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Muhammad A Memon, Burcak Karaca, Rasha Aboelhassan, Mohsen Barsoum, Mustafa Erman, Mert Basaran, Alper Sevinc, Djedi Hanene, Cassandra Slader, Virginia Pilipovic, Kerboua Esma, Bouzid Kamel
PURPOSE: Soft tissue sarcomas (STS) are a heterogeneous group of rare mesenchymal neoplasms, accounting for < 1% of all newly diagnosed malignancies. These tumors can occur in almost any anatomic site though they most frequently occur in the extremities. The objective of the study was to describe the epidemiology, treatment paradigm, and real-world outcomes in the clinical management of metastatic STS (mSTS) in the Middle East and North Africa (MEA) region. METHODS: MOON was an observational, multicenter, retrospective patient chart review study which included 200 patients with mSTS in the final analysis...
August 13, 2018: Journal of Cancer Research and Clinical Oncology
Halil Ibrahim Guler, Esma Ceylan, Sabriye Canakcı, Ali Osman Belduz
A cryptic plasmid pHIG22 from Thermus scotoductus sp. K6, an isolate from the Alangullu Hot Spring (Aydin, Turkey), was sequenced and characterized. The pHIG22 plasmid is a multicopy, double stranded and 2222 bp circular molecule with 62.78% GC content, which shows a characteristical nucleotide sequence without any homology to other known plasmids. Five open reading frames were predicted based on the nucleotide sequence analysis. The deduced amino acid sequence of all predicted ORFs didn't show any similarity with any known proteins...
August 6, 2018: Gene
Abdul Albilali, Esma Dilli
PURPOSE OF REVIEW: To provide an updated overview of Photophobia with a particular focus on photophobia related to migraine. RECENT FINDINGS: Melanopsin-containing photoreceptors called intrinsically photosensitive retinal ganglion cells (ipRGCs) have been identified in the retina and explain the rational for photophobia in individuals who are blind. Photophobia, a sensory disturbance provoked by light, is a common neurological and ophthalmological symptom. Migraine, a common neurological condition, is pathognomonic of photophobia; however, other primary headache conditions, traumatic brain injury, and impairment of the optic pathway can cause photophobia...
July 30, 2018: Current Neurology and Neuroscience Reports
Sunah Kang, Ji Won Seo, Chan Joo Ahn, Bita Esmaeli, Ho-Seok Sa
AIM: To calculate a regression formula for intraoperative lagophthalmos to determine the amount of correction in levator resection for mild to moderate congenital ptosis. METHODS: This retrospective study included 38 eyelids from 28 consecutive children with congenital ptosis with levator function of 4 mm or better who showed satisfactory surgical outcomes defined as postoperative margin reflex distance-1 (MRD1) ≥3 mm in each eye and difference in MRD1 ≤1 mm between eyes at 6 months after levator resection...
July 26, 2018: British Journal of Ophthalmology
Füsun Erdenen, Hülya Güngel, Esma Altunoğlu, Duygu Şak, Cüneyt Müderrisoğlu, Atakan Koro, Pınar Akça Güler, Muzaffer Ece Hakan Sahin, Gonul Simsek, Hafize Uzun
BACKGROUND: Diabetic retinopathy (DR) is mainly caused by metabolic factors, vascular inflammation, and endothelial dysfunction. We aimed to evaluate the relationship of DR with inflammatory and biochemical alterations in type 2 diabetics. METHODS: A total of 89 diabetic patients with retinopathy [(DR (+) (n = 30)], without retinopathy [(DR (-) (n = 32)], and 27 control subjects were involved in the study. Demographic properties, biochemical values, ophtalmologic evaluation, C-reactive protein (CRP), and pentraxin-3 (PTX-3) levels were recorded...
July 23, 2018: Metabolic Syndrome and related Disorders
Martine J Jager, Niels J Brouwer, Bita Esmaeli
No abstract text is available yet for this article.
