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Zezhou Xie, Peipei Ma
BACKGROUND: The main aim of this study was to evaluate the expression and specific role of miR-33 in the progression of coronary heart disease (CAD), thereby evaluating their diagnostic ability and use in treatment in CAD patients. METHODS: Real time PCR was carried out to explore the level of miR-33 in the plasma of CAD patients and controls. ELISA was performed to analyze the level of placenta growth factor fragment (PLGF). Correlations between miR-33 and PLGF as well as other biochemical parameters were performed with Pearson's correlation analysis...
October 1, 2018: Clinical Laboratory
Li Zhou, Shao-Bin Wang, Shu-Guang Chen, Qiang Qu, Jing-An Rui
BACKGROUND: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AST to ALT ratio (AAR) were shown to be associated with prognosis in some groups of hepatocellular carcinoma (HCC). However, their clinicopathologic and prognostic roles in HCC patients with B-type hepatitis-associated cirrhosis (HBAC) have not been comprehensively investigated. The present study aimed to address the issues. METHODS: A total of 125 patients with HCC and HBAC after radical hepatectomy were included...
October 1, 2018: Clinical Laboratory
Xiao Yang, Hao Zhang, Yuting Jiang, Hongguo Zhang, Xiaonan Hu, Dongliang Zhu, Dongfeng Geng, Ruizhi Liu
BACKGROUND: Non-obstructive azoospermia (NOA) is an important factor leading to male infertility and the genetic mechanism is not yet clear. It requires investigation to reveal its occurrence based on sequencing technology from the genetic level. Our previous genome wide association study (GWAS) using targeted high-throughput sequencing technology has identified suspected genetic variants including rs162036, rs161870, rs1677016R and rs1106042R associated with non-obstructive azoospermia (data not published)...
October 1, 2018: Clinical Laboratory
Said M Afify, Ashraf Tabll, Hend M Nawara, Mohamed El Kassas, Ashraf Elfert, Masaharu Seno, Salah El-Kousy
BACKGROUND: Liver fibrosis is a dynamic procedure that results from an irregularity between fibrogenesis and fibrolysis. After time this procedure can lead to cirrhosis of the liver. Liver fibrosis and cirrhosis assessment is very important for both therapeutic decisions and prognostic evaluations. In this study, we tried to use serum ferritin (SF) together with five fibrosis tests (Age-Platelet index (API), aspartate aminotransferase to alanine aminotransferase ratio (AAR), AST to platelet ratio index (APRI), Fibrosis 4 score (FIB-4), and fibro-quotient (Fibro-Q)) to assess liver fibrosis and cirrhosis and estimate possible correlation between inflammation and SF...
October 1, 2018: Clinical Laboratory
Chuanyin Sun, Guanhua Xu, Jin Lin
BACKGROUND: It can be difficult to distinguish between IgG4-related lymphadenopathy and multicentric Castleman's disease (MCD) because these conditions cannot be differentially diagnosed using immunohistochemical staining alone. In this study, we analyzed the clinical features of IgG4-related lymphadenopathy and MCD patients. METHODS: We retrospectively analyzed 27 patients with MCD, including 20 with plasma cell-type (PC-type) and 7 with hyaline vascular (HV) features (mixed-type)...
October 1, 2018: Clinical Laboratory
Yan L Ge, Cong H Liu, Jing Xu, Zi Y Cui, Wei C Guo, Hui L Li, Ai S Fu, Hong Y Wang, Hai F Zhang, Xiao Y Zhu
BACKGROUND: The CURB-65 scoring system is a simple tool in assessment and prognosis prediction for communityacquired pneumonia (CAP) patients. However, the variations in performance of CURB-65 in young and elderly patients, underestimation or overestimation of the severity, and mortality have often been reported. The aim of this study was to investigate the usefulness of serum high-sensitivity C reactive protein (hs-CRP) combined with CURB-65 in predicting ICU admission and 30-day mortality in CAP patients...
October 1, 2018: Clinical Laboratory
Simone Kiel, Elisabeth Hey, Annekathrin Haase, Ariane Chaudhuri, Jean-François Chenot
BACKGROUND:  For the correct intake and safe handling of their own medication it is important that patients know about their own medication and can give certain information. This study examines what information patients can provide about their prescribed medication and which factors influence the ability to provide information. METHODS:  A cross-sectional study was conducted. In 10 General Practice, 637 patients (participation rate 57 %) were asked about the name, dosage, frequency of intake and indication of their prescribed medication...
