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Perindopril

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https://www.readbyqxmd.com/read/27893331/multidisciplinary-approach-to-novel-therapies-in-cardio-oncology-research-manticore-101-breast-a-randomized-trial-for-the-prevention-of-trastuzumab-associated-cardiotoxicity
#1
Edith Pituskin, John R Mackey, Sheri Koshman, Davinder Jassal, Marshall Pitz, Mark J Haykowsky, Joseph J Pagano, Kelvin Chow, Richard B Thompson, Larissa J Vos, Sunita Ghosh, Gavin Y Oudit, Justin A Ezekowitz, D Ian Paterson
Purpose The primary toxicity of trastuzumab therapy for human epidermal growth factor receptor 2-overexpressing (HER2-positive) breast cancer is dose-independent cardiac dysfunction. Angiotensin-converting enzyme inhibitors and β-blockers are recommended first-line agents for heart failure. We hypothesized that angiotensin-converting enzyme inhibitors and β-blockers could prevent trastuzumab-related cardiotoxicity. Patients and Methods In this double-blinded, placebo-controlled trial, patients with HER2-positive early breast cancer were randomly assigned to receive treatment with perindopril, bisoprolol, or placebo (1:1:1) for the duration of trastuzumab adjuvant therapy...
November 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27878562/full-dose-perindopril-indapamide-in-the-treatment-of-difficult-to-control-hypertension-the-fortissimo-study
#2
Yuri Aleksandrovich Karpov
BACKGROUND AND OBJECTIVE: Blood pressure (BP) control in hypertensive patients remains poor worldwide, particularly in high-risk patients with hypertension and diabetes. Guidelines recommend that such patients receive prompt pharmacological therapy at maximal doses to rapidly control BP. We aimed to evaluate efficacy and safety of single-pill combination (SPC) perindopril/indapamide (PER/IND) at full dose (10/2.5 mg) in hypertensive patients, including diabetics, with BP uncontrolled by previous medication...
November 22, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27787528/the-active-modulation-of-drug-release-by-an-ionic-field-effect-transistor-for-an-ultra-low-power-implantable-nanofluidic-system
#3
Giacomo Bruno, Giancarlo Canavese, Xuewu Liu, Carly S Filgueira, Adriano Sacco, Danilo Demarchi, Mauro Ferrari, Alessandro Grattoni
We report an electro-nanofluidic membrane for tunable, ultra-low power drug delivery employing an ionic field effect transistor. Therapeutic release from a drug reservoir was successfully modulated, with high energy efficiency, by actively adjusting the surface charge of slit-nanochannels 50, 110, and 160 nm in size, by the polarization of a buried gate electrode and the consequent variation of the electrical double layer in the nanochannel. We demonstrated control over the transport of ionic species, including two relevant hypertension drugs, atenolol and perindopril, that could benefit from such modulation...
November 10, 2016: Nanoscale
https://www.readbyqxmd.com/read/27777044/renin-angiotensin-aldosterone-system-inhibitors-in-hypertension-is-there-evidence-for-benefit-independent-of-blood-pressure-reduction
#4
REVIEW
Chirag Bavishi, Sripal Bangalore, Franz H Messerli
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the pathogenesis of hypertension (HTN). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are first line anti-HTN drug classes that are potent, effective and largely safe. Direct renin inhibitors (DRIs) have shown similar blood pressure (BP) reduction but more side effects. The efficacy of ACEIs and ARBs (for cardiovascular, cerebrovascular and renal protection) has been promoted to extend beyond what could be explained by BP reduction alone...
