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Thrombosis research

Masayuki Endo, Younes Jahangiri, Masahiro Horikawa, John A Kaufman, Ryan C Schenning, Kenneth J Kolbeck, Robert E Barton, Yasufumi Ohuchi, Keng Wei Liang, Khashayar Farsad
PURPOSE: To examine the effectiveness of antithrombotic medications to prevent venous stent malfunction for iliocaval occlusive disease. MATERIALS AND METHODS: A retrospective analysis was performed on 62 patients who underwent technically successful endovascular iliocaval stent placement between May 2008 and April 2017. Clinical records were reviewed for demographic information, procedure details, post-stenting antithrombotic prophylaxis and stent patency on follow-up...
August 17, 2018: Cardiovascular and Interventional Radiology
Hsueh-Yi Lu, Kuang-Ming Liao
BACKGROUND: Previous studies have shown that chronic kidney disease increases the risk of deep vein thrombosis (DVT). DVT is the risk of pulmonary embolism among persons with end-stage renal disease (ESRD). Information on the incidence of DVT in ESRD is limited, and no studies have been conducted in the Asian population. The aim of our study was to investigate the incidence of DVT in Asian ESRD patients by comparing with the non-ESRD patients and to identify the associated risk factors...
August 16, 2018: BMC Nephrology
Farshad Roghani-Dehkordi, Omid Hashemifard, Masoumeh Sadeghi, Rohollah Mansouri, Mehdi Akbarzadeh, Asieh Dehghani, Mojtaba Akbari
BACKGROUND: Trans-radial and trans-ulnar accesses have been practiced and recommended as default and alternative techniques for coronary angiography and angioplasty in recent years. In this study, we present new innovative approaches using more distal access points, i.e. trans-snuff box and trans-palmar approaches. METHODS: We conducted dorsal hand access (trans-snuff box) for angiography and/or angioplasty on 235 patients, and trans-palmar access (superficial palmar branch of ulnar artery) on 175 patients in 3 hospitals in Isfahan City, Iran...
March 2018: ARYA Atherosclerosis
Yesim Ozguler, Pietro Leccese, Robin Christensen, Sinem Nihal Esatoglu, Dongsik Bang, Bahram Bodaghi, Aykut Ferhat Çelik, Farida Fortune, Julien Gaudric, Ahmet Gul, Ina Kötter, Alfred Mahr, Robert J Moots, Jutta Richter, David Saadoun, Carlo Salvarani, Francesco Scuderi, Petros P Sfikakis, Aksel Siva, Miles Stanford, Ilknur Tugal-Tutkun, Richard West, Sebahattin Yurdakul, Ignazio Olivieri, Hasan Yazici, Gulen Hatemi
Objective: To assess the efficacy and safety of treatment modalities for major organ involvement of Behçet's syndrome (BS), in order to inform the update of the EULAR recommendations for the management of BS. Methods: A systematic literature review of all randomized controlled trials, controlled clinical trials, or open label trials assessing eye, vascular, nervous system or gastrointestinal system involvement of BS was performed. If controlled trials were not available for answering a specific research question, uncontrolled studies or case series were also included...
August 13, 2018: Rheumatology
Céline Chauleur, Jean-Christophe Gris, Silvy Laporte, Céline Chapelle, Laurent Bertoletti, Véronique Equy, Pascal Gaucherand, Eva Bazan, Olivier Dupuis, Denis Gallot, Patrick Mismetti
BACKGROUND:  Management of pregnant women at risk of venous thromboembolism (VTE) and placental vascular complications (PVCs) remains complex. Guidelines do not definitively specify optimal strategies. OBJECTIVE:  Our objective was to evaluate the impact of employing risk score-driven prophylaxis strategies on VTE and PVC rates in at-risk pregnant women. MATERIALS AND METHODS:  This study, conducted in 21 French maternity units, compared VTE and PVC rates before and after implementation of a risk scoring system to determine prophylactic strategies...
August 13, 2018: Thrombosis and Haemostasis
T E Warkentin
Heparin-induced thrombocytopenia (HIT) is an acquired immune-mediated hypercoagulability state strongly associated with thrombosis. During the 1970s and 1980s, the prevailing concept was that HIT was associated only with arterial thrombosis, through its unique pathogenesis via heparin-dependent, platelet-activating IgG antibodies. Yet, in 1990, when I began to encounter HIT in my clinical practice, I found that most such patients developed symptomatic venous thrombosis. This historical sketch summarizes some of the research that challenged the dogma of HIT as a mainly arterial prothrombotic disorder...
