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Beatrice Ruggerone, Marco Giraldi, Saverio Paltrinieri, Paola Scarpa
BACKGROUND: Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed-specific approach is more often required. OBJECTIVES: The aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed-specific RIs, where appropriate...
October 18, 2018: Veterinary Clinical Pathology
Hanno C Erythropel, Sairam V Jabba, Tamara M DeWinter, Melissa Mendizabal, Paul T Anastas, Sven E Jordt, Julie B Zimmerman
Introduction: "Vaping" electronic cigarettes (e-cigarettes) is increasingly popular with youth, driven by the wide range of available flavors, often created using flavor aldehydes. The objective of this study was to examine whether flavor aldehydes remain stable in e-cigarette liquids or whether they undergo chemical reactions, forming novel chemical species that may cause harm to the user. Methods: Gas chromatography was used to determine concentrations of flavor aldehydes and reaction products in e-liquids and vapor generated from a commercial e-cigarette...
October 18, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Hui Ye, Xiang-Yu Cui, Hui Ding, Su-Ying Cui, Xiao Hu, Yu-Tong Liu, Hui-Ling Zhao, Yong-He Zhang
Background: Previous anatomical and behavioral studies have shown that melanin-concentrating hormone (MCH) is involved in the modulation of emotional states. However, little is known about brain regions other than the dorsal raphe nucleus that relate the MCH-ergic system to depressive states. Numerous studies have shown that the locus coeruleus (LC) is involved in the regulation of depression and sleep. Although direct physiological evidence is lacking, previous studies suggest that MCH release in the LC decreases neuronal discharge...
October 18, 2018: International Journal of Neuropsychopharmacology
Oksana Savchak, Tyler Morrison, Konstantin G Kornev, Olga Kuksenok
Using theoretical and computational modeling, we focus on dynamics of gels filled with uniformly dispersed ferromagnetic nanoparticles subjected to electromagnetic (EM) irradiation within the GHz frequency range. As a polymer matrix, we choose poly(N-isopropylacrylamide) gel, which has a low critical solution temperature and shrinks upon heating. When these composites are irradiated with a frequency close to the Ferro-Magnetic Resonance (FMR) frequency, the heating rate increases dramatically. The energy dissipation of EM signals within the magnetic nanoparticles results in the heating of the gel matrix...
October 18, 2018: Soft Matter
Romain Lhermerout, Kristina Davitt
Small-scale heterogeneities have long been understood to give rise to contact angle hysteresis. More recently, the question of how they influence contact line dynamics has generated interest. Models that express the hysteresis or dynamics in terms of defect properties exist but have yet to be conclusively tested by experiment. Here we produce heterogeneous surfaces and thoroughly characterize individual defects. Precise dynamical measurements allow us to conclude that there is no evidence of a thermally activated dynamics due to their presence, but that the hysteresis scales with their concentration and the square of their height, as predicted by some simple models...
October 18, 2018: Soft Matter
Haobin Zhao, Junjun Li, Yawen Zhang, Shuzhen Lei, Xixi Zhao, Dongyan Shao, Chunmei Jiang, Junling Shi, Hui Sun
The iturin produced by Bacillus subtilis was previously found to exhibit significant antifungal activities, showing potential for application to food to protect it from spoilage and decay. However, its safe level must be evaluated before it can be used in foods consumed by mammals. Therefore, we carried out acute toxicity (7 days) and subacute toxicity (28 days) evaluations by intragastric administration of the iturin at 5000 mg per kg (bw) and 2000 mg per kg (bw) to Kunming mice. At the end of the subacute toxicity evaluation, the blood parameters of the mice were evaluated, and the visceral organs and intestinal flora were examined...
October 18, 2018: Food & Function
Xing Li, Li Wang, Yan Deng, Zheng Luo, Qiao Zhang, Shengyi Dong, Chengyou Han
We found that TC7 not only self-assembles into one-dimensional supramolecular aggregates in chloroform, but also forms cross-linked supramolecular polymers via host-guest complexation between benzo-21-crown-7 and secondary ammonium salts. Compared with one-dimensional linear supramolecular polymers, soft and long viscous fibers were pulled out from a concentrated solution of cross-linked supramolecular polymers as a result of higher viscosity and lower diffusion coefficients.