August 2018: Ophthalmology
Esma Islamaj, René J Wubbels, Peter W T de Waard
PURPOSE: To compare a Baerveldt implant and trabeculectomy with respect to intraocular pressure (IOP) and failure rate at 1 year of follow-up. Secondary outcomes are pharmacological therapy and complications at 1 year of follow-up. METHODS: This was a randomized, comparative study. A total of 119 glaucoma patients without previous ocular surgery were included at the Rotterdam Eye Hospital, the Netherlands. One eye of each subject was randomized to either a Baerveldt glaucoma drainage device (BGI) or trabeculectomy (TE)...
July 19, 2018: Acta Ophthalmologica
Oded Sagiv, Priyadharsini Nagarajan, Renata Ferrarotto, Thomas J Kandl, Sudip D Thakar, Bonnie S Glisson, Mehmet Altan, Bita Esmaeli
BACKGROUND/AIMS: Locally advanced (T4 per American Joint Committee on Cancer (AJCC) 8th edition) periocular basal cell carcinoma (BCC) can lead to loss of the eye. We report the neoadjuvant use of vismodegib followed by surgery in patients with such lesions with eye preservation as primary goal. METHODS: This retrospective interventional study includes all patients with a T4 periocular BCC (per 8th edition AJCC for eyelid carcinoma) treated by the senior author between 2013 and 2017 with neoadjuvant vismodegib prior to definitive surgery...
July 18, 2018: British Journal of Ophthalmology
George P Arraj, Giampiero Rossi-Fedele, Esma J Doğramacı
The objective of this review of association (etiology) is to identify the relationship between different overjet measurements and developing a traumatic dental injury (TDI) across different dentition stages. Specifically, the review will elucidate the critical level, in millimetres, at which an overjet will place an individual at an increased risk of developing a TDI within each specific dentition stage. The specific review questions are.
July 2018: JBI Database of Systematic Reviews and Implementation Reports
Lauriane Bonnet, Mohammed Amine Hachemi, Esma Karkeni, Charlene Couturier, Julien Astier, Catherine Defoort, Ljubica Svilar, Jean-Charles Martin, Franck Tourniaire, Jean-François Landrier
Low circulating levels of total and free 25-hydroxyvitamin D (25(OH)D) indicative of vitamin D status have been associated with obesity in humans. Moreover, obesity is thought to play a causal role in the reduction of 25(OH)D levels, and several theories have been put forward to explain this relationship. Here we tested the hypothesis that obesity disrupts vitamin D homeostasis in key organs of vitamin D metabolism. Male C57BL6 mice were fed for 7 or 11 weeks on either a control diet (control, 10% energy from fat) or a high-fat diet (HF, 60% energy from fat) formulated to provide equivalent vitamin D3 intake in both groups...
July 7, 2018: Journal of Steroid Biochemistry and Molecular Biology
A Martin, D Maladry, A Esmaeli, S Gaucher, H-J Philippe
AIM: Fat grafting has well-recognized effects in terms of volume gain, skin trophicity, relieving of post-wound nevralgia. Recent publications suggest a regenerative action on hair follicles. The objective of our study was to compare lipofilling and nanofat grafting in hairy areas of head and neck so as to determine a convenient fat injection technique for those areas in the prospect of treating alopecia. MATERIAL AND METHODS: Our study compared lipofilling and nanofat grafting, in a cadaveric study involving one body...
June 28, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Anastasija Panic, Julijana Stanimirovic, Milan Obradovic, Emina Sudar-Milovanovic, Milan Perovic, Milena Lackovic, Nina Petrovic, Esma R Isenovic
This study aimed to investigate in vivo effects of estradiol on the regulation of hepatic inducible nitric oxide synthase (iNOS) expression in the high fat (HF) diet-induced obesity. Also, we aimed to investigate whether activation of the extracellular regulated kinase (ERK1/2), adenosine monophosphate-activated protein kinase (AMPK), Src kinase, and miR-221 is involved in estradiol-mediated regulation of iNOS in the liver of obese male Wistar rats. Male Wistar rats were fed a standard laboratory diet or a HF diet for ten weeks...
June 29, 2018: Biotechnology and Applied Biochemistry
Emmanuelle Bompas, Loïc Campion, Antoine Italiano, Axel Le Cesne, Christine Chevreau, Nicolas Isambert, Maud Toulmonde, Olivier Mir, Isabelle Ray-Coquard, Sophie Piperno-Neumann, Esma Saada-Bouzid, Maria Rios, Jean-Emmanuel Kurtz, Corinne Delcambre, Pascale Dubray-Longeras, Florence Duffaud, Marie Karanian, François Le Loarer, Patrick Soulié, Nicolas Penel, Jean-Yves Blay
Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database...