October 2018: Deutsche Medizinische Wochenschrift
Sindhu K Srinivas, Katy Kozhimannil, Peiyin Hung, Laura Attanasio, Judy Jou, William A Grobman
BACKGROUND:  A recent document by the American Congress of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine introduced the concept of uniform levels of maternal care (LMCs). OBJECTIVE:  We assessed LMC across hospitals and measured their association with maternal morbidity, focusing on women with high-risk conditions. STUDY DESIGN:  We collected data from hospitals from May to November 2015 and linked survey responses to Statewide Inpatient Databases (SID) hospital discharge data in a retrospective cross-sectional study of 247,383 births admitted to 236 hospitals...
October 18, 2018: American Journal of Perinatology
Elvira V Bräuner, Jeanette T Jørgensen, Anne Katrine Duun-Henriksen, Claus Backalarz, Jens E Laursen, Torben H Pedersen, Mette K Simonsen, Zorana J Andersen
BACKGROUND: Growing evidence supports the concept that traffic noise exposure leads to long-term health complications other than annoyance, including cardiovascular disease. Similar effects may be expected from wind turbine noise exposure, but evidence is sparse. Here, we examined the association between long-term exposure to wind turbine noise and incidence of myocardial infarction (MI). METHODS: We used the Danish Nurse Cohort with 28,731 female nurses and obtained data on incidence of MI in the Danish National Patient and Causes of Death Registries until ultimo 2013...
October 15, 2018: Environment International
Sonal Sekhar M, Unnikrishnan M K, Gabriel Sunil Rodrigues, Navya Vyas, Chiranjay Mukhopadhyay
PURPOSE: Diabetic foot infections (DFIs) are major public health concerns. In the view of the ever increasing burden of multidrug-resistant (MDR) organisms, improving the use of antimicrobial agents (AMAs) is a national priority. Objective of the study was to determine antimicrobial susceptibility (AMS) pattern of aerobes in DFIs. METHODS: A cross-sectional study was conducted for a period of 3 years at Department of Surgery, Kasturba hospital, Manipal, India during which, 260 DFUs patients admitted in the general surgery wards were enrolled for the study...
July 11, 2018: Foot
Ébe Dos Santos Monteiro Carbone, Mayara Ronzini Takaki, Maria Gabriela Baumgarten Kuster Uyeda, Marair Gracio Ferreira Sartori
PURPOSE: To implement a physical therapy intervention protocol targeting patients admitted for gynaecological surgery to the gynaecological ward of XXXX Hospital. METHOD: A prospective, cross-sectional and observational study was conducted with women admitted to the gynaecology ward, from June 2014 through June 2015. The study was divided into three phases with data on admissions to the gynaecology ward. A total of 565 women were included, corresponding to phases I (197), II (178) and III (190)...
October 10, 2018: International Journal of Surgery Case Reports
Ana P Costa, Jakob S Møller, Helle K Iversen, Sadasivan Puthusserypady
This paper describes the implementation of a Brain Computer Interface (BCI) scheme using a common spatial patterns (CSP) filter in combination with a Recursive Least Squares (RLS) approach to iteratively update the coefficients of the CSP filter. The proposed adaptive CSP (ACSP) algorithm is made more robust by introducing regularization using Diagonal Loading (DL), and thus will be able to significantly reduce the length of training sessions when introducing new patients to the BCI system. The system is tested on a 4-class multi-limb motor imagery (MI) data set from the BCI competition IV (2a), and a more complex single limb 3-class MI dataset recorded in-house...
October 11, 2018: Computers in Biology and Medicine
Evert-Ben van Veen
Insights into the incidence and survival of cancer, the influence of lifestyle and environmental factors and the interaction of treatment regimens with outcomes are hugely dependent on observational research, patient data derived from the healthcare system and from volunteers participating in cohort studies, often non-selective. Since 25th May 2018, the European General Data Protection Regulation (GDPR) applies to such data. The GDPR focusses on more individual control for data subjects of 'their' data. Yet, the GDPR was preceded by a long debate...
October 15, 2018: European Journal of Cancer
Fredric Parenmark, Göran Karlström, Thomas Nolin, Mats Fredrikson, Sten M Walther
PURPOSE: Discharge from an intensive care unit (ICU) during the night is an independent risk factor for adverse outcomes. A quality improvement project was conducted with the aim of reducing the incidence and the associated mortality after night-time discharge. MATERIALS AND METHODS: ICUs that submitted data to the Swedish Intensive Care Registry (SIR) agreed to appoint night-time discharge as a national quality indicator with detailed public display on the internet of various discharge proportions and outcomes...
