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Necrotizing soft tissue infections

Michael D April, Brit Long
No abstract text is available yet for this article.
August 13, 2018: Annals of Emergency Medicine
Karl T Clebak, Michael A Malone
The primary care provider will commonly see skin and soft tissue infections in the outpatient setting. Skin and soft tissue infections range from the uncomplicated impetigo to the potentially lethal necrotizing fasciitis. This article reviews these infections based on their underlying etiology: bacterial, fungal, and viral causes. This article discusses the etiology, presentation, evaluation, and management of impetigo, bullous impetigo, erysipelas, cellulitis, periorbital cellulitis, orbital cellulitis, folliculitis, furuncles, carbuncles, abscess, necrotizing fasciitis, sporotrichosis, tinea corporis, tinea pedis, tinea capitis, Herpes Simplex Virus, zoster, molluscum contagiosum, and warts...
September 2018: Primary Care
María Fernández-Ibieta
Case Report  An 11-month-old female infant presented on the first postoperative (PO) day following an elective pyeloplasty, a dark bluish erythema of her lumbotomy wound, plus a satellite lesion of the same characteristics. Fever and sepsis developed, and despite broad spectrum antibiotics (meropenem and vancomycin) were started, a diagnosis of necrotizing soft-tissue infection (NSTI or necrotizing fasciitis) was established. Surgical debridement of both lesions was performed on day 3 PO, and a surgical contamination (ring retractor blade) was suspected, due to the particular geography of the lesion...
July 2018: Surgery Journal
Rui Hu, Yi-Jun Ren, Li Yan, Xin-Cheng Yi, Fan Ding, Qiong Han, Wen-Jun Cheng
Background: Gustilo Anderson III B/C open tibial fractures are more difficult to manage than I, II, and III A fractures. These open tibial fractures are often associated with wound infection, soft tissue necrosis, bone nonunion, osteomyelitis or amputation. Staged treatment for this severe trauma is very necessary. Materials and Methods: 25 cases of Gustilo Anderson IIIB/C open tibial fractures with serious soft-tissue defects treated between January 2010 and January 2015 were included in this study...
July 2018: Indian Journal of Orthopaedics
Noriyoshi Takano, Midori Sasaki Yatabe, Junichi Yatabe, Masaaki Kato, Daisuke Sueoka, Shigekazu Iguchi, Atsushi Yoshida, Yutaka Uzawa, Ken Kikuchi, Kimitaka Tani, Shinpei Ogawa, Michio Itabashi, Masakazu Yamamoto, Daisuke Watanabe, Takashi Ando, Satoshi Morimoto, Atsuhiro Ichihara
BACKGROUND: Clostridium ramosum is a generally non-pathogenic enteric anaerobe, and Fournier's gangrene is a rare necrotizing soft tissue infection with male predisposition affecting the perineum and the genital area. We report, to our knowledge, the first case of Fournier's gangrene caused by C. ramosum in a female patient with multiple underlying conditions. CASE PRESENTATION: A 44-year-old woman with a 6-year history of insulin-dependent diabetes mellitus after total pancreatectomy and an 11-year history of central diabetes insipidus developed a pain in the genital area after a month of urinary catheter use...
August 2, 2018: BMC Infectious Diseases
A Rasooli, M Nouri, S Esmaeilzadeh, A Ghadiri, D Gharibi, M Javaheri Koupaei, M Moazeni
This report describes an outbreak of purulent mandibular and/or maxillary osteomyelitis caused by Pseudomonas aeruginosa in a sheep flock located in the Khuzestan province, Iran. Jaw bones of almost 100 out of 500 mature sheep in a flock became severely deformed with a variably sized firm swelling, without any signs of inflammation in the surrounding soft tissues. The affected animals showed anorexia, depression, swelling of the mandibular and/or maxillary area, loss of cheek teeth and poor body condition. ‏These animals were gradually culled in a period of 3 months...
2018: Iranian Journal of Veterinary Research
Sachinka Ranasinghe, Michael Williams, Brent Cohen, Sachin Perera, James Carroll, Daniel Walker, Carl Lisec, Jason Brown
No abstract text is available yet for this article.
