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Thrombosis research

Peter Langhorne, Janice M Collier, Patricia J Bate, Matthew Nt Thuy, Julie Bernhardt
BACKGROUND: Very early mobilisation (VEM) is performed in some stroke units and recommended in some acute stroke clinical guidelines. However, it is unclear whether very early mobilisation independently improves outcome after stroke. OBJECTIVES: To determine whether very early mobilisation (started as soon as possible, and no later than 48 hours after onset of symptoms) in people with acute stroke improves recovery (primarily the proportion of independent survivors) compared with usual care...
October 16, 2018: Cochrane Database of Systematic Reviews
Andreas Bender Jonsson, Sofie Louise Rygård, Lene Russell, Anders Perner, Morten Hylander Møller
BACKGROUND: Thrombocytopenia is a common condition in critically ill patients in the intensive care unit (ICU). It is associated with prolonged stay in the ICU, increased transfusion requirements, risk of bleeding and mortality. The evidence regarding the use of prophylactic platelet transfusion and thrombosis prophylaxis in patients with thrombocytopenia in the ICU is unknown. To direct future research, we aim to assess the current evidence regarding prophylactic platelet transfusion and thrombosis prophylaxis on patient-important benefits and harms in the ICU population...
October 14, 2018: Acta Anaesthesiologica Scandinavica
X Feng, X F Shi
Hepatitis B remains a worldwide health problem with a high mortality rate associated with end-stage liver diseases. The Model for End-Stage Liver Disease and Child-Pugh score is still widely used as the prognostic model for liver cirrhosis and inflammatory reaction, B-type natriuretic peptide and portal vein thrombosis are independent risk factors. Many new models have been proposed for liver failure, including a new model HINAT ACLF. HINAT ACLF is better than its preceding models and increased neutrophil-to-lymphocyte ratio is a single factor to promote thyroid hormone, cholinesterase, and antiviral treatment response in this model...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Elham E Amin, Arina J Ten Cate-Hoek, Annemieke C Bouman, Karina Meijer, Lidwine Tick, Saskia Middeldorp, Guy Mostard, Marije Ten Wolde, Simone van den Heiligenberg, Sanne van Wissen, Marlene van de Poel, Sabina Villalta, Erik Serné, Hans Martin Otten, Edith Klappe, Paolo Prandoni, Martin H Prins, Hugo Ten Cate, Manuela A Joore
BACKGROUND: The IDEAL DVT study showed that it was safe to shorten the duration of elastic compression therapy on an individualised basis after deep vein thrombosis for prevention of post-thrombotic syndrome. In this study, we assessed the cost-effectiveness of this strategy. METHODS: IDEAL DVT was a multicentre, randomised, non-inferiority trial that included patients with acute proximal deep vein thrombosis of the leg. After 6 months of elastic compression therapy, patients were randomly assigned (1:1) to the standard 2 years of elastic stocking compression therapy or shortened duration of compression therapy based on the patient's Villalta score...
October 9, 2018: Lancet Haematology
Julia Tilburg, Reheman Adili, Thankam S Nair, Megan E Hawley, David C Tuk, Madeline Jackson, Henri M Spronk, Henri H Versteeg, Thomas E Carey, Bart J M van Vlijmen, Chrissta X Maracle, Michael Holinstat
INTRODUCTION: Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute Carrier Family 44 Member 2 protein (SLC44A2). Thus far, SLC44A2 has not been studied in the context of thrombosis, and may be a unique contributor to thrombotic disease. Here we utilize mice lacking SLC44A2 (Slc44a2-/- ) to evaluate a possible role of SLC44A2 in hemostasis. METHODS: Slc44a2-/- mice were evaluated in key aspects of normal hemostasis including a challenge of vascular damage by applying laser induced injury to the cremaster muscle arteriole...
September 26, 2018: Thrombosis Research
Wojciech Wańha, Maksymilian Mielczarek, Grzegorz Smolka, Tomasz Roleder, Miłosz Jaguszewski, Dariusz Ciećwierz, Brunon Tomasiewicz, Piotr Kubler, Jarosław Gorol, Michał Chmielecki, Stanisław Bartuś, Eliano Pio Navarese, Michał Kasprzak, Adam Sukiennik, Jacek Kubica, Andrzej Lekston, Michał Hawranek, Krzysztof Reczuch, Marcin Gruchała, Andrzej Ochała, Wojciech Wojakowski
BACKGROUND: There is a paucity of data on left main (LM) percutaneous coronary intervention (PCI) therapy with dedicated DES platforms. The LM-STENTYS is a multicenter registry aimed at evaluating clinical outcome after PCI of LM performed with a self-apposing Stentys DES implantation. METHODS: The registry consists of 175 consecutive patients treated with Stentys DES implanted to LM. The primary endpoint was the composite of major adverse cardiac and cerebral events (MACCE) defined as cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stroke assessed after 1 year...
