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https://www.readbyqxmd.com/read/29475214/micro-environment-and-intracellular-metabolism-modulation-of-adipose-tissue-macrophage-polarization-in-relation-to-chronic-inflammatory-diseases
#1
REVIEW
Xiao Zhu, Yixuan Tu, Hainan Chen, Ampadu O Jackson, Vaibhav Patel, Kai Yin
BACKGROUND: The accumulation and pro-inflammatory polarization of immune cells, mainly macrophages, in adipose tissue (AT) are considered crucial factors for obesity-induced chronic inflammatory diseases. SCOPE OF REVIEW: In this review, we highlighted the role of adipose tissue macrophage (ATM) polarization on AT function in the obese state and the effect of the micro-environment and intracellular metabolism on the dynamic switch of ATMs into their pro-inflammatory or anti-inflammatory phenotypes, which may have distinct influences on obesity-related chronic inflammatory diseases...
February 23, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29475212/the-effects-of-vitamin-d-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-among-women-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Maryam Akbari, Vahidreza Ostadmohammadi, Kamran B Lankarani, Reza Tabrizi, Fariba Kolahdooz, Seyed Taghi Heydari, Seyed Habibollah Kavari, Naghmeh Mirhosseini, Alireza Mafi, Majid Dastorani, Zatollah Asemi
The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome (PCOS). Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related randomized-controlled articles (RCTs) published up to November 2017. Two researchers assessed study eligibility, extracted data, and evaluated risk of bias of included RCTs, independently...
February 23, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29475133/reactive-oxygen-species-promote-tubular-injury-in-diabetic-nephropathy-the-role-of-the-mitochondrial-ros-txnip-nlrp3-biological-axis
#3
Yachun Han, Xiaoxuan Xu, Chengyuan Tang, Peng Gao, Xianghui Chen, Xiaofen Xiong, Ming Yang, Shikun Yang, Xuejing Zhu, Shuguang Yuan, Fuyou Liu, Li Xiao, Yashpal S Kanwar, Lin Sun
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS overproduction is accompanied by decreases in TRX expression and TXNIP up-regulation. In addition, we discovered that mtROS overproduction is also associated with increases in NLRP3/IL-1β and TGF-β expression in the kidneys of patients with DN and db/db mice...
February 15, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475100/new-thiazolidinedione-lpsf-gq-2-inhibits-nf%C3%AE%C2%BAb-and-mapk-activation-in-lps-induced-acute-lung-inflammation
#4
Laise Aline Martins Dos Santos, Gabriel Barros Rodrigues, Fernanda Virgínia Barreto Mota, Maria Eduarda Rocha de França, Karla Patrícia de Souza Barbosa, Wilma Helena de Oliveira, Sura Wanessa Santos Rocha, Deniele Bezerra Lós, Amanda Karolina Soares Silva, Teresinha Gonçalves da Silva, Christina Alves Peixoto
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as potential drugs for the treatment of ALI and ARDS due to their anti-inflammatory efficacy. The present study aims to evaluate the potential anti-inflammatory effects of new TZDs derivatives, LPSF/GQ-2 and LPSF/RA-4, on ALI induced by LPS...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#5
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475098/xq-1h-protects-against-ischemic-stroke-by-regulating-microglia-polarization-through-ppar%C3%AE-pathway-in-mice
#6
Rui Liu, Junjian Diao, Shucheng He, Binbin Li, Yuxiang Fei, Yunman Li, Weirong Fang
Cerebral ischemic and reperfusion injury often accompany with inflammation, and lead to severe neuronal damage, which further result in neurological disorders and memory disorders. In this study, we researched XQ-1H, a novel derivative of ginkgolide B, protecting against ischemic stroke in mice through regulation of microglia polarization. Middle cerebral artery occlusion (MCAO)/reperfusion in mice is applied to mimic ischemic stroke in vivo. Immediately after MCAO, mice are intragastric administrated with different dose (31 or 62 mg/kg) of XQ-1H for one or continuative three days...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475097/kaempferol-3-o-%C3%AE-d-glucuronate-exhibit-potential-anti-inflammatory-effect-in-lps-stimulated-raw-264-7-cells-and-mice-model
#7
Vidushi Khajuria, Shilpa Gupta, Neha Sharma, Harshita Tiwari, Subhash Bhardwaj, Prabhu Dutt, Naresh Satti, Amit Nargotra, Asha Bhagat, Zabeer Ahmed
Kaempferol-3-O-β-d-glucuronide (K3G) having various pharmacological effects was explored for its anti-inflammatory effect in LPS induced RAW 264.7 cells and mice model. K3G significantly inhibited various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. It upregulated the secretion of anti-inflammatory cytokine IL-10. K3G is found to reduce inflammation when studied for parameters like phagocytic index, carrageenan induced paw edema in mice and organ weight. It reduced inflammation in a dose dependent manner both in-vitro and in-vivo...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475096/phenotypic-and-functional-profile-of-th17-and-treg-cells-in-allergic-fungal-sinusitis