July 22, 2018: ANZ Journal of Surgery
Shujuan Wang, Hongyu Chen, Xiaoqin Xu, Gengjia Tian, Li Zhang
OBJECTIVE: To develop a washing tube for minimally invasive treatment of sinus cavity pressure ulcer, and to observe its clinical effect. METHODS: Using transparent non-toxic PU plastic to make sinus cavity flushing and drainage tube, and with rounded hemispherical blunt head for the entry of the sinus, the perforated tube in the sinus cavity was designed with perforated holes (3 rows, 5 for each row); the end of the tube is blocked with heparin cap. The invented sinus cavity flushing tube was used for clinical observation and its use effect was observed...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Bryce Haac, Sharon Henry, Jose Diaz, Thomas Scalea, Deborah Stein
Soft tissue diseases including necrotizing soft tissue infections are associated with high mortality and morbidity with hospital-acquired infection rates up to 76 per cent. Critically ill patients with soft tissue infections have increased metabolic requirements; however, the effect of early nutrition on inhospital morbidity including nosocomial infection rates remains unclear. We hypothesized that enteral nutrition within 48 hours of intensive care unit admission would be associated with fewer hospital-acquired infections...
June 1, 2018: American Surgeon
Young Lee, Jasmine Bhinder, Sandeep Sirsi, Dhanan Etwaru, Armand Asarian, Philip Xiao
There is lack of information in the literature on long-term complications of suprapubic catheters. The most common complications include urinary tract infection, bladder calculi, urine leakage and neoplastic changes. We report a case of an unusual complication of bladder prolapse, with subsequent diagnosis of urothelial carcinoma, leading to a necrotizing soft tissue infection after a radical cystectomy in a patient with long-term catheterization and its management. Due to the rarity of this complication, its management has not been well studied...
June 2018: Journal of Surgical Case Reports
Mohamed Elshazzly, Fuad Bashjawish, Muhammad A Shahid, Dana A Marrero, Joel Horowitz
BACKGROUND Crohn's disease (CD) is an inflammatory bowel disease affecting approximately 1 in 3000 people in the United States. Since the inflammation of CD is transmural, patients are at risk for fistula and abscess formation. Retroperitoneal abscesses are one type of which physicians must be aware. CASE REPORT We present the case of a 29-year-old woman with CD who complained of right hip and flank pain that began when she was 6-months pregnant. After delivery, she continued to complain of severe right flank pain and was admitted to the hospital 1 month later...
July 2, 2018: American Journal of Case Reports
Theodore Delmonico, Andrew H Stephen, Daithi S Heffernan
BACKGROUND: Necrotizing soft tissue infection (NSTI) is a rapidly progressive infection characterized by tissue necrosis, septic shock, and is associated with a high risk of death. Key aspects of successful treatment include early recognition and emergent surgical source control. Necrotizing soft tissue infection may occur from a range of etiologies but may also occur rarely from gastrointestinal routes. We report a case of severe lumbar NSTI arising from an ileal pouch fistula in a patient with inflammatory bowel disease...
July 2018: Surgical Infections
Heidi Wolfmeier, Sarah C Mansour, Leo T Liu, Daniel Pletzer, Annette Draeger, Eduard B Babiychuk, Robert E W Hancock
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), typified by the pulse-field type USA300, is an emerging endemic pathogen that is spreading rapidly among healthy people. CA-MRSA causes skin and soft tissue infections, life-threatening necrotizing pneumonia and sepsis, and is remarkably resistant to many antibiotics. Here we show that engineered liposomes composed of naturally occurring sphingomyelin were able to sequester cytolytic toxins secreted by USA300 and prevent necrosis of human erythrocytes, peripheral blood mononuclear cells and bronchial epithelial cells...
June 20, 2018: EBioMedicine
Dakshika A Gunaratne, Evan A Tseros, Zubair Hasan, Akshay S Kudpaje, Anand Suruliraj, Mark C Smith, Faruque Riffat, Carsten E Palme
BACKGROUND: Cervical necrotizing fasciitis is a progressive soft tissue infection with significant morbidity and mortality. METHODS: A case review of cervical necrotizing fasciitis managed at our institution (2007-2017) and a systematic review of PubMed, MEDLINE, and EMBASE databases using the algorithm "(cervical OR neck) AND necrotizing fasciitis." RESULTS: There were 1235 cases from 207 articles which were included in our clinical review...
