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Fatemeh Nejat Pish-Kenari, Durdi Qujeq, Hossein Maghsoudi
Oesophageal adenocarcinoma is one of the most fatal tumours to affect the digestive tract and is the eighth most common malignancy worldwide. Gastro-oesophageal reflux has an important role in the incidence of adenocarcinoma of the oesophagus. Gastro-oesophageal reflux disease (GERD) is a multifactorial, acid-peptic disorder that results from the reflux of noxious material from the stomach into the oesophagus. The refluxed material causes the occurrence of oesophageal inflammation which creates a condition that is called reflux oesophagitis...
October 15, 2018: Journal of Cellular and Molecular Medicine
Leticia Burton, Gregory L. Falk, Stephen Parsons, Mel Cusi, Hans Van Der Wall
Objectives: Gastro-oesophageal reflux disease (GORD) is both common and troubling with a prevalence of 20-40%. We assessed the utility of a scintigraphic reflux study to evaluate the oesophageal and extra-oesophageal manifestation of disease compared to the standard tests such as pH monitoring and manometry. Methods: Patients were recruited into a prospective database of referrals to a tertiary referral center for either resistance to maximal medical therapy or extra-oesophageal symptoms of GORD...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
Reem Alfattouh, Nedaa Aldairi, Nazish Masud, Asma Awadalla
The retrospective study was planned to assess the outcome of extensive investigations done for infants admitted with apparent life-threatening event (ALTE), and comprised chart review of 275 infants admitted to King Abdul-Aziz Medical City (KAMC), Riyadh, Saudi Arabia, between 2012 and 2015. The outcome of each investigation was compared in terms of whether the test was performed or not performed, and, if performed, whether the test report was normal or abnormal. Also, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) was assessed for each test...
October 2018: JPMA. the Journal of the Pakistan Medical Association
S Uday, S Sakka, J H Davies, T Randell, V Arya, C Brain, M Tighe, J Allgrove, P Arundel, R Pryce, W Högler, N J Shaw
OBJECTIVES: Hypophosphataemic rickets (HR) is usually secondary to renal phosphate wasting but may occur secondary to reduced intake or absorption of phosphate. We describe a series of cases of HR associated with the use of Neocate® , an amino-acid based formula (AAF). METHODS: A retrospective review of cases with HR associated with AAF use presenting to centres across the United Kingdom. RESULTS: 10 cases were identified, over a 9 month period, all associated with Neocate® use...
September 28, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Mentore Ribolsi, Michele Cicala, Patrizia Zentilin, Matteo Neri, Aurelio Mauro, Konstantinos Efthymakis, Tommasangelo Petitti, Vincenzo Savarino, Roberto Penagini
BACKGROUND: The real size of the gastro-oesophageal reflux disease (GERD) population not responding to proton pump inhibitor (PPI) therapy has still not been fully elucidated. Causes of PPI refractoriness include incorrect diagnosis and lack of adherence to therapy, in terms of incorrect dosage and timing. AIMS: To evaluate the prevalence of refractoriness to optimal PPI therapy and the contribution of non-erosive reflux disease (NERD), reflux hypersensitivity, and functional heartburn, to PPI refractoriness...
October 7, 2018: Alimentary Pharmacology & Therapeutics
G L Falk, S C Little
We report a case of delayed presentation of a gastro-oesophageal fistula following a Heller myotomy and anterior fundoplication for achalasia in a 28-year-old man. After a period of symptom resolution following initial operation, dysphagia and severe heartburn commenced temporarily, related to non-steroidal anti-inflammatory drug (NSAID) use. Endoscopy demonstrated a secondary opening in the lower oesophagus and a barium swallow showed an oesophageal fistula to the stomach. Currently, reasonable symptom control has been obtained on double dose pantoprazole...
October 5, 2018: Annals of the Royal College of Surgeons of England
Joanne Wilkinson, Alan Wade, S Jane Thomas, Bartosz Jenner, Victoria Hodgkinson, Cathal Coyle
BACKGROUND: The alginate-antacid Gaviscon Double Action (Gaviscon DA) has a combined acid-neutralizing and reflux-suppressing action. Response to treatment in a symptomatic gastro-oesophageal reflux disease (GERD) population has not yet been tested in a large-scale clinical study. AIM: The aim of this study was to assess the efficacy and safety of Gaviscon DA compared with matched placebo tablets in the reduction of upper gastrointestinal symptoms in patients with GERD...