October 21, 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27754299/lbos-01-06-integrated-approach-improved-blood-pressure-control-in-non-adherent-motivated-hypertensive-patients-prisma-study
#5
Svetlana Villevalde, Zhanna Kobalava
OBJECTIVE: Antihypertensive medication nonadherence is significant contributor to poor BP control. Patient-related factors (lack of motivation or risk understanding) are important. The aim of PRISMA study was to determine the impact of integrated approach with therapy based on perindopril arginine in the improvement of motivation, adherence to antihypertensive treatment and BP control. DESIGN AND METHOD: 906 (315 male, 56.0 ± 10.6 years) non-adherent (score < 4 in Morisky and Green Test for Measure of Adherence to Therapy) hypertensive patients with planning or action stages of behavior changes (Prochaska and DiClemente model) with uncontrolled hypertension (BP > 140/90 mmHg) were randomly assigned to 2 strategies: integrated approach with therapy based on perindopril arginine with added-on therapy if necessary (G1, n = 755) or routine practice (G2, n = 151)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754028/yia-03-04-epigenetic-changes-after-acute-treatment-with-acute-angiotensin-converting-enzyme-inhibitors-acei
#6
Nathan De Vries, Priscilla Prestes, Indrajeet Rana, Stephen B Harrap, Fadi J Charchar
OBJECTIVE: The 'legacy effect' of hypertension treatment is where short term treatment with blood pressure (BP) lowering drugs such as angiotensin converting enzyme inhibitors (ACEi) is followed by a persistent reduction in BP, reduced cardiovascular complications and increased lifespan. However, the involvement of epigenetics mechanisms remains unclear. DNA methylation is the binding of a methyl group to DNA which inhibits gene transcription. The aim of this study is to investigate DNA methylation changes after short term treatment with ACEi...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753981/pl-02-3-management-of-elderly-hypertension-whom-to-treat-and-how-low-to-go
#7
Michael Weber
: Age is the most powerful cardiovascular risk factor. Based on a meta-analysis of a million control patients in hypertension trials, the Clinical Trialists Collaboration has estimated that doubling of major cardiac and stroke events occurs with age increments of < 10 years (1). Data from the ACCOMPLISH trial, which will be presented at this ISH meeting for the first time, show that patients aged > 70 (mean: 75.2), compared with those < 70 (mean: 63.7), had a 2.82-fold greater event rate for cardiovascular death and a 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643297/lbos-01-06-integrated-approach-improved-blood-pressure-control-in-non-adherent-motivated-hypertensive-patients-prisma-study
#8
Svetlana Villevalde, Zhanna Kobalava
OBJECTIVE: Antihypertensive medication nonadherence is significant contributor to poor BP control. Patient-related factors (lack of motivation or risk understanding) are important. The aim of PRISMA study was to determine the impact of integrated approach with therapy based on perindopril arginine in the improvement of motivation, adherence to antihypertensive treatment and BP control. DESIGN AND METHOD: 906 (315 male, 56.0 ± 10.6 years) non-adherent (score < 4 in Morisky and Green Test for Measure of Adherence to Therapy) hypertensive patients with planning or action stages of behavior changes (Prochaska and DiClemente model) with uncontrolled hypertension (BP > 140/90 mmHg) were randomly assigned to 2 strategies: integrated approach with therapy based on perindopril arginine with added-on therapy if necessary (G1, n = 755) or routine practice (G2, n = 151)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642946/yia-03-04-epigenetic-changes-after-acute-treatment-with-acute-angiotensin-converting-enzyme-inhibitors-acei
#9
Nathan De Vries, Priscilla Prestes, Indrajeet Rana, Stephen B Harrap, Fadi J Charchar
OBJECTIVE: The 'legacy effect' of hypertension treatment is where short term treatment with blood pressure (BP) lowering drugs such as angiotensin converting enzyme inhibitors (ACEi) is followed by a persistent reduction in BP, reduced cardiovascular complications and increased lifespan. However, the involvement of epigenetics mechanisms remains unclear. DNA methylation is the binding of a methyl group to DNA which inhibits gene transcription. The aim of this study is to investigate DNA methylation changes after short term treatment with ACEi...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642892/pl-02-3-management-of-elderly-hypertension-whom-to-treat-and-how-low-to-go
