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İsmail Uçar, Batuhan Turgay, Orhan Küçükşahin, Esma Özkan Uçar, Murat Turgay
Background/aim: The aim of the study was to investigate the effect of systemic sclerosis (SSc) on quality of life and sexual function in female patients. Materials and methods: The study included 30 sexually active female patients with SSc and 30 healthy control subjects. For all participants in both the patient and control groups, the female sexual index and SF-36 forms were completed and a detailed medical and sexual history was taken. Results: The mean age was 45...
December 12, 2018: Turkish Journal of Medical Sciences
Isabel T Ramos, Markus Henningsson, Maryam Nezafat, Begoña Lavin, Silvia Lorrio, Pierre Gebhardt, Andrea Protti, Thomas R Eykyn, Marcelo E Andia, Ulrich Flögel, Alkystis Phinikaridou, Ajay M Shah, René M Botnar
Background: Optimal healing of the myocardium following myocardial infarction (MI) requires a suitable degree of inflammation and its timely resolution, together with a well-orchestrated deposition and degradation of extracellular matrix (ECM) proteins. Methods and Results: MI and SHAM-operated animals were imaged at 3,7,14 and 21 days with 3T magnetic resonance imaging (MRI) using a 19 F/1 H surface coil. Mice were injected with 19 F-perfluorocarbon (PFC) nanoparticles to study inflammatory cell recruitment, and with a gadolinium-based elastin-binding contrast agent (Gd-ESMA) to evaluate elastin content...
November 2018: Circulation. Cardiovascular Imaging
Kumaranchira Ramankutty Krishnadas, Ganapati Natarajan, Ananya Baksi, Atanu Ghosh, Esma Khatun, Thalappil Pradeep
We discuss the role of the metal-ligand (M-L) interfaces in the chemistry of ligand protected, atomically precise noble metal clusters, a new and expanding family of nanosystems, in solution as well as in gas phase. A few possible mechanisms in which the structure and dynamics of M-L interfaces could trigger intercluster exchange reactions are presented first. How interparticle chemistry can be a potential mechanism of Ostwald ripening, a well-known particle coarsening process, is also discussed. Reaction of Ag59(2,5-DCBT)32 (DCBT = dichlorobenzenethiol) with 2,4-DCBT leading to the formation of Ag44(2,4-DCBT)30 is presented, demonstrating the influence of the ligand structure in ligand-induced chemical transformations of clusters...
December 6, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Yasemin Behram Kandemir, Esma Konuk, Mustafa Behram, Muzaffer Sindel
Objective: To analyze the effects of melatonin on vascular endothelial growth factor A (VEGF-A) expression and follicle reserve in rat ovary. Materials and Methods: A total of 45 female Wistar rats were used in the present study. Rats were divided into three groups: group 1 (control), group 2 (vehicle), and group 3 (melatonin). Rats in the melatonin group were treated with an intraperitoneal injection of melatonin at a dose of 50 mg/kg/day for 56 days. We investigated VEGF-A expression in rat ovary in all the groups using Western blot and reverse transcription-polymerase chain reaction...
October 2018: Eurasian Journal of Medicine
Soumia Fenni, Julien Astier, Lauriane Bonnet, Esma Karkeni, Erwan Gouranton, Lourdes Mounien, Charlene Couturier, Franck Tourniaire, Volker Böhm, Habib Hammou, Jean-François Landrier
SCOPE: Although about 90% of lycopene in dietary sources occurs in the linear all-trans conformation, a large proportion of the lycopene found in human tissues is of the cis-isomer type, notably (5Z)-lycopene. The biological effects of this (5Z) isomer have been under-researched. The aim of this study was to evaluate some biological functions of (5Z)-lycopene in adipocytes and to compare them with those of (all-E)-lycopene. METHODS AND RESULTS: (all-E)- and (5Z)-Lycopene displayed strong similarities in global gene expression profile and biological pathways impacted...
