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Inflammation

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https://www.readbyqxmd.com/read/29684880/exposure-to-air-pollution-interacts-with-obesogenic-nutrition-to-induce-tissue-specific-response-patterns
#1
Michal Pardo, Yael Kuperman, Liron Levin, Assaf Rudich, Yulia Haim, James J Schauer, Alon Chen, Yinon Rudich
Obesity and exposure to particular matter (PM) have become two leading global threats to public health. However, the exact mechanisms and tissue-specificity of their health effects are largely unknown. Here we investigate whether a metabolic challenge (early nutritional obesity) synergistically interacts with an environmental challenge (PM exposure) to alter genes representing key response pathways, in a tissue-specific manner. Mice subjected to 7 weeks obesogenic nutrition were exposed every other day during the final week and a half to aqueous extracts of PM collected in the city of London (UK)...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684860/polyphenol-rich-extract-of-ocimum-gratissimum-leaves-ameliorates-colitis-via-attenuating-colonic-mucosa-injury-and-regulating-pro-inflammatory-cytokines-production-and-oxidative-stress
#2
Quadri K Alabi, Rufus O Akomolafe, Joseph G Omole, Modinat A Adefisayo, Olaofe L Ogundipe, Ayodeji Aturamu, Joseph O Sanya
Colitis is a chronic inflammation and ulcer on the inner lining of the large intestine. For many centuries Ocimum gratissimum (OG) leaves have been used in folk medicine in Nigeria to treat inflammatory bowel diseases, however, to date, the anti-colitis effects of OG have not been scientifically proven. In this study we investigated the effects of polyphenol rich extract of Ocimum gratissimum (PREOG) leaf on colonic mucosa injury in colitis, its mechanisms, initial administration time and dosage. Dextran sodium sulfate (DSS)-induced rat colitis models was used...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684853/naringenin-improve-hepatitis-c-virus-infection-induced-insulin-resistance-by-increase-pten-expression-via-p53-dependent-manner
#3
Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684816/gaba-regulates-the-proliferation-and-apoptosis-of-mac-t-cells-through-the-lps-induced-tlr4-signaling-pathway
#4
Yue-Ying Wang, Shi-Ping Sun, He-Shui Zhu, Xian-Qin Jiao, Kai Zhong, Yu-Jie Guo, Guang-Ming Zha, Li-Qiang Han, Guo-Yu Yang, He-Ping Li
Subacute ruminal acidosis (SARA) can cause rapid lipopolysaccharide (LPS) elevation and milk yield decline in lactating ruminants. LPS has been shown to promote apoptosis and reduce the proliferation of mammary epithelial cells. Previous studies have shown that γ- amino butyric acid (GABA) can enhance production performance, regulating β-cell apoptosis and proliferation. Whether GABA can regulate apoptosis and proliferation induced by LPS in mammary epithelial cells is unknown. In this paper, we detected the role of GABA on proliferation and apoptosis as well as inflammation induced by LPS in bovine mammary epithelial cells (MAC-T cell line)...
