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Inflammation

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https://www.readbyqxmd.com/read/29241208/exosomes-from-mir-126-overexpressing-adscs-are-therapeutic-in-relieving-acute-myocardial-ischaemic-injury
#1
Qiancheng Luo, Dongfeng Guo, Guorong Liu, Guo Chen, Min Hang, Mingming Jin
BACKGROUND/AIMS: Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study is to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-126 have a more protective effect on acute myocardial infarction (AMI). METHODS: Exosomes were characterized by transmission electron microscopy, and the exosome particles were further examined using nanoparticle tracking analyses...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241205/glaucocalyxin-b-alleviates-lipopolysaccharide-induced-parkinson-s-disease-by-inhibiting-tlr-nf-%C3%AE%C2%BAb-and-activating-nrf2-ho-1-pathway
#2
Wei Xu, Deyu Zheng, Yuanyuan Liu, Ji Li, Li Yang, Xiuli Shang
BACKGROUND/AIMS: Parkinson's disease (PD) is a common neurodegenerative disease in the old population, characterized by dopaminergic neuron loss, inflammation and oxidative stress injury in the substantia nigra. Glaucocalyxin B (GLB), an ent-kauranoid diterpenoid isolated from Rabdosia japonica, has anti-inflammation and anti-tumor effects. However, its effects on PD remain unclear. METHODS: PD was introduced in rats via injection of lipopolysaccharide (LPS) into cerebral corpus striatum, and GLB was given intracerebroventricularly to these rats...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241199/change-in-hemoglobin-trajectory-and-darbepoetin-dose-approaching-end-stage-renal-disease-data-from-the-trial-to-reduce-cardiovascular-events-with-aranesp-therapy-trial
#3
Finnian R Mc Causland, Brian Claggett, Marc A Pfeffer, Emmanuel A Burdmann, Kai-Uwe Eckardt, Andrew S Levey, John J V McMurray, Giuseppe Remuzzi, Ajay K Singh, Scott D Solomon, Robert D Toto, Patrick Parfrey
BACKGROUND: The pathogenesis of chronic kidney disease associated anemia is multifactorial and includes decreased production of erythropoietin (EPO), iron deficiency, inflammation, and EPO resistance. To better understand the trajectory of these parameters, we described temporal trends in hemoglobin (Hb), ferritin, transferrin saturation, C-reactive protein (CRP), and darbepoetin dosing in the Trial to Reduce cardiovascular Events with Aranesp Therapy (TREAT). METHODS: We performed a post hoc analysis of 4,038 participants in TREAT...
December 14, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29241192/microrna-92a-3p-regulates-aggrecanase-1-and-aggrecanase-2-expression-in-chondrogenesis-and-il-1%C3%AE-induced-catabolism-in-human-articular-chondrocytes
#4
Guping Mao, Peihui Wu, Ziji Zhang, Zhiqi Zhang, Weiming Liao, Yukang Li, Yan Kang
BACKGROUND/AIMS: Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) are secreted enzymes belonging to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family that play significant roles in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5 in chondrogenesis and inflammation is regulated by microRNA-92a-3p (miR-92a-3p). METHODS: MiR-92a-3p and ADAMTS-4/5 expressions were determined by quantitative polymerase chain reaction (qPCR)...
November 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241159/oxymatrine-prevents-synovial-inflammation-and-migration-via-blocking-nf-%C3%AE%C2%BAb-activation-in-rheumatoid-fibroblast-like-synoviocytes
#5
Jiang Liang, Boyang Chang, Mingcheng Huang, Weichen Huang, Wukai Ma, Yang Liu, Wan Tai, Yi Long, Yun Lu
The fibroblast-like synoviocytes (FLSs) has the aggressive phenotype, which is very important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the increased FLSs migration, activation and proliferation are essential factors. Oxymatrine is a traditional Chinese herb, which is the extraction from the root of Sophora flavescens and regarded as quinolizidine alkaloid compounds and has been shown to inhibit inflammation, proliferation and migration in vitro or vivo. However, whether oxymatrine effects in the treatment of RA FLSs is undefined...
December 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29240923/neutrophil-activation-signature-in-juvenile-idiopathic-arthritis-indicates-the-presence-of-low-density-granulocytes
#6
Kavitha Ramanathan, Anna Glaser, Hanna Lythgoe, Joanne Ong, Michael W Beresford, Angela Midgley, Helen L Wright
Objective: JIA is an autoimmune, inflammatory disease with involvement of innate and adaptive immune responses. However, the role of neutrophils in JIA pathogenesis remains unclear. This study aimed to identify and validate neutrophil gene expression signatures in JIA using public microarray datasets and new clinical samples. Methods: Three suitable datasets were analysed by significance analysis of microarray and Ingenuity. Neutrophils and peripheral blood mononuclear cells (PBMCs) were isolated from a new cohort of JIA patients and healthy paediatric controls (HCs)...
