keyword
https://read.qxmd.com/read/36831084/horse-derived-ceramide-accentuates-glucosylceramide-synthase-and-ceramide-synthase-3-by-activating-ppar%C3%AE-%C3%AE-and-or-ppar%C3%AE-to-stimulate-ceramide-synthesis
#21
JOURNAL ARTICLE
Tami Igarashi, Hiroki Yanagi, Masayuki Yagi, Masamitsu Ichihashi, Genji Imokawa
Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal ceramide metabolism, and we characterized those effects using reconstructed human epidermal equivalents. Lipid analysis, RT-PCR and Western blotting revealed that HC significantly increased the total ceramide content of the stratum corneum (SC), accompanied by significantly increased gene and/or protein expression levels of ceramide synthase (CERS) 3, fatty acid elongase (ELOVL) 4, glucosylceramide synthase (GCS), β-glucocerebrosidase, sphingomyelin synthase and acid sphingomyelinase...
February 13, 2023: Biomedicines
https://read.qxmd.com/read/36718839/cera-glow-ferment-lysates-of-lacticaseibacillus-rhamnosus-idcc-3201-improves-skin-barrier-function-in-clinical-study
#22
JOURNAL ARTICLE
Minjee Lee, Myun Soo Kim, Sung Hee Jang, Hayoung Kim, Gwang Seob Kim, Hyerin Lee, Hyun Min Park, Jungwoo Yang
BACKGROUND: Ceramides are essential lipids in stratum corneum for skin permeability barrier function in that they retain the skin moisture and protect from the invasion of foreign pathogens. Previously, we demonstrated that ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201 enhanced ceramide production in human epidermal keratinocytes. Furthermore, for comprehensive knowledge of this effect, in vitro experiments and multi-omics analysis were conducted to explore the underlying mechanisms...
January 31, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/36674974/sphingosine-1-phosphate-as-essential-signaling-molecule-in-inflammatory-skin-diseases
#23
REVIEW
Burkhard Kleuser, Wolfgang Bäumer
Sphingolipids are crucial molecules of the mammalian epidermis. The formation of skin-specific ceramides contributes to the formation of lipid lamellae, which are important for the protection of the epidermis from excessive water loss and protect the skin from the invasion of pathogens and the penetration of xenobiotics. In addition to being structural constituents of the epidermal layer, sphingolipids are also key signaling molecules that participate in the regulation of epidermal cells and the immune cells of the skin...
January 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36609802/staphylococcus-aureus-causes-aberrant-epidermal-lipid-composition-and-skin-barrier-dysfunction
#24
JOURNAL ARTICLE
Jihyun Kim, Byung Eui Kim, Evgeny Berdyshev, Irina Bronova, Lianghua Bin, Jaewoong Bae, Seok-Jin Kim, Hye-Young Kim, Unha Lee, Myoung Shin Kim, Hyunmi Kim, Jinyoung Lee, Clifton F Hall, Jessica Hui-Beckman, Yunhee Chang, Anna Sofia Bronoff, Dasom Hwang, Hae-Young Lee, Elena Goleva, Kangmo Ahn, Donald Y M Leung
BACKGROUND: Staphylococcus (S) aureus colonization is known to cause skin barrier disruption in atopic dermatitis (AD) patients. However, it has not been studied how S. aureus induces aberrant epidermal lipid composition and skin barrier dysfunction. METHODS: Skin tape strips (STS) and swabs were obtained from 24 children with AD (6.0 ± 4.4 yr) and 16 healthy children (7.0 ± 4.5 yr). Lipidomic analysis of STS samples was performed by mass spectrometry...
January 7, 2023: Allergy
https://read.qxmd.com/read/36563946/lipidomic-profiling-reveals-metabolic-signatures-in-psoriatic-skin-lesions
#25
JOURNAL ARTICLE
Panpan Liu, Guixue Hou, Yehong Kuang, Lei Li, Chao Chen, Bei Yan, Wu Zhu, Jie Li, Mingliang Chen, Juan Su, Liang Lin, Xiang Chen, Cong Peng
Psoriasis is a chronic immune-mediated inflammatory disease. Lipids play an important role in regulating the inflammatory response. However, the alteration of lipids involved in psoriasis particular in skin lesions remain unclear. Here, we performed the lipidomics to investigate lipid profiling in the skin lesions of the imiquimod-induced psoriasis-like dermatitis and psoriasis patients. The findings showed that ceramides phosphate (CerP) and ceramides were enriched in psoriatic lesions compared with controls from both psoriasis patients and psoriasis-like mouse model...