April 18, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29684674/natural-products-targeting-er-stress-pathway-for-the-treatment-of-cardiovascular-diseases
#5
REVIEW
Ker Woon Choy, Dharmani Murugan, Mohd Rais Mustafa
Endoplasmic reticulum (ER) is the main organelle for the synthesis, folding, and processing of secretory and transmembrane proteins. Pathological stimuli including hypoxia, ischaemia, inflammation and oxidative stress interrupt the homeostatic function of ER, leading to accumulation of unfolded proteins, a condition referred to as ER stress. ER stress triggers a complex signalling network referred as the unfolded protein response (UPR). Extensive studies have demonstrated that ER stress plays an important role in the pathogenesis of various cardiovascular diseases such as heart failure, ischemic heart disease and atherosclerosis...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29684628/inflammatory-markers-and-their-possible-effects-on-cognitive-function-in-women-with-posttraumatic-stress-disorder
#6
Risa Imai, Hiroaki Hori, Mariko Itoh, Mingming Lin, Madoka Niwa, Keiko Ino, Sei Ogawa, Makiko Ishida, Atsushi Sekiguchi, Mie Matsui, Hiroshi Kunugi, Tatsuo Akechi, Toshiko Kamo, Yoshiharu Kim
Posttraumatic stress disorder (PTSD) has been associated with increased inflammation, albeit with some controversy. Another key feature of PTSD is compromised function in wide-ranging cognitive domains. Increased peripheral inflammation can contribute to cognitive dysfunction, although this relationship has not been studied in patients with PTSD. Here, we examined blood inflammatory markers in adult patients with PTSD compared to healthy controls taking account of potentially confounding effects of childhood maltreatment and comorbid major depressive disorder (MDD), and explored the association between inflammation and cognition...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29684613/low-or-excess-levels-of-dietary-cholesterol-impaired-immunity-and-aggravated-inflammation-response-in-young-grass-carp-ctenopharyngodon-idella
#7
Xiao-Zhong Wang, Wei-Dan Jiang, Lin Feng, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Xiao-Qiu Zhou
The present study explored the effect of cholesterol on the immunity and inflammation response in the immune organs (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella) fed graded levels of dietary cholesterol (0.041-1.526%) for 60 days and then infected with Aeromonas hydrophila for 14 days. The results showed that low levels of cholesterol (1) depressed the innate immune components [lysozyme (LZ), acid phosphatase (ACP), complements and antimicrobial peptides] and adaptive immune component [immunoglobulin M (IgM)], (2) up-regulated the mRNA levels of pro-inflammatory cytokines [interleukin 1β (IL-1β), IL-6, IL-8, IL-12p35, IL-12p40, IL-15, IL-17D, tumor necrosis factor α (TNF-α) and interferon γ2 (IFN-γ2)], partly due to the activated nuclear factor kappa B (NF-κB) signalling, and (3) down-regulated the mRNA levels of anti-inflammatory cytokines [IL-4/13B, IL-10, IL-11, transforming growth factor (TGF)-β1 and TGF-β2], partly due to the suppression of target of rapamycin (TOR) signalling in the immune organs of young grass carp...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684557/regiospecificity-of-a-novel-bacterial-lipoxygenase-from-myxococcus-xanthus-for-polyunsaturated-fatty-acids
#8
Jung-Ung An, Seung-Hye Hong, Deok-Kun Oh
Lipoxygenase (LOX) is the key enzyme involved in the synthesis of oxylipins as signaling compounds that are important for cell growth and development, inflammation, and pathogenesis in various organisms. The regiospecificity of LOX from Myxococcus xanthus, a gram-negative bacterium, was investigated. The enzyme catalyzed oxygenation at the n-9 position in C20 and C22 polyunsaturated fatty acids (PUFAs) to form 12S- and 14S-hydroxy fatty acids (HFAs), respectively, and oxygenation at the n-6 position in C18 PUFAs to form 13-HFAs...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684554/short-term-oral-gavage-administration-of-adenine-induces-a-model-of-fibrotic-kidney-disease-in-rats
#9
Chang Z Zhu, Kelly J Doyle, Arthur L Nikkel, Lauren Olsen, Marian T Namovic, Katherine Salte, Deborah Widomski, Zhi Su, Diana L Donnelly-Roberts, Murali M Gopalakrishnan, Steve McGaraughty
INTRODUCTION: The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression and can result in significant mortality. In the current study, the amount of adenine delivered to rats was controlled by utilizing oral gavage administration over a short period in an attempt to induce robust renal pathology while addressing variability and viability of the animals. METHODS: Adenine (150 or 200 mg/kg) was administered via oral gavage for 10 consecutive days, and assessed over a total of 20 days...
April 20, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29684510/the-rodent-tibia-fracture-model-a-critical-review-and-comparison-with-the-complex-regional-pain-syndrome-literature
#10
REVIEW
Frank Birklein, Alaa Ibrahim, Tanja Schlereth, Wade S Kingery
Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified as the primary source of cutaneous cytokines and NGF...