September 19, 2018: Journal of Critical Care
Samaah Sullivan, Heval M Kelli, Muhammad Hammadah, Matthew Topel, Kobina Wilmot, Ronnie Ramadan, Brad D Pearce, Amit Shah, Bruno B Lima, Jeong Hwan Kim, Shakia Hardy, Oleksiy Levantsevych, Malik Obideen, Belal Kaseer, Laura Ward, Michael Kutner, Allison Hankus, Yi-An Ko, Michael R Kramer, Tené T Lewis, J Douglas Bremner, Arshed Quyyumi, Viola Vaccarino
Living in neighborhoods characterized by poverty may act as a chronic stressor that results in physiological dysregulation of the sympathetic nervous system. No previous study has assessed neighborhood poverty with hemodynamic, neuroendocrine, and immune reactivity to stress. We used data from 632 patients with coronary artery disease. Patients' residential addresses were geocoded and merged with poverty data from the 2010 American Community Survey at the census-tract level. A z-transformation was calculated to classify census tracts (neighborhoods) as either having 'high' or 'low' poverty...
October 1, 2018: Psychoneuroendocrinology
Ikumi Kuno, Hiroshi Yoshida, Hanako Shimizu, Takashi Uehara, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
OBJECTIVES: Incidentally discovered lymphangioleiomyomatosis (LAM) in sampled lymph nodes are infrequent but intractable issues for gynecologists. The aims of this study were to elucidate the prevalence of incidental nodal LAM in a consecutive cohort of gynecologic surgical specimens from Japanese patients, to document clinicopathological features of nodal LAM cases, and to investigate the association between the subsequent development of pulmonary LAM and tuberous sclerosis complex (TSC)...
October 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Leonello Tacconi, Roberto Spinelli, Francesco Signorelli
BACKGROUND: Traditional wound closure techniques include skin sutures and metal clips. Cyanoacrylate (2-Octyl-Cyanoacrylate "Dermabond C", by Ethicon, Germany) has good neovascularization, epithelialization and antimicrobial activity properties and a fast application procedure. This study presents our long-term experience. METHODS: We retrospectively selected 362 patients who underwent brain surgery from January 2007 to March 2017. Exclusion criteria was applied for repeat surgeries, emergency/post-traumatic procedures, wound infections, wounds longer than 16 centimeters, skull base cases, post-operative patients who stayed in the ICU more than 1 day...
October 15, 2018: World Neurosurgery
Gilles Guerrier, Christine Agostini, Marion Antona, Fiorella Sponzini, Anne Paoletti, Isabelle Martin, Jean-Michel Ekherian, Christophe Baillard
PURPOSE: The optimal size of the I-Gel® remains unclear since the manufacturer's weight-based formula (size 3 for weight < 50 kg, size 4 for weight 50-90 kg, and size 5 for weight > 90 kg) for the laryngeal mask airway I-Gel® is not evidence-based. We hypothesised that sex may also guide the choice of I-Gel® size. METHODS: Insertion success rates of the I-Gel® chosen according to the weight-based formula were prospectively recorded and compared with those of a patients' cohort ventilated with an I-Gel® chosen according to the sex-based formula recorded...
October 15, 2018: Anaesthesia, Critical Care & Pain Medicine
Daphne Levin, Gili Grinfeld, Vladislav Greenberg, Yoav Lipsky, Svetlana Zalmanov-Fayerman, Yonina Tova, Rephael Pfeffer
PURPOSE: For high dose per fraction treatments such as stereotactic body radiotherapy (SBRT) in our department we require a physician to perform the pre-treatment on board imaging (OBI) match. The purpose of this study was to determine if patient matching positioning performed by radiation therapists (RTTs) is as accurate as physician matching. METHODS: Sixteen RTTs and five physicians participated in this study. Data were collected from 113 patients totaling 324 measurements...
October 15, 2018: Practical Radiation Oncology
Shingo Hashimoto, Masaki Katsurada, Rie Muramatsu, Kumiko Asai, Kenichiro Tanaka, Kensuke Hayashi, Yoshiaki Kibe, Koichiro Nakajima, Yukiko Hattori, Hiromitsu Iwata, Jun-Etsu Mizoe, Hiroyuki Ogino, Yuta Shibamoto
PURPOSE: Suppression of respiratory movement of the liver would be desirable for high-precision radiation therapy for liver tumors. We aimed to investigate the effect of our original device-free compressed shell fixation method and breathing instruction on suppression of respiratory movement. The characteristics of liver motion based on the movement of a fiducial marker were also analyzed. METHODS: First, respiratory amplitudes of the liver with the device-free compressed shell were analyzed from the data of 146 patients...
October 15, 2018: Practical Radiation Oncology
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