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A Laliotis, T Hettiarachchi, F Rashid, A Hindmarsh, V Sujendran
Surgical management of oesophageal and gastro-oesophageal junction malignancies is one of the most challenging situations confronting the surgeon. Attaining a complete circumferential resection margin of lower-third oesophageal and gastro-oesophageal junction locally advanced carcinomas requires en-bloc resection of the hiatus and all the peri-oesophageal tissue and pleura. This results in an increased risk of herniation of the abdominal organs through the enlarged hiatus, which carries significant risk of morbidity and mortality...
August 16, 2018: Annals of the Royal College of Surgeons of England
Ganesh Raghu, Carlos A Pellegrini, Eric Yow, Kevin R Flaherty, Keith Meyer, Imre Noth, Mary Beth Scholand, John Cello, Lawrence A Ho, Sudhakar Pipavath, Joyce S Lee, Jules Lin, James Maloney, Fernando J Martinez, Ellen Morrow, Marco G Patti, Stan Rogers, Paul J Wolters, Robert Yates, Kevin J Anstrom, Harold R Collard
BACKGROUND: Abnormal acid gastro-oesophageal reflux (GER) is hypothesised to play a role in progression of idiopathic pulmonary fibrosis (IPF). We aimed to determine whether treatment of abnormal acid GER with laparoscopic anti-reflux surgery reduces the rate of disease progression. METHODS: The WRAP-IPF trial was a randomised controlled trial of laparoscopic anti-reflux surgery in patients with IPF and abnormal acid GER recruited from six academic centres in the USA...
August 9, 2018: Lancet Respiratory Medicine
Ujjal Poddar
BACKGROUND: Gastro-oesophageal reflux (GER) and gastro-oesophageal reflux disease (GERD) are common in infants and children. AIMS: To review the recent literature on GERD in children and to outline the approach to diagnosis and management. METHODS: A literature search in PubMed was conducted with regard to the prevalence, clinical features, diagnosis and management of GER and GERD in children with special attention to low- and middle-income countries...
August 6, 2018: Paediatrics and International Child Health
Hazel Lote, Nicola Valeri, Ian Chau
Human epidermal growth factor receptor 2 (HER2)-inhibition is an important therapeutic strategy in HER2-amplified gastro-oesophageal cancer (GOC). A significant proportion of GOC patients display HER2 amplification, yet HER2 inhibition in these patients has not displayed the success seen in HER2 amplified breast cancer. Much of the current evidence surrounding HER2 has been obtained from studies in breast cancer, and we are only recently beginning to improve our understanding of HER2-amplified GOC. Whilst there are numerous licensed HER2 inhibitors in breast cancer, trastuzumab remains the only licensed HER2 inhibitor for HER2-amplified GOC...
July 15, 2018: World Journal of Gastrointestinal Oncology
John Hanrahan, Joseph Frantzias, Jose P Lavrador, Istvan Bodi, Bassel Zebian
INTRODUCTION: Arachnoid cysts (ACs) account for a small proportion of all intracranial lesions. They are often incidental but can become symptomatic and even cause a threat to life. Symptoms are usually due to direct compression of neural elements and/or raised intracranial pressure. CASE REPORT: We report the case of an infant with an enlarging posterior fossa arachnoid cyst (PFAC) causing torticollis and gastro-oesophageal reflux (GOR), the combination of which had been previously unreported in this context...
July 30, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
M J McDonnell, D O'Toole, C Ward, J P Pearson, J L Lordan, A De Soyza, M Loebinger, J D Chalmers, J G Laffey, R M Rutherford
Gastro-oesophageal reflux disease (GORD) is a common comorbidity in bronchiectasis, and is often associated with poorer outcomes. The cause and effect relationship between GORD and bronchiectasis has not yet been fully elucidated and a greater understanding of the pathophysiology of the interaction and potential therapies is required. This review explores the underlying pathophysiology of GORD, its clinical presentation, risk factors, commonly applied diagnostic tools, and a detailed synthesis of original articles evaluating the prevalence of GORD, its influence on disease severity and current management strategies within the context of bronchiectasis...