June 22, 2018: Head & Neck
Fabio Henrique Luiz Leonardo, Mariana Anabuki, Allan Christian Pieroni Gonçalves
Necrotizing fasciitis is a severe infection of the subcutaneous tissue characterized by necrosis of the superficial fascia and overlying skin and is usually associated with previous trauma and comorbidities. Periorbital necrotizing fasciitis is rare and commonly causes visual loss and soft tissue defects. A better prognosis relies critically on early diagnosis, prompt medical treatment, and timely surgical intervention. We describe a rare case of periorbital necrotizing fasciitis in the absence of an inciting event...
June 2018: Arquivos Brasileiros de Oftalmologia
Sarah E Wills, Hugues H Beaufrère, Brigitte A Brisson, Russell S Fraser, Dale A Smith
A 1-y-old spayed female ferret (Mustela putorius furo) was referred for additional diagnostic evaluation after physical examination by the referring veterinarian revealed a cranial abdominal mass. The ferret had a 2-wk history of inappetence, weight loss, and lethargy. On presentation, the ferret was thin, and an approximately 3-cm mass was palpable in the cranial abdomen. No other abnormalities were noted. Abdominal ultrasonography confirmed the presence of a soft-tissue structure, with a moderate blood supply and mesenteric lymphadenopathy...
June 1, 2018: Comparative Medicine
Disha Kumar, Nicolás W Cortés-Penfield, Hanine El-Haddad, Daniel M Musher
BACKGROUND: Fournier's gangrene is a necrotizing soft-tissue infection (NSTI) that often originates from a break in bowel integrity and affects the perineum, anus, or genitalia. Although the pathogenesis is similar, NSTI caused by a break in bowel integrity less commonly presents as infection of other sites. OBJECTIVE: To characterize NSTIs originating from bowel perforation and presenting as infection of the abdominal wall, flank, or thigh but that largely spare the perineum, anus, and genitalia...
July 2018: Surgical Infections
Anshu Babbar, Trond Bruun, Ole Hyldegaard, Michael Nekludov, Per Arnell, Dietmar H Pieper, Andreas Itzek
Background: Necrotizing soft-tissue infections (NSTI) are the most severe form of bacterial-induced tissue pathology. Their unpredictable onset and rapid development into life-threatening conditions considerably complicate patient treatment. Understanding the risk factors for NSTI in individual patients is necessary for selecting the appropriate therapeutic option. Methods: We investigated the role of pathogen-specific antibodies in the manifestation of NSTI by performing a comparative serologic approach, using plasma samples and bacterial isolates from patients with clinical NSTIs or nonnecrotizing STIs caused by Streptococcus pyogenes...
June 5, 2018: Journal of Infectious Diseases
Camille Hua, Romain Bosc, Emilie Sbidian, Nicolas De Prost, Carolyn Hughes, Patricia Jabre, Olivier Chosidow, Laurence Le Cleach
BACKGROUND: Necrotizing soft tissue infections (NSTIs) are severe and rapidly spreading soft tissue infections of the subcutaneous tissue, fascia, or muscle, which are mostly caused by bacteria. Associated rates of mortality and morbidity are high, with the former estimated at around 23%, and disability, sequelae, and limb loss occurring in 15% of patients. Standard management includes intravenous empiric antimicrobial therapy, early surgical debridement of necrotic tissues, intensive care support, and adjuvant therapies such as intravenous immunoglobulin (IVIG)...
May 31, 2018: Cochrane Database of Systematic Reviews
Serhat Uysal, Anil Murat Ozturk, Meltem Tasbakan, Ilgin Yildirim Simsir, Aysegul Unver, Nevin Turgay, Husnu Pullukcu
BACKGROUND: Myiasis complication of diabetic foot ulcer has only been presented in a few case reports. Therefore, there is a need for additional data on this infestation. OBJECTIVE: Evaluate clinical characteristics of human myiasis in patients with diabetic foot. DESIGN: Case series. SETTINGS: A tertiary referral healthcare institution and a diabetic foot center. PATIENTS AND METHODS: Patients with diabetic foot infection com...
May 2018: Annals of Saudi Medicine
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