#10
Michael Weber
UNLABELLED: Age is the most powerful cardiovascular risk factor. Based on a meta-analysis of a million control patients in hypertension trials, the Clinical Trialists Collaboration has estimated that doubling of major cardiac and stroke events occurs with age increments of < 10 years (1). Data from the ACCOMPLISH trial, which will be presented at this ISH meeting for the first time, show that patients aged > 70 (mean: 75.2), compared with those < 70 (mean: 63.7), had a 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638854/overexpression-of-angiotensinogen-downregulates-aquaporin-1-expression-via-modulation-of-nrf2-ho-1-pathway-in-renal-proximal-tubular-cells-of-transgenic-mice
#11
Shiao-Ying Chang, Chao-Sheng Lo, Xin-Ping Zhao, Min-Chun Liao, Isabelle Chenier, Richard Bouley, Julie R Ingelfinger, John Sd Chan, Shao-Ling Zhang
INTRODUCTION: We aimed to examine the regulation of aquaporin 1 expression in an angiotensinogen transgenic mouse model, focusing on underlying mechanisms. METHODS: Male transgenic mice overexpressing rat angiotensinogen in their renal proximal tubular cells (RPTCs) and rat immortalised RPTCs stably transfected with rat angiotensinogen cDNA were used. RESULTS: Angiotensinogen-transgenic mice developed hypertension and nephropathy, changes that were either partially or completely attenuated by treatment with losartan or dual renin-angiotensin system blockade (losartan and perindopril), respectively, while hydralazine prevented hypertension but not nephropathy...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27621182/regulation-of-the-ku70-and-apoptosis-related-proteins-in-experimental-diabetic-nephropathy
#12
Matem Tunçdemir, Melek Öztürk
BACKGROUND: Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats. MATERIALS AND METHODS: Animals were divided into five groups of eight each, four of which received STZ (60mg/kg in a single dose, i...
October 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27562846/angiotensin-converting-enzyme-inhibitors-ameliorate-brain-inflammation-associated-with-microglial-activation-possible-implications-for-alzheimer-s-disease
#13
Nofar Torika, Keren Asraf, Ella Roasso, Abraham Danon, Sigal Fleisher-Berkovich
Angiotensin converting enzyme (ACE) converts Angiotensin I to a potent vasoconstrictor angiotensin II (ANG II). ACE inhibitors (ACEIs) are widely used for the management of hypertension. All components of the renin-angiotensin system (RAS) have also been identified in the brain. In addition to cytokines, neuromodulators such as ANG II can induce neuroinflammation. Moreover, in Alzheimer's disease (AD) models, where neuroinflammation occurs and is thought to contribute to the propagation of the disease, increased levels of ANG II and ACE have been detected...
August 25, 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/27546817/antihypertensive-treatment-decreases-arterial-stiffness-at-night-but-not-during-the-day-results-from-the-hypertension-in-the-very-elderly-trial
#14
Christopher J Bulpitt, Richard Webb, Nigel Beckett, Ruth Peters, Elizabeth Cheek, Craig Anderson, Riitta Antikainen, Jan A Staessen, Chakravarthi Rajkumar
The main Hypertension in the Very Elderly Trial (HYVET) demonstrated a very marked reduction in cardiovascular events by treating hypertensive participants 80 years or older with a low dose, sustained release prescription of indapamide (indapamide SR, 1.5 mg) to which was added a low dose of an angiotensin converting enzyme inhibitor in two-thirds of cases (perindopril 2-4 mg). This report from the ambulatory blood pressure sub-study investigates whether changes in arterial stiffness and ambulatory blood pressure (BP) could both explain the benefits observed in the main trial...
August 22, 2016: Blood Pressure
https://www.readbyqxmd.com/read/27539314/protective-effect-of-perindopril-on-tumor-progression-and-angiogenesis-in-animal-model-of-breast-cancer
#15
Snehal S Patel, Surender Nakka
BACKGROUND: Studies have shown the renin angiotensin system via angiogenesis is involved in tumor development. OBJECTIVE: Therefore, the objective of present study was to examine the effect of perindopril on tumor growth and angiogenesis in animal model of breast cancer. METHODS: In the present study, we investigated the effect of perindopril on tumor development of mammary gland cancer induced by 7,12-dimethylbenz[a]anthracene, mouse tumor xenograft and corneal micropocket model...
