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Jithma P Abeykoon, Saurabh Zanwar, Stephen M Ansell, Jeffrey Winters, Morie A Gertz, Rebecca L King, David Murray, Thomas Habermann, David Dingli, Eli Muchtar, Ronald S Go, Nelson Leung, David J Inwards, Francis K Buadi, Angela Dispenzieri, Martha Q Lacy, Yi Lin, Wilson I Gonsalves, Taxiarchis Kourelis, Thomas E Witzig, Carrie Thompson, S Vincent Rajkumar, Robert A Kyle, Shaji Kumar, Prashant Kapoor
Symptomatic hyperviscosity is a well-established phenomenon in Waldenström macroglobulinemia (WM). Monoclonal IgM can variably impact intrinsic serum viscosity, leading to widely disparate symptomatic thresholds for development of hyperviscosity-related symptoms. Data regarding the predictors of symptomatic hyperviscosity and outcomes related to this complication remain scarce and a recent study proposed that IgM >6000 mg/dL be considered a new criterion for initiating therapy in otherwise asymptomatic (smoldering) WM to pre-empt hyperviscosity-related injury...
August 19, 2018: American Journal of Hematology
Dennis Paliga, Fabian Raudzus, Stephen H Leppla, Rolf Heumann, Sebastian Neumann
The orphan transcription factor nuclear receptor-related 1 protein (Nurr1, also known as NR4A2) plays a key role in embryonic development and maintenance of mesencephalic dopaminergic neurons in the substantia nigra. Nurr1 deficiency is associated with Parkinson's disease where dopaminergic neurons degenerate suggesting that counter-regulation of Nurr1 activity may have therapeutic effects. Here, we bacterially expressed and isolated a human Nurr1 fusion protein containing a N-terminal cell delivery domain derived from detoxified anthrax lethal factor followed by wild type ubiquitin with deubiquitinating enzyme recognition site for intracellular cleavage...
August 18, 2018: Molecular Neurobiology
Lang Cao, Yong Xue, Zixiong Yang, Yanhong Li, Hongmei Li, Xuanqin Chen, Rongtao Li, Dan Liu
The anti-inflammatory effects of shikonofuran E from Onosma paniculatum on RAW 264.7 murine macrophage cells induced by lipopolysaccharide (LPS) were first time examined. A series of non-cytotoxic concentrations of shikonofuran E (< 10 μM) treatments were found to reduce the accumulation of pro-inflammatory cytokine, including tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-1β (IL-1β), and inhibit the expression of nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) in the LPS-stimulated macrophages as compared to the LPS-only treated cells...
August 18, 2018: Journal of Natural Medicines
A N Evdokimenko, T S Gulevskaya, L D Druina, A O Chechetkin, A A Shabalina, M V Kostyreva, K N Kulichenkova, A D Pryamikov, M M Tanashyan
The study demonstrates significant variety of neovascularization degree and vessel diameter in the carotid atherosclerotic plaque. It is suggested that the increase in the number of vessels with a diameter <20 μ can be indicative of increased atherosclerosis activity, while the increase in the number of vessels with a diameter ≥40 μ indicates "reparative potential" of plaques. Duplex contrast-enhanced ultrasound scanning allows characterization of the localization and number of vessels with a diameter of ≥30 μ in the plaque, while even slight elevation of plasma concentration of basic fibroblast growth factor attests, first of all, to increased content of small vessels <30 μ in the plaque...
August 18, 2018: Bulletin of Experimental Biology and Medicine
V M Chertok, V A Nevzorova, N V Zakharchuk
We measured the content of HIF-1α and HIF-2α-immunopositive neurons and microvessels in the brain of Wistar rats during the first 24 h of tissue hypoxia induced by subcutaneous injection of cobalt dichloride (50 mg/kg). In control rats (without hypoxia), immunohistochemical marker HIF-2α in cortex of parietal lobe was not detected, and HIF-1α was detected only in few weakly stained pale neurons and capillaries. In 30 min after injection of the cobalt salt, the number of HIF-1α+ neurons increased by 25...
August 18, 2018: Bulletin of Experimental Biology and Medicine
P N Shevtsov, E F Shevtsova, O K Savushkina, G Sh Burbaeva, S O Bachurin
Phosphorylation of τ-protein, a component of microtubules in brain neurons, is a key pathomorphological sign of Alzheimer's disease. The development of this intracellular defect can be promoted by Al3+ , Fe3+ , and Zn2+ ions. The concentrations of these ions in the brain are considerably elevated in Alzheimer's disease. We performed a comparative study of phosphorylation of microtubular proteins of rat brain in the presence of Al3+ , Fe3+ , and Zn2+ ions in concentrations of 10-500 μM and microtubular proteins of brain of patients with Alzheimer's disease...