September 27, 2018: European Journal of Gastroenterology & Hepatology
Frances Notman, Terry Porteous, Peter Murchie, Christine M Bond
OBJECTIVES: Limited awareness of cancer symptoms results in patient delay in seeking help and contributes to delay in diagnosis. Few UK studies have investigated the potential for community pharmacists to facilitate earlier detection of cancer. This study aimed to investigate what actions patients take to manage their early cancer symptoms, to identify the extent of current community pharmacy involvement and to consider the potential role for community pharmacists to facilitate appropriate management and appraisal of potential early cancer symptoms...
September 25, 2018: International Journal of Pharmacy Practice
Ozkan Ilhan, Meltem Bor, Tansel Gunendi, Mustafa Erman Dorterler
Development of hypertrophic pyloric stenosis (HPS) after a few weeks of repair of an oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF) is a rare condition in early infancy. Although vomiting or feeding intolerance in operated cases of OA+TOF are attributed to oesophageal stricture, gastro-oesophageal reflux and oesophageal dysmotility, it may also be caused by HPS. Herein, we report a newborn infant who had OA and TOF operation on day 2 of life and diagnosed to have HPS at 15th day of age. Even though it is a rare anomaly, HPS should be kept on mind in the presence of persistent vomiting following repair of OA...
September 21, 2018: BMJ Case Reports
Brigida E Annicchiarico, Concetta Santonocito, Massimo Siciliano, Margherita Scapaticci, Donatella Guarino, Carmine Di Stasi, Maria E Riccioni, Enrico Di Stasio, Ettore Capoluongo, Antonio Gasbarrini
BACKGROUND: In liver cirrhosis, the renin-angiotensin-aldosterone system is involved in the pathogenesis of portal hypertension. Its effector, angiotensin II, is generated by angiotensin-converting enzyme (ACE). Serum ACE levels are affected by I/D polymorphism of its gene, with alleles I and D being associated, respectively, with lesser and greater activity of the enzyme. In cirrhotic patients carrying the ACE I allele, an increased risk for gastro-oesophageal varices was observed. AIM: The aim of our study was to evaluate whether ACE I/D polymorphism influenced portal pressure...
August 28, 2018: Digestive and Liver Disease
Giandomenico Roviello, Daniele Generali
No abstract text is available yet for this article.
October 2018: Lancet Oncology
Josep Tabernero, Paulo M Hoff, Lin Shen, Atsushi Ohtsu, Manish A Shah, Karen Cheng, Chunyan Song, Haiyan Wu, Jennifer Eng-Wong, Katherine Kim, Yoon-Koo Kang
BACKGROUND: Adding pertuzumab to trastuzumab and chemotherapy improves survival in HER2-positive early breast cancer and metastatic breast cancer. We assessed the efficacy and safety of pertuzumab versus placebo in combination with trastuzumab and chemotherapy in first-line HER2-positive metastatic gastric or gastro-oesophageal junction cancer. METHODS: JACOB was a double-blind, placebo-controlled, randomised, multicentre, phase 3 trial in patients aged 18 years or older with HER2-positive metastatic gastric or gastro-oesophageal junction cancer...
October 2018: Lancet Oncology
Xiaolong Qi, Annalisa Berzigotti, Andres Cardenas, Shiv Kumar Sarin
Clinically significant portal hypertension is associated with an increased risk of developing gastro-oesophageal varices and hepatic decompensation. Hepatic venous pressure gradient measurement and oesophagogastroduodenoscopy are the gold-standard methods for assessing clinically significant portal hypertension (hepatic venous pressure gradient ≥10 mm Hg) and gastro-oesophageal varices, respectively. However, invasiveness, cost, and feasibility limit their widespread use, especially if repeated and serial evaluations are required to assess the efficacy of pharmacotherapy...
October 2018: Lancet. Gastroenterology & Hepatology
Sebastiano Emanuele Torrisi, Ada Vancheri, Mauro Pavone, Gianluca Sambataro, Stefano Palmucci, Carlo Vancheri
Idiopathic Pulmonary Fibrosis (IPF) is a severe parenchymal lung disease characterized by an intense deposition of collagen in the interstitial spaces. The introduction of anti-fibrotic drugs increased patients' life expectancy highlighting the role of comorbidities in patients' management and prognosis. IPF is frequently associated with other diseases mainly because of its onset during middle age and sometimes because of the presence of common pathogenic pathways such as in the case of lung cancer. Comorbidities may differently influence prognosis of IPF patients...
