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A Gilmartin, M Ryan
Aim To evaluate thyroid nodules and to determine the incidence of thyroid cancer. Methods This retrospective cohort study collected data from ten patients who presented with thyroid nodules to Barrington’s Hospital Limerick. Ultrasound/FNA results of thyroid nodules were used to measure the incidence of thyroid cancer. Results The number of thyroid nodules diagnosed as malignant was significantly greater than benign nodules (***p-value <0.0004, 95% confidence interval (-1.109 to -0.399)). This data indicates that females are more likely to develop thyroid cancer than males...
September 10, 2018: Irish Medical Journal
R González-Rubio, D Parra-Blázquez, I San-Juan-Sanz, G Ruiz-Carrascoso, S Gallego, L Escosa-García, A Robustillo-Rodela
OBJECTIVE: The aim of this study is to describe the evolution of the incidence of infected and colonized patients with carbapenemase VIM-producing bacteria (CPB-VIM) at a national referral pediatric center in Madrid, Spain, between 2012 and 2015. METHODS: Descriptive epidemiological surveillance study. The surveillance system included case detection (screening for BPC colonization in all admitted patients, with periodicity according to the ward) and control measures (contact precautions, identification of previously colonized patients at admission, environmental cleaning, education, supervision of contact precautions, and patient cohort)...
December 13, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
[Introduction: Each year, more than 1.2 million deaths in the world are due to road accidents. It is the leading cause of mortality in young people between the ages of 15 and 29 years. Road accidents and associated injuries have a major impact on health and development. Many international reports have evaluated the mortality and morbidity related to road accidents, but these studies are based on limited data, often with limited robustness. Based on a study conducted in Ouagadougou, the capital of Burkina Faso, to estimate the mortality and morbidity of road accident victims, the objective of this article was to evaluate social, spatial and health inequalities of populations killed or injured as a result of a road accident.Methods: Between February and July 2015, all road accidents were recorded by policemen using a mobile telephone data collection system, including geolocation of accidents. Three quantitative and prospective survey phases were then performed on injured patients admitted to Yalgado Ouedraogo hospital, the reference centre for these patients.Results: A total of 1,867 emergency department admissions were reported. The majority (95%) of road accident victims were vulnerable users. More than 30% of accidents occurred in one central quarter and two peripheral quarters. The mean management time as 1 hour 3 minutes for victims rescued by firemen and 3 hours 10 minutes for those who attended the emergency department on their own. The mean total cost of management was 126,799 CFA francs (€193) [400-2,000,000 CFA francs].Discussion].
Emmanuel Bonnet, Amandine Fillol, Aude Nikiema, Lucie Lechat, Mohamed Tall, Songahir Christophe Da, Valery Ridde
INTRODUCTION: Each year, more than 1.2 million deaths in the world are due to road accidents. It is the leading cause of mortality in young people between the ages of 15 and 29 years. Road accidents and associated injuries have a major impact on health and development. Many international reports have evaluated the mortality and morbidity related to road accidents, but these studies are based on limited data, often with limited robustness. Based on a study conducted in Ouagadougou, the capital of Burkina Faso, to estimate the mortality and morbidity of road accident victims, the objective of this article was to evaluate social, spatial and health inequalities of populations killed or injured as a result of a road accident...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Ting-An Lin, Ching-Fen Yang, Yao-Chung Liu, Jin-Hwang Liu, Tzeon-Jye Chiou, Liang-Tsai Hsiao, Hsiu-Ju Yen, Chia-Jen Liu, Hao-Yuan Wang, Po-Shen Ko, Sheng-Hsuan Chien, Jyh-Pyng Gau
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare form of cytotoxic T-cell lymphoma. It is believed that SPTL in patients without hemophagocytic syndrome (HPS) follows an indolent course; in contrast, SPTL in patients with HPS has been associated with unfavorable survival. To provide more clinical data on SPTL in Asian populations and to identify optimal therapeutic strategies for SPTL, we assessed the clinicopathological features and long-term follow-up data of 10 Taiwanese SPTL patients diagnosed at a single center...
December 13, 2018: International Journal of Hematology
Pietro Caggiano, Mervi Jehkonen
A review of patients with brain injury showing personal neglect is presented. The aim is to shed light on this aspect of neglect often unresearched or only indirectly investigated, and to discuss recent findings concerning the methods used to assess personal neglect, its neural correlates and its association with the more often explored aspect of extrapersonal neglect. The review was performed using PubMed and PsychInfo databases to search for papers published in the last 123 years (until January 2018). We reviewed 81 papers describing either single or group studies for a total of 2247 patients...