August 18, 2018: Bulletin of Experimental Biology and Medicine
N A Pal'chikova, V G Selyatitskaya, O I Kuz'minova, K V Pasechnaya
The glucocorticoid status and activities of ALT, AST, and tyrosine aminotransferase in the liver are studied in rats with streptozotocin-induced diabetes mellitus in response to repeated intraperitoneal injections of mifepristone. Diabetic rats develop an increase of the blood corticosterone and liver aminotransferase levels in response to mifepristone. These results indicate that in diabetic animals the glucocorticoid hormones with high blood concentrations, increasing still more in response to mifepristone, overcome the receptor blockade, and realize their regulatory functions in hepatocytes...
August 18, 2018: Bulletin of Experimental Biology and Medicine
Maryline Calonne-Salmon, Katia Plouznikoff, Stéphane Declerck
The accumulation of phosphorus (P) in plants increases their biomass and resistance/tolerance to organic pollutants. Both characteristics are mandatory for the utilization of plants in phytoremediation. Arbuscular mycorrhizal (AM) fungi improve plant P nutrition, and thus growth. However, only a few studies have focused on the dynamics of inorganic P (Pi) uptake in AM fungal-colonized plants in the presence of organic pollutants. Indeed, most of the results so far were obtained after harvesting the plants, thus by evaluating P concentration and content at a single time point...
August 18, 2018: Mycorrhiza
Svyatoslav Valeryevich Lebedev, Irina Aleksandrovna Gavrish, Lyudmila Vyacheslavovna Galaktionova, Anastasia Mickhailovna Korotkova, Elena Anatolyevna Sizova
Investigation of SiO2 nanoparticles (NPs) effect on Eisenia fetida showed no toxic effect of the metal at a concentration of 250, 500 and 1000 mg per kg of soil, but conversely, a biomass increase from 23.5 to 29.5% (at the protein level decrease from 60 to 80%). The reaction of the earthworm organism fermentative system was expressed in the decrease in the level of superoxide dismutase (SOD) on the 14th day and in the increase in its activity to 27% on the 28th day. The catalase level (CAT) showed low activity at average element concentrations and increase by 39...
August 18, 2018: Environmental Geochemistry and Health
Baptiste Houyvet, Bruno Zanuttini, Erwan Corre, Gildas Le Corguillé, Joël Henry, Céline Zatylny-Gaudin
No antimicrobial peptide has been identified in cephalopods to date. Annotation of transcriptomes or genomes using basic local alignment Search Tool failed to yield any from sequence identities. Therefore, we searched for antimicrobial sequences in the cuttlefish (Sepia officinalis) database by in silico analysis of a transcriptomic database. Using an original approach based on the analysis of cysteine-free antimicrobial peptides selected from our Antimicrobial Peptide Database (APD3), the online prediction tool of the Collection of Anti-Microbial Peptides (CAMPR3 ), and a homemade software program, we identified potential antibacterial sequences...
August 18, 2018: Amino Acids
Mengmeng Luo, Qing Li, Dongmei Wang, Chaoxiang Ge, Jingjie Wang, Kaihui Nan, Sen Lin
Chitosan (CS) based nanoparticles (NPs) have several advantages in delivering drugs. They are usually prepared in a micro-emulsion solvent system but this route can leave significant levels of potentially harmful organic solvent residue in the NPs. In this study, we prepared CS based nanocomposites using charge driven self-assembly in an aqueous buffer, thus avoiding the use of organic solvents. Doxorubicin (DOX) was covalently attached to positive charged CS with a legumain substrate peptide to confer targeted drug release property, since legumain is often overexpressed in tumors or tumor associated micro environments...
August 18, 2018: Journal of Materials Science. Materials in Medicine
Kai-Ming Duan, Sai-Ying Wang, Ji-Ye Yin, Xi Li, Jia-Hui Ma, Zhen-Dong Huang, Ying-Yong Zhou, He-Ya Yu, Mi Yang, Hong-Hao Zhou, Zhao-Qian Liu
Postpartum depressive symptoms (PDS) are not an uncommon mood disorder in postpartum women. Our previous research indicated a role for increased tryptophan (TRP) metabolism along the kynurenine pathway (KP) in the pathogenesis of PDS. Accordingly, this study was going to investigate the association of indoleamine-2,3-dioxygenase (IDO, a key enzyme of KP) genetic polymorphisms with PDS. Seven hundred twenty-five women receiving cesarean section were enrolled in this study. PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13...
August 18, 2018: Archives of Women's Mental Health
Daniela Calvetti, Annalisa Pascarella, Francesca Pitolli, Erkki Somersalo, Barbara Vantaggi
A recently proposed iterated alternating sequential (IAS) MEG inverse solver algorithm, based on the coupling of a hierarchical Bayesian model with computationally efficient Krylov subspace linear solver, has been shown to perform well for both superficial and deep brain sources. However, a systematic study of its ability to correctly identify active brain regions is still missing. We propose novel statistical protocols to quantify the performance of MEG inverse solvers, focusing in particular on how their accuracy and precision at identifying active brain regions...