December 20, 2022: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/36557209/the-role-of-sphingolipids-in-the-pathogenesis-of-psoriasis
#26
REVIEW
Mateusz Matwiejuk, Hanna Mysliwiec, Adrian Chabowski, Iwona Flisiak
Psoriasis is a complex, chronic, immunologically mediated disease which involves skin and joints. Psoriasis is commonly connected with numerous other diseases such as liver diseases, metabolic syndrome, impaired glucose tolerance, diabetes mellitus, atherosclerosis, hypertension, and ischemic heart disease. Interestingly, comorbidities of psoriasis are an attention-grabbing issue. Additionally, it can cause impairment of quality of life and may be associated with depressive disorders. Altered levels of ceramides in psoriatic skin may lead to anti-apoptotic and pro-proliferative states, consequently leading to an over-proliferation of keratinocytes and the development of skin lesions...
November 24, 2022: Metabolites
https://read.qxmd.com/read/36541108/the-effect-of-ppar-isoform-de-activation-on-the-lipid-composition-in-full-thickness-skin-models
#27
JOURNAL ARTICLE
Richard W J Helder, Jannik Rousel, Walter A Boiten, Gerrit S Gooris, Andreea Nadaban, Abdoelwaheb El Ghalbzouri, Joke A Bouwstra
Human Skin Equivalents (HSEs) are 3D-cultured human skin models that mimic many aspects of native human skin (NHS). Although HSEs resemble NHS very closely, the barrier located in the stratum corneum (SC) is impaired. This is caused by an altered lipid composition in the SC of HSEs compared to NHS. One of the most pronounced changes in this lipid composition is a high level of monounsaturation. One key-enzyme in this change is Stearoyl-CoA Desaturase-1 (SCD1), which catalyzes the monounsaturation of lipids...
December 21, 2022: Experimental Dermatology
https://read.qxmd.com/read/36522440/menopause-induces-changes-to-the-stratum-corneum-ceramide-profile-which-are-prevented-by-hormone-replacement-therapy
#28
JOURNAL ARTICLE
Alexandra C Kendall, Suzanne M Pilkington, Jonathan R Wray, Victoria L Newton, Christopher E M Griffiths, Mike Bell, Rachel E B Watson, Anna Nicolaou
The menopause can lead to epidermal changes that are alleviated by hormone replacement therapy (HRT). We hypothesise that these changes could relate to altered ceramide production, and that oestrogen may have a role in keratinocyte ceramide metabolism. White Caucasian women were recruited into three groups: pre-menopausal (n = 7), post-menopausal (n = 11) and post-menopausal taking HRT (n = 10). Blood samples were assessed for hormone levels, transepidermal water loss was measured to assess skin barrier function, and stratum corneum lipids were sampled from photoprotected buttock skin...
December 15, 2022: Scientific Reports
https://read.qxmd.com/read/36243114/herpes-simplex-virus-1-protein-pul21-alters-ceramide-metabolism-by-activating-the-inter-organelle-transport-protein-cert
#29
JOURNAL ARTICLE
Tomasz H Benedyk, Viv Connor, Eve R Caroe, Maria Shamin, Dmitri I Svergun, Janet E Deane, Cy M Jeffries, Colin M Crump, Stephen C Graham
Herpes simplex virus (HSV)-1 dramatically alters the architecture and protein composition of cellular membranes during infection, but its effects upon membrane lipid composition remain unclear. HSV-1 pUL21 is a virus-encoded protein phosphatase adaptor that promotes dephosphorylation of multiple cellular and virus proteins, including the cellular ceramide transport protein CERT. CERT mediates non-vesicular ceramide transport from the ER to the trans-Golgi network, whereupon ceramide is converted to sphingomyelin and other sphingolipids that play important roles in cellular proliferation, signaling, and membrane trafficking...
October 12, 2022: Journal of Biological Chemistry
https://read.qxmd.com/read/36198624/screening-of-plant-derived-natural-extracts-to-identify-a-candidate-extract-capable-of-enhancing-lipid-synthesis-in-keratinocytes
#30
JOURNAL ARTICLE
Sang-Hoon Lee, Hee-Seok Seo, Seong Jun Seo, Chang-Deok Kim, Seung-Phil Hong
BACKGROUND: Reduced lipid content in the stratum corneum is a major cause of skin-barrier dysfunction in various pathological conditions. Promoting lipid production is a potential strategy to improve skin-barrier function. Recent evidence supports the beneficial effects of adiponectin on lipid metabolism and senescence in keratinocytes. OBJECTIVE: This study aimed to investigate whether plant extracts can enhance skin-barrier function. METHODS: We screened fruit and herb extracts that enhance the lipid synthesis of keratinocytes via AMP-activated protein kinase (AMPK) activation and SIRT1 signaling in the adiponectin pathway...