October 11, 2018: Catheterization and Cardiovascular Interventions
Zakaria Jalal, Pierre-Emmanuel Seguela, Alban-Elouen Baruteau, David Benoist, Olivier Bernus, Olivier Villemain, Younes Boudjemline, Xavier Iriart, Jean-Benoit Thambo
As for any preclinical development of new implantable device, bench testing has been followed by experimental studies on large animal models for the development of atrial septal defect closure devices. Various models have been used according to studied species (porcine, ovine or canine model) and whether the septal defect was percutaneously or surgically created. Animal models of percutaneous atrial septal defect closure aim to assess the healing process and device endothelialisation, as well as the development of magnetic resonance imaging guided procedures, the short-term effects of volume overload on right ventricular contractility through haemodynamic studies and the understanding of other complications such as nickel hypersensitivity...
September 2018: Journal of Thoracic Disease
Sadie Bennett, Duwarakan Satchithananda, Gareth Law
Summary: A 42-year-old male was admitted with shortness of breath secondary to suspected heart failure and chest infection. An echocardiogram revealed a dilated and impaired left ventricle; ejection fraction 29%, with a large, mobile thrombus within the left ventricular apex. Due to the presence of liver dysfunction, vitamin K antagonists were deemed inappropriate; thus, the decision was taken to use the novel anticoagulation agent Apixaban. After 6 days of receiving Apixaban, a cardiac magnetic resonance scan was preformed, which showed complete resolution of the LV apical thrombus...
December 1, 2018: Echo Research and Practice
Harish Seethapathy, Vincent M Brandenburg, Smeeta Sinha, Rokea A El-Azhary, Sagar U Nigwekar
Calciphylaxis is a disease of significant morbidity and mortality, predominantly affecting dialysis patients. The term 'calciphylaxis' was coined by Seyle et al in 1961 to describe calcium deposition in the skin and subcutaneous soft tissue of uremic rats in response to 'triggers' (e.g. trauma, metallic salts) after exposure to 'sensitizing agents' (e.g. vitamin D and parathyroid hormone). In humans, calciphylaxis, however, is not a disorder of induced hypersensitivity. Instead, it is a disorder of cutaneous microvascular occlusion caused by thrombosis and calcification...
October 10, 2018: QJM: Monthly Journal of the Association of Physicians
Barry Burstein, Rodrigo S Barbosa, Michelle Samuel, Eli Kalfon, François Philippon, David Birnie, Iqwal Mangat, Damian Redfearn, Roopinder Sandhu, Laurent Macle, John Sapp, Atul Verma, Jeff S Healey, Giuliano Becker, Vijay Chauhan, Benoit Coutu, Jean-François Roux, Peter Leong-Sit, Jason G Andrade, George D Veenhuyzen, Jacqueline Joza, Martin Bernier, Vidal Essebag
PURPOSE: Femoral venous access is required for most electrophysiology procedures. Limited data are available regarding post-procedure venous thromboembolism (VTE), specifically deep vein thrombosis (DVT) and pulmonary embolism (PE). Potential preventative strategies are unclear. We aimed to survey Canadian centers regarding incidence of VTE and strategies for prevention of VTE after procedures that do not require post-procedure anticoagulation. METHODS: An online survey was distributed to electrophysiologists representing major Canadian EP centers...
October 8, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Xiaomiao Qiu, Junjun Zhou, Weiting Wang, Zhuanyou Zhao, Lida Tang, Shuangyong Sun
In recent years, oral factor Xa inhibitors have become a research focus as anticoagulant drugs. Zifaxaban is the first oral FXa inhibitor to enter clinical trials in China. The aim of this study was to determine the inhibitory effect of zifaxaban on thrombosisthrough a model ofinferior vena cava (IVC) thrombosis in rabbits. IVC thrombosis model was established by electrical injury and stenosis, and zifaxaban was administered (p.o.) for 5 consecutive days, then coagulation indicators and bleeding were observed...
October 8, 2018: Journal of Thrombosis and Thrombolysis
Nam S Hoang, Winifred Hwang, Danielle A Katz, Sean C Mackey, Lawrence V Hofmann
INTRODUCTION: Patient-reported outcomes are important for clinical research and will likely be used in the near future as a metric for physician reimbursement. This study aims to evaluate the implementation of an electronic data collection system for deep vein thrombosis and lymphedema quality-of-life (QOL) questionnaires in a tertiary care interventional radiology practice. METHODS: A single provider's clinic patients were automatically e-mailed validated questionnaires 1 week before their appointments...
October 5, 2018: Journal of the American College of Radiology: JACR
A V Belyaev, J L Dunster, J M Gibbins, M A Panteleev, V Volpert
No abstract text is available yet for this article.
