read/28764153/correlation-of-adiposity-indices-with-electrocardiographic-ventricular-variables-and-vascular-stiffness-in-young-adults
#13
Varrshine Ravikumar, Hemamalini Ramasamy VajraVelu, Saravanan Ayyavoo, Balaji Ramraj
INTRODUCTION: Excess adiposity constitute an important public health problem because of the associated increased risk of hypertension, coronary heart disease, type 2 diabetes and other disorders. Not only the contribution of general measures of adiposity but also central measures of adiposity have been observed. AIM: To compare and correlate the central and general adiposity indices with ventricular electrocardiographic variables and vascular stiffness indices in normal, overweight and obese young adults...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28739084/the-repeatability-and-characteristics-of-right-ventricular-longitudinal-strain-imaging-by-speckle-tracking-echocardiography-in-healthy-dogs
#14
T Morita, K Nakamura, T Osuga, N Yokoyama, N Khoirun, K Morishita, N Sasaki, H Ohta, M Takiguchi
INTRODUCTION: To assess the repeatability and characteristics of echocardiographic indices of the right ventricular (RV) function derived from speckle-tracking echocardiography. ANIMALS: Fourteen laboratory Beagles and 103 privately owned dogs without cardiac disease were involved in this study. MATERIALS AND METHODS: Right ventricular longitudinal strain, strain rate, and a strain-related index for assessing RV dyssynchrony derived from speckle-tracking echocardiography were obtained by two different observers using five Beagles...
August 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28577867/effects-of-mir-29a-and-mir-101a-expression-on-myocardial-interstitial-collagen-generation-after-aerobic-exercise-in-myocardial-infarcted-rats
#15
Li Xiao, Huimin He, Lele Ma, Miaomiao Da, Sinan Cheng, Yan Duan, Qian Wang, Huayi Wu, Xigui Song, Wei Duan, Zhenjun Tian, Yingchun Hou
BACKGROUND AND AIMS: Myocardial infarction (MI) is accompanied by increased collagen deposition, cell necrosis and angiogenesis in cardiac tissue, which results in reduced ventricular compliance. Both microRNA-29a (miR-29a) and microRNA-101a (miR-101a) target the mRNAs encoding collagens and other proteins involved in fibrosis. METHODS: We assessed the effects of intermittent aerobic exercise on the expression of cardiac miR-29a and miR-101a and following effects on the TGFβ, fos, Smad2/3, COL1A1 and COL3A1 in MI model of rats...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28410579/assessing-the-usability-by-clinicians-of-vision-a-hierarchical-display-of-patient-collected-physiological-information-to-clinicians
#16
Cubby L Gardner, Fang Liu, Paul Fontelo, Michael C Flanagan, Albert Hoang, Harry B Burke
BACKGROUND: The inability of patients to accurately and completely recount their clinical status between clinic visits reduces the clinician's ability to properly manage their patients. One way to improve this situation is to collect objective patient information while the patients are at home and display the collected multi-day clinical information in parallel on a single screen, highlighting threshold violations for each channel, and allowing the viewer to drill down to any analog signal on the same screen, while maintaining the overall physiological context of the patient...
April 14, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28373014/the-combyn%C3%A2-ecg-adding-haemodynamic-and-fluid-leads-for-the-ecg-part-ii-prediction-of-total-body-water-tbw-extracellular-fluid-ecf-ecf-overload-fat-mass-fm-and-dry-appendicular-muscle-mass-appmm
#17
Falko Skrabal, Georg P Pichler, Mathias Penatzer, Johannes Steinbichl, Anna-Katharina Hanserl, Alfred Leis, Herbert Loibner
Simultaneous with a 12 channel ECG, body composition was analysed by segmental multi-frequency impedance analysis in 101 healthy subjects and in 118 patients with chronic heart failure (CHF, n= 40), chronic renal failure with haemodialysis (HD, n= 20), and miscellaneous internal diseases (n= 58). Whole body DXA and sodium bromide dilution were used as reference methods for total body water (TBW), extracellular fluid (ECF), appendicular muscle mass (AppMM) and fat mass (FM). Empirical prediction equations were developed in a randomized evaluation sample and then evaluated in unknowns...
March 31, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28348930/effects-of-various-factors-on-doppler-flow-ultrasonic-radial-and-coccygeal-artery-systolic-blood-pressure-measurements-in-privately-owned-conscious-dogs
#18
Allison P Mooney, Dianne I Mawby, Joshua M Price, Jacqueline C Whittemore
OBJECTIVE: The purpose of this study was to assess the effects of age, body condition score (BCS) and muscle condition score (MCS) on indirect radial and coccygeal Doppler systolic arterial blood pressure (SAP) measurements in dogs. METHODS: Sixty-two privately-owned dogs were enrolled between June and July 2016. The BCS and MCS were determined by two investigators. Blood pressure was measured per published guidelines and using headphones, and the order of measurement site was randomized...
2017: PeerJ
https://www.readbyqxmd.com/read/28320381/variation-in-readmission-and-mortality-following-hospitalisation-with-a-diagnosis-of-heart-failure-prospective-cohort-study-using-linked-data
#19
Rosemary J Korda, Wei Du, Cathy Day, Karen Page, Peter S Macdonald, Emily Banks
BACKGROUND: Hospitalisation for heart failure is common and post-discharge outcomes, including readmission and mortality, are often poor and are poorly understood. The purpose of this study was to examine patient- and hospital-level variation in the risk of 30-day unplanned readmission and mortality following discharge from hospital with a diagnosis of heart failure. METHODS: Prospective cohort study using data from the Sax Institute's 45 and Up Study, linking baseline survey (Jan 2006-April 2009) to hospital and mortality data (to Dec 2011)...
March 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28202635/short-term-subclinical-zinc-deficiency-in-weaned-piglets-affects-cardiac-redox-metabolism-and-zinc-concentration
#20
RANDOMIZED CONTROLLED TRIAL
Daniel Brugger, Wilhelm M Windisch
Background: Subclinical zinc deficiency (SZD) represents the common zinc malnutrition phenotype. However, its association with oxidative stress is not well understood. The heart muscle may be a promising target for studying early changes in redox metabolism. Objective: We investigated the effects of short-term SZD on cardiac redox metabolism in weaned piglets. Methods: Forty-eight weaned German Large White × Landrace × Piétrain piglets (50% castrated males and 50% females; body weight of 8.5 kg) were fed diets with different zinc concentrations for 8 d...
April 2017: Journal of Nutrition
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