April 20, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29684507/angiotensin-ii-type-1a-receptors-in-the-subfornical-organ-modulate-neuroinflammation-in-the-hypothalamic-paraventricular-nucleus-in-heart-failure-rats
#11
Yang Yu, Shun-Guang Wei, Robert M Weiss, Robert B Felder
Inflammation in the hypothalamic paraventricular nucleus (PVN) contributes to neurohumoral excitation and its adverse consequences in systolic heart failure (HF). The stimuli that trigger inflammation in the PVN in HF are not well understood. Angiotensin II (AngII) has pro-inflammatory effects, and circulating levels of AngII increase in HF. The subfornical organ (SFO), a circumventricular structure that lacks an effective blood-brain barrier and senses circulating AngII, contains PVN-projecting neurons. We hypothesized that activation of AngII type 1a receptors (AT1a R) in the SFO induces neuroinflammation downstream in the PVN...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684478/vitamin-d-deficiency-promotes-prostatic-hyperplasia-in-middle-age-mice-through-exacerbating-local-inflammation
#12
Zhi-Hui Zhang, Biao Luo, Shen Xu, Lin Fu, Yuan-Hua Chen, Cheng Zhang, Hua Wang, Dong-Dong Xie, De-Xiang Xu
Vitamin D deficiency is especially prevalent in pregnant women and children. Our recent study demonstrated that vitamin D deficiency in early life disturbed testicular development. This study investigated the effects of vitamin D deficiency in early life on prostatic hyperplasia in middle-aged mice. In control group, dams and their male pups were fed with standard-chow diets. In VDD group, dams were fed with vitamin D deficient (VDD) diets throughout pregnancy and lactation. After weaning, male pups continued to be fed with VDD diets...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29684446/angiotensin-receptor-blocker-losartan-ameliorates-neuroinflammation-and-behavioral-consequences-of-lipopolysaccharide-injection
#13
Hossein Salmani, Mahmoud Hosseini, Farimah Beheshti, Yousef Baghcheghi, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Mohammad Naser Shafei, Majid Khazaei
AIMS: Neuroinflammation has a critical role in brain diseases. Angiotensin II (Ang II) is an important player in inflammation via stimulating of Ang II type 1 receptor (AT1R). In this study, the effects of losartan, an Ang II receptor blocker, on the brain inflammation, oxidative stress and behavioral consequences of lipopolysaccharide (LPS) injection were investigated. MAIN METHODS: Rats were intraperitoneally (i.p.) injected with 1 or 3 mg/kg losartan or saline for 24 continuous days...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684396/jsh-23-prevents-depressive-like-behaviors-in-mice-subjected-to-chronic-mild-stress-effects-on-inflammation-and-antioxidant-defense-in-the-hippocampus
#14
Qi Wang, Xiaomei Dong, Nannan Li, Yan Wang, Xiaofeng Guan, Yiwei Lin, Jiguang Kang, Xia Zhang, Yuchen Zhang, Xiaobai Li, Tianchao Xu
Nuclear factor-kappa B (NF-κB), which is reported to play an important role in the pathogenesis of depression, also has a central role in the genesis and progression of inflammation. Here, we have targeted the nuclear translocation of NF-κB using 4-methyl-N1-(3-phenyl-propyl)-benzene-1,2-diamine (JSH-23) to elucidate its role in depression. We investigated the antidepressant-like effects of JSH-23 in the chronic mild stress (CMS) mouse model, which is a valid, reasonably reliable, and useful model of depression...
