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Cardiovascular prevention

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https://www.readbyqxmd.com/read/29912978/mediterranean-diet-and-quality-of-life-baseline-cross-sectional-analysis-of-the-predimed-plus-trial
#1
Iñigo Galilea-Zabalza, Pilar Buil-Cosiales, Jordi Salas-Salvadó, Estefanía Toledo, Carolina Ortega-Azorín, Javier Díez-Espino, Zenaida Vázquez-Ruiz, María Dolores Zomeño, Jesús Vioque, José Alfredo Martínez, Dora Romaguera, Napoleón Perez-Farinos, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep Antoni Tur, Francisco Tinahones, Lluis Serra-Majem, Alba Marcos-Delgado, Manuel Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Diaz-López, Nancy Babio, Miguel Angel Muñoz, Montse Fitó, Sandra González-Palacios, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ángel Martínez-González
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone...
2018: PloS One
https://www.readbyqxmd.com/read/29912869/reporting-bias-in-the-literature-on-the-associations-of-health-related-behaviors-and-statins-with-cardiovascular-disease-and-all-cause-mortality
#2
Leandro Fórnias Machado de Rezende, Juan Pablo Rey-López, Thiago Hérick de Sá, Nicholas Chartres, Alice Fabbri, Lauren Powell, Emmanuel Stamatakis, Lisa Bero
Reporting bias in the literature occurs when there is selective revealing or suppression of results, influenced by the direction of findings. We assessed the risk of reporting bias in the epidemiological literature on health-related behavior (tobacco, alcohol, diet, physical activity, and sedentary behavior) and cardiovascular disease mortality and all-cause mortality and provided a comparative assessment of reporting bias between health-related behavior and statin (in primary prevention) meta-analyses. We searched Medline, Embase, Cochrane Methodology Register Database, and Web of Science for systematic reviews synthesizing the associations of health-related behavior and statins with cardiovascular disease mortality and all-cause mortality published between 2010 and 2016...
June 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29912156/vasodilator-activity-of-compounds-isolated-from-plants-used-in-mexican-traditional-medicine
#3
Francisco J Luna-Vázquez, César Ibarra-Alvarado, María Del Rayo Camacho-Corona, Alejandra Rojas-Molina, J Isela Rojas-Molina, Abraham García, Moustapha Bah
Arterial hypertension is one of the main risk factors in the development of cardiovascular diseases. Therefore, it is important to look for new drugs to treat hypertension. In this study, we carried out the screening of 19 compounds (triterpenes, diterpenes, sesquiterpenes, lignans, and flavonoids) isolated from 10 plants used in Mexican traditional medicine to determine whether they elicited vascular smooth muscle relaxation and, therefore, could represent novel anti-hypertension drug candidates. The vasorelaxant activity of these compounds was evaluated on the isolated rat aorta assay and the results obtained from this evaluation showed that three compounds induced a significant vasodilatory effect: meso -dihydroguaiaretic acid [half maximal effective concentration (EC50 ), 49...
June 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29912070/the-impact-of-massage-and-reading-on-children-s-pain-and-anxiety-after-cardiovascular-surgery-a-pilot-study
#4
Sandra L Staveski, Karen Boulanger, Lee Erman, Li Lin, Christina Almgren, Chloe Journel, Stephen J Roth, Brenda Golianu
OBJECTIVES: The purpose of this pilot study was three-fold: 1) to evaluate the safety and feasibility of instituting massage therapy in the immediate postoperative period after congenital heart surgery, 2) to examine the preliminary results on effects of massage therapy versus standard of care plus three reading visits on postoperative pain and anxiety, and 3) to evaluate preliminary effects of opioid and benzodiazepine exposure in patients receiving massage therapy compared with reading controls...
June 14, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29911498/exploring-spatial-patterns-of-cardiovascular-disease-in-sweden-between-2000-and-2010
#5
Mohammadreza Rajabi, Ali Mansourian, Petter Pilesjö, Daniel Oudin Åström, Klas Cederin, Kristina Sundquist
AIMS: Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity worldwide, including in Sweden. The main aim of this study was to explore the temporal trends and spatial patterns of CVD in Sweden using spatial autocorrelation analyses. METHODS: The CVD admission rates between 2000 and 2010 throughout Sweden were entered as the input disease data for the analytic processes performed for the Swedish capital, Stockholm, and also for the whole of Sweden...