October 18, 2018: Chemical Communications: Chem Comm
I V Ekimova, A R Gazizova, M N Karpenko, D V Plaksina
Parkinson's disease (PD) is one of incurable socially significant diseases. Success in the PD treatment is associated with the development of the technology of preclinical diagnosis and neuroprotective treatment of the disease. In the experimental model of the preclinical PD stage in rats created by intranasal administration of the proteasome inhibitor lactacystin, signs of depression as an anhedonia symptom were detected for the first time. Anhedonia was combined with the death of about one third of dopamine (DA)-ergic neurons in the ventral tegmental area of the midbrain and their axons in the ventral striatum; and a decrease of dopamine concentration in the ventral striatum (by 40%) and the tyrosine hydroxylase level in surviving DA-ergic neurons...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
A V Deryugina, E A Antipenko
AIM: To study an impact of cytoflavin on the functional state of erythrocytes in patients with Charcot - Marie - Toota disease (CMTD). MATERIAL AND METHODS: Thirty patients with CMTD were examined. The main group (n=17) received cytoflavin along with basic therapy (intravenously dropwise 10 ml per 200 ml of 5% glucose solution for 10 days). The comparison group (n=13) received only basic therapy. Functional parameters of erythrocytes, including electrophoretic mobility of erythrocytes (EFME), concentration of malonic dialdehyde (MDA), content of ATP and 2...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
I T Murkamilov, I S Sabirov, V V Fomin, J A Murkamilova, K A Aitbaev, Z R Rayimzhanov
AIM: To study a role of cystatin C in the nephrocerebral risk in chronic kidney disease at the initial stage of the disease. MATERIAL AND METHODS: One hundred and twenty-eight patients (63 men and 65 women) with chronic kidney disease (CKD) were examined at the pre-dialysis stage of the disease. All patients underwent a complex clinical and laboratory examination with determination of the lipid spectrum, uric acid, fibrinogen, calcium and cystatin C, and subsequent calculation of the glomerular filtration rate (GFR)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Maciej Horyniecki, Beata Łącka-Gaździk, Ewa Niewiadomska, Bogdan Mazur, Mirosław Śnit, Beata Łabuz-Roszak
Introduction Chronic kidney disease (CKD) is one of stroke risk factors and may be associated with impaired platelet reactivity. Objectives The aim of the study was to evaluate the platelet reactivity in patients with CKD using acetylsalicylic acid (ASA). Patients and methods 108 patients with CKD and 41 controls without CKD taking ASA were enrolled in the study. Platelet function was assessed by impedance aggregometry in the whole blood using a multi-channel platelet function analyzer (Multiplate®). Urine concentration of 11-dehydrotromboxane was measured by AspirinWorks®...
October 18, 2018: Polish Archives of Internal Medicine
Qi Zhang, Mingyu Cong, Ningning Wang, Xueyan Li, Hao Zhang, Keyong Zhang, Ming Jin, Nan Wu, Changchun Qiu, Jingping Li
Angiotensin-converting enzyme 2 (ACE2) plays an important role in the development of essential hypertension (EH). The aim of this study was to investigate the relationship of ACE2 gene polymorphisms and enzymatic activity with EH in the northeastern Chinese Han population. 34 single-nucleotide polymorphism (SNP) loci of ACE2 were detected in 1024 EH patients and 956 normotensive (NT) controls by Sequenom Mass-ARRAY RS1000. Five SNPs (rs1514283, rs4646155, rs4646176, rs2285666, and rs879922) in ACE2 gene were determined to significantly associate with EH in female participants, while no SNP locus was linked to male group...
October 2018: Medicine (Baltimore)
Yugo Takaki, Tatsuki Mizuochi, Junko Nishioka, Keisuke Eda, Shuichi Yatsuga, Yushiro Yamashita
RATIONALE: Nonalcoholic fatty liver disease (NAFLD), among the commonest chronic liver disorders in children and adolescents, is considered a reflection of the current obesity epidemic in children and adults. This liver disease has been linked with various metabolic disorders, but not with prolactinoma (PRLoma). PATIENT CONCERNS: A 13-year-old Japanese girl manifested obesity, serum transaminase and γ-glutamyltransferase elevations, and amenorrhea. Abdominal ultrasonography showed fatty liver...