December 4, 2018: Molecular Nutrition & Food Research
Jenny Häggström, Ulf Rosenhall, Christina Hederstierna, Per Östberg, Esma Idrizbegovic
Background/Aim: Central auditory processing disorder (CAPD) might precede the onset of Alzheimer's disease (AD). A method of evaluating CAPD is the dichotic digits test (DDT). The aim was to address this in a longitudinal setting. Methods: A total of 136 individuals were assessed with peripheral and central hearing tests at baseline and at 5-year follow-up. Results: Subjects with AD showed a significant decline in DDT scores of the right ear from baseline to follow-up...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Florence Duffaud, Olivier Mir, Pascaline Boudou-Rouquette, Sophie Piperno-Neumann, Nicolas Penel, Emanuelle Bompas, Corinne Delcambre, Elsa Kalbacher, Antoine Italiano, Olivier Collard, Christine Chevreau, Esma Saada, Nicolas Isambert, Jessy Delaye, Camille Schiffler, Corinne Bouvier, Vincent Vidal, Sylvie Chabaud, Jean-Yves Blay
BACKGROUND: Regorafenib has proven activity in patients with pretreated gastrointestinal stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to assess the efficacy and safety of regorafenib for patients with progressive metastatic osteosarcoma and other bone sarcomas. This trial comprised four parallel independent cohorts: osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. In this Article, we report the results of the osteosarcoma cohort. METHODS: In this non-comparative, double-blind, placebo-controlled, phase 2 trial, patients aged 10 years or older with histologically confirmed osteosarcoma whose disease had progressed after treatment with one to two previous lines of chemotherapy for metastatic disease and an Eastern Cooperative Oncology Group performance status of 0 or 1 were enrolled...
November 23, 2018: Lancet Oncology
İrem Okman Koçoğlu, Pınar Esra Erden, Adnan Kenar, Esma Kılıç
The use of a central composite design (CCD) for the optimization of electrode surface composition and its application to develop an amperometric glucose biosensor as a model system are described. A five-level three-factorial CCD was applied to determine the optimum electrode surface composition for three critical variables: amounts of carboxylated multiwall carbon nanotubes (c-MWCNT), titanium dioxide nanoparticles (TiO2 NP), and glucose oxidase (GOx). The statistical significance of the model and factors were evaluated using the variance analysis (ANOVA) at 95% of confidence level...
November 22, 2018: Analytical and Bioanalytical Chemistry
Michael Skoumal, Kyle B Woodward, Hong Zhao, Feng Wang, Esma S Yolcu, Ryan M Pearson, Kevin R Hughes, Andrés J García, Lonnie D Shea, Haval Shirwan
Intraportal allogeneic islet transplantation has been demonstrated as a potential therapy for type 1 diabetes (T1D). The placement of islets into the liver and chronic immunosuppression to control rejection are two major limitations of islet transplantation. We hypothesize that localized immunomodulation with a novel form of FasL chimeric with streptavidin, SA-FasL, can provide protection and long-term function of islets at an extrahepatic site in the absence of chronic immunosuppression. Allogeneic islets modified with biotin and engineered to transiently display SA-FasL on their surface showed sustained survival following transplantation on microporous scaffolds into the peritoneal fat in combination with a short course (15 days) of rapamycin treatment...
November 13, 2018: Biomaterials
Esma Cetinkaya, Sinan Gok, Mesut Sahin
Development of micro electrode arrays for neural recording is an active field that thrives on novel materials and fabrication techniques offered by micro fabrication technology. The material and mechanical properties of microelectrode arrays have a critical role on the quality and longevity of neural signals. In this study, carbon fiber microelectrode (CFME) bundles were developed and implanted in the spinal cord of experimental animals for textbf{\textit{in vivo{recording. Neural data analysis revealed that single spikes could successfully be recorded and sorted...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mehdi Khalfallah, Esma Leila Gouta, Wejih Dougaz, Hichem Jerraya, Imene Samaali, Ramzi Nouira, Ibtissem Bouasker, Chadli Dziri
BACKGROUND: Major amputation of the lower limb is defined by a leg or thigh amputation. The aim of our work was identifying predictive factors for lower limb major amputation in patients with diabetes admitted on for foot lesions through using an administrative data base. METHODS: It was a retrospective study ranging from June 1st, 2008 to December 31st, 2011, which included all the patients admitted on for an infected diabetic foot to the surgery unit B of Charles Nicolle hospital in Tunis...
May 2018: La Tunisie Médicale
Esma Leila Gouta, Wejih Dougaz, Mehdi Khalfallah, Ibtissem Bouasker, Chadli Dziri
BACKGROUND: Laparoscopic surgery has become the gold standard for many procedures owing to its advantages such as a shorter post-operative stay, a faster recovery and less postoperative pain. However, choosing laparoscopic approach in an emergency situationsuch as in the management of a perforated duodenal peptic ulcer is still debated because of the absence of significant benefits. This study aimed to assess the management of perforated duodenal peptic ulcer treated by suture. METHODS: It's a retrospective study enrolling 81 patients operated on for duodenal perforated peptic ulcer between June 1st, 2012 and December 31st, 2016 who underwent surgery in the surgical department B of Charles Nicolle's Hospital...