December 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/29240916/study-on-the-anti-endotoxin-effect-of-sinomenine-using-an-agilent-genome-array
#7
Yiyi Hu, Bin Li, Libin Wen, Kongwang He
Background: Endotoxin is a significant contributing factor underlying the occurrence of fever, diarrhea, inflammation, edema, coagulation, shock, and other syndromes associated with Gram-negative bacterial infections. To date, there is no effective treatment for endotoxemia. Aim: The aim of this study was to characterize differentially expressed genes in sinomenine-treated and LPS-induced endothelial cells by microarray analysis, and to determine the potential pharmacological activity of sinomenine...
December 12, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29240880/assessment-of-histological-remission-in-ulcerative-colitis-discrepancies-between-daily-practice-and-expert-opinion
#8
Tessa E H Römkens, Pim Kranenburg, Arjan van Tilburg, Carolien Bronkhorst, Iris D Nagtegaal, Joost P H Drenth, Frank Hoentjen
Background and aims: Histological remission (HR) is a potential treatment target in ulcerative colitis (UC). Limited 'real world ' data is available on reliability of histological scoring when assessing minimal histological inflammation. The aim of our study was to investigate the reliability of UC histological scores in colonic biopsies showing mucosal healing (MH) and limited histological inflammation, and to compare the 'daily practice' histological assessment with expert reviews by gastrointestinal (GI)-pathologists...
December 12, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29240822/acne-keloidalis-nuchae-in-asian-a-single-institutional-experience
#9
Kiyong Na, Sang Ho Oh, Sang Kyum Kim
Acne keloidalis nuchae, a type of folliculitis involving the back of the neck, is common in black men, although rare cases have been reported in patients of other ethnicities. We analyzed the clinicopathological features of acne keloidalis nuchae in 17 Asians. Patients' age at the time of presentation ranged from 20 to 69 years. Most patients experienced the disease over 2 years (range, 3 months-20 years); follow-up data were available for 11 (65%) patients (range, 2-95 months). Nine (53%) patients had comorbidities, but none had a history of other skin disease or a family history of acne keloidalis nuchae...
2017: PloS One
https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#10
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29240802/systemic-factors-related-to-soluble-pro-renin-receptor-in-plasma-of-patients-with-proliferative-diabetic-retinopathy
#11
Keitaro Hase, Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, Susumu Ishida
(Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR). In this study, we investigated systemic factors related to plasma levels of soluble form of (P)RR [s(P)RR] in patients with PDR. Twenty type II diabetic patients with PDR and 20 age-matched, non-diabetic patients with idiopathic macular diseases were enrolled, and plasma levels of various molecules were measured by enzyme-linked immunosorbent assays...
2017: PloS One
https://www.readbyqxmd.com/read/29240761/microorganisms-in-the-human-placenta-are-associated-with-altered-cpg-methylation-of-immune-and-inflammation-related-genes
#12
Martha Scott Tomlinson, Paige A Bommarito, Elizabeth M Martin, Lisa Smeester, Raina N Fichorova, Andrew B Onderdonk, Karl C K Kuban, T Michael O'Shea, Rebecca C Fry
Microorganisms in the placenta have been linked to adverse pregnancy outcomes as well as neonatal illness. Inflammation in the placenta has been identified as a contributing factor in this association, but the underlying biological mechanisms are not yet fully understood. The placental epigenome may serve as an intermediate between placental microbes and inflammation, contributing to adverse outcomes in the offspring. In the present study, genome-wide DNA methylation (n = 486,428 CpG sites) of 84 placentas was analyzed in relation to 16 species of placental microorganisms using samples collected from the Extremely Low Gestation Age Newborns (ELGAN) cohort...
2017: PloS One
https://www.readbyqxmd.com/read/29240685/fibrinogen-as-a-pleiotropic-protein-causing-human-diseases-the-mutational-burden-of-a%C3%AE-b%C3%AE-and-%C3%AE-chains
#13
Elvezia Maria Paraboschi, Stefano Duga, Rosanna Asselta
Fibrinogen is a highly pleiotropic protein that is involved in the final step of the coagulation cascade, wound healing, inflammation, and angiogenesis. Heterozygous mutations in Aα, Bβ, or γ fibrinogen-chain genes (FGA, FGB, FGG) have been described as being responsible for fibrinogen deficiencies (hypofibrinogenemia, hypo-dysfibrinogenemia, dysfibrinogenemia) and for more rare conditions, such as fibrinogen storage disease and hereditary renal amyloidosis. Instead, biallelic mutations have been associated with afibrinogenemia/severe hypofibrinogenemia, i...