October 2018: Medicine (Baltimore)
Jun Shimizu, Yoshihisa Yamano, Kimito Kawahata, Noboru Suzuki
Relapsing polychondritis (RP) is a multisystem disorder of cartilaginous tissues. Previously, we found that patients with respiratory involvement and patients with auricular involvement were mutually exclusive in the RP cohort, which suggests a strong inverse relationship between respiratory and auricular involvement. Here, we examined the clinical manifestation patterns in a subgroup of patients with respiratory involvement (R subgroup) and a subgroup of patients with auricular involvement (A subgroup) and investigated the clinical and laboratory characteristics of each subgroup...
October 2018: Medicine (Baltimore)
Yijie Guo, Meng Xun, Jing Han
Antimicrobial peptides (AMPs) exhibit multiple activities against bacteria and fungi. A bovine myeloid antimicrobial peptide (BMAP-28) belongs to the cathelicidin-derived AMPs and has antimicrobial activity. Due to the rapidly increasing number of infections and outbreaks caused by pan-drug-resistant Acinetobacter baumannii (PDRAB), we sought to determine whether BMAP-28 and its 4 analog peptides (A837, A838, A839, and A840) have antimicrobial activity against PDRAB. Furthermore, we clarified the possible mechanism of inhibition by which of BMAP-28 acts against PDRAB...
October 2018: Medicine (Baltimore)
Junguo Cao, Ting Lei, Fan Chen, Chaochao Zhang, Chengyuan Ma, Haiyan Huang
RATIONALE: A sellar mass in children is most often seen in craniopharyngeal tumors, intracranial germ cell tumors, or pituitary adenomas. However, pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is not commonly seen in children. PATIENT CONCERNS: A 10-year-old girl was admitted due to growth retardation and obesity for 4 years. On physical examination, the patient had a height of 118 cm, body weight of 46 kg, body mass index (BMI) of 33.0 kg/m...
October 2018: Medicine (Baltimore)
Fay H Johnston, Farhad Salimi, Grant J Williamson, Sarah B Henderson, Jiayun Yao, Martine Dennekamp, Karen Smith, Michael J Abramson, Geoffrey G Morgan
BACKGROUND: Ambulance data provide a useful source of population-based and spatiotemporally resolved information for assessing health impacts of air pollution in non-hospital settings. We used the clinical records of paramedics to quantify associations between PM2.5 and diabetic, cardiovascular, and respiratory conditions commonly managed by those responding to calls for emergency ambulance services. METHODS: We evaluated 394,217 paramedic assessments from three states in Southeastern Australia (population 13...
October 16, 2018: Epidemiology
V P Mantripragada, W A Bova, C Boehm, N S Piuzzi, N A Obuchowski, R J Midura, G F Muschler
BACKGROUND: Current decisions on cellular therapies for osteoarthritis are based primarily on clinical experience or on assumptions about preferred cell sourcing. They have not been informed by rigorous standardized measurements of the chondrogenic connective-tissue progenitors (CTP-Cs) or their intrinsic diversity of chondrogenic potential. The goal of this study was to quantitatively define the CTP-Cs resident in cartilage of different grades of osteoarthritis and to compare their concentration, prevalence, and biological potential...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
Joshua D Namm, Randal P Morris, Fred L Speck, Ronald W Lindsey
BACKGROUND: The objective of this study was to determine the impact of the type and orientation of peripheral screw placement in an eccentrically positioned locking plate on the structural integrity of the plate-diaphyseal bone interface. We hypothesized that central placement of the screw at the end of the plate in this setting is more important than screw type (locking versus nonlocking) to limiting the risk of subsequent fracture. METHODS: Twenty osteoporotic fourth-generation composite left humeri were divided into 4 groups and plated with stainless-steel 6-hole locking plates and 4...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
Ciaran S Hill, David K Menon, Michael P Coleman
The antiapoptotic, neuroprotective compound P7C3-A20 reduces neurological deficits when administered to murine in-vivo models of traumatic brain injury. P7C3-A20 is thought to exert its activity through small-molecule activation of the enzyme nicotinamide phosphoribosyltransferase. This enzyme converts nicotinamide to nicotinamide mononucleotide, the precursor to nicotinamide adenine dinucleotide synthesis. Alterations to this bioenergetic pathway have been shown to induce Wallerian degeneration (WD) of the distal neurite following injury...
October 16, 2018: Neuroreport
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