October 3, 2018: Physics of Life Reviews
Miao Wang, Lili Bao, Xinyu Qiu, Xiaoshan Yang, Siying Liu, Yuting Su, Lulu Wang, Bo Liu, Qing He, Shiyu Liu, Yan Jin
In recent years, rapid development of tissue engineering technology provides possibilities for the construction of artificial tissues or organs. In construction of engineered kidneys, researchers used native decellularized extracellular matrix (ECM) as the scaffolds to recellularization. However, thrombosis has been a great issue that hinders the progress of transplantation in vivo. In this study, heparin was immobilized to the collagen part of decellularized scaffold with collagen-binding peptide (CBP). Through the anticoagulant and endothelial cell reperfusion experiments, it can be demonstrated that the heparinized scaffolds absorbed less platelets and red blood cells which can effectively reduce the formation of thrombosis...
September 27, 2018: Science China. Life Sciences
Moses M Obimbo, Yan Zhou, Michael T Mcmaster, Craig R Cohen, Zahida Qureshi, John Ong'ech, Julius A Ogeng'o, Susan J Fisher
BACKGROUND: Preterm birth (PTB) is a major cause of infant morbidity and mortality in developing countries. Recent data suggest that in addition to HIV infection, use of antiretroviral therapy (ART) increases the risk of PTB. As the mechanisms remain unexplored, we conducted this study to determine if HIV and ART were associated with placental changes that could contribute to PTB. SETTING: We collected and evaluated placentas from 38 HIV-positive women on ART and 43 HIV-negative women who had preterm deliveries in Nairobi, Kenya...
September 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Maria-Inacia Estevão-Costa, Raquel Sanz-Soler, Benjamin Johanningmeier, Johannes A Eble
Both mythologically and logically, snakes have always fascinated man. Snakes have attracted both awe and fear not only because of the elegant movement of their limbless bodies, but also because of the potency of their deadly venoms. Practically, in 2017, the world health organization (WHO) listed snake envenomation as a high priority neglected disease, as snakes inflict up to 2.7 million poisonous bites, around 100.000 casualties, and about three times as many invalidities on man. The venoms of poisonous snakes are a cocktail of potent compounds which specifically and avidly target numerous essential molecules with high efficacy...
September 24, 2018: International Journal of Biochemistry & Cell Biology
Mary J Kwasny, Adam I Edelstein, David W Manning
BACKGROUND: Elevated body mass index (BMI) is considered a risk factor for complications after THA and TKA. Stakeholders have proposed BMI cutoffs for those seeking arthroplasty. The research that might substantiate BMI cutoffs is sensitive to the statistical methods used, but the impact of the statistical methods used to model BMI has not been defined. QUESTIONS/PURPOSES: (1) How does the estimated postarthroplasty risk of minor and major complications vary as a function of the statistical method used to model BMI? (2) What is the prognostic value of BMI for predicting complications with each statistical method? METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2012, we investigated the impact of BMI on major and minor complication risk for THA and TKA...
September 25, 2018: Clinical Orthopaedics and related Research
M Pach, F Horáček
URPOSE OF THE STUDY The aim of this study was to summarise the current approaches to diagnostics and therapy of the medial meniscus tear, and to evaluate the short-term results of meniscus repair by outside-in and all-inside techniques. MATERIALS AND METHODS The study included 24 patients who underwent medial meniscus repair for vertical longitudinal tear 10 mm or longer in length localised in the rear two-thirds of meniscus in the red-red or red-white zone at the author's workplace between June 2012 and December 2014...
2018: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Jin-Cheng Wang, An-Liang Xia, Yong Xu, Xiao-Jie Lu
Portal vein tumor thrombosis (PVTT) is one of the most common complications in hepatocellular carcinoma (HCC). HCC with PVTT usually indicates poor prognosis, which has a number of characteristics including a rapidly progressive disease course, worse liver function, complications connected with portal hypertension, and poorer tolerance to treatment. The exact mechanisms of PVTT remain unknown, even though some concerned signal transduction or molecular pathways have been identified. In western countries, sorafenib is the only recommended therapeutic strategy regardless of PVTT types...
September 6, 2018: Journal of Cellular Physiology
Vigil James, Gene Yong-Kwang Ong
BACKGROUND: Orbital cellulitis is an uncommon ophthalmological emergency in children, but rapid emergency department (ED) diagnosis is essential. CASE REPORT: A 13-year-old boy presented to our pediatric ED with left orbital cellulitis secondary to pansinusitis. Emergency bedside ocular ultrasonography was used to evaluate and expedite his management. Besides inflammatory changes observed on ultrasound of his affected orbit, the patient had an elevated optic disc height and increased nerve sheath diameter, which were not commonly reported in published literature on orbital cellulitis...
September 22, 2018: Journal of Emergency Medicine
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