April 20, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29684382/maternal-plasma-concentrations-of-macrophage-migration-inhibitory-factor-at-first-trimester-as-a-predictive-biomarker-of-preterm-delivery-in-chinese-women
#15
Hui Zhu, Mei-Jun Yang
BACKGROUND: Infection and/or inflammation have been proposed play role in the preterm delivery (PTD) pathogenesis. Macrophage migration inhibitory factor(MIF), a mediator of innate immunity and inflammation, is induced in various infections, including those that occur during pregnancy. We assessed the relation between maternal early pregnancy plasma concentrations of MIF and PTD. METHODS: Women were recruited before 14 weeks gestation and were followed up until delivery...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29684360/interleukin-6-drives-neutrophil-mediated-pulmonary-inflammation-associated-with-bacteraemia-in-murine-models-of-colitis
#16
Sean W Mateer, Andrea Mathe, Jessica Bruce, Gang Liu, Steven Maltby, Michael Fricker, Bridie J Goggins, Hock L Tay, Ellen Marks, Grace Burns, Richard Y Kim, Kyra Minahan, Marjorie M Walker, Robert C Callister, Paul S Foster, Jay C Horvat, Philip M Hansbro, Simon Keely
Inflammatory bowel disease (IBD) is associated with a number of immune-mediated extra-intestinal manifestations. Over half of all IBD patients have some form of respiratory pathology, most commonly neutrophil-mediated diseases such as bronchiectasis and chronic bronchitis. Using murine models of colitis, we aimed to identify the immune mechanisms driving pulmonary manifestations of IBD. We found increased neutrophil numbers in lung tissue associated with the pulmonary vasculature in both trinitrobenzenesulfonic acid- and dextran sulfate sodium-induced models of colitis...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684359/the-g-protein-coupled-receptor-alx-fpr2-regulates-adaptive-immune-responses-in-mouse-submandibular-glands
#17
Ching-Shuen Wang, Olga J Baker
ALX/FPR2 is a G-protein-coupled receptor that has multiple binding partners, including the endogenous lipid mediators resolvin D1 (RvD1), lipoxin A4 (LXA4 ), and the Ca2+ -dependent phospholipid-binding protein Annexin A1. Previous studies demonstrated that RvD1 activates ALX/FPR2 to resolve salivary gland inflammation in the NOD/ShiLtJ mouse model for Sjögren's syndrome. Moreover, mice lacking the ALX/FPR2 display an exacerbated salivary gland inflammation in response to lipopolysaccharide. Additionally, activation of ALX/FPR2 has been shown to be important for regulating antibody production in B cells...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684347/developmental-endothelial-locus-1-prevents-development-of-peritoneal-adhesions-in-mice
#18
Yan Fu, Jiaywei Tsauo, Yucheng Sun, Zhe Wang, Kun Yung Kim, Seung-Hwan Lee, Dong-Young Kim, Feifeng Jing, Dahae Lim, Ho-Young Song, Hoon Hyun, Eun Young Choi
Postoperative peritoneal adhesions, fibrous bands formed in the peritoneal cavity following surgery, represent a common, challenging and costly problem faced by surgeons and patients, for which effective therapeutic options are lacking. Since aberrant inflammation is one of the key mechanisms underlying peritoneal adhesion formation, here we set out to study the role of developmental endothelial locus-1 (Del-1), which has been recently identified as an endogenous inhibitor of inflammation, in the formation of postoperative peritoneal adhesions using a mouse model of peritoneal adhesions induced by ischemic buttons...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684222/liver-disease-in-a-residential-cohort-with-elevated-polychlorinated-biphenyl-exposures
#19
Heather B Clair, Christina M Pinkston, Shesh N Rai, Marian Pavuk, Nina D Dutton, Guy Brock, Russell A Prough, K Cameron Falkner, Craig J McClain, Matthew C Cave
Endocrine and metabolism disrupting chemicals (EDCs/MDCs) have been associated with environmental liver diseases including toxicant-associated steatohepatitis (TASH). TASH has previously been characterized by hepatocellular necrosis, disrupted intermediary metabolism, and liver inflammation. Polychlorinated biphenyls (PCBs) are environmental EDCs/MDCs associated with the genesis and progression of steatohepatitis in animal models and human liver injury in epidemiology studies. The cross-sectional Anniston Community Health Survey (ACHS) investigates ortho-substituted PCB exposures and health effects near a former PCB manufacturing complex...
April 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29684205/neurodegenerative-diseases-have-genetic-hallmarks-of-autoinflammatory-disease
#20
Robert I Richards, Sarah A Robertson, Daniel L Kastner
The notion that one common pathogenic pathway could account for the various clinically distinguishable, typically late-onset neurodegenerative diseases might appear unlikely given the plethora of diverse primary causes of neurodegeneration. On the contrary, an autoinflammatory pathogenic mechanism allows diverse genetic and environmental factors to converge into a common chain of causality. Inflammation has long been known to correlate with neurodegeneration. Until recently this relationship was seen as one of consequence rather than cause - with inflammatory cells and events acting to "clean up the mess" after neurological injury...
April 19, 2018: Human Molecular Genetics
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