August 12, 2018: Journal of Thrombosis and Haemostasis: JTH
Homam Ibrahim, Matthew T Rondina, Neal S Kleiman
Since the approval of the first transcatheter aortic valve replacement (TAVR) device in 2011, this technology has undergone substantial enhancements and exponential growth. However, valve thrombosis and residual paravalvular leaks (PVL) are among the challenges that require further investigation. Recently, monitoring von Willebrand factor (vWF) multimers has emerged as a tool to help evaluate the severity of PVL after TAVR. Following TAVR, vWF large multimers recovery have been documented. The role of large vWF multimers recovery and their interactions with platelets, and the endothelium have not been entirely elucidated...
July 30, 2018: Thrombosis Research
John De Heide, Christiaan J Vroegh, Rohit E Bhagwandien, Sip A Wijchers, Tamas Szili-Torok, Felix Zijlstra, Mattie J Lenzen, S C Yap
PURPOSE: The safety and efficacy of a minimally interrupted novel oral anticoagulant (NOAC) strategy at the time of atrial fibrillation (AF) ablation is uncertain. The purpose of this study was to compare rates of bleeding and thromboembolic events between minimally interrupted NOAC and uninterrupted vitamin K antagonist (VKA) in patients undergoing AF ablation. METHODS: This was a retrospective single-center cohort study of consecutive patients who underwent AF catheter ablation between January 2013 and April 2017...
August 3, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
R Todd Stravitz
Patients with advanced liver disease have traditionally been considered at risk for bleeding complications. However, although bleeding in patients with cirrhosis frequently occurs due to complications of portal hypertension, research performed within the last 15 years has increasingly shown that hemostasis in patients with liver failure generally achieves a state of "rebalance", whereby compensatory systems restore a relatively neutral or even slightly pro-thrombotic state. Much recent clinical and in vitro research has, in fact, shown over-compensation, such that patients with acute and stable chronic liver failure may have a thrombotic tendency, which may participate in the progression of liver disease and cause systemic and portal thrombosis...
July 31, 2018: Hepatology International
J Cao, X G Lü, Y Li, Q Q Jin, X Y Chu, Y Y Wang, J H Sun
OBJECTIVES: To study the urinary metabolic profile in rats with deep venous thrombosis (DVT) based on metabolomics and to screen out small molecular biomarkers for the diagnosis and forensic identification of DVT. METHODS: Inferior vena cava of rats was ligated to construct DVT models. The rats were randomly divided into three groups: DVT, sham, and control groups, 10 in each group. The urine of DVT and sham rats was collected during 24 hours in the metabolic cage at 48 hours after operating, meanwhile, 24 hours urine was collected in control group...
June 2018: Fa Yi Xue za Zhi
Arina J Ten Cate-Hoek
<AbstractText>Post thrombotic syndrome (PTS) is a common chronic complication of deep vein thrombosis of the leg (DVT). Treatment options are limited therefore emphasis is placed on its prevention. Several risk factors have been recognized, but were so far not used for risk stratification or translation into prediction models. Early interventions did not yet result in more successful preventive treatment strategies; for the acute phase of DVT there is equipoise on the value of elastic compression, as well as on catheter directed thrombolysis...
April 2018: Research and practice in thrombosis and haemostasis
Julia Hews-Girard, Christine Guelcher, Jennifer Meldau, Ellen McDonald, Fiona Newall
<AbstractText>Prior work regarding patient education has identified the importance of using learning theory and educational models to develop and deliver content that will improve patient outcomes. Current literature appears to examine implementation of teaching strategies without clear identification of educational principles. This review aimed to identify educational principles and theory currently utilized in the planning and delivery of patient education in disorders of thrombosis and hemostasis. The majority of articles reviewed evaluated the impact of educational interventions on patient outcomes; links between educational principles and changes in outcomes was lacking...
October 2017: Research and Practice in Thrombosis and Haemostasis
Mary Cushman, Emma Brink
No abstract text is available yet for this article.
October 2017: Research and Practice in Thrombosis and Haemostasis
Michelle Lavin, Sonia Aguila, Niall Dalton, Margaret Nolan, Mary Byrne, Kevin Ryan, Barry White, Niamh M O'Connell, Jamie M O'Sullivan, Jorge Di Paola, Paula D James, James S O'Donnell
Gynecological bleeding is frequently reported in women with von Willebrand disease (VWD). Low von Willebrand factor (VWF) may be associated with significant bleeding phenotype despite only mild plasma VWF reductions. The contribution of gynecological bleeding to this phenotype has yet to be described. The optimal clinical bleeding assessment tool (BAT) to evaluate bleeding remains unclear. Using a standardized approach to phenotypic assessment, we evaluated gynecological bleeding and directly compared the Condensed Molecular and Clinical Markers for the Diagnosis and Management of type 1 VWD (Condensed MCMDM-1 VWD) and International Society on Thrombosis and Haemostasis (ISTH) BAT scores in 120 women enrolled in the Low von Willebrand in Ireland Cohort study...