October 2022: Annals of Dermatology
https://read.qxmd.com/read/35900871/biogeographic-and-disease-specific-alterations-in-epidermal-lipid-composition-and-single-cell-analysis-of-acral-keratinocytes
#31
JOURNAL ARTICLE
Alexander A Merleev, Stephanie T Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina I Marusina, Steven M Watkins, Forum Patel, Allison C Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J Michelle Kahlenberg, Fu-Tong Liu, Iannis E Adamopoulos, Elizabeth A Wang, Chelsea Ma, Michelle Y Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C Tsoi, Carlito B Lebrilla, Johann E Gudjonsson, Emanual Maverakis
The epidermis is the outermost layer of skin. Here, we used targeted lipid profiling to characterize the biogeographic alterations of human epidermal lipids across 12 anatomically distinct body sites, and we used single-cell RNA-Seq to compare keratinocyte gene expression at acral and nonacral sites. We demonstrate that acral skin has low expression of EOS acyl-ceramides and the genes involved in their synthesis, as well as low expression of genes involved in filaggrin and keratin citrullination (PADI1 and PADI3) and corneodesmosome degradation, changes that are consistent with increased corneocyte retention...
August 22, 2022: JCI Insight
https://read.qxmd.com/read/35843358/undescribed-glucosylceramide-flavonol-triglycoside-and-oleanane-saponin-from-the-halophyte-agathophora-alopecuroides-promising-candidates-for-stimulating-ceramide-synthesis
#32
JOURNAL ARTICLE
Ahmed Othman, Yhiya Amen, Maki Nagata, Kuniyoshi Shimizu
The phytochemical study of Agathophora alopecuroides (Chenopodiaceae) led to the isolation of previously undescribed glucosylceramide, flavonol triglycoside, and triterpene oleanane saponin, together with eight known compounds. Their structures were elucidated using NMR analysis and HR-MS as (2'R, 12E) N-[(2S, 3S, 4R)-1-(β-D-glucopyranosyloxy)-3,4-dihydroxy-octadec-2-yl]-2-hydroxytetracos-12-enamide, namely Agathophamide A; isorhamnetin-3-O-[β-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 6)]-β-D-galactopyranoside, namely Agathophoroside A; and 3-O-[4'-(β-D-xylopyranosyl)-β-D-glucuronopyranosyl]-28-O-β-D-glucopyranosyl-olean-12-en-3β-ol-28-oic acid, namely Solysaponin A...
July 14, 2022: Phytochemistry
https://read.qxmd.com/read/35681438/exogenous-ceramide-serves-as-a-precursor-to-endogenous-ceramide-synthesis-and-as-a-modulator-of-keratinocyte-differentiation
#33
JOURNAL ARTICLE
Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park
Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated in commercial topical agents to improve barrier function. Topical ceramide localizes on the skin surface and in the stratum corneum, but certain amounts of ceramide penetrate the stratum granulosum, becoming precursors to endogenous ceramide synthesis following molecular modification. Moreover, exogenous ceramide as a lipid mediator could modulate keratinocyte proliferation/differentiation...
May 25, 2022: Cells
https://read.qxmd.com/read/35654151/whole-picture-of-human-stratum-corneum-ceramides-including-the-chain-length-diversity-of-long-chain-bases
#34
JOURNAL ARTICLE
Madoka Suzuki, Yusuke Ohno, Akio Kihara
Ceramides are essential lipids for skin permeability barrier function, and a wide variety of ceramide species exist in the stratum corneum (SC). Although ceramides with long-chain bases (LCBs) of various lengths have been identified in the human SC, a quantitative analysis that distinguishes ceramide species with different LCB chain lengths has not been yet published. Therefore, the whole picture of human SC ceramides remains unclear. Here, we conducted LC/MS/MS analyses to detect individual ceramide species differing in both the LCB and FA chain lengths and quantified 1,327 unbound ceramides and 254 protein-bound ceramides: the largest number of ceramide species reported to date...
July 2022: Journal of Lipid Research
https://read.qxmd.com/read/35455428/-euphorbia-supina-extracts-block-nadph-oxidase-mediated-ceramide-induced-apoptosis-initiated-by-diesel-particulate-matter
#35
JOURNAL ARTICLE
Kyong-Oh Shin, Sungeun Kim, Bokyung Kim, Hye-Yoon Park, Eunhee Jung, Garyun Kim, Donghee Kim, Hwang Eui Cho, Yoshikazu Uchida, Kyungho Park
Air pollutants contribute to the development of diseases such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary cancer, cardiovascular problems, and some skin diseases. We recently found that a major air pollutant, diesel particulate matter (DPM), induces apoptosis in human keratinocytes by increasing a proapoptotic lipid mediator, ceramide. DPM activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), which stimulates sphingomyelinase, leading to an increased conversion of sphingomyelin to ceramide...