June 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29911035/subclinical-hypothyroidism-and-cardiac-risk-lessons-from-a-south-indian-population-study
#6
Sashi Niranjan Nair, Harish Kumar, Manoj Raveendran, V Usha Menon
Introduction: The benefits of treating subclinical hypothyroidism are currently under debate, prevention of adverse cardiac events purporting to be one of the main benefits. The effect of subclinical hypothyroidism on the cardiovascular health of the Indian sub-population is largely unknown. This study was designed to examine these effects and to help guide treatment of this disorder. Methods: A cross-sectional adult population survey was carried out in urban coastal area of central Kerala...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910068/leisure-time-physical-activity-at-moderate-and-high-intensity-is-associated-with-parameters-of-body-composition-muscle-strength-and-sarcopenia-in-aged-adults-with-obesity-and-metabolic-syndrome-from-the-predimed-plus-study
#7
Nuria Rosique-Esteban, Nancy Babio, Andrés Díaz-López, Dora Romaguera, J Alfredo Martínez, Vicente Martin Sanchez, Helmut Schröder, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales, Jadwiga Konieczna, Itziar Abete, Jordi Salas-Salvadó
AIMS: We aimed to examine the associations of leisure-time physical activity (PA) and sedentary behavior (SB) with the prevalence of sarcopenia, body composition and muscle strength among older adults having overweight/obesity and metabolic syndrome, from the PREDIMED-Plus trial. METHODS: Cross-sectional baseline analysis including 1539 men and women (65 ± 5 y). Sarcopenia was defined as low muscle mass (according to FNIH cut-offs) plus low muscle strength (lowest sex-specific tertile for 30-s chair-stand test)...
June 6, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29909641/factors-associated-with-non-participation-in-and-dropout-from-cardiac-rehabilitation-programmes-a-systematic-review-of-prospective-cohort-studies
#8
Davinia Maria Resurrección, Patricia Moreno-Peral, Marta Gómez-Herranz, Maria Rubio-Valera, Luis Pastor, Jose Miguel Caldas de Almeida, Emma Motrico
BACKGROUND: Although evidence exists for the efficacy of cardiac rehabilitation programmes to reduce morbidity and mortality among patients with cardiovascular disease, cardiac rehabilitation programmes are underused. We aimed systematically to review the evidence from prospective cohort studies on factors associated with non-participation in and/or dropping out from cardiac rehabilitation programmes. METHODS: MedLine, Embase, Scopus, Open Grey and Cochrane Database were searched for relevant publications from inception to February 2018...
June 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29909377/effect-of-aspirin-on-cancer-chemoprevention-in-japanese-patients-with-type-2-diabetes-10-year-observational-follow-up-of-a-randomized-controlled-trial
#9
Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma, Chisa Matsumoto, Hirofumi Soejima, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Yoshihiko Saito
OBJECTIVE: This study analyzed the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes. RESEARCH DESIGN AND METHODS: This study was a posttrial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial. Participants in the JPAD trial (2,536 Japanese patients with type 2 diabetes and without preexisting cardiovascular disease) were randomly allocated to receive aspirin (81 or 100 mg daily) or no aspirin...
June 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29909238/autophagy-as-an-emerging-target-in-cardiorenal-metabolic-disease-from-pathophysiology-to-management
#10
REVIEW
Yingmei Zhang, Adam T Whaley-Connell, James R Sowers, Jun Ren
Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909156/high-dose-influenza-vaccine-to-reduce-clinical-outcomes-in-high-risk-cardiovascular-patients-rationale-and-design-of-the-invested-trial
#11
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29908781/-impact-of-cardiovascular-risk-factors-on-the-consumption-of-resources-in-primary-care-according-to-clinical-risk-groups
#12
Magdalena Millá Perseguer, Natividad Guadalajara Olmeda, David Vivas Consuelo
OBJECTIVE: To analyze the prevalence of Cardiovascular Risk Factors (CVRF) in the context of a Basic Health Area and the impact they generate on morbidity and consumption of healthcare resources in the stratified population according to the Clinical System Risk Groups (CRG) in Primary Care, with the purpose of identifying the population with multimorbidity to apply preventive measures, as well as the one that generates the highest care burden and social needs. DESIGN: Observational, cross-sectional and population-based study for a basic health area during 2013...
June 13, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29908361/incidence-of-upper-and-lower-gastrointestinal-bleeding-in-new-users-of-low-dose-aspirin
#13
Lucía Cea Soriano, Angel Lanas, Montse Soriano-Gabarró, Luis A García Rodríguez
BACKGROUND & AIMS: There are few data on the incidence of upper and lower gastrointestinal bleeding (UGIB and LGIB) from observational studies of low-dose aspirin users. We aimed to estimate incidence rates of UGIB and LGIB in a large cohort of new users of low-dose aspirin in the United Kingdom, with sub-analyses of hospitalization status and fatalities. METHODS: We performed a population-based study of 199,079 new users of low-dose aspirin (median age, 64...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908295/hyperglycaemic-impairment-of-par2-mediated-vasodilation-prevention-by-inhibition-of-aortic-endothelial-sodium-glucose-co-transporter-2-and-minimizing-oxidative-stress
#14
Mahmoud El-Daly, Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Sean Kang, Paul W M Fedak, Laurie A Alston, Simon A Hirota, Hong Ding, Chris R Triggle, Morley D Hollenberg
Hyperglycaemia is a major contributor to diabetic cardiovascular disease with hyperglycaemia-induced endothelial dysfunction recognized as the initiating cause. Coagulation pathway-regulated proteinase-activated receptors (PARs) that can regulate vascular tone in vivo cause eNOS-mediated endothelium-dependent vasodilation; but, the impact of hyperglycaemia on this vasodilatory action of PAR stimulation and the signalling pathways involved are unknown. We hypothesized that vascular sodium-glucose co-transporter 2 activity and hyperglycaemia-induced oxidative stress involving Src-kinase, EGF receptor-kinase, Rho-kinase and protein-kinase-C biochemical signalling pathways would compromise PAR2-mediated endothelium-dependent vasodilation...