August 17, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27517656/dose-effect-relationship-of-perindopril-10-14-and-20mg-assessed-by-urine-and-plasma-acsdkp-levels-in-mildly-sodium-depleted-healthy-volunteers
#16
Matthieu Monge, Valérie Paquet, Damien Bergerot, Valentina Zhygalina, Anne Blanchard
BACKGROUND: We describe a pharmacodynamic study of the dose-effect relationship of perindopril arginine at 10, 14, and 20mg with in vivo angiotensin-converting enzyme (ACE) activity, assessed by urine and plasma AcSDKP levels, as well as the effect on plasma active renin concentrations and blood pressure. METHODS: This randomized, double-blind, four-period, crossover study involved single-dose administration of perindopril arginine (10, 14, and 20mg or placebo) to 32 healthy male normotensive mildly sodium-depleted volunteers...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27508756/-op-5c-09-age-related-treatment-benefit-of-an-ace-inhibitor-on-cardiovascular-events-the-emerging-role-of-bradykinin
#17
J Brugts, R Ferrari
OBJECTIVE: Angiotensin-converting enzyme inhibitors are known to provide significant benefits on cardiovascular event reduction and survival by regulating the balance between bradykinin and angiotensin II. We performed a combined analysis of three randomized trials including the ACE inhibitor perindopril to determine the variability of the response to treatment depending on age. DESIGN AND METHOD: In the ADVANCE, EUROPA and PROGRESS trials, we analyzed the age-dependent of perindopril on the composite endpoint of cardiovascular mortality, nonfatal myocardial infarction and stroke compared to placebo with multivariate Cox regression...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508713/-op-4c-08-role-of-the-fixed-dose-triple-combination-therapy-in-the-management-of-uncontrolled-hypertension-from-the-randomized-clinical-trials-to-clinical-practice
#18
A Mazza, S Lenti, L Schiavon, E Ramazzina, D Bernardini, E Casiglia
OBJECTIVE: Blood pressure (BP) control is difficult to achieve with current BP-lowering drugs. Therefore, uncontrolled hypertension (HT) despite drug treatment with free recommended combinations remains the main goal in clinical practice. In this study the efficacy of a triple fixed-combination (TFC) of anti-hypertensive drugs in hypertensive subjects with uncontrolled HT was evaluated.(Figure is included in full-text article.) DESIGN AND METHOD: : Forty-one hypertensives (mean age 59...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27491146/-efficacy-of-standard-two-year-comprehensive-therapy-to-achieve-target-blood-pressure-and-regression-degrees-of-remodeling-of-the-left-ventricular-hypertrophy-in-patients-after-acute-myocardial-infarction-with-comorbid-hypertension
#19
E V Denesiuk
The study involved 23 men after acute myocardial infarction (AMI) with comorbid arterial hypertension (AH). Mean age of patients was 56.7 years. Recurrent myocardial infarction was determined in 38.4%, cardiac failure I-III functional classes--100% of the cases. All patients underwent clinical examination, electrocardiography and echocardiography, blood lipid profile. Standard comprehensive treatment for two years included an perindopril 5-10 mg/day, beta-blocker bisoprolol--5-10 mg/day, antisclerotic drug atorvastatin--20 mg/day and aspirin--75 mg/day...
October 2015: Likars'ka Sprava
https://www.readbyqxmd.com/read/27488944/an-evaluation-of-the-effect-of-an-angiotensin-converting-enzyme-inhibitor-on-the-growth-rate-of-small-abdominal-aortic-aneurysms-a-randomised-placebo-controlled-trial-aardvark
#20
Gaia Kiru, Colin Bicknell, Emanuela Falaschetti, Janet Powell, Neil Poulter
BACKGROUND: Although data are inconsistent, angiotensin-converting enzyme inhibitors (ACE-Is) have been associated with a reduced incidence of abdominal aortic aneurysm (AAA) rupture in analysis of administrative databases. OBJECTIVES: (1) To investigate whether or not the ACE-I perindopril (Coversyl arginine, Servier) reduces small AAA growth rate and (2) to evaluate blood pressure (BP)-independent effects of perindopril on small AAA growth and to compare the repeatability of measurement of internal and external aneurysm diameters...
July 2016: Health Technology Assessment: HTA
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