December 13, 2018: Neuropsychology Review
Julien Chiquet, Guillem Rigaill, Martina Sundqvist
This chapter addresses the problem of reconstructing regulatory networks in molecular biology by integrating multiple sources of data. We consider data sets measured from diverse technologies all related to the same set of variables and individuals. This situation is becoming more and more common in molecular biology, for instance, when both proteomic and transcriptomic data related to the same set of "genes" are available on a given cohort of patients.To infer a consensus network that integrates both proteomic and transcriptomic data, we introduce a multivariate extension of Gaussian graphical models (GGM), which we refer to as multiattribute GGM...
2019: Methods in Molecular Biology
Sung G Lee, Andrew J Russ, Mark A Casillas
BACKGROUND: Transanal minimally invasive surgery (TAMIS) has gained worldwide popularity as a method for the local excision of rectal neoplasms. However, it is technically demanding due to limited working space. Robotic TAMIS offers potential enhanced dexterity and ability while allowing for a more aggressive resection with a stable platform. The objective of this study was to review a single institution experience between laparoscopic (L-TAMIS) and robotic TAMIS (R-TAMIS) for treatment of rectal neoplasms and determine if there are significant differences on outcomes...
December 13, 2018: Surgical Endoscopy
Katharina Schütz, Diana Alecsandru, Bodo Grimbacher, Jamanda Haddock, Annemarie Bruining, Gertjan Driessen, Esther de Vries, Peter M van Hagen, Ieneke Hartmann, Francesco Fraioli, Cinzia Milito, Milica Mitrevski, Isabella Quinti, Goffredo Serra, Peter Kelleher, Michael Loebinger, Jiri Litzman, Vera Postranecka, Vojtech Thon, Judith Babar, Alison M Condliffe, Andrew Exley, Dinakantha Kumararatne, Nick Screaton, Alison Jones, Maria P Bondioni, Vassilios Lougaris, Alessandro Plebani, Annarosa Soresina, Cesare Sirignano, Giuseppe Spadaro, Nermeen Galal, Luis I Gonzalez-Granado, Sabine Dettmer, Robert Stirling, Helen Chapel, Mary Lucas, Smita Patel, Claire-Michele Farber, Isabelle Meyts, Arpan K Banerjee, Scott Hackett, John R Hurst, Klaus Warnatz, Benjamin Gathmann, Ulrich Baumann
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency...
December 13, 2018: Journal of Clinical Immunology
Erina Sasaki, Angela T Byrne, Ethna Phelan, Desmond W Cox, William Reardon
The filamin A gene (FLNA) on Xq28 encodes the filamin A protein. Mutation in FLNA causes a wide spectrum of disease including skeletal dysplasia, neuronal migration abnormality, cardiovascular malformation, intellectual disability and intestinal obstruction. Recently, childhood-onset interstitial lung disease associated with a range of FLNA mutations has been recognised and reported. We document our personal experience of this emerging disorder and compile a comprehensive overview of clinical features and molecular changes in all identifiable published cases...
December 13, 2018: European Journal of Pediatrics
Damon F Ogburn, Victor J Schoenbach, Andrew Edmonds, Brian W Pence, Kimberly A Powers, Becky L White, Nicole Dzialowy, Erika Samoff
Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009-2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with "probable current depression" and with 100% ART dose adherence...
December 13, 2018: AIDS and Behavior
Robin Detering, Wernard A A Borstlap, Lisa Broeders, Linda Hermus, Corrie A M Marijnen, Regina G H Beets-Tan, Willem A Bemelman, Henderik L van Westreenen, Pieter J Tanis
BACKGROUND: The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after chemoradiotherapy (CRT) on short- and long-term outcomes. METHODS: Patients were selected from a collaborative rectal cancer research project including 71 Dutch centres, and were subdivided into two groups according to time interval from the start of preoperative CRT to surgery (< 14 and ≥ 14 weeks)...
December 13, 2018: Annals of Surgical Oncology
Hsi-Yu Yu, Chih-Hsien Wang, Nai-Hsin Chi, Shu-Chien Huang, Heng-Wen Chou, Nai-Kuan Chou, Yih-Sharng Chen
PURPOSE: Caseloads of extracorporeal cardiopulmonary resuscitation (ECPR) have increased considerably, and hospital mortality rates remain high and unpredictable. The present study evaluated the effects of the interplay between age and prolonged low-flow duration (LFD) on hospital survival rates in elderly patients to identify subgroups that can benefit from ECPR. METHODS: Adult patients who received ECPR in our institution (2006-2016) were classified into groups 1, 2, and 3 (18-65, 65-75, and > 75 years, respectively)...
December 13, 2018: Intensive Care Medicine
Nena Karavasiloglou, Katarina L Matthes, Claudia Berlin, Manuela Limam, Miriam Wanner, Dimitri Korol, Sabine Rohrmann
PURPOSE: Increase in in situ breast cancer (BCIS) incidence has been reported across Europe and the USA. However, little is known about the trends in BCIS incidence in regions without population-based mammographic screening programs. We set out to investigate these trends in Zurich, Switzerland, where only opportunistic mammographic screening exists. METHODS: Data from 989 women diagnosed with a primary BCIS between 2003 and 2014 were used in our analyses. Age-standardized incidence rates per 100,000 person-years (ASR) were computed per year...