September 4, 2018: Pulmonary Pharmacology & Therapeutics
Yin-Jiang Liu, Jun Fan, Huang-He He, Shu-Sheng Zhu, Qiu-Lan Chen, Rong-Hua Cao
OBJECTIVE: To investigate the characteristics and predictors for anastomotic leakage after oesophagectomy for oesophageal carcinoma from the perspective of anastomotic level. DESIGN: Retrospective cohort study. SETTINGS: A single tertiary medical centre in China. PARTICIPANTS: From January 2010 to December 2016, all patients with oesophageal cancer of the distal oesophagus or gastro-oesophageal junction undergoing elective oesophagectomy with a curative intent for oesophageal carcinoma with intrathoracic oesophagogastric anastomosis (IOA) versus cervical oesophagogastric anastomosis (COA) were included...
September 4, 2018: BMJ Open
Syeda Kashfi Qadri, Veena Logarajah, Shireen Anne Nah, Saumya Shekhar Jamuar
A 10-month-old girl, with spondyloepiphyseal dysplasia congenita and posterior cleft palate had presented at 23 days of life with history of feeding difficulties. A diagnosis of oropharyngeal dysphagia and gastro-oesophageal reflux disease was made, for which she was started on nasogastric tube feeding and oral ranitidine. However, she continued to have poor development of oropharyngeal skills, persistent reflux as well as poor growth and was planned for gastrostomy at 10 months of age. She underwent soluble upper gastrointestinal contrast study prior to gastrostomy placement to rule out anatomical causes of vomiting, which showed the greater curvature of the stomach to be lying above the lesser curvature, suggesting a diagnosis of gastric volvulus, likely chronic, given that she did not have a history of abdominal distension, irritability or recurrent vomiting...
August 23, 2018: BMJ Case Reports
Francesco Di Mattia, Robyn Fary, Kevin J Murray, Erin Howie, Anne Smith, Susan Morris
OBJECTIVE: To investigate a cohort of children with symptomatic joint hypermobility. METHODS: Case notes for 318 children with joint hypermobility attending a rheumatology clinic were reviewed for clinical presentation, medical history, psychosocial factors and physical examination findings. Seven key variables were extracted and used as indicator variables in a latent class analysis to estimate the presence and number of subgroups of children with symptomatic joint hypermobility...
August 17, 2018: Archives of Disease in Childhood
A Laliotis, T Hettiarachchi, F Rashid, A Hindmarsh, V Sujendran
Surgical management of oesophageal and gastro-oesophageal junction malignancies is one of the most challenging situations confronting the surgeon. Attaining a complete circumferential resection margin of lower-third oesophageal and gastro-oesophageal junction locally advanced carcinomas requires en-bloc resection of the hiatus and all the peri-oesophageal tissue and pleura. This results in an increased risk of herniation of the abdominal organs through the enlarged hiatus, which carries significant risk of morbidity and mortality...
August 16, 2018: Annals of the Royal College of Surgeons of England
Ganesh Raghu, Carlos A Pellegrini, Eric Yow, Kevin R Flaherty, Keith Meyer, Imre Noth, Mary Beth Scholand, John Cello, Lawrence A Ho, Sudhakar Pipavath, Joyce S Lee, Jules Lin, James Maloney, Fernando J Martinez, Ellen Morrow, Marco G Patti, Stan Rogers, Paul J Wolters, Robert Yates, Kevin J Anstrom, Harold R Collard
BACKGROUND: Abnormal acid gastro-oesophageal reflux (GER) is hypothesised to play a role in progression of idiopathic pulmonary fibrosis (IPF). We aimed to determine whether treatment of abnormal acid GER with laparoscopic anti-reflux surgery reduces the rate of disease progression. METHODS: The WRAP-IPF trial was a randomised controlled trial of laparoscopic anti-reflux surgery in patients with IPF and abnormal acid GER recruited from six academic centres in the USA...
September 2018: Lancet Respiratory Medicine
Ujjal Poddar
BACKGROUND: Gastro-oesophageal reflux (GER) and gastro-oesophageal reflux disease (GERD) are common in infants and children. AIMS: To review the recent literature on GERD in children and to outline the approach to diagnosis and management. METHODS: A literature search in PubMed was conducted with regard to the prevalence, clinical features, diagnosis and management of GER and GERD in children with special attention to low- and middle-income countries...
August 6, 2018: Paediatrics and International Child Health
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