March 31, 2022: Pharmaceuticals
https://read.qxmd.com/read/35318678/epidermal-1-o-acylceramides-appear-with-the-establishment-of-the-water-permeability-barrier-in-mice-and-are-produced-by-maturating-keratinocytes
#36
JOURNAL ARTICLE
Mariona Rabionet, Pauline Bernard, Melanie Pichery, Christian Marsching, Aline Bayerle, Shaalee Dworski, Mustafa A Kamani, Chandramohan Chitraju, Nina L Gluchowski, Katlyn R Gabriel, Abolfazl Asadi, Philipp Ebel, Menno Hoekstra, Sabrina Dumas, James M Ntambi, Anders Jacobsson, Klaus Willecke, Jeffrey A Medin, Nathalie Jonca, Roger Sandhoff
1-O-Acylceramides (1-OACs) have a fatty acid esterified to the 1-hydroxyl of the sphingosine head group of the ceramide, and recently we identified these lipids as natural components of human and mouse epidermis. Here we show epidermal 1-OACs arise shortly before birth during the establishment of the water permeability barrier in mice. Fractionation of human epidermis indicates 1-OACs concentrate in the stratum corneum. During in vitro maturation into reconstructed human epidermis, human keratinocytes dramatically increase 1-OAC levels indicating they are one source of epidermal 1-OACs...
May 2022: Lipids
https://read.qxmd.com/read/35122447/effects-of-the-epidermal-growth-factor-receptor-inhibitor-gefitinib-on-lipid-and-hyaluronic-acid-synthesis-in-cultured-hacat-keratinocytes
#37
JOURNAL ARTICLE
Jang-Hee Oh, Woojune Hur, Na Li, Seong Jin Jo
Epidermal growth factor receptor inhibitors (EGFRIs) are widely used for treating various cancers, including lung, colon, head and neck cancers. However, EGFRIs have unique dermatological side effects, including acneiform eruption, dry skin, paronychia and pruritus. In this study, we investigated the molecular changes induced by an EGFRI, gefitinib, in the expression of lipogenic enzymes and hyaluronic acid (HA) regulatory proteins in HaCaT keratinocytes, and whether EGF restored these changes. HaCaT cells were treated with gefitinib, with or without EGF, and treated with tumor necrosis factor α (TNFα) for inducing an inflammatory response...
June 2022: Experimental Dermatology
https://read.qxmd.com/read/35081394/effect-of-estrogen-progesterone-ratio-on-the-differentiation-and-the-barrier-function-of-epidermal-keratinocyte-and-three-dimensional-cultured-human-epidermis
#38
JOURNAL ARTICLE
Kanna Murakami, Akiko Sawada, Toshihiro Mori, Shu Sakuyama, Yoshihiro Tokudome
AIMS: Estrogen (E) and progesterone (P) are the major female hormones and are secreted with changing concentration ratios throughout the menstrual cycle. These hormones have been studied individually regarding their physiological function in the skin, but their concentration ratio (E/P) and its effect on the skin has not yet been investigated. The purpose of this study was to clarify the effect of the E/P ratio on skin barrier function. The menstrual cycle was divided into the menstrual, follicular, ovulation, and luteal phases...
January 23, 2022: Life Sciences
https://read.qxmd.com/read/35053118/konjac-ceramide-kcer-mediated-signal-transduction-of-the-sema3a-pathway-promotes-hacat-keratinocyte-differentiation
#39
JOURNAL ARTICLE
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Kohei Yuyama, Daisuke Mikami, Katsuyuki Mukai, Yasuyuki Igarashi
Histamines suppress epidermal keratinocyte differentiation. Previously, we reported that konjac ceramide (kCer) suppresses histamine-stimulated cell migration of HaCaT keratinocytes. kCer specifically binds to Nrp1 and does not interact with histamine receptors. The signaling mechanism of kCer in HaCaT cells is also controlled by an intracellular signaling cascade activated by the Sema3A-Nrp1 pathway. In the present study, we demonstrated that kCer treatment induced HaCaT keratinocyte differentiation after migration of immature cells...
January 12, 2022: Biology
https://read.qxmd.com/read/34946675/a-practical-approach-for-the-in-vitro-safety-and-efficacy-assessment-of-an-anti-ageing-cosmetic-cream-enriched-with-functional-compounds
#40
JOURNAL ARTICLE
Nicola Zerbinati, Sabrina Sommatis, Cristina Maccario, Serena Di Francesco, Maria Chiara Capillo, Giulia Grimaldi, Raffaele Rauso, Martha Herrera, Pier Luca Bencini, Roberto Mocchi
(1) Background: Cosmeceuticals are topical products applied to human skin to prevent skin ageing and maintain a healthy skin appearance. Their effectiveness is closely linked to the compounds present in a final formulation. In this article, we propose a panel of in vitro tests to support the efficacy assessment of an anti-ageing cream enriched with functional compounds. (2) Methods: biocompatibility and the irritant effect were evaluated on reconstructed human epidermis (RHE) and corneal epithelium (HCE) 3D models...
December 15, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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