December 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29240668/heat-shock-proteins-in-vascular-diabetic-complications-review-and-future-perspective
#14
REVIEW
Stefania Bellini, Federica Barutta, Raffaella Mastrocola, Luigi Imperatore, Graziella Bruno, Gabriella Gruden
Heat shock proteins (HSPs) are a large family of proteins highly conserved throughout evolution because of their unique cytoprotective properties. Besides assisting protein refolding and regulating proteostasis under stressful conditions, HSPs also play an important role in protecting cells from oxidative stress, inflammation, and apoptosis. Therefore, HSPs are crucial in counteracting the deleterious effects of hyperglycemia in target organs of diabetes vascular complications. Changes in HSP expression have been demonstrated in diabetic complications and functionally related to hyperglycemia-induced cell injury...
December 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29240666/induction-of-inflammation-in-vivo-by-electrocardiogram-sensor-operation-using-wireless-power-transmission
#15
Jin-Chul Heo, Beomjoon Kim, Yoon-Nyun Kim, Dae-Kwang Kim, Jong-Ha Lee
Prolonged monitoring by cardiac electrocardiogram (ECG) sensors is useful for patients with emergency heart conditions. However, implant monitoring systems are limited by lack of tissue biocompatibility. Here, we developed an implantable ECG sensor for real-time monitoring of ventricular fibrillation and evaluated its biocompatibility using an animal model. The implantable sensor comprised transplant sensors with two electrodes, a wireless power transmission system, and a monitoring system. The sensor was inserted into the subcutaneous tissue of the abdominal area and operated for 1 h/day for 5 days using a wireless power system...
December 14, 2017: Sensors
https://www.readbyqxmd.com/read/29240645/resveratrol-downregulates-biomarkers-of-sepsis-via-inhibition-of-proteasome-s-proteases
#16
Neerupma Silswal, Nidhi S Reddy, Asaf A Qureshi, Nilofer Qureshi
LPS is the main agonist of Gram-negative bacteria and initiates inflammation. We recently reported that plasmas from sepsis patients revealed increased levels of following group of biomarkers; VCAM-1, ICAM1, CRP, resistin, and proteasome LMP subunits. Our objective here was to compare effects of resveratrol (shown to be a non-specific proteasome inhibitor by us) and a known LMP7 inhibitor (ONX-0914, specific inhibitor) on proteasome's activities, as well as on inflammatory markers mentioned above in human blood monocytes...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240643/temporally-distinct-regulation-of-pathways-contributing-to-cardiac-proteostasis-during-the-acute-and-recovery-phases-of-sepsis
#17
Kristen T Crowell, Samantha Moreno, Jennifer L Steiner, Catherine S Coleman, David I Soybel, Charles H Lang
BACKGROUND: Cardiac dysfunction is a common manifestation of sepsis and is associated with early increases in inflammation and decreases in myocardial protein synthesis. However, little is known regarding the molecular mechanisms regulating protein homeostasis during the recovery phase after the removal of the septic nidus. Therefore, the purpose of this study was to investigate diverse signal transduction pathways that regulate myocardial protein synthesis and degradation. METHODS: Adult male C57BL/6 mice were used to identify potential mechanisms mediating the acute (24 h) effect of cecal ligation and puncture (CLP) as well as long-term changes that manifest during the chronic (10 d) recovery phase...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240317/inflammations-of-the-mammary-gland
#18
Tuomo Meretoja, Hanna Ihalainen, Marjut Leidenius
Breast inflammation, i.e. mastitis is an entity with a variable etiology and severity, typically affecting women of fertile age. In most cases, anamnesis reveals the etiology of the disease, bacterial puerperal mastitis associated with breastfeeding being the most common. Periductal mastitis is a breast inflammation typically associated with smoking in women of 40 to 50 years of age, localized to the region of the areola. Granulomatous mastitis and other rare breast inflammations usually require specialized care...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240273/endothelial-dysfunction-may-promote-keloid-growth
#19
Chikage Noishiki, Gen Takagi, Yoshiaki Kubota, Rei Ogawa
Keloid is a cutaneous fibroproliferative disorder. It results from impaired wound healing that generates persistent inflammation and extensive deposition of collagen fibers in the wound/scar. Keloids tend to be worse in hypertensive patients. The present prospective cross-sectional study assessed whether endothelial dysfunction, which occurs in hypertension, associates with keloid formation and progression. This study included randomly-selected patients with keloids who were assessed for surgical keloid treatment in 2013-2014...
December 14, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29239984/profiling-inflammatory-markers-during-the-competitive-season-and-post-season-in-collegiate-wrestlers
#20
Joe Roth, Taylor Szczygiel, Mary Moore, Paul O'Connor, Jeffrey Edwards, Naveen Sharma, Ryan Pettit-Mee, Micah Zuhl
The purpose of this study was to determine if biological markers of muscle damage and inflammation coincide with subjective measures of muscle fatigue and sleep quality among Division I collegiate wrestlers. The goal was to provide practitioners with noninvasive techniques to evaluate a wrestlers inflammatory state. METHODS: Subjects from the Central Michigan University Division I collegiate wrestling team (n=6) were analyzed on six separate occasions throughout the course of the competitive season and post season...
December 11, 2017: Journal of Strength and Conditioning Research
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