#8
Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Neelima Gupta, Sonal Sharma, Naseem Akhter, Vishnampettai G Ramachandran, Shafiul Haque, Sajad Ahmad Dar
Interleukin-17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal rhinosinusitis (AFRS) patients of different ethnicities has mystified its pathogenesis. To better understand the pathophysiological mechanisms involved in AFRS, we conducted a prospective, analytical, case-control study involving 40 confirmed immunocompetent AFRS patients and 20 healthy controls...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475038/astaxanthin-protects-against-kainic-acid-induced-seizures-and-pathological-consequences
#9
Yi Chang, Cheng Wei Lu, Yi Jing Chen, Tzu Yu Lin, Shu Kuei Huang, Su Jane Wang
Excitotoxic damage caused by increased glutamate levels is involved in the pathogenesis of neurodegenerative diseases. Astaxanthin, a natural carotenoid with multiple health benefits, inhibits glutamate release from the brain tissue; however, whether it possesses the ability to affect glutamate-induced brain injury is unknown. The present study investigated the neuroprotective effects of astaxanthin on kainic acid (KA)-induced excitotoxicity in rats and the possible underlying intracellular signaling pathway...
February 20, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29475023/the-multifaceted-roles-of-perlecan-in-fibrosis
#10
REVIEW
Megan S Lord, Fengying Tang, Jelena Rnjak-Kovacina, James G W Smith, James Melrose, John M Whitelock
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix...
February 20, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29475018/kynurenine-pathway-metabolism-and-the-neurobiology-of-treatment-resistant-depression-comparison-of-multiple-ketamine-infusions-and-electroconvulsive-therapy
#11
A P Allen, M Naughton, J Dowling, A Walsh, R O'Shea, G Shorten, L Scott, D M McLoughlin, J F Cryan, G Clarke, T G Dinan
Current first-line antidepressants can take weeks or months to decrease depressive symptoms. Low dose ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, shows potential for a more rapid antidepressant effect, with efficacy also evident in previously treatment-resistant populations. However, a greater understanding of the physiological mechanisms underlying such effects is required. We assessed the potential impact of ketamine infusion on neurobiological drivers of kynurenine pathway metabolism in major depression (HPA axis hyperactivity, inflammation) in patients with treatment-resistant depression compared to gender-matched healthy controls...
February 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29474945/neutralization-of-il-17c-reduces-skin-inflammation-in-mouse-models-of-psoriasis-and-atopic-dermatitis
#12
Nick Vandeghinste, Jürgen Klattig, Catherine Jagerschmidt, Stéphanie Lavazais, Florence Marsais, Jan D Haas, Marielle Auberval, Felix Lauffer, Tara Moran, Mate Ongenaert, Maarten Van Balen, Sonia Dupont, Liên Lepescheux, Teresa Garcia, Stefan Härtle, Kilian Eyerich, Padraic G Fallon, Reginald Brys, Stefan Steidl
Interleukin-17C (IL-17C) is a functionally distinct member of the IL-17 family that was implicated to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C is involved in psoriasis and explored potential roles for IL-17C in atopic dermatitis (AD). An anti-IL-17C antibody, MOR106, was generated that potently and selectively binds to human and mouse IL-17C, thereby inhibiting the binding of IL-17C to its IL-17RE receptor. The antibody inhibited cutaneous inflammation in an IL-23-induced psoriatic-like skin inflammation model...
February 20, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29474889/human-gut-microbiota-and-gastrointestinal-cancer
#13
REVIEW
Changting Meng, Chunmei Bai, Thomas D Brown, Leroy Hood, Qiang Tian
Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts understanding various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways...
February 20, 2018: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29474875/rig-i-is-involved-in-inflammation-through-the-ips-1-traf-6-pathway-in-astrocytes-under-chemical-hypoxia
#14
Lei Li, Rongli Yang, Meijiang Feng, YiChen Guo, YuXuan Wang, Jun Guo, Xiang Lu
The retinoic acid-inducible gene I (RIG-I) is a crucial cytoplasmic pathogen recognition receptor involved in neuroinflammation in degenerative diseases. In the present study, in vitro human astrocytes were subjected to a chemical hypoxia model using cobalt chloride pretreatment. Chemical hypoxia induces the up-regulation of RIG-I in astrocytes and results in the expression of inflammatory cytokines IL-1β, IL-6, and TNF-α in an NF-κB dependent manner. Elevated RIG-I modulates the interaction of interferon-β promoter stimulator-1 (IPS-1) and TNF receptor-associated factor 6 (TRAF6) following chemical hypoxia...