August 2018: Respiratory Medicine
Y-J Bang, E Yañez Ruiz, E Van Cutsem, K-W Lee, L Wyrwicz, M Schenker, M Alsina, M-H Ryu, H-C Chung, L Evesque, S-E Al-Batran, S H Park, M Lichinitser, N Boku, M H Moehler, J Hong, H Xiong, R Hallwachs, I Conti, J Taieb
Background: There currently are no internationally recognised treatment guidelines for patients with advanced gastric cancer/gastro-oesophageal junction cancer (GC/GEJC) in whom two prior lines of therapy have failed. The randomised, phase 3 JAVELIN Gastric 300 trial compared avelumab vs physician's choice of chemotherapy as third-line therapy in patients with advanced GC/GEJC. Patients and methods: Patients with unresectable, recurrent, locally advanced, or metastatic GC/GEJC were recruited at 147 sites globally...
July 24, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
C Hopkins, P Surda, F Bast, R Hettige, A Walker, P W Hellings
Prevention of chronicity of disease and minimising its impact with individualized treatment is a fundamental tenet of precision medicine. A review of the literature has been undertaken to explore how this may apply to chronic rhinosinusitis (CRS). Prevention may be thought of across 3 main domains. Primary prevention of CRS focuses on the avoidance of exposure to environmental factors associated with increased incidence of disease. This includes avoidance of tobacco smoke and occupational toxins. Although allergic rhinitis, respiratory infections and gastro-oesophageal reflux have been shown to be risk factors, there is no evidence as yet that treatment of these conditions is associated with reduced incidence of CRS...
July 27, 2018: Rhinology
Nurten Ozen, Stijn Blot, Volkan Ozen, Ayse Arikan Donmez, Pınar Gurun, Fatma Ilknur Cinar, Sonia Labeau
BACKGROUND: Gastric residual volume measurement is routinely used to evaluate the feeding tolerance and gastro-oesophageal reflux in patients receiving enteral feeding therapy in the intensive care unit. However, little supportive evidence for this intervention is available as the usefulness of gastric residual volume measurements in patients receiving enteral feeding therapy in the intensive care is controversial. AIM: The aim of this study was to assess the practice of intensive care unit nurses related to gastric residual volume measurement in patients receiving enteral nutrition...
July 24, 2018: Nursing in Critical Care
Nina Droz, Julie Chaleard, Marine Laurent, Laurent Mandelbrot, Bogdan Cojocaru
More and more newborns are being taken to paediatric emergency departments in France. A study was carried out between 2013 and 2015 to identify the reasons for non-emergency consultations, and to analyse the risk factors. The most common diagnoses were: rhinitis, gastro-oesophageal reflux and colic. There were three main predictive factors for consultation: the young age of the mother, primiparity and the short stay in the maternity hospital.
July 2018: Soins. Pédiatrie, Puériculture
Kamal Mahawar, Chetan Parmar, Yitka Graham
INTRODUCTION: One Anastomosis Gastric Bypass (OAGB) is now a recognised mainstream bariatric procedure being adopted by an increasing number of surgeons. The purpose of this review was to present an evidence-based summary of its key technical aspects and prevention and management of its specific complications. EVIDENCE ACQUISITION: We examined PubMed for all published articles on OAGB, including the ones published under one of its various other names. EVIDENCE SYNTHESIS: An ideal OAGB procedure has a long, narrow pouch constructed carefully to avoid going too close to the greater curvature of the stomach especially at the bottom of the pouch, and maintains a safe distance from the angle of His...
July 18, 2018: Minerva Chirurgica
Elda Dermyshi, Charley Mackie, Phoebe Kigozi, Bernard Schoonakker, Jon Dorling
Background: Gastro-oesophageal reflux is prevalent in preterm infants. Despite widespread use in clinical practice, there is still much controversy over the efficacy and safety of drug interventions, particularly antacid therapy. Objective: To systematically review the effects of antacid therapy on preterm infants with symptoms of gastro-oesophageal reflux, and to assess the safety of these interventions. Methods: We carried out an electronic search of the Cochrane central register of controlled trials (CENTRAL, The Cochrane Library), MEDLINE (1966-present), EMBASE (1980-present) and CINAHL (1982-present) as well as other online sources...