August 18, 2018: Brain Topography
Lixia Tao, Qiaoli Yue, Yining Hou, Yongping Wang, Chunying Chen, Chen-Zhong Li
An aptamer based method is described for the determination of 8-hydroxy-2'-deoxyguanosine (8-OHdG) using resonance light scattering (RLS). Magnetic nanoparticles (MNPs) were employed as RLS probes. The probe DNA was placed on the surface of MNPs, which produces a rather low RLS signal. If, however, probe DNA hybridizes with the aptamer against 8-OHdG, a sandwich structure will be formed. This results in a significant enhancement of RLS intensity. The aptamer was used as the recognition element to capture 8-OHdG...
August 18, 2018: Mikrochimica Acta
B S Harish, Kiran Babu Uppuluri
Protease inhibitors control major biological protease activities to maintain physiological homeostasis. Marine bacteria isolated from oligotrophic conditions could be taxonomically distinct, metabolically unique, and offers a wide variety of biochemicals. In the present investigation, marine sediments were screened for the potential bacteria that can produce trypsin inhibitors. A moderate halotolerant novel marine bacterial strain of Oceanimonas sp. BPMS22 was isolated, identified, and characterized. The effect of various process parameters like salt concentration, temperature, and pH was studied on the growth of the bacteria and production of trypsin inhibitor...
August 18, 2018: Marine Biotechnology
Richard M Cubbon, Judith E Lowry, Michael Drozd, Marlous Hall, John Gierula, Maria F Paton, Rowena Byrom, Lorraine C Kearney, Julian H Barth, Mark T Kearney, Klaus K Witte
PURPOSE: Low 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with adverse outcomes in selected populations with established chronic heart failure (CHF). However, it remains unclear whether 25[OH]D deficiency is associated with mortality and hospitalisation in unselected patients receiving contemporary medical and device therapy for CHF. METHODS: We prospectively examined the prevalence and correlates of 25[OH]D deficiency in 1802 ambulatory patients with CHF due to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 45%) attending heart failure clinics in the north of England...
August 18, 2018: European Journal of Nutrition
B Grabowska-Polanowska, P Miarka, M Skowron, G Chmiel, A Pietrzycka, I Śliwka
BACKGROUND: The measurement of trimethylamine and isoprene in exhaled breath collected from dialysed patients indicates the changes in concentration of both compounds during dialysis. The aim of the presented study was to confirm diagnostic usefulness of TMA and isoprene detected in breath, as potential biomarkers of hemodialysis efficiency. METHODS: The samples of exhaled breath were collected from 22 dialyzed patients (9 women, 13 men) before and after hemodialysis (HD)...
August 18, 2018: Clinical and Experimental Nephrology
Jiangru Wang, Jialuo Yu, Xiaoyan Wang, Liyan Wang, Bowei Li, Dazhong Shen, Qi Kang, Lingxin Chen
Manganese-doped ZnS quantum dots (ZnS:Mn(II) QDs) were synthesized and modified with L-cysteine (L-Cys) and 6-mercaptonicotinic acid (MNA). This prevents the aggregation of the QDs and makes them available for the interaction with Cu(II) ions via Cu(II)-S interaction. As a result, the fluorescence of the QDs is quenched by Cu(II) due to an electron transfer mechanism. The QDs display two emission peaks under 325 nm excitation, one (being red) peaking at 593 nm, the other (blue) at 412 nm. The red fluorescence is strongly quenched, while the blue fluorescence is not affected...
August 18, 2018: Mikrochimica Acta
Wei Feng, Jinwen Li, Yanjun Liang, Yongqiang Zhang, Shu Jie Li
Tom40, the central component of the preprotein translocase of the mitochondrial outer membrane (TOM complex), forms the import pore that facilitates the translocation of preproteins across the outer membrane. Though the function of Tom40 has been intensively studied, the details of the interactions between presequence peptides and Tom40 remain unclear. In this study, we expressed rat Tom40 in Escherichia coli and purified it from inclusion bodies before investigating the refolded protein by fluorescence spectroscopy and circular dichroism (CD) spectroscopy...
August 18, 2018: European Biophysics Journal: EBJ
Noelia S La Colla, Sandra E Botté, Vanesa L Negrin, Analía V Serra, Jorge E Marcovecchio
Coastal areas are urbanized and industrialized environments, affected by dredging operations, discharges of untreated municipal wastewaters, and farming. Developing countries are in continuous growth and will deal, in a close future, with the highest rate of coastal transformation, posing serious risks for the ecological and environmental value of ecosystem assets. This research aims to study the dissolved and particulate Cr, Ni, Pb and Zn values within an argentinean estuarine environment which is currently under human-induced pressures...
August 18, 2018: Environmental Monitoring and Assessment
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