December 13, 2018: Journal of Cancer Research and Clinical Oncology
David Roh, Andrew Martin, Chung-Huan Sun, Andrew Eisenberger, Amelia Boehme, Mitchell S V Elkind, Josephine U Pucci, Santosh Murthy, Hooman Kamel, Lauren Sansing, Soojin Park, Sachin Agarwal, Edward Sander Connolly, Jan Claassen, Eldad Hod, Richard O Francis
BACKGROUND/PURPOSE: Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH). METHODS: Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia University Irving Medical Center from 2009 to 2016 were evaluated. Primary ICH patients with admission blood type testing were evaluated for HE differences, defined as > 33% relative HE...
December 13, 2018: Neurocritical Care
Du Hyun Ro, Heejin Jin, Jae-Young Park, Myung Chul Lee, Sungho Won, Hyuk-Soo Han
PURPOSE: This study hypothesized that the use of bisphosphonates (BPs) after total joint arthroplasty (TJA) is associated with a lower implant revision rate. This study aimed (1) to investigate the association between BP use and the revision rate of TJA and (2) to determine the relationship between the medication period and the revision rate of TJA. METHODS: National Health Insurance Service data on surgeries, medications, diagnoses, and screenings of 50 million Koreans were reviewed...
December 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Masaya Takahashi, Katsuyuki Takahashi, Kazuki Ogawa, Tsutomu Takashima, Yuka Asano, Shinichiro Kashiwagi, Satoru Noda, Naoyoshi Onoda, Masaichi Ohira, Katsuya Nagayama
PURPOSE: The purpose of this study was to compare the efficacy of the pre-prescription of garenoxacin mesylate hydrate (GRNX) with that of moxifloxacin hydrochloride (MFLX) in the management of breast cancer patients with low-risk febrile neutropenia. METHODS: Data from female patients who had been instructed to take previously prescribed oral GRNX or MFLX for 3 days during adjuvant and neoadjuvant chemotherapy if their body temperature exceeded 38 °C were analyzed...
December 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Seyyed Mohammad Reza Kazemi-Bajestani, Harald Becher, Charles Butts, Naveen S Basappa, Michael Smylie, Anil Abraham Joy, Randeep Sangha, Andrea Gallivan, Quincy Chu, Vickie E Baracos
PURPOSE: Currently, there is no approved therapy for cancer cachexia. According to European and American regulatory agencies, physical function improvements would be approvable co-primary endpoints of new anti-cachexia medications. As physical functioning is in part dependent on cardiac functioning, we aimed to explore the cardiac status of a group of patients meeting current criteria for inclusion in cachexia clinical trials. METHODS: Seventy treatment-naive patients with metastatic NSCLC [36 (51...
December 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
David W Bearl, Debra A Dodd, Cary Thurm, Matt Hall, Jonathan H Soslow, Brian Feingold, Justin Godown
Right ventricular (RV) failure is a potentially fatal complication following heart transplantation (HTx). Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that is used to decrease pulmonary vascular resistance immediately post-HTx to reduce the risk of RV failure. The aim of this study was to describe utilization patterns, costs, and outcomes associated with post-transplant iNO use in children. All pediatric HTx recipients (2002-2016) were identified from a unique linked PHIS/SRTR dataset. Post-HTx iNO use was determined based on hospital billing data...
December 13, 2018: Pediatric Cardiology
Aaron Yarlas, Stephen M Maher, Martha S Bayliss, Andrew Lovley, Joseph C Cappelleri, Marco D DiBonaventura
Patients with ulcerative colitis, a type of inflammatory bowel disease, report negative impacts of disease symptoms on work-related outcomes, including absenteeism and presenteeism. As a way to better understand the impact of this disease and its treatment on work-related outcomes, the current review examines the use of the Work Productivity and Activity Impairment Questionnaire (WPAI), a patient-reported outcomes measure of absenteeism, presenteeism, and impairment in other activities, in studies of patients with ulcerative colitis...
December 13, 2018: Journal of patient-reported outcomes
Quirine F Manson, Willemijne A M E Schrijver, Natalie D Ter Hoeve, Cathy B Moelans, Paul J van Diest
Programmed death-1 (PD-1) is an immune checkpoint that is able to inhibit the immune system by binding to its ligand programmed death-ligand 1 (PD-L1). In many cancer types, among which breast cancer, prognostic and/or predictive values have been suggested for both PD-1 and PD-L1. Previous research has demonstrated discrepancies in PD-L1 expression between primary breast tumors and distant metastases, however data so far have been scarce. We therefore evaluated immunohistochemical expression levels of PD-1 and PD-L1 in primary breast tumors and their paired distant metastases, and evaluated prognostic values...
December 13, 2018: Clinical & Experimental Metastasis
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