2018: BMJ Paediatrics Open
T'ng Chang Kwok, Shalini Ojha, Jon Dorling
No abstract text is available yet for this article.
2018: BMJ paediatrics open
Hey-Long Ching, Ailish Healy, Victoria Thurston, Melissa F Hale, Reena Sidhu, Mark E McAlindon
AIM: To test the feasibility and performance of a novel upper gastrointestinal (GI) capsule endoscope using a nurse-led protocol. METHODS: We conducted a prospective cohort analysis of patients who declined gastroscopy (oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water (containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol...
July 14, 2018: World Journal of Gastroenterology: WJG
M A Amer, M D Smith, C H Khoo, G P Herbison, J L McCall
BACKGROUND: Proton pump inhibitors are the mainstay of treatment for gastro-oesophageal reflux disease, but are associated with ongoing costs and side-effects. Antireflux surgery is cost-effective and is preferred by many patients. A total (360o or Nissen) fundoplication is the traditional procedure, but other variations including partial fundoplications are also commonly performed, with the aim of achieving durable reflux control with minimal dysphagia. Many RCTs and some pairwise meta-analyses have compared some of these procedures but there is still uncertainty about which, if any, is superior...
July 13, 2018: British Journal of Surgery
Katarzyna Kozak, Barbara Łochowska, Józef Kozak, Mariusz Łochowski
No abstract text is available yet for this article.
2018: Przegla̜d Gastroenterologiczny
Chetan D Parmar, Kamal K Mahawar
The One Anastomosis (Mini) Gastric Bypass is rapidly gaining acceptance. This review reports cumulative results of 12,807 procedures in obese patients with a mean age of 41.18 years and BMI of 46.6 kg/m2 . The overall mortality was 0.10% and the leak rate was 0.96%. The follow-up duration ranged from 6 months to 12 years. A marginal ulceration rate of 2.7% and an anaemia rate of 7.0% were reported. Approximately 2.0% of patients reported postoperative gastro-oesophageal reflux and 0.71% developed malnutrition...
July 11, 2018: Obesity Surgery
Steen Riisgaard de Blanck, Jonas Scherman-Rydhög, Mette Siemsen, Merete Christensen, Lene Baeksgaard, Rasmus Irming Jølck, Lena Specht, Thomas Lars Andresen, Gitte Fredberg Persson
OBJECTIVE: To evaluate the feasibility of a new liquid fiducial marker for use in image-guided radiotherapy for oesophageal cancer. METHODS: Liquid fiducial markers were implanted in patients with metastatic or inoperable locally advanced oesophageal or gastro-oesophageal junction cancer receiving radiotherapy. Markers were implanted using a conventional gastroscope equipped with a 22 G Wang needle. Marker visibility was evaluated on fluoroscopy, CT, MRI and cone beam CT scans...
July 9, 2018: British Journal of Radiology
Andrew G N Robertson, Andrew J Cameron, Brian Joyce, Phil Le Page, Bruce Tulloh, Andrew C de Beaux, Peter J Lamb
Introduction: There are concerns that laparoscopic sleeve gastrectomy (LSG) can cause severe gastro-oesophageal reflux disease (GORD). The aim of this study was to assess GORD symptoms and quality of life following LSG. Methods: A prospective study of patients undergoing LSG (2014-2016) was performed with follow-up by DeMeester Reflux/Regurgitation Score, Bariatric Quality of Life Index (BQLI) and Bariatric Analysis and Reporting Outcome System (BAROS) Score pre-operatively, 6 months and 1-year post-operatively...
June 27, 2018: Journal of Minimal Access Surgery
Lorenzo Fornaro, Enrico Vasile, Giuseppe Aprile, Thorsten Oliver Goetze, Caterina Vivaldi, Alfredo Falcone, Salah-Eddin Al-Batran
Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting...
June 18, 2018: Cancer Treatment Reviews
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