July 2018: La Tunisie Médicale
Tine Gadegaard Olsen, Frederik Holm, Lauge Hjorth Mikkelsen, Peter Kristian Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu Jin Khong, Penelope A McKelvie, Kaustubh Mulay, Lene Dissing Sjö, Geeta K Vemuganti, Bradley A Thuro, Steffen Heegaard
PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma. DESIGN: Retrospective, interventional case series. METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary end points were overall survival, disease-specific survival and progression-free survival...
November 9, 2018: American Journal of Ophthalmology
Thalappil Pradeep, Bodiuzzaman Mohammad, Atanu Ghosh, Korath Shivan Sugi, Abhijit Nag, Esma Khatun, Babu Varghese, Ganesan Paramasivam, Sudhadevi Antharjanam, Ganapati Natarajan
Two ligand protected new nanoscale pieces of silver - namely, [Ag46(SPhMe2)24(PPh3)8](NO3)2 and [Ag40(SPhMe2)24(PPh3)8](NO3)2 (abbreviated as Ag46 and Ag40, respectively) with almost the same shell but different cores were synthesized simultaneously. As their external structures were identical, the clusters were not able to distinguish each other separately and they got crystallized in the same crystal. The occupancy of each cluster was 50% in the co-crystal. The outer shell of both the clusters is composed of Ag32S24P8 which is reminiscent of fullerenes, and it encapsulates a well-studied core, Ag14 and a completely new core, Ag8 which correspond to a face-centered cube and a simple cube, respectively resulting in the Ag46 and Ag40 clusters...
November 8, 2018: Angewandte Chemie
Esma Karaarslan, Ahmet Topal, Onur Avcı, Sema Tuncer Uzun
OBJECTIVES: We aimed to retrospectively investigate the efficacy of ultrasound guided rectus sheath block (RSB) method in our study. METHODS: We scanned 235 patient files operated for abdominal pathology. Patients meeting the criteria were evaluated for intra-operative rectus sheath block and two different groups were formed. In these two groups of patients visual analogue scale (VAS) values recorded from the postoperative pain follow-up form and analgesic delivery (DEL) and analgesic demand (DEM) values recorded from patient controlled analgesia (PCA) device were compared...
October 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
Ahmet Osman Kılıç, Eyup Sari, Husniye Yucel, Melahat Melek Oğuz, Emine Polat, Esma Altinel Acoglu, Saliha Senel
The present study was conducted to determine young children's (aged 1-60 months) exposure to and use of mobile devices. The study included 422 parents of children aged 1-60 months admitted to pediatric outpatient clinics. A questionnaire was administered to the parents via face-to-face interview. Children's overall exposure to mobile devices was 75.6% (n = 319). Of the children, 24.4% (n = 103) had never used a mobile device. Among the children that had used a mobile device, 20.6% (n = 66) were aged between 1 and 12 months; 24...
November 6, 2018: European Journal of Pediatrics
Hayrullah Alp, Esma Keleş Alp
No abstract text is available yet for this article.
November 2018: Anatolian Journal of Cardiology
Oded Sagiv, Diana Bell, Yunxia Guo, Shirley Su, Sara T Wester, Kailun Jiang, Vivian T Yin, Roman Shinder, Brent Hayek, Hee Joon Kim, Michael T Tetzlaff, Bita Esmaeli
PURPOSE: A risk assessment score for metastasis based on age, tumor size, and mitotic figures has been suggested for nonorbital solitary fibrous tumor (SFT)/hemangiopericytoma. The authors herein examine the clinicopathological features of recurrent and metastatic orbital SFT and evaluate the existing risk assessment score for orbital SFT. METHODS: The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried for patients with recurrent or malignant orbital hemangiopericytoma/SFT...
October 26, 2018: Ophthalmic Plastic and Reconstructive Surgery
Oded Sagiv, Stephanie Ding, Renata Ferrarotto, Bonnie Glisson, Mehmet Altan, Faye Johnson, Yasir Elamin, Sudip D Thakar, Priyadharsini Nagarajan, Bita Esmaeli
PURPOSE: To test the hypothesis that the US Food and Drug Administration approval of vismodegib in early 2012 has reduced the prevalence of orbital exenteration for locally advanced periocular basal cell carcinoma (BCC). METHODS: Following institutional review board approval, the authors reviewed clinical and pathological data of patients with locally advanced periocular BCC (T4 per the eyelid carcinoma classification in the 8th edition of the AJCC Cancer Staging Manual) treated by the senior author during 2006-2018...
October 24, 2018: Ophthalmic Plastic and Reconstructive Surgery
Esma Kocaoğlu, Oktay Talaz, Hüseyin Çavdar, Murat Şentürk, Claudiu T Supuran, Deniz Ekinci
Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8 m, 8 n, and 8 q, were determined to be the most powerful among them...
December 2019: Journal of Enzyme Inhibition and Medicinal Chemistry
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