June 13, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29908098/modelling-the-population-effectiveness-of-the-national-seasonal-influenza-vaccination-programme-in-scotland-the-impact-of-targeting-all-individuals-aged-65-years-and-over-flu-vaccination-programme-effectiveness
#15
Stephen Corson, Chris Robertson, Arlene Reynolds, Jim McMenamin
BACKGROUND: For the last 17 years, the UK has employed a routine influenza vaccination programme with the aim of reducing the spread of seasonal influenza. In mid-2000, the programme moved from a purely risk-based approach to a risk and age group targeted approach with all those aged 65+ years being included. To date, there has been no assessment of the population effectiveness of this age targeted policy in Scotland. OBJECTIVES: Statistical modelling techniques were used to determine what impact the routine vaccination of those aged 65+ years has had on influenza related morbidity and mortality in Scotland...
June 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29907995/fifteen-years-of-life-losartan-intervention-for-endpoint-reduction-in-hypertension-lessons-learned-for-losartan-an-old-dog-playing-good-tricks
#16
REVIEW
Niki Katsiki, Konstantinos Tsioufis, Dilek Ural, Massimo Volpe
There is an unmet need to prevent cardiovascular disease and chronic kidney disease development and progression worldwide. Losartan, the first angiotensin receptor blocker, was shown to exert significant cardioprotective and renoprotective effects in the LIFE (Losartan Intervention for Endpoint Reduction in Hypertension) and RENAAL (Reduction of Endpoints in NIDDM With the Angiotensin II Antagonist Losartan) trials. Losartan significantly prevented stroke and decreased serum uric acid levels and the rates of new-onset diabetes mellitus and atrial fibrillation...
June 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29907363/critical-roles-of-inflammation-in-atherosclerosis
#17
REVIEW
Junji Moriya
There is accumulating evidence that vascular inflammation plays critical roles in pathophysiology of atherosclerosis. It is widely accepted that both innate and adaptive immune responses are important for initiation and progression of atherosclerosis, which mainly consist of monocytes, macrophages, neutrophils, T lymphocytes, and B lymphocytes. Moreover, inflammatory biomarkers such as high-sensitivity C-reactive protein and interleukin-6 are known to predict future cardiovascular events, as well as conventional low-density or high-density lipoprotein cholesterol...
June 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29907155/green-leafy-vegetables-in-diets-with-a-25-1-omega-6-omega-3-fatty-acid-ratio-modify-the-erythrocyte-fatty-acid-profile-of-spontaneously-hypertensive-rats
#18
Melissa Johnson, Ralphenia D Pace, Wendell H McElhenney
BACKGROUND: In addition to the actual composition of the diet (i.e. nutrient composition, food groups), the omega-6/omega-3 fatty acid ratio has been demonstrated to influence the tissue fatty acid profile and subsequently the risk for cardiovascular and other diseases. Likewise, the consumption of green leafy vegetables (GLVs) may favorably reduce the risks associated with disease. Although an ~ 3:1 omega-6/omega-3 fatty acid ratio (ω-6/ω-3 FAR) is recommended, the typical American diet has an ~ 25:1 ω-6/ω-3 FAR...
June 15, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29906534/anti-inflammatory-effect-of-low-molecular-weight-fucoidan-from-saccharina-japonica-on-atherosclerosis-in-apoe-knockout-mice
#19
Yingjie Xu, Jie Xu, Keli Ge, Qingwu Tian, Peng Zhao, Yunliang Guo
Atherosclerosis (AS) is the key cause of many cardiovascular and cerebrovascular diseases. The inflammatory response and lipid metabolism disorders contribute to the development and progression of AS. This work aims to study the anti-inflammatory effect and mechanism of low molecular weight fucoidan (LMWF) obtained from Saccharina japonica on atherosclerosis in apoE-knockout mice. The experimental results showed that LMWF statistically decreased the levels of triglyceride (TRIG) and oxidative low-density lipoproteins (ox-LDL) and stabilized established atherosclerotic lesions...
June 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29906479/evaluating-several-biomarkers-as-predictors-of-aortic-stiffness-in-young-and-older-africans-not-consuming-alcohol-based-on-self-report
#20
Melissa Maritz, Carla Mt Fourie, Johannes M VAN Rooyen, Aletta E Schutte
AIMS: Black populations from sub-Saharan Africa have a high prevalence of cardiovascular disease, which places significant strain on public health systems. Aortic stiffness is a prominent risk factor for cardiovascular disease development. We reported earlier that excessive alcohol use predicts aortic stiffness. However, we require a better understanding of other biomarkers involved in stiffness development, beyond alcohol use. Therefore, we determined which biomarkers (metabolic, inflammatory, endothelial activation and oxidative stress) relate to aortic stiffness in young and older black South Africans, self-reporting no alcohol-use...
June 12, 2018: Diabetes Research and Clinical Practice
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