February 20, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29474863/attenuated-strength-gains-during-prolonged-resistance-exercise-training-in-older-adults-with-high-inflammatory-status
#15
Roland W J Hangelbroek, Pim Knuiman, Michael Tieland, Lisette C P G M de Groot
OBJECTIVES: Chronic systemic low grade inflammation is associated with the age-related loss of muscle mass. Resistance exercise has been suggested to reduce or lower chronic systemic low grade inflammation. However, systemic chronic low-grade inflammation may adversely affect the adaptive response to exercise training. We investigated the effect of resistance exercise training on systemic chronic low-grade inflammation in older adults. In addition, we studied the association between systemic chronic low-grade inflammation and the adaptive response to exercise training...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474842/inkt-cell-mediated-xcl1-xcr1-axis-promotes-allergic-airway-hyperresponsiveness-by-recruiting-cd103-dendritic-cells
#16
Yeon Duk Woo, Jaemoon Koh, Hye-Ryun Kang, Hye Young Kim, Doo Hyun Chung
BACKGROUND: The XCL1-XCR1 axis has been reported to play a role in immune homeostasis and inflammation. However, it is not known whether this axis has a critical function in allergic asthma. OBJECTIVE: In the present study, we explored that the iNKT cell-mediated XCL1-XCR1 axis regulated the allergic asthma. METHODS: Ovalbumin (OVA) or house dust mite (HDM)-induced asthma was developed in XCL1 or XCR1 knockout (KO) mice. RESULTS: XCL1 or XCR1 KO mice showed attenuation in airway hyperresponsiveness (AHR), numbers of CD103+ dendritic cells (DCs), and Th2 responses in the lungs compared with wild-type (WT) mice during OVA or HDM-induced asthma...
February 20, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29474830/erythema-nodosum-leprosum-update-and-challenges-on-the-treatment-of-a-neglected-condition
#17
REVIEW
Perpétua do Socorro Silva Costa, Lucas Rosa Fraga, Thayne Woycinck Kowalski, Egon Luiz Rodrigues Daxbacher, Lavínia Schuler-Faccini, Fernanda Sales Luiz Vianna
Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication of multibacillary leprosy and is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of disability. In addition, ENL is a major health problem in countries where leprosy is endemic. Therefore, adequate control of this condition is important. The management of ENL aims to control acute inflammation and neuritis and prevent the onset of new episodes...
February 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29474803/exercise-and-taurine-in-inflammation-cognition-and-peripheral-markers-of-blood-brain-barrier-integrity-in-older-women
#18
Matheus Uba Chupel, Luciele Guerra Minuzzi, Guilherme E Furtado, Mário Leonardo Santos, Eef Hogervorst, Edith Filaire, Ana Maria Teixeira
Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of blood-brain barrier, inflammation, and cognition of elderly women. Forty-eight elderly women (83.58±6.9 years) participated in the study, and were allocated into combined exercise training (CET: n=13), taurine supplementation (TAU: n=12), exercise training associated with taurine (CET+TAU: n=11), or control group (CG: n=12)...
February 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29474749/mek-erk-signaling-diametrically-controls-the-stimulation-of-il-23p19-and-ebi3-expression-in-epithelial-cells-by-il-36%C3%AE
#19
Glen M Scholz, Jacqueline E Heath, Katrina A Walsh, Eric C Reynolds
Interleukin (IL)-36 (IL-36) cytokines are important regulators of mucosal homeostasis and inflammation. We previously established that oral epithelial cells strongly upregulate IL-36γ expression in response to the bacterial pathogen Porphyromonas gingivalis. Here, we have established that IL-36γ stimulates the expression of the IL-12 cytokine family members, IL-23p19 and Epstein-Barr Virus-Induced Gene 3 (EBI3), by oral epithelial cells; their expression was also selectively stimulated by IL-36α. Notably, IL-23p19 and EBI3 expression was not stimulated by P...
February 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29474707/immune-relevant-models-for-ocular-inflammatory-diseases
#20
Brian C Gilger
Ocular inflammatory diseases, such as dry eye and uveitis, are common, painful, difficult to treat, and may result in vision loss or blindness. Ocular side effects from the use of antiinflammatory drugs (such as corticosteroids or nonsteroidal antiinflammatories) to treat ocular inflammation have prompted development of more specific and safer medications to treat inflammatory and immune-mediated diseases of the eye. To assess the efficacy and safety of these new therapeutics, appropriate immune-relevant animal models of ocular inflammation are needed...
February 21, 2018: ILAR Journal
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