June 28, 2018: Cancer Medicine
Scott M Morris, Janakiraman Subramanian, Esma S Gel, George C Runger, Eric J Thompson, David W Mallery, Glen J Weiss
[This corrects the article DOI: 10.1371/journal.pone.0196556.].
2018: PloS One
Esma Saada-Bouzid, Gérard Milano, Juliette Thariat
Squamous cell carcinomas are the most frequent subgroup among head and neck malignant tumors (HNSCC). Tobacco (±alcohol) and HPV infection, the two main risk factors, define two entities with distinct anatomo-clinical and genetic features. HPV-positive, non-tobacco-related HNSCCs are associated with a better prognosis, a rather simple genomic profile, frequent activating mutations of genes involved in pi3kinase-pathway, and the scarcity of mutations of tumor suppressor genes. HPV-negative, tobacco-related HNSCC are genetically more complex, are characterized by almost mandatory inactivating mutations/deletions of tumor suppressor genes (TP53, CDKN2A) and the possible, but less frequent, activating mutations or amplifications of some oncogenes that encode for cell cycle proteins or receptors with tyrosine kinase activity...
June 21, 2018: Bulletin du Cancer
Oded Sagiv, John Stewart, Bita Esmaeli
No abstract text is available yet for this article.
July 2018: Ophthalmology
Oded Sagiv, Thomas J Kandl, Sudip D Thakar, Bradley A Thuro, Naifa L Busaidy, Maria Cabanillas, Camilo Jimenez, Ramona Dadu, Paul H Graham, J Matthew Debnam, Bita Esmaeli
PURPOSE: To describe thyroid eye disease (TED)-like orbital inflammatory syndrome in 3 cancer patients treated with immune checkpoint inhibitors. METHODS: All consecutive patients treated by the senior author who were receiving immune checkpoint inhibitors and developed TED-like orbital inflammation were included. RESULTS: Three cancer patients treated with immune checkpoint inhibitors developed orbital inflammation. The first patient was treated with a combination of a cytotoxic T-lymphocyte antigen-4 inhibitor and a programmed cell death protein 1 inhibitor and developed TED-like orbital inflammation with normal thyroid function and antibody levels...
June 19, 2018: Ophthalmic Plastic and Reconstructive Surgery
Stephanie Ding, Oded Sagiv, Yunxia Guo, Thomas J Kandl, Sudip D Thakar, Bita Esmaeli
PURPOSE: To evaluate the frequency and nature of changes in T category when eyelid carcinomas are staged using the criteria in the 8th edition instead of the 7th edition of the American Joint Committee on Cancer staging manual. METHODS: Following Institutional Review Board approval, a retrospective review was conducted for all consecutive patients with the diagnosis of eyelid carcinoma treated by the senior author from January 2012 through December 2016. After a review of the clinical and pathologic data, each patient's disease was staged using both the 7th-edition and 8th-edition American Joint Committee on Cancer criteria for eyelid carcinomas...
June 5, 2018: Ophthalmic Plastic and Reconstructive Surgery
Devon M Headen, Kyle B Woodward, María M Coronel, Pradeep Shrestha, Jessica D Weaver, Hong Zhao, Min Tan, Michael D Hunckler, William S Bowen, Christopher T Johnson, Lonnie Shea, Esma S Yolcu, Andrés J García, Haval Shirwan
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice...
August 2018: Nature Materials
Chelsea C Pinnix, Bouthaina S Dabaja, Sarah A Milgrom, Grace L Smith, Zeinab Abou, Loretta Nastoupil, Jorge Romaguera, Francesco Turturro, Nathan Fowler, Luis Fayad, Jason Westin, Sattva Neelapu, Michelle A Fanale, Maria A Rodriguez, Frederick Hagemeister, Hun Ju Lee, Yasuhiro Oki, Michael Wang, Felipe Samaniego, Linda Chi, Bita Esmaeli
No abstract text is available yet for this article.
June 2018: Head & Neck
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