July 24, 2018: Blood Advances
Delphine Gomez, Richard A Baylis, Brittany G Durgin, Alexandra A C Newman, Gabriel F Alencar, Sidney Mahan, Cynthia St Hilaire, Werner Müller, Ari Waisman, Sheila E Francis, Emmanuel Pinteaux, Gwendalyn J Randolph, Hermann Gram, Gary K Owens
Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial, in which post-myocardial infarction subjects were treated with an IL-1β antibody. Here, we performed intervention studies in which smooth muscle cell (SMC) lineage-tracing Apoe-/- mice with advanced atherosclerosis were treated with anti-IL-1β or IgG control antibodies...
July 23, 2018: Nature Medicine
Tingzhang Hu, Chun Yang, Song Lin, Qingsong Yu, Guixue Wang
Cardiovascular diseases are one of the major causes of human death in the world. Endovascular stents are the most important implantation devices in cardiovascular intervention, and their efficacy determines the success of cardiovascular disease treatment. In order to reduce the long-term side effects of permanent metallic stents, such as subacute thrombosis and in-stent restenosis, a new generation of endovascular stents so-called "biodegradable stents (BDSs)" is currently being vigorously developed and considered as the most promising candidate...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Sergio Raposeiras-Roubín, Berenice Caneiro Queija, Fabrizio D'Ascenzo, Tim Kinnaird, Albert Ariza-Solé, Sergio Manzano-Fernández, Christian Templin, Lazar Velicki, Ioanna Xanthopoulou, Enrico Cerrato, Giorgio Quadri, Andrea Rognoni, Giacome Boccuzzi, Andrea Montabone, Salma Taha, Alessandro Durante, Sebastiano Gili, Giulia Magnani, Michele Autelli, Alberto Grosso, Pedro Flores Blanco, Alberto Garay, Ferdinando Varbella, Francesco Tomassini, Rafael Cobas Paz, María Cespón Fernández, Isabel Muñoz Pousa, Diego Gallo, Umberto Morbiducci, Alberto Domínguez-Rodríguez, José Antonio Baz-Alonso, Francisco Calvo-Iglesias, Mariano Valdés, Ángel Cequier, Fiorenzo Gaita, Dimitrios Alexopoulos, Andrés Íñiguez-Romo, Emad Abu-Assi
INTRODUCTION AND OBJECTIVES: The PARIS score allows combined stratification of ischemic and hemorrhagic risk in patients with ischemic heart disease treated with coronary stenting and dual antiplatelet therapy (DAPT). Its usefulness in patients with acute coronary syndrome (ACS) treated with ticagrelor or prasugrel is unknown. We investigated this issue in an international registry. METHODS: Retrospective multicenter study with voluntary participation of 11 centers in 6 European countries...
July 17, 2018: Revista Española de Cardiología
Eoghan M Cunnane, Justin S Weinbaum, Fergal J O'Brien, David A Vorp
Vascular tissue engineering is an area of regenerative medicine that attempts to create functional replacement tissue for defective segments of the vascular network. One approach to vascular tissue engineering utilizes seeding of biodegradable tubular scaffolds with stem (and/or progenitor) cells wherein the seeded cells initiate scaffold remodeling and prevent thrombosis through paracrine signaling to endogenous cells. Stem cells have received an abundance of attention in recent literature regarding the mechanism of their paracrine therapeutic effect...
2018: Frontiers in Cardiovascular Medicine
Timothy Wen, Jason D Wright, Dena Goffman, Mary E D'Alton, William J Mack, Frank J Attenello, Alexander M Friedman
BACKGROUND: There are limited data on when postpartum readmissions for thromboembolism occur after delivery hospitalizations on a population basis in the United States. OBJECTIVE: We sought to characterize risk factors for and timing of postpartum venous thromboembolism readmission after delivery hospitalization discharge. STUDY DESIGN: The Healthcare Cost and Utilization Project Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk for readmission for venous thromboembolism within 60 days of discharge from a delivery hospitalization...
July 11, 2018: American Journal of Obstetrics and Gynecology
Paul Monagle
Since Maureen Andrew began systematically describing thrombosis in children in 1994, there has been surprisingly slow process in advancing our knowledge in terms of diagnosis, prevention and treatment of thrombosis in children. There are a variety of reasons for this slow progress. Overwhelmingly the low incidence of thrombosis in children has been a major barrier. Second, the developmental, age related, changes in haemostasis mean that the physiology of haemostasis in children, and the interaction of the haemostatic system with anticoagulant drugs is constantly changing...
July 14, 2018: Thrombosis Research
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